HK1003788A1 - Staurosporine derivatives substituted for the nitrogen atom of the methylamino group - Google Patents
Staurosporine derivatives substituted for the nitrogen atom of the methylamino groupInfo
- Publication number
- HK1003788A1 HK1003788A1 HK98102862A HK98102862A HK1003788A1 HK 1003788 A1 HK1003788 A1 HK 1003788A1 HK 98102862 A HK98102862 A HK 98102862A HK 98102862 A HK98102862 A HK 98102862A HK 1003788 A1 HK1003788 A1 HK 1003788A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nitrogen atom
- methylamino group
- derivatives substituted
- staurosporine derivatives
- formula
- Prior art date
Links
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical group C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title abstract 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 125000004433 nitrogen atom Chemical group N* 0.000 title 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH224487 | 1987-06-15 | ||
CH144088 | 1988-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1003788A1 true HK1003788A1 (en) | 1998-11-06 |
Family
ID=25687663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98102862A HK1003788A1 (en) | 1987-06-15 | 1998-04-04 | Staurosporine derivatives substituted for the nitrogen atom of the methylamino group |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0296110B1 (fi) |
JP (1) | JP2708047B2 (fi) |
KR (1) | KR970001529B1 (fi) |
AT (1) | ATE134375T1 (fi) |
AU (1) | AU617324B2 (fi) |
CA (1) | CA1337763C (fi) |
DE (1) | DE3855015D1 (fi) |
DK (1) | DK175507B1 (fi) |
ES (1) | ES2083956T3 (fi) |
FI (1) | FI89362C (fi) |
GR (1) | GR3019064T3 (fi) |
HK (1) | HK1003788A1 (fi) |
HU (1) | HU201329B (fi) |
IE (1) | IE70523B1 (fi) |
IL (1) | IL86632A0 (fi) |
MY (1) | MY104316A (fi) |
NO (1) | NO170634C (fi) |
NZ (1) | NZ225018A (fi) |
PT (1) | PT87719B (fi) |
YU (1) | YU115488A (fi) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62220196A (ja) * | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ucn―01 |
EP0383919A4 (en) * | 1988-02-04 | 1992-08-05 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
USRE36736E (en) * | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
AU2866992A (en) * | 1991-10-10 | 1993-05-03 | Schering Corporation | 4'-(n-substituted-n-oxide)staurosporine derivatives |
EP0541486A1 (de) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
WO1993018771A1 (fr) * | 1992-03-24 | 1993-09-30 | Asahi Kasei Kogyo Kabushiki Kaisha | INHIBITEUR DE L'AGGLUTINATION PLAQUETTAIRE CONTENANT UN DERIVE DE STAUROSPORINE η-LACTAME |
US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
CA2123895A1 (en) * | 1992-09-21 | 1994-03-31 | Tatsuya Tamaoki | A therapeutic agent for thrombocytopenia |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
EP2324829A1 (en) | 1993-01-28 | 2011-05-25 | Boston Scientific Limited | Therapeutic inhibitors of vascular smooth muscle cells |
PH30300A (en) * | 1993-05-07 | 1997-01-20 | Ciba Geigy Ag | Polycyclic compounds and processes for the preparation thereof |
AU7080994A (en) * | 1993-07-09 | 1995-02-06 | Institute Of Cancer Research, The | Protein tyrosine kinase and ligands thereof |
GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
EP0711557A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage |
UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
US6184217B1 (en) | 1996-06-25 | 2001-02-06 | Cephalon, Inc. | Use of K-252a derivative |
BR9808109A (pt) | 1997-03-31 | 2000-03-08 | Neorx Corp | Inibidor terapêutico de células vasculares da musculatura lisa |
ES2211197T3 (es) * | 1998-11-23 | 2004-07-01 | Novartis Ag | Uso de derivados de estaurosporina para tratar enfermedades neovasculares oculares. |
SI3351246T1 (sl) | 2001-02-19 | 2019-08-30 | Novartis Pharma Ag | Derivat rapamicina za zdravljenje trdnega tumorja, povezanega z deregulirano angiogenezo |
US20040167134A1 (en) | 2001-05-16 | 2004-08-26 | Christian Bruns | Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent |
WO2003037347A1 (en) | 2001-10-30 | 2003-05-08 | Novartis Ag | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
JP5227492B2 (ja) | 2002-05-16 | 2013-07-03 | ノバルティス アーゲー | 癌におけるedgレセプター結合剤の使用 |
CN101897662B (zh) * | 2002-07-23 | 2013-05-22 | 诺瓦提斯公司 | 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物 |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
PE20050158A1 (es) | 2003-05-19 | 2005-05-12 | Irm Llc | Compuestos inmunosupresores y composiciones |
