NO882613L - BY METHYLAMINO NITROGENS SUBSTITUTED DERIVATIVES OF STAUROSPORIN. - Google Patents
BY METHYLAMINO NITROGENS SUBSTITUTED DERIVATIVES OF STAUROSPORIN.Info
- Publication number
- NO882613L NO882613L NO882613A NO882613A NO882613L NO 882613 L NO882613 L NO 882613L NO 882613 A NO882613 A NO 882613A NO 882613 A NO882613 A NO 882613A NO 882613 L NO882613 L NO 882613L
- Authority
- NO
- Norway
- Prior art keywords
- staurosporin
- substituted derivatives
- methylamino
- formula
- nitrogens substituted
- Prior art date
Links
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical class C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title abstract 3
- -1 METHYLAMINO Chemical class 0.000 title 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
N-Substituted derivatives of staurosporin of the formula [Stau]-N(CH3)-R (I> in which [Stau] represents the radical of the sub-formula <IMAGE> in which R represents a hydrocarbyl R<0> or an acyl Ac, which preferably have at most 30 C atoms, and salts of compounds of the formula I having salt-forming properties, are distinguished as selective inhibitors of protein kinase C. They are prepared by conventional alkylation or acylation of staurosporin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH224487 | 1987-06-15 | ||
| CH144088 | 1988-04-19 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO882613D0 NO882613D0 (en) | 1988-06-14 |
| NO882613L true NO882613L (en) | 1988-12-16 |
| NO170634B NO170634B (en) | 1992-08-03 |
| NO170634C NO170634C (en) | 1992-11-11 |
Family
ID=25687663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO882613A NO170634C (en) | 1987-06-15 | 1988-06-14 | ANALOGY PROCEDURE FOR THE PREPARATION OF STAUROSPORINE SUBSTITUTED DERIVATIVES BY THE METYLAMINON NITROGEN |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0296110B1 (en) |
| JP (1) | JP2708047B2 (en) |
| KR (1) | KR970001529B1 (en) |
| AT (1) | ATE134375T1 (en) |
| AU (1) | AU617324B2 (en) |
| CA (1) | CA1337763C (en) |
| DE (1) | DE3855015D1 (en) |
| DK (1) | DK175507B1 (en) |
| ES (1) | ES2083956T3 (en) |
| FI (1) | FI89362C (en) |
| GR (1) | GR3019064T3 (en) |
| HK (1) | HK1003788A1 (en) |
| HU (1) | HU201329B (en) |
| IE (1) | IE70523B1 (en) |
| IL (1) | IL86632A0 (en) |
| MY (1) | MY104316A (en) |
| NO (1) | NO170634C (en) |
| NZ (1) | NZ225018A (en) |
| PT (1) | PT87719B (en) |
| YU (1) | YU115488A (en) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62220196A (en) * | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | Ucn-01 and production thereof |
| WO1989007105A1 (en) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
| IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
| USRE36736E (en) * | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
| DE3924538A1 (en) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | INDOLOCARBAZOL AND THEIR USE |
| US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
| US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
| WO1993007153A1 (en) * | 1991-10-10 | 1993-04-15 | Schering Corporation | 4'-(n-substituted-n-oxide)staurosporine derivatives |
| EP0541486A1 (en) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclic conjugates |
| WO1993018771A1 (en) * | 1992-03-24 | 1993-09-30 | Asahi Kasei Kogyo Kabushiki Kaisha | PLATELET AGGLUTINATION INHIBITOR CONTAINING STAUROSPORINE η-LACTAM DERIVATIVE |
