DK324888D0 - SUBSTITUTED STAUROSPORIN DERIVATIVES - Google Patents

SUBSTITUTED STAUROSPORIN DERIVATIVES

Info

Publication number
DK324888D0
DK324888D0 DK324888A DK324888A DK324888D0 DK 324888 D0 DK324888 D0 DK 324888D0 DK 324888 A DK324888 A DK 324888A DK 324888 A DK324888 A DK 324888A DK 324888 D0 DK324888 D0 DK 324888D0
Authority
DK
Denmark
Prior art keywords
substituted
staurosporin
formula
stau
staurosporin derivatives
Prior art date
Application number
DK324888A
Other languages
Danish (da)
Other versions
DK175507B1 (en
DK324888A (en
Inventor
Giorgio Caravatti
Andreas Fredenhagen
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK324888D0 publication Critical patent/DK324888D0/en
Publication of DK324888A publication Critical patent/DK324888A/en
Application granted granted Critical
Publication of DK175507B1 publication Critical patent/DK175507B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

N-Substituted derivatives of staurosporin of the formula [Stau]-N(CH3)-R (I> in which [Stau] represents the radical of the sub-formula <IMAGE> in which R represents a hydrocarbyl R<0> or an acyl Ac, which preferably have at most 30 C atoms, and salts of compounds of the formula I having salt-forming properties, are distinguished as selective inhibitors of protein kinase C. They are prepared by conventional alkylation or acylation of staurosporin.
DK198803248A 1987-06-15 1988-06-14 N-substituted staurosporine derivatives and salts thereof, process for their preparation, pharmaceutical compositions containing them and use of the N-substituted staurosporine derivatives for the preparation of pharmaceutical preparations DK175507B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH224487 1987-06-15
CH224487 1987-06-15
CH144088 1988-04-19
CH144088 1988-04-19

Publications (3)

Publication Number Publication Date
DK324888D0 true DK324888D0 (en) 1988-06-14
DK324888A DK324888A (en) 1988-12-16
DK175507B1 DK175507B1 (en) 2004-11-15

Family

ID=25687663

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198803248A DK175507B1 (en) 1987-06-15 1988-06-14 N-substituted staurosporine derivatives and salts thereof, process for their preparation, pharmaceutical compositions containing them and use of the N-substituted staurosporine derivatives for the preparation of pharmaceutical preparations

Country Status (20)

