FI120094B - Menetelmä terapeuttisesti käyttökelpoisten 1, 4- dihydrokinoksaliini-2,3-dionijohdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 1, 4- dihydrokinoksaliini-2,3-dionijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI120094B FI120094B FI946005A FI946005A FI120094B FI 120094 B FI120094 B FI 120094B FI 946005 A FI946005 A FI 946005A FI 946005 A FI946005 A FI 946005A FI 120094 B FI120094 B FI 120094B
- Authority
- FI
- Finland
- Prior art keywords
- dione
- dihydroquinoxaline
- nitro
- glycine
- dichloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/54—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90308092A | 1992-06-22 | 1992-06-22 | |
US90308092 | 1992-06-22 | ||
US99516792A | 1992-12-22 | 1992-12-22 | |
US99516792 | 1992-12-22 | ||
US6927493A | 1993-05-28 | 1993-05-28 | |
US6927493 | 1993-05-28 | ||
US9305859 | 1993-06-17 | ||
PCT/US1993/005859 WO1994000124A1 (en) | 1992-06-22 | 1993-06-17 | Glycine receptor antagonists and the use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
FI946005A0 FI946005A0 (fi) | 1994-12-21 |
FI946005A FI946005A (fi) | 1995-02-21 |
FI120094B true FI120094B (fi) | 2009-06-30 |
Family
ID=27371510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI946005A FI120094B (fi) | 1992-06-22 | 1994-12-21 | Menetelmä terapeuttisesti käyttökelpoisten 1, 4- dihydrokinoksaliini-2,3-dionijohdannaisten valmistamiseksi |
Country Status (15)
Country | Link |
---|---|
US (3) | US5514680A (de) |
EP (1) | EP0647137B1 (de) |
JP (1) | JP3301024B2 (de) |
KR (1) | KR100304017B1 (de) |
AT (1) | ATE404201T1 (de) |
AU (1) | AU672617B2 (de) |
CA (1) | CA2138026C (de) |
DE (1) | DE69334237D1 (de) |
DK (1) | DK0647137T3 (de) |
ES (1) | ES2313714T3 (de) |
FI (1) | FI120094B (de) |
NO (1) | NO310022B1 (de) |
NZ (1) | NZ254404A (de) |
PT (1) | PT647137E (de) |
WO (1) | WO1994000124A1 (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9100028D0 (en) * | 1991-01-02 | 1991-02-20 | Ici Plc | Compounds |
GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
US5834479A (en) * | 1993-03-05 | 1998-11-10 | Mayer; David J. | Method and composition for alleviating pain |
CA2115792C (en) | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
US5631373A (en) | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
WO1995018616A2 (en) * | 1994-01-03 | 1995-07-13 | Acea Pharm Inc | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor |
FR2717805B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant . |
FR2717812B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
FR2717811B1 (fr) * | 1994-03-28 | 1996-04-26 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant. |
FR2717813B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant . |
HU217837B (hu) * | 1994-05-18 | 2000-04-28 | EGIS Gyógyszergyár Rt. | Savamidok, ezeket tartalmazó gyógyászati készítmények és eljárás a hatóanyagok előállítására |
US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
DE4428152A1 (de) * | 1994-06-22 | 1996-01-04 | Basf Ag | Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung |
EP0705834A1 (de) * | 1994-07-27 | 1996-04-10 | Ciba-Geigy Ag | Azaaliphatisch Überbrückte Chinoxalin-2,3-dione |
US5597922A (en) * | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
EP0705835A1 (de) * | 1994-09-01 | 1996-04-10 | Ciba-Geigy Ag | Oxa- oder thiaaliphatisch überbrückte Chinoxalin-2,3-dione |
GB9418443D0 (en) * | 1994-09-13 | 1994-11-02 | Pfizer Ltd | Therapeutic agents |
GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
US5801183A (en) * | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
GB9604400D0 (en) * | 1996-03-01 | 1996-05-01 | Pfizer Ltd | Compounds useful in therapy |
WO1997046539A1 (en) | 1996-06-05 | 1997-12-11 | Warner-Lambert Company | Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
WO1997049684A1 (en) * | 1996-06-24 | 1997-12-31 | Novo Nordisk A/S | Factor vii-binding reagent |
ID21927A (id) * | 1996-10-24 | 1999-08-12 | Novartis Ag | Asam aminoalkanafosfonat tersubstitusi |
WO1998035948A1 (en) * | 1997-02-18 | 1998-08-20 | American Home Products Corporation | 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists |
US5922715A (en) * | 1997-02-18 | 1999-07-13 | American Home Products Corporation | 5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones |
WO1998047878A1 (en) * | 1997-04-18 | 1998-10-29 | Abbott Laboratories | A process for the preparation of highly pure 6,7-dichloro-5- nitro-2,3-dihydroquinoxaline-2,3-dione |
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DE19814257A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
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CA2400578C (en) | 2000-02-08 | 2007-01-02 | Euro-Celtique, S.A. | Controlled-release compositions containing opioid agonist and antagonist |
