DE60300252D1 - Verfahren zur industriellen Herstellung von 5-Amino-3-carboxymethyl-4-cyano-2-thiphencarboxydimethylester - Google Patents
Verfahren zur industriellen Herstellung von 5-Amino-3-carboxymethyl-4-cyano-2-thiphencarboxydimethylesterInfo
- Publication number
- DE60300252D1 DE60300252D1 DE60300252T DE60300252T DE60300252D1 DE 60300252 D1 DE60300252 D1 DE 60300252D1 DE 60300252 T DE60300252 T DE 60300252T DE 60300252 T DE60300252 T DE 60300252T DE 60300252 D1 DE60300252 D1 DE 60300252D1
- Authority
- DE
- Germany
- Prior art keywords
- thiphencarboxydimethylester
- carboxymethyl
- cyano
- amino
- industrial preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211764A FR2844796A1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR0211764 | 2002-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60300252D1 true DE60300252D1 (de) | 2005-02-03 |
| DE60300252T2 DE60300252T2 (de) | 2005-12-22 |
Family
ID=29415190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60300252T Expired - Lifetime DE60300252T2 (de) | 2002-09-24 | 2003-09-22 | Verfahren zur industriellen Herstellung von 5-Amino-3-carboxy-methyl-4-cyano2-thiophencarboxydimethylester |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US7105683B2 (de) |
| EP (1) | EP1403264B1 (de) |
| JP (1) | JP4136865B2 (de) |
| KR (1) | KR100551503B1 (de) |
| CN (2) | CN100393707C (de) |
| AP (1) | AP1942A (de) |
| AR (1) | AR041356A1 (de) |
| AT (1) | ATE286041T1 (de) |
| AU (2) | AU2003248279B2 (de) |
| BR (1) | BR0304194A (de) |
| CA (1) | CA2442875C (de) |
| DE (1) | DE60300252T2 (de) |
| DK (1) | DK1403264T3 (de) |
| EA (1) | EA007496B1 (de) |
| EC (1) | ECSP055742A (de) |
| ES (1) | ES2235144T3 (de) |
| FR (1) | FR2844796A1 (de) |
| GE (1) | GEP20074140B (de) |
| HK (2) | HK1061845A1 (de) |
| HR (1) | HRP20050360B1 (de) |
| IL (1) | IL167314A (de) |
| IS (1) | IS2136B (de) |
| MA (1) | MA26101A1 (de) |
| ME (1) | ME00451B (de) |
| MX (1) | MXPA03008645A (de) |
| MY (1) | MY131939A (de) |
| NI (1) | NI200500065A (de) |
| NO (1) | NO328697B1 (de) |
| NZ (1) | NZ528400A (de) |
| OA (1) | OA12933A (de) |
| PL (1) | PL214414B1 (de) |
| PT (1) | PT1403264E (de) |
| RS (1) | RS50929B (de) |
| SG (1) | SG110070A1 (de) |
| SI (1) | SI1403264T1 (de) |
| TN (1) | TNSN05089A1 (de) |
| UA (1) | UA79991C2 (de) |
| WO (1) | WO2004029035A1 (de) |
| ZA (1) | ZA200307410B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| CA2524610C (en) * | 2003-05-07 | 2014-03-25 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| AU2004237439B2 (en) * | 2003-05-07 | 2009-09-10 | Osteologix A/S | Treating cartilage/bone conditions with water-soluble strontium salts |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| AU2005216596B2 (en) * | 2004-02-26 | 2011-03-24 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
| ATE443541T1 (de) | 2004-06-25 | 2009-10-15 | Strontin Aps | Zusammensetzungen mit strontium und vitamin d und ihre verwendungen |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011110597A1 (de) | 2010-03-11 | 2011-09-15 | Azad Pharmaceutical Ingredients Ag | Verfahren zur herstellung von strontiumranelat |
| CN103319454B (zh) * | 2013-06-14 | 2014-06-18 | 广东众生药业股份有限公司 | 一种高纯度雷尼酸四乙酯及其中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR415850A (fr) | 1909-07-22 | 1910-10-05 | Gustave Auguste Ferrie | Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables |
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844797B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
-
2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
-
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 EP EP03292317A patent/EP1403264B1/de not_active Expired - Lifetime
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Application Discontinuation
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active IP Right Cessation
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
-
2004
- 2004-07-05 HK HK04104808A patent/HK1061845A1/xx not_active IP Right Cessation
-
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/xx unknown
- 2005-04-21 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
-
2006
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related
-
2007
- 2007-02-01 HK HK07101197A patent/HK1096661A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |