NO882613L - Ved metylamino-nitrogener substituerte derivater av staurosporin. - Google Patents

Ved metylamino-nitrogener substituerte derivater av staurosporin.

Info

Publication number
NO882613L
NO882613L NO882613A NO882613A NO882613L NO 882613 L NO882613 L NO 882613L NO 882613 A NO882613 A NO 882613A NO 882613 A NO882613 A NO 882613A NO 882613 L NO882613 L NO 882613L
Authority
NO
Norway
Prior art keywords
staurosporin
substituted derivatives
methylamino
formula
nitrogens substituted
Prior art date
Application number
NO882613A
Other languages
English (en)
Other versions
NO882613D0 (no
NO170634C (no
NO170634B (no
Inventor
Giorgio Caravatti
Andreas Fredenhagen
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO882613D0 publication Critical patent/NO882613D0/no
Publication of NO882613L publication Critical patent/NO882613L/no
Publication of NO170634B publication Critical patent/NO170634B/no
Publication of NO170634C publication Critical patent/NO170634C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
NO882613A 1987-06-15 1988-06-14 Analogifremgangsmaate ved fremstilling av ved metylaminonitrogenet substituerte derivater av staurosporin NO170634C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH224487 1987-06-15
CH144088 1988-04-19

Publications (4)

Publication Number Publication Date
NO882613D0 NO882613D0 (no) 1988-06-14
NO882613L true NO882613L (no) 1988-12-16
NO170634B NO170634B (no) 1992-08-03
NO170634C NO170634C (no) 1992-11-11

Family

ID=25687663

Family Applications (1)

Application Number Title Priority Date Filing Date
NO882613A NO170634C (no) 1987-06-15 1988-06-14 Analogifremgangsmaate ved fremstilling av ved metylaminonitrogenet substituerte derivater av staurosporin

Country Status (20)

Country Link
EP (1) EP0296110B1 (no)
JP (1) JP2708047B2 (no)
KR (1) KR970001529B1 (no)
AT (1) ATE134375T1 (no)
AU (1) AU617324B2 (no)
CA (1) CA1337763C (no)
DE (1) DE3855015D1 (no)
DK (1) DK175507B1 (no)
ES (1) ES2083956T3 (no)
FI (1) FI89362C (no)
GR (1) GR3019064T3 (no)
HK (1) HK1003788A1 (no)
HU (1) HU201329B (no)
IE (1) IE70523B1 (no)
IL (1) IL86632A0 (no)
MY (1) MY104316A (no)
NO (1) NO170634C (no)
NZ (1) NZ225018A (no)
PT (1) PT87719B (no)
YU (1) YU115488A (no)

