DE602004001627D1 - Methode zur Racemisierung von (S)-(+)- und (R)-(-)-10,11-Dihydro-10-hydroxy-5H-dibenzib,föazepine-5-carboxamiden und optisch angereicherten Mischungen davon - Google Patents

Methode zur Racemisierung von (S)-(+)- und (R)-(-)-10,11-Dihydro-10-hydroxy-5H-dibenzib,föazepine-5-carboxamiden und optisch angereicherten Mischungen davon

Info

Publication number
DE602004001627D1
DE602004001627D1 DE602004001627T DE602004001627T DE602004001627D1 DE 602004001627 D1 DE602004001627 D1 DE 602004001627D1 DE 602004001627 T DE602004001627 T DE 602004001627T DE 602004001627 T DE602004001627 T DE 602004001627T DE 602004001627 D1 DE602004001627 D1 DE 602004001627D1
Authority
DE
Germany
Prior art keywords
föazepine
dibenzib
racemization
carboxamides
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004001627T
Other languages
English (en)
Other versions
DE602004001627T2 (de
Inventor
David Alexander Learmonth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
Original Assignee
Bial Portela and Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Publication of DE602004001627D1 publication Critical patent/DE602004001627D1/de
Application granted granted Critical
Publication of DE602004001627T2 publication Critical patent/DE602004001627T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004001627T 2003-05-12 2004-05-11 Methode zur Racemisierung von (S)-(+)- und (R)-(-)-10,11-Dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamiden und optisch angereicherten Mischungen davon Expired - Lifetime DE602004001627T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0310856A GB2401605A (en) 2003-05-12 2003-05-12 Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof
GB0310856 2003-05-12

Publications (2)

Publication Number Publication Date
DE602004001627D1 true DE602004001627D1 (de) 2006-09-07
DE602004001627T2 DE602004001627T2 (de) 2007-08-23

Family

ID=9957887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004001627T Expired - Lifetime DE602004001627T2 (de) 2003-05-12 2004-05-11 Methode zur Racemisierung von (S)-(+)- und (R)-(-)-10,11-Dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamiden und optisch angereicherten Mischungen davon

Country Status (20)

Country Link
US (1) US7189846B2 (de)
EP (1) EP1477480B1 (de)
JP (1) JP2006525985A (de)
KR (1) KR20060055456A (de)
CN (1) CN100519535C (de)
AR (1) AR044296A1 (de)
AT (1) ATE334118T1 (de)
AU (1) AU2004236022B2 (de)
BR (1) BRPI0410282A (de)
CA (1) CA2525419C (de)
DE (1) DE602004001627T2 (de)
DK (1) DK1477480T3 (de)
ES (1) ES2270293T3 (de)
GB (1) GB2401605A (de)
MX (1) MXPA05012209A (de)
PL (1) PL1477480T3 (de)
PT (1) PT103115A (de)
RU (1) RU2345986C2 (de)
SI (1) SI1477480T1 (de)
WO (1) WO2004099153A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101236227B1 (ko) * 2005-05-06 2013-02-21 바이알 - 포르텔라 앤드 씨에이 에스에이 에스리카르바제핀 아세테이트 및 그의 사용방법
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB2437078A (en) * 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) * 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
EP2459198A1 (de) 2009-07-27 2012-06-06 Bial-Portela & CA, S.A. Verwendung von 5h-dibenz / b, f/ azepin-5-carboxamid-derivaten zur behandlung von fibromyalgie
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
EP2383261B1 (de) 2010-04-23 2013-09-04 Euticals GmbH Verfahren zur asymmetrischen Hydrierung von Ketonen
WO2012156987A2 (en) * 2011-05-19 2012-11-22 Glenmark Generics Limited A novel process for the preparation of eslicarbazepine
JP2015519333A (ja) * 2012-05-07 2015-07-09 セリックスビオ プライヴェート リミテッド 神経疾患の治療のための組成物および方法
EP3064490A1 (de) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Verbessertes verfahren zur herstellung von eslicarbazepin und eslicarbazepinacetat
CN105130899A (zh) * 2015-08-25 2015-12-09 安徽省新星药物开发有限责任公司 一种醋酸艾司利卡西平的合成方法
FR3047172B1 (fr) * 2016-01-29 2020-05-08 Societe Industrielle Limousine D'application Biologique Agent cosmetique tenseur et/ou filmogene constitue par des galactomannanes et/ou des galactanes sulfates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH605791A5 (de) * 1974-09-27 1978-10-13 Ciba Geigy Ag
CH642950A5 (en) 1979-10-30 1984-05-15 Ciba Geigy Ag Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
GB0111566D0 (en) 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide

Also Published As

Publication number Publication date
BRPI0410282A (pt) 2006-05-16
CN100519535C (zh) 2009-07-29
US20040266754A1 (en) 2004-12-30
CN1823047A (zh) 2006-08-23
KR20060055456A (ko) 2006-05-23
JP2006525985A (ja) 2006-11-16
ES2270293T3 (es) 2007-04-01
DE602004001627T2 (de) 2007-08-23
CA2525419C (en) 2014-07-22
GB0310856D0 (en) 2003-06-18
US7189846B2 (en) 2007-03-13
ATE334118T1 (de) 2006-08-15
AU2004236022A1 (en) 2004-11-18
PT103115A (pt) 2004-11-30
EP1477480B1 (de) 2006-07-26
RU2345986C2 (ru) 2009-02-10
PL1477480T3 (pl) 2006-12-29
MXPA05012209A (es) 2006-02-10
AR044296A1 (es) 2005-09-07
EP1477480A1 (de) 2004-11-17
SI1477480T1 (sl) 2006-12-31
CA2525419A1 (en) 2004-11-18
RU2005138516A (ru) 2007-06-20
DK1477480T3 (da) 2006-11-27
GB2401605A (en) 2004-11-17
WO2004099153A1 (en) 2004-11-18
AU2004236022B2 (en) 2010-09-23

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIAL - PORTELA & CA., S.A., S. MAMEDE DO CORON, PT