FI117830B - Förfarande för syntetisering av substituerade sulfoxider - Google Patents

Förfarande för syntetisering av substituerade sulfoxider Download PDF

Info

Publication number
FI117830B
FI117830B FI970102D FI970102D FI117830B FI 117830 B FI117830 B FI 117830B FI 970102 D FI970102 D FI 970102D FI 970102 D FI970102 D FI 970102D FI 117830 B FI117830 B FI 117830B
Authority
FI
Finland
Prior art keywords
alkyl
eller
alkoxy
halogen
och
Prior art date
Application number
FI970102D
Other languages
English (en)
Finnish (fi)
Inventor
Erik Magnus Larsson
Urban Jan Stenhede
Henrik Soerensen
Unge Per Oskar Sverker Von
Hanna Kristina Cotton
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20394753&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI117830(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of FI117830B publication Critical patent/FI117830B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (12)

1. IW ^COOCHa Nx\ II // ch2-s- yN XX^^CHy flc) H OCH.Cr, i% A o .·. : X"^ \,„ // *. ·: ch2-s-</ :...: N^\X^ (Id) ....: / * 1 5 h • t · • · • · ♦ 1 · .. och3 * 1 I J « t «> I X J\ O N\.^%/oc,,F;' ·: XX X n // I η ;**·. ch--1—\ V (Ie) .·. : / *. ·: h • 1 · • · • 1 *·1 * m ·1· ·1·. * 1 f"~ 57 ~ ' " " 117830 OCH2CH2CH2OCH3 : kA ! ch2-s— (10 H ch3 N-CH2CH(CH3)2 %A\ ? CH;-S-f' I OS) H : II 0 CH3o'^%?^^-\--S-Ä ( / / (Ih) V·! 5 \_/ H * ·· * · • * • · · ....: 7. Förfarande cnligt nägot av patentkraven 1-4, kännetecknat av att den pro- ' .·*·. chirala sulfiden med formel II oxideras med ett oxidationsmedel i form av kumen- « * y[‘ hydroperoxid, • *· 10 * * « *’ 8. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att titankomple- xet framställs av en titan(IV)förening. ··· • · · A • ·
9. Förfarande enligt patentkrav 8, kännetecknat av att titan(IV)föreningen är en 15 titan(IV)alkoxid. • · > * » • « • · "·\ 10. Förfarande enligt patentkrav 9, kännetecknat av att titan(IV)alkoxiden är titan(IV)isopropoxid. * ····· * · 117830 ' ; 1 58
11. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att den chirala liganden i titankomplexet är en chiral grenad eller ogrenad alkyldiol eller en aroma- ·ί tisk diol. 5 12. Förfarande enligt patentkrav 11, kännetecknat av att den chirala diolen är en chiral ester av vinsyra.
13. Förfarande enligt patentkrav 12, kännetecknat av att den chirala estern väljs ur gruppen (+)-dietyl-L-tartrat och (-)-dietyl-D-tartrat. 10
14. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att mängden av chiralt titankomplex är 0,05-0,50 ckvivalenter. 1 . -T *
15. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att oxidations- i 15 reaktionen utförs vid en temperatur mellan 20 och 40 °C, företrädesvis vid rumstem- peratur.
16. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att det organis- ^ ka lösningsrnedlet väljs ur gruppen toluen och etylacetat. 20
17. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att oxidationen ; utförs i närvaro av en bas vald ur gruppen organiska baser. • t * * · • · · • · t"]; 18. Förfarande enligt patentkrav 17, kännetecknat av att basen är en amin. • * 25 . * · ];·** 19, Förfarande enligt patentkrav 18, kännetecknat av att aminen är vald ur grup- • * : ** pen trietylamin och N,N-diisopropyletylamin. • * · * · ·
20. Förfarande enligt patentkrav 3 eller 4, kännetecknat av att en längvarig 30 framställningstid för framställning av det chirala titankomplexet är 1-5 timmar. **« • · * * ··· #/ : 21. Förfarande enligt patentkrav 3 eller 4, kännetecknat av att förhöjd temperatur *..* för framställningen av det chirala komplexet är 30-70 °C. • e * · t/.l 35 22. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att förfarandet ·:”· dessutom innefattar ett steg för behandling av den bildade produkten med en vatten- bascrad ammoniaklösning. ’ ;ϊ ... > _ ' ' . % ' 117830 ' . 59
23. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att förfarandet dcssutom innefattar steg för kristallisation av dcn crhällna räprodukten.
24. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att sulfoxiden 5 framställd med hjälp av förfarandet är (+)-5-metoxi-2-[[(4-metoxi-3,5-dimetyl-2- pyridinyl)-metyl]sulfinyl]-lH-bensimidazol eller ett farmaceutiskt acceptabelt sait därav framställd (framställt) enligt nägot av patentkraven 1-23.
25. Förfarande enligt nägot av patentkraven 1-4, kännetecknat av att sulfoxiden 10 framställd med hjälp av förfarandet är (-)-5-metoxi-2-[[(4-metoxi-3,5-dimetyl-2- pyridinyl)-metyl]sulfinyl]-lH-bensimidazol eller ett farmaceutiskt acceptabelt sait därav framställd (framställt) i enlighet med nägot av patentkraven 1-23. * · • 1 · • 1 1 ♦ ·· < · • « * *···· * · ·· • · * m Λ 1 ·· ' • · * · 1 * · ♦ • · 1 1 · * * * - ··1 • 1 • ·1· ... « • · • · · • · · * · • · · * · • 1 • « m · · · • ·· » · ·····1 , H
FI970102D 1994-07-15 1997-01-10 Förfarande för syntetisering av substituerade sulfoxider FI117830B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9402510A SE504459C2 (sv) 1994-07-15 1994-07-15 Förfarande för framställning av substituerade sulfoxider
SE9402510 1994-07-15
SE9500818 1995-07-03
PCT/SE1995/000818 WO1996002535A1 (en) 1994-07-15 1995-07-03 Process for synthesis of substituted sulphoxides

