DE602004022337D1 - Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere - Google Patents
Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomereInfo
- Publication number
- DE602004022337D1 DE602004022337D1 DE602004022337T DE602004022337T DE602004022337D1 DE 602004022337 D1 DE602004022337 D1 DE 602004022337D1 DE 602004022337 T DE602004022337 T DE 602004022337T DE 602004022337 T DE602004022337 T DE 602004022337T DE 602004022337 D1 DE602004022337 D1 DE 602004022337D1
- Authority
- DE
- Germany
- Prior art keywords
- preparing
- enantiomer
- pyridinylmethyl
- enriched form
- individual enantiomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- QQTZYHKWYUCCFC-UHFFFAOYSA-N 1-(pyridin-2-ylmethyl)benzimidazole Chemical class C1=NC2=CC=CC=C2N1CC1=CC=CC=N1 QQTZYHKWYUCCFC-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 abstract 1
- 229960004770 esomeprazole Drugs 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960000381 omeprazole Drugs 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2004/000118 WO2005105786A1 (en) | 2004-04-28 | 2004-04-28 | A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004022337D1 true DE602004022337D1 (de) | 2009-09-10 |
Family
ID=35241611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004022337T Expired - Lifetime DE602004022337D1 (de) | 2004-04-28 | 2004-04-28 | Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere |
Country Status (8)
Country | Link |
---|---|
US (3) | US7176319B2 (de) |
EP (1) | EP1740571B1 (de) |
AT (1) | ATE437869T1 (de) |
DE (1) | DE602004022337D1 (de) |
DK (1) | DK1740571T3 (de) |
ES (1) | ES2327926T3 (de) |
PT (1) | PT1740571E (de) |
WO (1) | WO2005105786A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006514108A (ja) * | 2002-12-19 | 2006-04-27 | テバ ファーマシューティカル インダストリーズ リミティド | パントプラゾールナトリウムの固体状態、それらの調製方法、及び公知のパントプラゾールナトリウム水和物の調製方法 |
CA2528993A1 (en) * | 2003-06-10 | 2004-12-23 | Teva Pharmaceutical Industries Ltd. | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
PT1748998E (pt) * | 2004-05-28 | 2010-03-24 | Hetero Drugs Ltd | Novo processo de síntese estereoselectiva de sulfóxidos de benzimidazol |
US7553857B2 (en) * | 2005-12-23 | 2009-06-30 | Lek Pharmaceuticals D.D. | S-omeprazole magnesium |
CA2678702A1 (en) | 2007-02-21 | 2008-08-28 | Cipla Limited | Process for the preparation of esomeprazole magnesium dihydrate |
FR2920428B1 (fr) * | 2007-08-29 | 2012-06-15 | Univ Rouen | Procede de dedoublement de sels de l'omeprazole |
PT2106397E (pt) | 2007-09-25 | 2012-01-23 | Hetero Drugs Ltd | Processo para a preparação de esomeprazol enantiomericamente puro |
EP2195309A4 (de) | 2007-10-08 | 2013-04-24 | Hetero Drugs Ltd | Polymorphe von esomeprazolsalzen |
EP2143722A1 (de) | 2008-07-09 | 2010-01-13 | Lek Pharmaceuticals D.D. | Verfahren zur Herstellung von Esomeprazol-Natrium von hoher chemischer Reinheit und neue Formen von Esomeprazol-Natrium |
WO2010039885A2 (en) * | 2008-09-30 | 2010-04-08 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of dexlansoprazole |
EP2346854A4 (de) | 2008-11-18 | 2012-10-17 | Hetero Research Foundation | Optische reinigung von esomeprazol |
US8748619B2 (en) | 2009-11-12 | 2014-06-10 | Hetero Research Foundation | Process for the resolution of omeprazole |
KR101985559B1 (ko) | 2011-09-27 | 2019-06-03 | 사우디 아라비안 오일 컴퍼니 | 산화적 탈황 반응 생성물의 선택적 액체-액체 추출 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US5984789A (en) * | 1983-11-15 | 1999-11-16 | Luk Lamellen Und Kupplungsbau Gmbh | Assembly for taking up and compensating for torque induced shocks |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
DE4035455A1 (de) * | 1990-11-08 | 1992-05-14 | Byk Gulden Lomberg Chem Fab | Enantiomerentrennung |
SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
US7036725B2 (en) * | 1995-06-06 | 2006-05-02 | Smart Media Of Delaware, Inc. | Shopping cart handle with built-in console for the input and display of consumer product information |
US6422462B1 (en) * | 1998-03-30 | 2002-07-23 | Morris E. Cohen | Apparatus and methods for improved credit cards and credit card transactions |
BR9912937A (pt) * | 1998-08-10 | 2001-05-08 | Partnership Of Michael E Garst | Pró-drogas de inibidores de bomba de prótons |
US6145741A (en) * | 1999-04-27 | 2000-11-14 | Wisdom; Juanita J. | Universal pre-paid gasoline and travel card |
WO2001031555A1 (en) * | 1999-10-28 | 2001-05-03 | Gould David B | Prepaid cash equivalent card and system |
US7099568B2 (en) * | 2000-03-21 | 2006-08-29 | Sony Corporation | Information playback apparatus and electronic pop advertising apparatus |
US7566274B2 (en) * | 2000-12-19 | 2009-07-28 | Paltronics, Inc. | Video table game apparatus, system, and method of use |
US7103573B2 (en) * | 2001-04-02 | 2006-09-05 | Privilegeone Networks, Llc | User rewards program and associated communications system |
US20020153424A1 (en) * | 2001-04-19 | 2002-10-24 | Chuan Li | Method and apparatus of secure credit card transaction |
US20020178063A1 (en) * | 2001-05-25 | 2002-11-28 | Kelly Gravelle | Community concept for payment using RF ID transponders |
WO2003027098A1 (fr) | 2001-09-25 | 2003-04-03 | Takeda Chemical Industries, Ltd. | Compose de benzymidazole, procede de production et d'utilisation de celui-ci |
US20030066073A1 (en) * | 2001-09-28 | 2003-04-03 | Rebh Richard G. | Methods and systems of interactive advertising |
US20040044574A1 (en) * | 2002-06-04 | 2004-03-04 | Kordex, Inc. | Apparatus for displaying local advertising to a display screen |
KR20050009751A (ko) | 2002-06-14 | 2005-01-25 | 다케다 야쿠힌 고교 가부시키가이샤 | E.g. 소화성 궤양의 치료에서 프로톤 펌프 억제제로서사용하기 위한 이미다졸 유도체의 프로드러그 |
WO2004002982A2 (en) | 2002-06-27 | 2004-01-08 | Dr. Reddy's Laboratories Limited | A process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof |
PT1556371E (pt) | 2002-07-19 | 2006-09-29 | Winston Pharmateuticals Llc | Derivados de benzimidazole e sua utilizacao como pro-farmacos de inibadores da bomba de protoes. |
CA2516187A1 (en) * | 2002-11-26 | 2004-06-10 | The Advertizing Firm, Inc. | Method and system of advertising |
US7593867B2 (en) * | 2004-01-12 | 2009-09-22 | The Coca-Cola Company | Interactive networked product container |
WO2006055634A2 (en) * | 2004-11-18 | 2006-05-26 | Goliath Solutions L.L.C. | Rf contact signal detector |
US7055740B1 (en) * | 2004-12-06 | 2006-06-06 | Target Brands, Inc. | Stored-value card adapted to be read by an electronic device |
US7290714B2 (en) * | 2005-01-18 | 2007-11-06 | Target Brands, Inc. | Stored-value card with light |
-
2004
- 2004-04-28 EP EP04729974A patent/EP1740571B1/de not_active Revoked
- 2004-04-28 US US10/503,830 patent/US7176319B2/en active Active
- 2004-04-28 DK DK04729974T patent/DK1740571T3/da active
- 2004-04-28 AT AT04729974T patent/ATE437869T1/de active
- 2004-04-28 PT PT04729974T patent/PT1740571E/pt unknown
- 2004-04-28 ES ES04729974T patent/ES2327926T3/es not_active Expired - Lifetime
- 2004-04-28 WO PCT/IN2004/000118 patent/WO2005105786A1/en not_active Application Discontinuation
- 2004-04-28 DE DE602004022337T patent/DE602004022337D1/de not_active Expired - Lifetime
-
2007
- 2007-01-08 US US11/620,830 patent/US7928240B2/en not_active Expired - Fee Related
- 2007-01-08 US US11/620,843 patent/US7435826B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1740571B1 (de) | 2009-07-29 |
US20070129406A1 (en) | 2007-06-07 |
EP1740571A1 (de) | 2007-01-10 |
DK1740571T3 (da) | 2009-11-02 |
ES2327926T3 (es) | 2009-11-05 |
US7176319B2 (en) | 2007-02-13 |
US20070129405A1 (en) | 2007-06-07 |
US20060089386A1 (en) | 2006-04-27 |
WO2005105786A1 (en) | 2005-11-10 |
US7435826B2 (en) | 2008-10-14 |
ATE437869T1 (de) | 2009-08-15 |
US7928240B2 (en) | 2011-04-19 |
PT1740571E (pt) | 2009-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |