ES2066798T3 - Derivados de indolocarbazol, procedimientos para su obtencion y los medicamentos que les contienen. - Google Patents

Derivados de indolocarbazol, procedimientos para su obtencion y los medicamentos que les contienen.

Info

Publication number
ES2066798T3
ES2066798T3 ES89101940T ES89101940T ES2066798T3 ES 2066798 T3 ES2066798 T3 ES 2066798T3 ES 89101940 T ES89101940 T ES 89101940T ES 89101940 T ES89101940 T ES 89101940T ES 2066798 T3 ES2066798 T3 ES 2066798T3
Authority
ES
Spain
Prior art keywords
atoms
group
radical
denote
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89101940T
Other languages
English (en)
Inventor
Jurgen Dr Kleinschroth
Johannes Dr Hartenstein
Hubert Dr Barth
Christoph Dr Schachtele
Claus Dr Rudolph
Gunter Dr Weinheimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Application granted granted Critical
Publication of ES2066798T3 publication Critical patent/ES2066798T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE INDFOLOCARBAZOL DE LA FORMULA GENERAL I, EN LA QUE R1 Y R (AL CUADRADO) (IGUALES O DISTINTOS) SON HIDROGENO, UN GRUPO ALQUILO DE CADENA SIMPLE O COMPLEJA CON 1 - 6 ATOMOC DE C, UN GRUPO BENCILO, UN GRUPO AMINOALQUILO CON HASTA 12 ATOMOS DE C, UN RESTO ALCOXICARBONILALQUILO CON HASTA 6 ATOMOS DE C, UN RESTO - CH2 - CO - NR3R4, SINEDO R3 Y R4 IGUALES O DISTINTOS, HIDROGENO, UN GRUPO ALQUILO CON 1 - 4 ATOMOS DE C O UN GRUPO BENCILO; O R1 Y/O R (AL CUADRADO) SON UN RESTO HALOGENALQUILO, HIDROXIALQUILO O ALCOXIALQUILO CON HASTA 6 ATOMOS DE C, UN RESTO BENZOILOXIALCOXIALQUILO, ACETILOXIALCOXIALQUILO O HIDROXIALCOXIALQUILO CON HASTA 11 ATOMOS DE C, UN GRUPO ACILO CON 1 - 4 ATOMOS DE C; O BIEN R1 Y R (AL CUADRADO) FORMAN JUNTOS UN GRUPO ALQUILENO CON 2 - 4 ATOMOS DE C, EN SU CASO, SUSTITUIDO POR HIDROXI, C1 - 4 - ALCOXI O AMINO; X E Y SON O IGUALES, CADA UNA HIDROGENO, O DISTINTAS, SIENDO UNO DE LOS RESTOS HIDROGENO Y EL OTRO UN GRUPO HIDROXI O ALCOXI CON HASTA 4 ATOMOS DE C, CON LA CONDICION DE QUE NO TODOS LOS RESTOS R1, R (AL CUADRADO) , X E Y SEAN HIDROGENO A LA VEZ. TAMBIEN SE REFIERE LA INVENCION A LAS SALES FARMACOLOGICAMENTE INOFENSIVAS DE ESTOS COMPUESTOS, AL PROCESO PARA OBTENER LOS COMPUESTOS I O DE MEZCLAS DE REGIOISOMEROS DE DOS DE ESTOS COMPUESTOS I, ASIO COMO MEDICAMENTOS QUE CONTIENEN AL MENOS UNO DE LOS COMPUESTOS I.
ES89101940T 1988-02-06 1989-02-03 Derivados de indolocarbazol, procedimientos para su obtencion y los medicamentos que les contienen. Expired - Lifetime ES2066798T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3803620A DE3803620A1 (de) 1988-02-06 1988-02-06 Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2066798T3 true ES2066798T3 (es) 1995-03-16

Family

ID=6346797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89101940T Expired - Lifetime ES2066798T3 (es) 1988-02-06 1989-02-03 Derivados de indolocarbazol, procedimientos para su obtencion y los medicamentos que les contienen.

Country Status (16)

Country Link
EP (1) EP0328000B1 (es)
JP (1) JP2866096B2 (es)
KR (1) KR890013035A (es)
CN (1) CN1035667A (es)
AT (1) ATE117304T1 (es)
AU (1) AU616468B2 (es)
CA (1) CA1337767C (es)
DD (1) DD283394A5 (es)
DE (2) DE3803620A1 (es)
DK (1) DK51489A (es)
ES (1) ES2066798T3 (es)
GR (1) GR3015194T3 (es)
HU (1) HU203758B (es)
IE (1) IE65256B1 (es)
PT (1) PT89623B (es)
ZA (1) ZA89861B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3010675B2 (ja) * 1989-03-23 2000-02-21 萬有製薬株式会社 抗腫瘍性物質ｂｅ―１３７９３ｃ
WO1991009034A1 (en) * 1989-12-14 1991-06-27 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
DE3942296A1 (de) * 1989-12-21 1991-06-27 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5668271A (en) * 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
WO1993018766A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
CA2163904C (en) * 1993-05-28 2000-01-25 Craig A. Dionne Use of indolocarbazole derivatives to treat a pathological condition of the prostate
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
HU219709B (hu) * 1993-12-07 2001-06-28 Eli Lilly And Co. Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
DK0657411T3 (da) * 1993-12-07 1999-11-15 Lilly Co Eli Forbedret syntese af bisindolylmaleimider
DK0817627T3 (da) * 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
EP1070068B2 (en) * 1998-03-13 2007-01-17 The University Of British Columbia Granulatimide derivatives for use in cancer treatment
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6855698B2 (en) 2001-03-22 2005-02-15 Bristol-Myers Squibb Company Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
CN117486782A (zh) * 2023-12-29 2024-02-02 中国医学科学院药用植物研究所 一种n-取代咔唑衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62155284A (ja) * 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
US4737496A (en) * 1986-10-01 1988-04-12 Ciba-Geigy Corporation 1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino-[1,2-a][1,4]benzodiazepines useful as serotonin-2 receptor antagonists

Also Published As

Publication number Publication date
IE890359L (en) 1989-08-06
DE58908892D1 (de) 1995-03-02
EP0328000B1 (de) 1995-01-18
CA1337767C (en) 1995-12-19
JPH02149520A (ja) 1990-06-08
AU2960789A (en) 1989-08-10
EP0328000A3 (de) 1991-04-03
ZA89861B (en) 1989-11-29
DD283394A5 (de) 1990-10-10
ATE117304T1 (de) 1995-02-15
CN1035667A (zh) 1989-09-20
PT89623B (pt) 1994-02-28
EP0328000A2 (de) 1989-08-16
AU616468B2 (en) 1991-10-31
DE3803620A1 (de) 1989-08-17
GR3015194T3 (en) 1995-05-31
DK51489A (da) 1989-08-07
JP2866096B2 (ja) 1999-03-08
PT89623A (pt) 1989-10-04
KR890013035A (ko) 1989-09-21
IE65256B1 (en) 1995-10-18
DK51489D0 (da) 1989-02-03
HU203758B (en) 1991-09-30

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