Publications (1)

Publication Number Publication Date
FI117830B true FI117830B (sv) 2007-03-15

Family

ID=20394753

Family Applications (2)

Application Number Title Priority Date Filing Date
FI970102D FI117830B (sv) 1994-07-15 1997-01-10 Förfarande för syntetisering av substituerade sulfoxider
FI970102A FI117672B (sv) 1994-07-15 1997-01-10 Förfarande för syntetisering av substituerade sulfoxider

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI970102A FI117672B (sv) 1994-07-15 1997-01-10 Förfarande för syntetisering av substituerade sulfoxider

Country Status (42)

Country Link
US (1) US5948789A (sv)
EP (1) EP0773940B2 (sv)
JP (1) JP3795917B2 (sv)
KR (1) KR100356252B1 (sv)
CN (1) CN1070489C (sv)
AR (1) AR003443A1 (sv)
AT (1) ATE242233T1 (sv)
AU (1) AU688074B2 (sv)
BR (1) BR9508292A (sv)
CA (1) CA2193994C (sv)
CZ (1) CZ297987B6 (sv)
DE (1) DE69530987T3 (sv)
DK (1) DK0773940T4 (sv)
DZ (1) DZ1911A1 (sv)
EE (1) EE03354B1 (sv)
EG (1) EG24534A (sv)
ES (1) ES2199998T5 (sv)
FI (2) FI117830B (sv)
HK (1) HK1008331A1 (sv)
HR (1) HRP950401B1 (sv)
HU (1) HU226361B1 (sv)
IL (1) IL114477A (sv)
IS (1) IS1772B (sv)
MA (1) MA23611A1 (sv)
MX (1) MX9700358A (sv)
MY (1) MY113180A (sv)
NO (1) NO312101B1 (sv)
NZ (1) NZ289959A (sv)
PL (1) PL186342B1 (sv)
PT (1) PT773940E (sv)
RU (1) RU2157806C2 (sv)
SA (1) SA95160294B1 (sv)
SE (1) SE504459C2 (sv)
SI (1) SI0773940T2 (sv)
SK (1) SK284059B6 (sv)
TN (1) TNSN95081A1 (sv)
TR (1) TR199500861A2 (sv)
TW (1) TW372971B (sv)
UA (1) UA47409C2 (sv)
WO (1) WO1996002535A1 (sv)
YU (1) YU49475B (sv)
ZA (1) ZA955724B (sv)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6747155B2 (en) 1997-05-30 2004-06-08 Astrazeneca Ab Process
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
SE510643C2 (sv) * 1997-06-27 1999-06-14 Astra Ab Termodynamiskt stabil omeprazol natrium form B
HUP0100179A3 (en) 1997-07-03 2002-12-28 Bristol Myers Squibb Pharma Co Imidazopyrimidine and imidazopyridine derivatives and pharmaceutical compositions thereof
SE9704183D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New process
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
CA2320963A1 (en) * 1998-01-30 1999-08-05 Sepracor, Inc. R-lansoprazole compositions and methods
CA2330324A1 (en) * 1998-04-30 1999-11-04 Sepracor Inc. S-rabeprazole compositions and methods
WO1999055157A1 (en) * 1998-04-30 1999-11-04 Sepracor Inc. R-rabeprazole compositions and methods
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
CN1087739C (zh) * 1998-12-28 2002-07-17 中国科学院成都有机化学研究所 光学纯的苯并咪唑类抗消化性溃疡药物的包结拆分制备法
SE9900274D0 (sv) 1999-01-28 1999-01-28 Astra Ab New compound
TWI275587B (en) 1999-06-17 2007-03-11 Takeda Chemical Industries Ltd A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
AU5705700A (en) 1999-06-30 2001-01-22 Takeda Chemical Industries Ltd. Crystals of benzimidazole compounds
AU6727700A (en) * 1999-08-25 2001-03-19 Takeda Chemical Industries Ltd. Process for the preparation of optically active sulfoxide derivatives