| US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5674867A (en) * | 1992-09-21 | 1997-10-07 | Kyowa Hakko Kogyo Co., Ltd. | Indolocarbazole derivatives and therapeutic method for stimulating megakaicyocyte production |
| ATE485825T1 (en) | 1993-01-28 | 2010-11-15 | Boston Scient Ltd | THERAPEUTIC INHIBITORS OF VASCULAR SMOOTH CELLS |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| PH30300A (en) * | 1993-05-07 | 1997-01-20 | Ciba Geigy Ag | Polycyclic compounds and processes for the preparation thereof |
| WO1995002057A1 (en) * | 1993-07-09 | 1995-01-19 | The Institute Of Cancer Research | Protein tyrosine kinase and ligands thereof |
| GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
| EP0711556A1 (en) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Intravenous solutions containing staurosporine derivatives |
| US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
| UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
| US6184217B1 (en) | 1996-06-25 | 2001-02-06 | Cephalon, Inc. | Use of K-252a derivative |
| BR9808109A (en) | 1997-03-31 | 2000-03-08 | Neorx Corp | Therapeutic smooth muscle vascular cell inhibitor |
| JP2002530342A (en) * | 1998-11-23 | 2002-09-17 | ノバルティス アクチエンゲゼルシャフト | Use of staurosporine derivatives for the treatment of ocular neovascular diseases |
| ES2728739T3 (en) | 2001-02-19 | 2019-10-28 | Novartis Pharma Ag | Rapamycin derivative for the treatment of a solid tumor associated with deregulated angiogenesis |
| BR0209647A (en) | 2001-05-16 | 2004-07-27 | Novartis Ag | A combination comprising n- {5- [4- (4-methyl-piperazine-methyl) -benzoylamido] -2-methyl-phenyl} -4- (3-pyridyl) -2-pyrimidine-amine and a chemotherapeutic agent |
| TWI302836B (en) * | 2001-10-30 | 2008-11-11 | Novartis Ag | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
| US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| CN1652757B (en) | 2002-05-16 | 2012-02-08 | 诺瓦提斯公司 | Use of EDG receptor binding agents in cancer |
| CN101897662B (en) * | 2002-07-23 | 2013-05-22 | 诺瓦提斯公司 | Ophtalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent |
| US7417065B2 (en) | 2003-05-19 | 2008-08-26 | Irm Llc | Immunosuppressant compounds and compositions |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| US20040246627A1 (en) * | 2003-06-06 | 2004-12-09 | Durrum Thomas M. | Disc drive pivot bearing assembly |
| MXPA06001524A (en) | 2003-08-08 | 2006-05-15 | Novartis Ag | Combinations comprising staurosporines. |
| TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
| GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| CA2576926C (en) * | 2004-08-31 | 2012-10-02 | Novartis Ag | Use of midostaurin for treating gastrointestinal stromal tumors |
| JO2897B1 (en) * | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
| KR20140012218A (en) | 2005-11-21 | 2014-01-29 | 노파르티스 아게 | Neuroendocrine tumor treatment using mtor inhibitors |
| CN102256942B (en) | 2008-12-18 | 2013-07-24 | 诺瓦提斯公司 | New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzyl) -azetidine-3-formic acid |
| RU2011129229A (en) | 2008-12-18 | 2013-01-27 | Новартис Аг | NEW SALTS |
| SI2379497T1 (en) | 2008-12-18 | 2013-12-31 | Novartis Ag | Hemifumarate salt of 1-(4-(1-(4-cyclohexyl-3-trifluoromethyl- benzyloxyimino)-ethyl)-2-ethyl-benzyl)-a zetidine-3-carboxylic acid |