US20040246627A1 (en) * | 2003-06-06 | 2004-12-09 | Durrum Thomas M. | Disc drive pivot bearing assembly |
US20070191338A1 (en) | 2003-08-08 | 2007-08-16 | Atadja Peter W | Combinations comprising staurosporines |
TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
BRPI0514765A (pt) * | 2004-08-31 | 2008-06-24 | Novartis Ag | compostos orgánicos |
JO2897B1 (en) * | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
NZ568182A (en) | 2005-11-21 | 2010-08-27 | Novartis Ag | Neuroendocrine tumor treatment using MTOR inhibitors |
KR20110101159A (ko) | 2008-12-18 | 2011-09-15 | 노파르티스 아게 | 신규 염 |
RU2518114C3 (ru) | 2008-12-18 | 2021-11-24 | Новартис Аг | Гемифумаратная соль 1-[4-[1-(4-циклогексил-3-трифторметилбензилоксиимино)этил]-2-этилбензил] азетидин-3-карбоновой кислоты |
BRPI0922457A2 (pt) | 2008-12-18 | 2015-12-15 | Novartis Ag | forma polimórfica de ácido 1-(4-{1-[(e)-4-ciclo-hexil-3-trifluormetil-benziloxi-imino]-etil)-2-etil-benzil)-azetidino-3-carboxílico" |
EP2327706A1 (en) | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013167403A1 (en) | 2012-05-09 | 2013-11-14 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
WO2019215759A1 (en) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | An improved process for preparation of midostaurin |
EP4058465A1 (en) | 2019-11-14 | 2022-09-21 | Cohbar Inc. | Cxcr4 antagonist peptides |
IT202000004291A1 (it) * | 2020-03-02 | 2021-09-02 | Indena Spa | Processo per la purificazione di alcaloidi indolo carbazolici |
CN112812129A (zh) * | 2020-12-31 | 2021-05-18 | 浙江海正药业股份有限公司 | 米哚妥林的新晶型及其制备方法和用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0383919A4 (en) * | 1988-02-04 | 1992-08-05 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
-
1988
- 1988-06-06 IL IL86632A patent/IL86632A0/xx not_active IP Right Cessation
- 1988-06-09 DE DE3855015T patent/DE3855015D1/de not_active Expired - Lifetime
- 1988-06-09 MY MYPI88000629A patent/MY104316A/en unknown
- 1988-06-09 AT AT88810383T patent/ATE134375T1/de not_active IP Right Cessation
- 1988-06-09 ES ES88810383T patent/ES2083956T3/es not_active Expired - Lifetime
- 1988-06-09 EP EP88810383A patent/EP0296110B1/de not_active Expired - Lifetime
- 1988-06-10 AU AU17571/88A patent/AU617324B2/en not_active Expired
- 1988-06-13 FI FI882808A patent/FI89362C/fi active IP Right Grant
- 1988-06-13 CA CA000569303A patent/CA1337763C/en not_active Expired - Lifetime
- 1988-06-14 IE IE178788A patent/IE70523B1/en not_active IP Right Cessation
- 1988-06-14 DK DK198803248A patent/DK175507B1/da not_active IP Right Cessation
- 1988-06-14 HU HU883048A patent/HU201329B/hu unknown
- 1988-06-14 KR KR1019880007102A patent/KR970001529B1/ko not_active IP Right Cessation
- 1988-06-14 YU YU01154/88A patent/YU115488A/xx unknown
- 1988-06-14 NO NO882613A patent/NO170634C/no not_active IP Right Cessation
- 1988-06-14 PT PT87719A patent/PT87719B/pt not_active IP Right Cessation
- 1988-06-14 NZ NZ225018A patent/NZ225018A/xx unknown
- 1988-06-15 JP JP63145937A patent/JP2708047B2/ja not_active Expired - Lifetime
-
1996
- 1996-02-22 GR GR960400221T patent/GR3019064T3/el unknown
-
1998
- 1998-04-04 HK HK98102862A patent/HK1003788A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
YU115488A (en) | 1989-12-31 |
PT87719A (pt) | 1988-07-01 |
CA1337763C (en) | 1995-12-19 |
EP0296110A2 (de) | 1988-12-21 |
KR970001529B1 (ko) | 1997-02-11 |
JP2708047B2 (ja) | 1998-02-04 |
AU617324B2 (en) | 1991-11-28 |
FI89362C (fi) | 1993-09-27 |
IE881787L (en) | 1988-12-15 |
KR890000494A (ko) | 1989-03-15 |
FI882808A0 (fi) | 1988-06-13 |
PT87719B (pt) | 1992-10-30 |
EP0296110B1 (de) | 1996-02-21 |
EP0296110A3 (de) | 1991-02-27 |
DK324888D0 (da) | 1988-06-14 |
NZ225018A (en) | 1990-09-26 |
DE3855015D1 (de) | 1996-03-28 |
DK175507B1 (da) | 2004-11-15 |
DK324888A (da) | 1988-12-16 |
ATE134375T1 (de) | 1996-03-15 |
MY104316A (en) | 1994-03-31 |
AU1757188A (en) | 1988-12-15 |
IE70523B1 (en) | 1996-12-11 |
NO170634C (no) | 1992-11-11 |
ES2083956T3 (es) | 1996-05-01 |
NO882613D0 (no) | 1988-06-14 |
HU201329B (en) | 1990-10-28 |
FI89362B (fi) | 1993-06-15 |
NO882613L (no) | 1988-12-16 |
IL86632A0 (en) | 1988-11-30 |
FI882808A (fi) | 1988-12-16 |
HUT47587A (en) | 1989-03-28 |
JPS6434989A (en) | 1989-02-06 |
NO170634B (no) | 1992-08-03 |
GR3019064T3 (en) | 1996-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20080608 |