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6369087B1 (en) * 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) * 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
CN1193024C (zh) * 2000-04-28 2005-03-16 武田药品工业株式会社 生产旋光的亚砜衍生物的方法
KR100869677B1 (ko) 2000-05-15 2008-11-21 다케다 야쿠힌 고교 가부시키가이샤 결정의 제조방법
US7169799B2 (en) 2000-05-15 2007-01-30 Takeda Pharmaceutical Company Limited Process for producing crystal
CA2417311C (en) 2000-08-04 2012-07-10 Takeda Chemical Industries, Ltd. Crystalline alkali metal salts of lansoprazole and their production and use
EP1337525B8 (en) * 2000-12-01 2011-10-05 Takeda Pharmaceutical Company Limited Process for the crystallization of (r)- or (s)-lansoprazole
US7064214B2 (en) * 2001-04-13 2006-06-20 Apsinterm Llc Methods of preparing sulfinamides and sulfoxides
GB2376231A (en) * 2001-06-06 2002-12-11 Cipla Ltd Benzimidazole-cyclodextrin inclusion complex
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
EP1487818B1 (en) 2002-03-05 2007-05-30 AstraZeneca AB Alkylammonium salts of omeprazole and esomeprazole
AU2003262375A1 (en) * 2002-04-22 2003-11-03 Sun Pharmaceutical Industries Limited Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts
EP1515963B1 (en) * 2002-06-27 2007-02-14 Dr. Reddy's Laboratories Ltd. A process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof
ES2534713T3 (es) 2002-10-16 2015-04-27 Takeda Pharmaceutical Company Limited Preparaciones sólidas estables
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
EA200500673A1 (ru) 2002-10-22 2005-12-29 Рэнбакси Лабораториз Лимитед Аморфная форма соли эзомепразола, способ ее получения и фармацевтическая композиция на её основе
DE10254167A1 (de) 2002-11-20 2004-06-09 Icon Genetics Ag Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen
DK1575941T3 (da) * 2002-12-06 2012-07-09 Nycomed Gmbh Fremgangsmåde til fremstilling af (S)-pantoprazol
AU2003289948B2 (en) * 2002-12-06 2009-12-24 Takeda Gmbh Process for preparing optically pure active compounds
EP1575937A2 (en) * 2002-12-16 2005-09-21 Ranbaxy Laboratories, Ltd. Rabeprazole calcium
FR2848555B1 (fr) 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
EP1572680A2 (en) 2002-12-19 2005-09-14 Eva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation.
CN1723208A (zh) * 2003-01-07 2006-01-18 兰贝克赛实验室有限公司 咪唑衍生物的镁盐
CA2517005A1 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
RU2005129513A (ru) * 2003-02-28 2006-03-10 Рэнбакси Лабораториз Лимитед (In) Полиморфы s-омепразола
US20040235904A1 (en) * 2003-03-12 2004-11-25 Nina Finkelstein Crystalline and amorphous solids of pantoprazole and processes for their preparation
WO2004080487A1 (ja) * 2003-03-13 2004-09-23 Eisai Co. Ltd. 歯ぎしりの予防剤または治療剤
FR2852956B1 (fr) * 2003-03-28 2006-08-04 Negma Gild Procede de preparation enantioselective de derives de sulfoxydes
JP2006523201A (ja) * 2003-03-28 2006-10-12 シデム ファーマ スルホキシド誘導体をエナンチオ選択的に調製する方法
WO2004099181A1 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Barium salt of benzimidazole derivative
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
SE0302382D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts II