| EP2327706A1 (en) | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013167403A1 (en) | 2012-05-09 | 2013-11-14 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
| WO2019215759A1 (en) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | An improved process for preparation of midostaurin |
| WO2021097256A1 (en) | 2019-11-14 | 2021-05-20 | Cohbar, Inc. | Cxcr4 antagonist peptides |
| IT202000004291A1 (en) * | 2020-03-02 | 2021-09-02 | Indena Spa | PROCESS FOR THE PURIFICATION OF CARBAZOLIC INDOLE ALKALOIDS |
| CN112812129A (en) * | 2020-12-31 | 2021-05-18 | 浙江海正药业股份有限公司 | Novel crystalline form of midostaurin, process for its preparation and its use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989007105A1 (en) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
-
1988
- 1988-06-06 IL IL86632A patent/IL86632A0/en not_active IP Right Cessation
- 1988-06-09 ES ES88810383T patent/ES2083956T3/en not_active Expired - Lifetime
- 1988-06-09 MY MYPI88000629A patent/MY104316A/en unknown
- 1988-06-09 DE DE3855015T patent/DE3855015D1/en not_active Expired - Lifetime
- 1988-06-09 EP EP88810383A patent/EP0296110B1/en not_active Expired - Lifetime
- 1988-06-09 AT AT88810383T patent/ATE134375T1/en not_active IP Right Cessation
- 1988-06-10 AU AU17571/88A patent/AU617324B2/en not_active Expired
- 1988-06-13 FI FI882808A patent/FI89362C/en active IP Right Grant
- 1988-06-13 CA CA000569303A patent/CA1337763C/en not_active Expired - Lifetime
- 1988-06-14 PT PT87719A patent/PT87719B/en not_active IP Right Cessation
- 1988-06-14 HU HU883048A patent/HU201329B/en unknown
- 1988-06-14 NZ NZ225018A patent/NZ225018A/en unknown
- 1988-06-14 NO NO882613A patent/NO170634C/en not_active IP Right Cessation
- 1988-06-14 DK DK198803248A patent/DK175507B1/en not_active IP Right Cessation
- 1988-06-14 IE IE178788A patent/IE70523B1/en not_active IP Right Cessation
- 1988-06-14 YU YU01154/88A patent/YU115488A/en unknown
- 1988-06-14 KR KR1019880007102A patent/KR970001529B1/en not_active IP Right Cessation
- 1988-06-15 JP JP63145937A patent/JP2708047B2/en not_active Expired - Lifetime
-
1996
- 1996-02-22 GR GR960400221T patent/GR3019064T3/en unknown
-
1998
- 1998-04-04 HK HK98102862A patent/HK1003788A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK175507B1 (en) | 2004-11-15 |
| FI89362C (en) | 1993-09-27 |
| EP0296110A3 (en) | 1991-02-27 |
| YU115488A (en) | 1989-12-31 |
| AU617324B2 (en) | 1991-11-28 |
| KR890000494A (en) | 1989-03-15 |
| EP0296110B1 (en) | 1996-02-21 |
| NZ225018A (en) | 1990-09-26 |
| PT87719B (en) | 1992-10-30 |
| HK1003788A1 (en) | 1998-11-06 |
| IE881787L (en) | 1988-12-15 |
| FI89362B (en) | 1993-06-15 |
| EP0296110A2 (en) | 1988-12-21 |
| ATE134375T1 (en) | 1996-03-15 |
| ES2083956T3 (en) | 1996-05-01 |
| HU201329B (en) | 1990-10-28 |
| KR970001529B1 (en) | 1997-02-11 |
| AU1757188A (en) | 1988-12-15 |
| CA1337763C (en) | 1995-12-19 |
| DK324888A (en) | 1988-12-16 |
| NO170634B (en) | 1992-08-03 |
| IL86632A0 (en) | 1988-11-30 |
| JP2708047B2 (en) | 1998-02-04 |
| PT87719A (en) | 1988-07-01 |
| NO882613D0 (en) | 1988-06-14 |
| JPS6434989A (en) | 1989-02-06 |
| NO170634C (en) | 1992-11-11 |
| DK324888D0 (en) | 1988-06-14 |
| FI882808A (en) | 1988-12-16 |
| IE70523B1 (en) | 1996-12-11 |
| FI882808A0 (en) | 1988-06-13 |
| MY104316A (en) | 1994-03-31 |
| DE3855015D1 (en) | 1996-03-28 |
| HUT47587A (en) | 1989-03-28 |
| GR3019064T3 (en) | 1996-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |