AU2960789A - Indolocarbazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Indolocarbazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
AU2960789A
AU2960789A AU29607/89A AU2960789A AU2960789A AU 2960789 A AU2960789 A AU 2960789A AU 29607/89 A AU29607/89 A AU 29607/89A AU 2960789 A AU2960789 A AU 2960789A AU 2960789 A AU2960789 A AU 2960789A
Authority
AU
Australia
Prior art keywords
atoms
group
radical
denote
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU29607/89A
Other versions
AU616468B2 (en
Inventor
Hubert Dr. Barth
Johannes Dr. Hartenstein
Jurgen DR. Kleinschroth
Claus Dr. Rudolph
Christoph Dr. Schachtele
Gunter Dr. Weinheimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Publication of AU2960789A publication Critical patent/AU2960789A/en
Application granted granted Critical
Publication of AU616468B2 publication Critical patent/AU616468B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Novel indolocarbazole derivatives of the general formula I <IMAGE> in which R<1> and R<2> are identical or different and denote hydrogen, a straight-chain or branched alkyl group having 1 to 6 C atoms, a benzyl group, an unsubstituted or substituted aminoalkyl group having up to 12 C atoms, an alkoxycarbonylalkyl radical having up to 6 C atoms, a radical -CH2-CO-NR<3>R<4> in which R<3> and R<4> are identical or different and represent hydrogen, an alkyl group having 1 to 4 C atoms or a benzyl group, or R<1> and/or R<2> denote a haloalkyl, hydroxyalkyl or alkoxyalkyl radical each having up to 6 C atoms, a benzoyloxyalkoxyalkyl, acetyloxyalkoxyalkyl or hydroxyalkoxyalkyl radical each having up to 11 C atoms, or an acyl group having 1 to 4 C atoms or R<1> and R<2> together denote an alkylene group having 2 to 4 C atoms, optionally substituted by hydroxyl, C1-4-alkoxy or amino, X and Y are either identical and in each case both denote hydrogen, or X and Y are different, one of the radicals X or Y representing hydrogen and the other of the two radicals denoting a hydroxyl or an alkoxy group having up to 4 C atoms, with the proviso that not all radicals R<1>, R<2>, X and Y simultaneously denote hydrogen, and their pharmacologically acceptable salts, process for the preparation of the compounds I or of regioisomer mixtures of two of these compounds I and medicines containing at least one of the compounds I.
AU29607/89A 1988-02-06 1989-02-03 Indolocarbazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them Ceased AU616468B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3803620 1988-02-06
DE3803620A DE3803620A1 (en) 1988-02-06 1988-02-06 INDOLOCARBAZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
AU2960789A true AU2960789A (en) 1989-08-10
AU616468B2 AU616468B2 (en) 1991-10-31

Family

ID=6346797

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29607/89A Ceased AU616468B2 (en) 1988-02-06 1989-02-03 Indolocarbazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (16)

Country Link
EP (1) EP0328000B1 (en)
JP (1) JP2866096B2 (en)
KR (1) KR890013035A (en)
CN (1) CN1035667A (en)
AT (1) ATE117304T1 (en)
AU (1) AU616468B2 (en)
CA (1) CA1337767C (en)
DD (1) DD283394A5 (en)
DE (2) DE3803620A1 (en)
DK (1) DK51489A (en)
ES (1) ES2066798T3 (en)
GR (1) GR3015194T3 (en)
HU (1) HU203758B (en)
IE (1) IE65256B1 (en)
PT (1) PT89623B (en)
ZA (1) ZA89861B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU634247B2 (en) * 1989-03-23 1993-02-18 Banyu Pharmaceutical Co., Ltd. Antitumor substance be-13793c

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
AU7035991A (en) * 1989-12-14 1991-07-18 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
DE3942296A1 (en) * 1989-12-21 1991-06-27 Goedecke Ag INDOLOCARBAZOL DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5668271A (en) * 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
WO1993018766A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
DE4243321A1 (en) * 1992-12-21 1994-06-23 Goedecke Ag Amino acid derivatives of heterocycles as PKC inhibitors
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
DE69409641T2 (en) * 1993-05-28 1998-11-26 Cephalon Inc APPLICATION OF INDOLOCARBAZOL DERIVATIVES FOR THE TREATMENT OF PROSTATE DISEASES
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
ES2134910T3 (en) * 1993-12-07 1999-10-16 Lilly Co Eli SYNTHESIS OF BISINDOLILMALEIMIDAS.
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
ES2162843T3 (en) * 1993-12-07 2002-01-16 Lilly Co Eli INHIBITORS OF PROTEIN QUINASA C.
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
DK0817627T3 (en) * 1993-12-23 2005-06-06 Lilly Co Eli Inhibitors of protein kinase C
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
WO1999047522A1 (en) * 1998-03-13 1999-09-23 The University Of British Columbia Granulatimide derivatives for use in cancer treatment
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
HUP0400265A2 (en) 2001-03-22 2004-08-30 Bristol-Myers Squibb Co. Topoisomerase i selective cytotoxic sugar derivatives of indolopyrrolocarbazoles and their use for preparation of pharmaceutical compositions
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
CN117486782A (en) * 2023-12-29 2024-02-02 中国医学科学院药用植物研究所 N-substituted carbazole derivative and preparation method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62155284A (en) * 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd Physiologically active substance k-252 derivative
US4737496A (en) * 1986-10-01 1988-04-12 Ciba-Geigy Corporation 1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino-[1,2-a][1,4]benzodiazepines useful as serotonin-2 receptor antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU634247B2 (en) * 1989-03-23 1993-02-18 Banyu Pharmaceutical Co., Ltd. Antitumor substance be-13793c

Also Published As

Publication number Publication date
EP0328000A3 (en) 1991-04-03
AU616468B2 (en) 1991-10-31
HU203758B (en) 1991-09-30
ES2066798T3 (en) 1995-03-16
JPH02149520A (en) 1990-06-08
ZA89861B (en) 1989-11-29
PT89623B (en) 1994-02-28
KR890013035A (en) 1989-09-21
CN1035667A (en) 1989-09-20
EP0328000B1 (en) 1995-01-18
PT89623A (en) 1989-10-04
DD283394A5 (en) 1990-10-10
JP2866096B2 (en) 1999-03-08
IE65256B1 (en) 1995-10-18
DK51489D0 (en) 1989-02-03
DE3803620A1 (en) 1989-08-17
ATE117304T1 (en) 1995-02-15
DK51489A (en) 1989-08-07
GR3015194T3 (en) 1995-05-31
IE890359L (en) 1989-08-06
CA1337767C (en) 1995-12-19
EP0328000A2 (en) 1989-08-16
DE58908892D1 (en) 1995-03-02

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