SE0302381D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts I
WO2005054228A1 (en) * 2003-12-05 2005-06-16 Hetero Drugs Limited A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers
SE0400410D0 (sv) * 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
DE602004022337D1 (de) 2004-04-28 2009-09-10 Hetero Drugs Ltd Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ES2338556T3 (es) * 2004-05-28 2010-05-10 Hetero Drugs Limited Sintesis estereoselectiva novedosa de sulfoxidos de benzimidazol.
CN1960987A (zh) * 2004-06-02 2007-05-09 奥坦纳医药公司 制备吡啶－2－基甲基亚磺酰基－1h－苯并咪唑类化合物的方法
JP5563735B2 (ja) 2004-06-16 2014-07-30 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド Ｐｐｉ多回剤形
MXPA06015031A (es) * 2004-06-24 2007-02-08 Astrazeneca Ab Nuevo proceso para la preparacion de modificaciones cristalinas para usarse en la preparacion de sal de sodio de esomeprazol.
US20080249134A1 (en) * 2004-06-24 2008-10-09 Ursula Hohlneicher New Esomeprazole Sodium Salt Crystal Modification
FR2876101B1 (fr) * 2004-10-05 2007-03-02 Sidem Pharma Sa Sa Procede de preparation enantioselective de derives de sulfoxydes
PL1802584T3 (pl) * 2004-10-11 2010-03-31 Ranbaxy Laboratories Ltd Sposób wytwarzania podstawionych sulfotlenków
US7592111B2 (en) * 2004-11-05 2009-09-22 Xerox Corporation Imaging member
CN101098867B (zh) * 2005-03-25 2010-08-11 丽珠医药集团股份有限公司 取代的亚砜类化合物和其制备方法及用途
ATE528301T1 (de) * 2005-03-25 2011-10-15 Livzon Pharmaceutical Group Verfahren zur herstellung von substituierten sulfoxidzusammensetzungen
WO2006120520A1 (en) * 2005-05-06 2006-11-16 Glenmark Pharmaceuticals Limited Esomeprazole strontium salt, process for its preparation and pharmaceutical compositions containing same
US8247566B2 (en) * 2005-06-08 2012-08-21 Lek Pharmaceuticals D.D. Crystalline solvate of omeprazole sodium
US20070043085A1 (en) * 2005-08-19 2007-02-22 Glenmark Pharmaceuticals Limited Process for the preparation of amorphous form of neutral esomeprazole
AU2006323245B2 (en) * 2005-12-05 2011-03-03 Astrazeneca Ab New process for the preparation of esomeprazole non-salt form
DE102005061720B3 (de) * 2005-12-22 2006-10-19 Ratiopharm Gmbh Enantioselektive Herstellung von Benzimidazolderivaten und ihren Salzen
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
US7553857B2 (en) 2005-12-23 2009-06-30 Lek Pharmaceuticals D.D. S-omeprazole magnesium
US7799925B2 (en) 2005-12-28 2010-09-21 Unión Químico Farmacéutica, S.A. Process for the preparation of the (S)-enantiomer of omeprazole
CN1810803B (zh) * 2006-02-17 2010-11-17 中国科学院上海有机化学研究所 高对映体选择性制备(s)-奥美拉唑的方法
US7579476B2 (en) * 2006-02-24 2009-08-25 Praktikatalyst Pharma, Llc Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
US8063074B2 (en) * 2006-05-04 2011-11-22 Dr. Reddy's Laboratories Limited Polymorphic forms of esomeprazole sodium
US7786309B2 (en) * 2006-06-09 2010-08-31 Apotex Pharmachem Inc. Process for the preparation of esomeprazole and salts thereof
WO2008004245A1 (en) 2006-07-05 2008-01-10 Lupin Limited Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds
CA2660112A1 (en) 2006-08-08 2008-02-14 Jubilant Organosys Limited Process for producing sulphoxide compounds
JP2009196894A (ja) * 2006-10-13 2009-09-03 Eisai R & D Management Co Ltd スルフィニルベンズイミダゾール化合物またはその塩の製造方法
WO2008047681A1 (fr) 2006-10-13 2008-04-24 Eisai R & D Management Co., Ltd. Benzimidazole présentant une activité inhibitrice de la sécrétion d'acide gastrique
EP1947099A1 (en) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Process for solvent removal from omeprazole salts
JP2010519284A (ja) * 2007-02-21 2010-06-03 シプラ・リミテッド エソメプラゾールマグネシウム二水和物の調製方法
EP2152691B1 (en) * 2007-06-07 2011-11-23 Aurobindo Pharma Limited An improved process for preparing an optically active proton pump inhibitor
CN101323609B (zh) * 2007-06-15 2013-05-01 成都福瑞生物工程有限公司 不对称氧化硫醚成亚砜合成对映体含量高的苯并咪唑衍生物的方法
US20100210848A1 (en) * 2007-10-03 2010-08-19 Ipca Laboratories Ltd. Process for optically active sulfoxide compounds
US8106210B2 (en) 2007-10-08 2012-01-31 Hetero Drugs Limited Polymorphs of esomeprazole salts
CA2702356C (en) 2007-10-12 2014-02-11 Takeda Pharmaceuticals North America, Inc. Pharmaceutical formulation comprising a proton pump inhibitor for the treatment of gastrointestinal conditions independent of food intake
FR2925899B1 (fr) * 2007-12-27 2012-12-21 Sidem Pharma Sa Procede de preparation enantioselective de sulfoxydes.
CN101492459B (zh) * 2008-01-25 2011-04-27 山东轩竹医药科技有限公司 含烷氧乙酰基二氢异噁唑并吡啶化合物
CN101497603B (zh) * 2008-01-30 2012-11-07 山东轩竹医药科技有限公司 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物
UY31695A (es) 2008-03-10 2009-11-10 Takeda Pharmaceutical Cristal de compuestos de bencimidazol
WO2009117489A1 (en) * 2008-03-18 2009-09-24 Dr. Reddy's Laboratories Ltd. Dexlansoprazole process and polymorphs
CN101538264A (zh) * 2008-03-19 2009-09-23 中国科学院成都有机化学有限公司 手性亚砜类化合物的制备新方法
WO2009145368A1 (en) * 2008-05-27 2009-12-03 Sk Chemicals Co., Ltd. Improved preparing method of (s)-omeprazole from omeprazole racemate using optical resolution agent
EP2143722A1 (en) 2008-07-09 2010-01-13 Lek Pharmaceuticals D.D. Process for preparation of esomeprazole sodium of high chemical purity and new forms of esomeprazole sodium
US20100113527A1 (en) * 2008-09-30 2010-05-06 Teva Pharmaceutical Industries Ltd. Crystalline forms of dexlansoprazole
EP2264024A1 (en) 2008-10-14 2010-12-22 LEK Pharmaceuticals d.d. Process for the preparation of enantiomerically enriched proton pump inhibitors
IT1391776B1 (it) 2008-11-18 2012-01-27 Dipharma Francis Srl Procedimento per la preparazione di dexlansoprazolo
CZ200990A3 (cs) * 2009-02-16 2010-08-25 Zentiva, K.S. Zpusob výroby (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolu
WO2010097583A1 (en) 2009-02-24 2010-09-02 Cipla Limited Esomeprazole potassium polymorph and its preparation
CZ2009172A3 (cs) * 2009-03-17 2010-09-29 Zentiva, K.S. Zpusob výroby (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolu
WO2010150276A2 (en) * 2009-06-02 2010-12-29 Sun Pharmaceutical Industries Limited Process for preparing sulphoxide compounds
IT1395118B1 (it) 2009-07-29 2012-09-05 Dipharma Francis Srl Procedimento per la preparazione di dexlansoprazolo cristallino
EP2499125B1 (en) 2009-11-12 2016-01-27 Hetero Research Foundation Process for the resolution of omeprazole
EP2528912A1 (en) 2010-01-29 2012-12-05 Ranbaxy Laboratories Limited Process for the preparation of crystalline forms of dexlansoprazole
JP2013529623A (ja) 2010-06-24 2013-07-22 シプラ・リミテッド デクスラベプラゾールの塩及び多形体
CN101914090B (zh) * 2010-08-13 2013-03-20 埃斯特维华义制药有限公司 左旋奥美拉唑的制备方法
CN102558150B (zh) * 2010-12-31 2014-03-12 正大天晴药业集团股份有限公司 取代亚砜化合物的合成方法
CN102321071B (zh) * 2011-07-20 2013-01-23 江苏奥赛康药业股份有限公司 一种高纯度埃索美拉唑钠的工业化生产方法
CN102977076A (zh) * 2011-09-02 2013-03-20 扬子江药业集团上海海尼药业有限公司 一种右兰索拉唑的制备方法
CN102329302A (zh) * 2011-10-22 2012-01-25 刘强 一种埃索美拉唑及其盐的制备方法
CN102408412A (zh) * 2011-10-25 2012-04-11 广东华南药业集团有限公司 高对映体选择性制备（s）- 奥美拉唑的方法
CN102432412A (zh) * 2011-10-28 2012-05-02 成都欣捷高新技术开发有限公司 一种手性亚砜类质子泵抑制剂或其可药用盐的制备方法
KR101300950B1 (ko) * 2011-10-31 2013-08-27 르노삼성자동차 주식회사 전기자동차의 공기 흡입 장치
WO2013140120A1 (en) 2012-03-22 2013-09-26 Cipla Limited Glycerol solvate forms of (r) - 2 - [ [ [3 -methyl -4 (2,2, 2 - trifluoroethoxy) pyridin- 2 - yl] methyl] sulphinyl] - 1h - ben zimidazole
CN102633776B (zh) * 2012-03-28 2014-06-18 中山市仁合药业有限公司 一种埃索美拉唑及其钠盐的制备方法
CN102659763B (zh) * 2012-04-27 2014-01-22 南京优科生物医药研究有限公司 一种右旋兰索拉唑合成与纯化的方法
CN103044402B (zh) * 2012-12-31 2015-01-14 康普药业股份有限公司 埃索美拉唑钠合成生产方法
CN103113351B (zh) * 2013-03-08 2015-01-21 苏州特瑞药业有限公司 一种光学纯手性亚砜类化合物的制备方法
CN104177336A (zh) * 2013-05-28 2014-12-03 上海汇伦生命科技有限公司 一种对映选择性合成右兰索拉唑的方法
EP2929885A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and proton pump inhibitors
EP2933002A1 (en) 2014-04-11 2015-10-21 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of dabigatran and proton pump inhibitors
EP2980086B1 (en) 2014-07-29 2016-06-15 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Efficient process for the preparation of esomeprazole (S)-binol complex
US10307748B2 (en) 2014-12-26 2019-06-04 The University Of Tokyo Method for producing proton pump inhibitor compound having optical activity
CN104610226A (zh) * 2014-12-31 2015-05-13 广东东阳光药业有限公司 一种右兰索拉唑的不对称氧化方法
ES2615637T3 (es) * 2015-03-06 2017-06-07 F.I.S.- Fabbrica Italiana Sintetici S.P.A. Procedimiento mejorado para la purificación óptica del esomeprazol
CN105218392B (zh) * 2015-07-09 2017-11-21 天津青松华药医药有限公司 D‑酒石酸单酯单酰胺类化合物
CN105218391B (zh) * 2015-07-09 2017-11-21 天津青松华药医药有限公司 L‑酒石酸单酯单酰胺类化合物
CN105968097B (zh) * 2016-05-17 2019-05-03 杭州华东医药集团新药研究院有限公司 左旋泮托拉唑的工业化生产方法
CN106083818A (zh) * 2016-06-08 2016-11-09 扬子江药业集团有限公司 一种高纯度埃索美拉唑钠的制备方法
CN106366070B (zh) * 2016-08-10 2019-06-11 上海万巷制药有限公司 一种高纯度埃索美拉唑钠的制备方法
CN106632249A (zh) * 2016-09-30 2017-05-10 青岛云天生物技术有限公司 一种制备(s)‑泮托拉唑钠的方法
CN106632248A (zh) * 2016-09-30 2017-05-10 青岛云天生物技术有限公司 一种左旋泮托拉唑钠的制备工艺
CN106866630B (zh) * 2017-04-01 2018-08-07 上海华源医药科技发展有限公司 一种右兰索拉唑的制备方法
CN110698482A (zh) * 2019-10-29 2020-01-17 株洲千金药业股份有限公司 一种s型手性亚砜类化合物的制备方法
CN110746428A (zh) * 2019-10-29 2020-02-04 株洲千金药业股份有限公司 一种r型手性亚砜类化合物的制备方法
CN113845510A (zh) * 2020-06-27 2021-12-28 鲁南制药集团股份有限公司 一种埃索美拉唑的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation

Also Published As

Publication number Publication date
SA95160294B1 (ar) 2006-07-31
EE03354B1 (et) 2001-02-15
CN1157614A (zh) 1997-08-20
EG24534A (en) 2009-08-30
TR199500861A2 (tr) 1996-06-21
HUT76642A (en) 1997-10-28
MY113180A (en) 2001-12-31
YU49475B (sh) 2006-05-25
DZ1911A1 (fr) 2002-02-17
DE69530987T2 (de) 2004-05-19
DK0773940T4 (da) 2011-02-07
PL186342B1 (pl) 2003-12-31
HU226361B1 (en) 2008-09-29
NO970153L (no) 1997-01-14
FI970102A (sv) 1997-01-10
FI117672B (sv) 2007-01-15
JP3795917B2 (ja) 2006-07-12
SI0773940T1 (en) 2004-02-29
ES2199998T5 (es) 2011-03-16
WO1996002535A8 (en) 1999-12-23
HK1008331A1 (en) 1999-05-07
DE69530987D1 (de) 2003-07-10
KR970704731A (ko) 1997-09-06
MX9700358A (es) 1997-04-30
AU2994895A (en) 1996-02-16
DE69530987T3 (de) 2011-07-07
IL114477A (en) 2001-07-24
CA2193994C (en) 2005-05-03
PT773940E (pt) 2003-10-31
EP0773940A1 (en) 1997-05-21
YU47695A (sh) 1998-07-10
IS4406A (is) 1996-12-27
US5948789A (en) 1999-09-07
UA47409C2 (uk) 2002-07-15
EP0773940B1 (en) 2003-06-04
NO970153D0 (no) 1997-01-14
DK0773940T3 (da) 2003-09-15
NZ289959A (en) 1998-01-26
KR100356252B1 (ko) 2002-11-18
JPH10504290A (ja) 1998-04-28
SK4897A3 (en) 1997-08-06
CZ297987B6 (cs) 2007-05-16
SE9402510D0 (sv) 1994-07-15
SK284059B6 (sk) 2004-09-08
PL318165A1 (en) 1997-05-26
EP0773940B2 (en) 2010-11-17
WO1996002535A1 (en) 1996-02-01
NO312101B1 (no) 2002-03-18
HRP950401B1 (en) 2004-04-30
AU688074B2 (en) 1998-03-05
SE9402510L (sv) 1996-01-16
ES2199998T3 (es) 2004-03-01
AR003443A1 (es) 1998-08-05
SE504459C2 (sv) 1997-02-17
HRP950401A2 (en) 1997-10-31
MA23611A1 (fr) 1996-04-01
FI970102A0 (sv) 1997-01-10
RU2157806C2 (ru) 2000-10-20
IL114477A0 (en) 1995-11-27
SI0773940T2 (sl) 2011-02-28
TW372971B (en) 1999-11-01
CN1070489C (zh) 2001-09-05
ZA955724B (en) 1996-01-15
ATE242233T1 (de) 2003-06-15
TNSN95081A1 (fr) 1996-02-06
CA2193994A1 (en) 1996-02-01
IS1772B (is) 2001-06-01
CZ6497A3 (en) 1997-06-11
BR9508292A (pt) 1997-12-23

Similar Documents

Publication Publication Date Title
FI117830B (sv) Förfarande för syntetisering av substituerade sulfoxider
CZ295430B6 (cs) Způsob optického čištění enantiomerně obohacených přípravků
US7452998B2 (en) Process for preparing optically pure active compounds
US7301030B2 (en) Process for preparing (S)-pantoprazole
CA2553877C (en) Compounds useful for the synthesis of s- and r-omeprazole and a process for their preparation
EA016814B1 (ru) Замещенные изотопами ингибиторы протонного насоса
US20100210848A1 (en) Process for optically active sulfoxide compounds
MXPA98000160A (en) A process for the optic purification of derivatives of benzimidazol enriquecidos enantiomericame