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JP2766360B2 (ja) * 1988-02-04 1998-06-18 協和醗酵工業株式会社 スタウロスポリン誘導体
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
USRE36736E (en) * 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
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US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
EP0540185A1 (en) * 1991-10-10 1993-05-05 Schering Corporation 4'-(N-substituted-N-oxide)staurosporine derivatives
EP0541486A1 (de) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclische Konjugate
WO1993018771A1 (fr) * 1992-03-24 1993-09-30 Asahi Kasei Kogyo Kabushiki Kaisha INHIBITEUR DE L'AGGLUTINATION PLAQUETTAIRE CONTENANT UN DERIVE DE STAUROSPORINE η-LACTAME
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5621101A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5621100A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. K-252a derivatives for treatment of neurological disorders
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
EP0630898B1 (en) * 1992-09-21 2001-11-28 Kyowa Hakko Kogyo Co., Ltd. Thrombocytopenia remedy
EP2324829A1 (en) 1993-01-28 2011-05-25 Boston Scientific Limited Therapeutic inhibitors of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
PH30300A (en) * 1993-05-07 1997-01-20 Ciba Geigy Ag Polycyclic compounds and processes for the preparation thereof
WO1995002057A1 (en) * 1993-07-09 1995-01-19 The Institute Of Cancer Research Protein tyrosine kinase and ligands thereof
GB9325395D0 (en) * 1993-12-11 1994-02-16 Ciba Geigy Ag Compositions
EP0711557A1 (de) * 1994-11-09 1996-05-15 Ciba-Geigy Ag Pharmazeutische Formulierungsgrundlage
UA67725C2 (en) 1996-06-03 2004-07-15 Cephalon Inc K-252a derivatives and a method for improvement of functioning and cell survival enhancement
US6875865B1 (en) 1996-06-03 2005-04-05 Cephalon, Inc. Selected derivatives of K-252a
CN1108799C (zh) 1996-06-25 2003-05-21 塞弗朗公司 K－252a衍生物用于治疗外周或中枢神经系统疾病以及细胞因子超量生产的用途
ES2226120T3 (es) 1997-03-31 2005-03-16 Boston Scientific Limited Inhibidor terapeutico de celulas del musculo liso vascular.
DE69912304T2 (de) * 1998-11-23 2004-07-22 Novartis Ag Verwendung von staurosporine derivaten zur behandlung von okularen neovaskularen erkrankungen
RU2322981C2 (ru) 2001-02-19 2008-04-27 Новартис Аг Комбинация и способ предупреждения рака молочной железы
PT1392313E (pt) 2001-05-16 2007-07-17 Novartis Ag Combinação que compreende n - ( 5- [ 4- ( metil-piperazinomrtil ) - benxoilamido ] - 2 -metilfenil ) - 4 -( 3 - piridil ) - 2 - pirimidina-amina e um agente quimioterapêutico
KR100926194B1 (ko) * 2001-10-30 2009-11-09 노파르티스 아게 Ｆｌｔ３ 수용체 티로신 키나아제 활성의 억제제로서의스타우로스포린 유도체
US6887864B2 (en) 2002-03-12 2005-05-03 Hoffmann-La Roche Inc. Azepane derivatives
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
JP5227492B2 (ja) 2002-05-16 2013-07-03 ノバルティス アーゲー 癌におけるｅｄｇレセプター結合剤の使用
EP2319493A3 (en) * 2002-07-23 2011-07-27 Novartis AG Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
JP4944613B2 (ja) 2003-05-19 2012-06-06 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
US20040246627A1 (en) * 2003-06-06 2004-12-09 Durrum Thomas M. Disc drive pivot bearing assembly
CA2533861A1 (en) 2003-08-08 2005-02-17 Novartis Ag Combinations comprising staurosporines
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
AU2005279344B2 (en) * 2004-08-31 2009-11-12 Novartis Ag Use of midostaurin for treating gastrointestinal stromal tumors
JO2897B1 (en) * 2004-11-05 2015-09-15 نوفارتيس ايه جي Organic compounds
AU2006314444C1 (en) 2005-11-21 2018-01-04 Novartis Ag Neuroendocrine tumor treatment using mTOR inhibitors
WO2010071794A1 (en) 2008-12-18 2010-06-24 Novartis Ag New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
CA2747558A1 (en) 2008-12-18 2010-07-15 Novartis Ag New salts
IL294514A (en) 2008-12-18 2022-09-01 Novartis Ag 1-[4-[1[(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid mipomarate salt
EP2327706A1 (en) 2009-11-30 2011-06-01 Novartis AG Polymorphous forms III and IV of N-benzoyl-staurosporine
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8846712B2 (en) 2011-09-12 2014-09-30 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013167403A1 (en) 2012-05-09 2013-11-14 Sanofi Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors
WO2019215759A1 (en) * 2018-05-09 2019-11-14 Alaparthi Lakshmi Prasad An improved process for preparation of midostaurin
EP4058465A1 (en) 2019-11-14 2022-09-21 Cohbar Inc. Cxcr4 antagonist peptides
IT202000004291A1 (it) * 2020-03-02 2021-09-02 Indena Spa Processo per la purificazione di alcaloidi indolo carbazolici
CN112812129A (zh) * 2020-12-31 2021-05-18 浙江海正药业股份有限公司 米哚妥林的新晶型及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2766360B2 (ja) * 1988-02-04 1998-06-18 協和醗酵工業株式会社 スタウロスポリン誘導体

Also Published As

Publication number Publication date
FI882808A0 (fi) 1988-06-13
JPS6434989A (en) 1989-02-06
HU201329B (en) 1990-10-28
HUT47587A (en) 1989-03-28
DK175507B1 (da) 2004-11-15
DE3855015D1 (de) 1996-03-28
GR3019064T3 (en) 1996-05-31
AU1757188A (en) 1988-12-15
ES2083956T3 (es) 1996-05-01
NO882613D0 (no) 1988-06-14
EP0296110A3 (de) 1991-02-27
IL86632A0 (en) 1988-11-30
FI882808A (fi) 1988-12-16
FI89362C (fi) 1993-09-27
KR970001529B1 (ko) 1997-02-11
AU617324B2 (en) 1991-11-28
NO170634C (no) 1992-11-11
YU115488A (en) 1989-12-31
NO170634B (no) 1992-08-03
HK1003788A1 (en) 1998-11-06
EP0296110A2 (de) 1988-12-21
CA1337763C (en) 1995-12-19
ATE134375T1 (de) 1996-03-15
NZ225018A (en) 1990-09-26
DK324888A (da) 1988-12-16
JP2708047B2 (ja) 1998-02-04
IE881787L (en) 1988-12-15
PT87719A (pt) 1988-07-01
DK324888D0 (da) 1988-06-14
IE70523B1 (en) 1996-12-11
PT87719B (pt) 1992-10-30
EP0296110B1 (de) 1996-02-21
MY104316A (en) 1994-03-31
FI89362B (fi) 1993-06-15
KR890000494A (ko) 1989-03-15

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Legal Events

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MK1K Patent expired