US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
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CA2424029C (en) | 2000-09-29 | 2008-01-29 | Cordis Corporation | Coated medical devices |
UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
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ATE431738T1 (de) | 2001-08-06 | 2009-06-15 | Euro Celtique Sa | Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist |
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US7250394B2 (en) * | 2001-08-20 | 2007-07-31 | Maiken Nedergaard | Treatment of glial tumors with glutamate antagonists |
EP1298581A1 (de) * | 2001-09-27 | 2003-04-02 | C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa | Verfahren und Anlage zum Berechnen von Neuronenwerten in einem neuronalen Netzwerk |
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DK1551372T3 (en) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES |
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EP2298303A1 (de) | 2003-09-25 | 2011-03-23 | Euro-Celtique S.A. | Pharmazeutische kombinationen von hydrocodon und naltrexon |
EP1604666A1 (de) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit |
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EP1702558A1 (de) * | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
CN101677963B (zh) | 2006-06-19 | 2012-05-30 | 奥尔制药公司 | 药物组合物 |
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DK2405915T3 (en) | 2009-03-10 | 2019-02-11 | Euro Celtique Sa | PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE INCLUDING OXYCODON AND NALOXON |
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CN103275021B (zh) * | 2013-05-24 | 2015-05-20 | 东北农业大学 | N-二氯乙酰基-6,7-二氯-1,2,3,4-四氢喹喔啉及其制备方法 |
KR20180037074A (ko) | 2013-07-23 | 2018-04-10 | 유로-셀티큐 에스.에이. | 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물 |
JP6472444B2 (ja) | 2013-10-23 | 2019-02-20 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 有害生物防除剤としての置換されているキノキサリン誘導体 |
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CA3067162A1 (en) | 2017-06-12 | 2018-12-20 | Glytech Llc. | Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists |
US11484532B2 (en) | 2017-07-18 | 2022-11-01 | University of Pittsburgh—Of the Commonwealth Sysetem of Higher Education | Glycine receptor modulators and methods of use |
CN109678727A (zh) * | 2018-12-26 | 2019-04-26 | 深圳市华先医药科技有限公司 | 一种微通道硝化反应合成2-乙基-5-硝基苯胺的方法 |
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-
1993
- 1993-06-17 PT PT93916620T patent/PT647137E/pt unknown
- 1993-06-17 AT AT93916620T patent/ATE404201T1/de active
- 1993-06-17 AU AU46412/93A patent/AU672617B2/en not_active Ceased
- 1993-06-17 CA CA002138026A patent/CA2138026C/en not_active Expired - Lifetime
- 1993-06-17 KR KR1019940704688A patent/KR100304017B1/ko not_active IP Right Cessation
- 1993-06-17 WO PCT/US1993/005859 patent/WO1994000124A1/en active Application Filing
- 1993-06-17 NZ NZ254404A patent/NZ254404A/xx not_active IP Right Cessation
- 1993-06-17 ES ES93916620T patent/ES2313714T3/es not_active Expired - Lifetime
- 1993-06-17 DE DE69334237T patent/DE69334237D1/de not_active Expired - Lifetime
- 1993-06-17 DK DK93916620T patent/DK0647137T3/da active
- 1993-06-17 JP JP50247594A patent/JP3301024B2/ja not_active Expired - Fee Related
- 1993-06-17 EP EP93916620A patent/EP0647137B1/de not_active Expired - Lifetime
- 1993-11-05 US US08/148,259 patent/US5514680A/en not_active Expired - Lifetime
-
1994
- 1994-12-20 NO NO944942A patent/NO310022B1/no not_active IP Right Cessation
- 1994-12-21 FI FI946005A patent/FI120094B/fi not_active IP Right Cessation
-
1995
- 1995-03-17 US US08/405,708 patent/US5620979A/en not_active Expired - Lifetime
- 1995-03-17 US US08/405,713 patent/US5622952A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT647137E (pt) | 2008-11-24 |
NZ254404A (en) | 1997-08-22 |
FI946005A0 (fi) | 1994-12-21 |
ATE404201T1 (de) | 2008-08-15 |
AU4641293A (en) | 1994-01-24 |
AU672617B2 (en) | 1996-10-10 |
EP0647137A4 (de) | 1998-09-16 |
US5514680A (en) | 1996-05-07 |
FI946005A (fi) | 1995-02-21 |
EP0647137B1 (de) | 2008-08-13 |
ES2313714T3 (es) | 2009-03-01 |
CA2138026A1 (en) | 1994-01-06 |
US5622952A (en) | 1997-04-22 |
CA2138026C (en) | 2003-09-09 |
JPH08501283A (ja) | 1996-02-13 |
KR100304017B1 (ko) | 2001-11-22 |
NO944942L (no) | 1995-02-22 |
WO1994000124A1 (en) | 1994-01-06 |
NO310022B1 (no) | 2001-05-07 |
DE69334237D1 (de) | 2008-09-25 |
EP0647137A1 (de) | 1995-04-12 |
JP3301024B2 (ja) | 2002-07-15 |
NO944942D0 (no) | 1994-12-20 |
DK0647137T3 (da) | 2008-12-08 |
US5620979A (en) | 1997-04-15 |
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