Country Link
EP (1) EP0296110B1 (en)
JP (1) JP2708047B2 (en)
KR (1) KR970001529B1 (en)
AT (1) ATE134375T1 (en)
AU (1) AU617324B2 (en)
CA (1) CA1337763C (en)
DE (1) DE3855015D1 (en)
DK (1) DK175507B1 (en)
ES (1) ES2083956T3 (en)
FI (1) FI89362C (en)
GR (1) GR3019064T3 (en)
HK (1) HK1003788A1 (en)
HU (1) HU201329B (en)
IE (1) IE70523B1 (en)
IL (1) IL86632A0 (en)
MY (1) MY104316A (en)
NO (1) NO170634C (en)
NZ (1) NZ225018A (en)
PT (1) PT87719B (en)
YU (1) YU115488A (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62220196A (en) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd Ucn-01 and production thereof
WO1989007105A1 (en) * 1988-02-04 1989-08-10 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives
IL89167A (en) * 1988-02-10 1994-02-27 Hoffmann La Roche Substituted pyrroles, their manufacture and pharmaceutical compositions containing them
USRE36736E (en) * 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
DE3924538A1 (en) * 1989-07-25 1991-01-31 Goedecke Ag INDOLOCARBAZOL AND THEIR USE
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
WO1993007153A1 (en) * 1991-10-10 1993-04-15 Schering Corporation 4'-(n-substituted-n-oxide)staurosporine derivatives
EP0541486A1 (en) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclic conjugates
WO1993018771A1 (en) * 1992-03-24 1993-09-30 Asahi Kasei Kogyo Kabushiki Kaisha PLATELET AGGLUTINATION INHIBITOR CONTAINING STAUROSPORINE η-LACTAM DERIVATIVE
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5621100A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. K-252a derivatives for treatment of neurological disorders
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
US5621101A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5674867A (en) * 1992-09-21 1997-10-07 Kyowa Hakko Kogyo Co., Ltd. Indolocarbazole derivatives and therapeutic method for stimulating megakaicyocyte production
ATE485825T1 (en) 1993-01-28 2010-11-15 Boston Scient Ltd THERAPEUTIC INHIBITORS OF VASCULAR SMOOTH CELLS
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
PH30300A (en) * 1993-05-07 1997-01-20 Ciba Geigy Ag Polycyclic compounds and processes for the preparation thereof
WO1995002057A1 (en) * 1993-07-09 1995-01-19 The Institute Of Cancer Research Protein tyrosine kinase and ligands thereof
GB9325395D0 (en) * 1993-12-11 1994-02-16 Ciba Geigy Ag Compositions
EP0711556A1 (en) * 1994-11-09 1996-05-15 Ciba-Geigy Ag Intravenous solutions containing staurosporine derivatives
US6875865B1 (en) 1996-06-03 2005-04-05 Cephalon, Inc. Selected derivatives of K-252a
UA67725C2 (en) 1996-06-03 2004-07-15 Cephalon Inc K-252a derivatives and a method for improvement of functioning and cell survival enhancement
US6184217B1 (en) 1996-06-25 2001-02-06 Cephalon, Inc. Use of K-252a derivative
BR9808109A (en) 1997-03-31 2000-03-08 Neorx Corp Therapeutic smooth muscle vascular cell inhibitor
JP2002530342A (en) * 1998-11-23 2002-09-17 ノバルティス アクチエンゲゼルシャフト Use of staurosporine derivatives for the treatment of ocular neovascular diseases
ES2728739T3 (en) 2001-02-19 2019-10-28 Novartis Pharma Ag Rapamycin derivative for the treatment of a solid tumor associated with deregulated angiogenesis
BR0209647A (en) 2001-05-16 2004-07-27 Novartis Ag A combination comprising n- {5- [4- (4-methyl-piperazine-methyl) -benzoylamido] -2-methyl-phenyl} -4- (3-pyridyl) -2-pyrimidine-amine and a chemotherapeutic agent
TWI302836B (en) * 2001-10-30 2008-11-11 Novartis Ag Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
US6887864B2 (en) 2002-03-12 2005-05-03 Hoffmann-La Roche Inc. Azepane derivatives
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
CN1652757B (en) 2002-05-16 2012-02-08 诺瓦提斯公司 Use of EDG receptor binding agents in cancer
CN101897662B (en) * 2002-07-23 2013-05-22 诺瓦提斯公司 Ophtalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
US7417065B2 (en) 2003-05-19 2008-08-26 Irm Llc Immunosuppressant compounds and compositions
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
US20040246627A1 (en) * 2003-06-06 2004-12-09 Durrum Thomas M. Disc drive pivot bearing assembly
MXPA06001524A (en) 2003-08-08 2006-05-15 Novartis Ag Combinations comprising staurosporines.
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
CA2576926C (en) * 2004-08-31 2012-10-02 Novartis Ag Use of midostaurin for treating gastrointestinal stromal tumors
JO2897B1 (en) * 2004-11-05 2015-09-15 نوفارتيس ايه جي Organic compounds
KR20140012218A (en) 2005-11-21 2014-01-29 노파르티스 아게 Neuroendocrine tumor treatment using mtor inhibitors
CN102256942B (en) 2008-12-18 2013-07-24 诺瓦提斯公司 New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzyl) -azetidine-3-formic acid
RU2011129229A (en) 2008-12-18 2013-01-27 Новартис Аг NEW SALTS
SI2379497T1 (en) 2008-12-18 2013-12-31 Novartis Ag Hemifumarate salt of 1-(4-(1-(4-cyclohexyl-3-trifluoromethyl- benzyloxyimino)-ethyl)-2-ethyl-benzyl)-a zetidine-3-carboxylic acid
EP2327706A1 (en) 2009-11-30 2011-06-01 Novartis AG Polymorphous forms III and IV of N-benzoyl-staurosporine
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8846712B2 (en) 2011-09-12 2014-09-30 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013167403A1 (en) 2012-05-09 2013-11-14 Sanofi Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors
WO2019215759A1 (en) * 2018-05-09 2019-11-14 Alaparthi Lakshmi Prasad An improved process for preparation of midostaurin
WO2021097256A1 (en) 2019-11-14 2021-05-20 Cohbar, Inc. Cxcr4 antagonist peptides
IT202000004291A1 (en) * 2020-03-02 2021-09-02 Indena Spa PROCESS FOR THE PURIFICATION OF CARBAZOLIC INDOLE ALKALOIDS
CN112812129A (en) * 2020-12-31 2021-05-18 浙江海正药业股份有限公司 Novel crystalline form of midostaurin, process for its preparation and its use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007105A1 (en) * 1988-02-04 1989-08-10 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives

Also Published As

Publication number Publication date
DK175507B1 (en) 2004-11-15
FI89362C (en) 1993-09-27
EP0296110A3 (en) 1991-02-27
YU115488A (en) 1989-12-31
NO882613L (en) 1988-12-16
AU617324B2 (en) 1991-11-28
KR890000494A (en) 1989-03-15
EP0296110B1 (en) 1996-02-21
NZ225018A (en) 1990-09-26
PT87719B (en) 1992-10-30
HK1003788A1 (en) 1998-11-06
IE881787L (en) 1988-12-15
FI89362B (en) 1993-06-15
EP0296110A2 (en) 1988-12-21
ATE134375T1 (en) 1996-03-15
ES2083956T3 (en) 1996-05-01
HU201329B (en) 1990-10-28
KR970001529B1 (en) 1997-02-11
AU1757188A (en) 1988-12-15
CA1337763C (en) 1995-12-19
DK324888A (en) 1988-12-16
NO170634B (en) 1992-08-03
IL86632A0 (en) 1988-11-30
JP2708047B2 (en) 1998-02-04
PT87719A (en) 1988-07-01
NO882613D0 (en) 1988-06-14
JPS6434989A (en) 1989-02-06
NO170634C (en) 1992-11-11
FI882808A (en) 1988-12-16
IE70523B1 (en) 1996-12-11
FI882808A0 (en) 1988-06-13
MY104316A (en) 1994-03-31
DE3855015D1 (en) 1996-03-28
HUT47587A (en) 1989-03-28
GR3019064T3 (en) 1996-05-31

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Legal Events

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AHS Application shelved for other reasons than non-payment
PUP Patent expired