IS2136B - Aðferð til nýmyndunar í iðnaði á metýldíester 5-amínó-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru - Google Patents
Aðferð til nýmyndunar í iðnaði á metýldíester 5-amínó-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýruInfo
- Publication number
- IS2136B IS2136B IS7808A IS7808A IS2136B IS 2136 B IS2136 B IS 2136B IS 7808 A IS7808 A IS 7808A IS 7808 A IS7808 A IS 7808A IS 2136 B IS2136 B IS 2136B
- Authority
- IS
- Iceland
- Prior art keywords
- carboxymethyl
- cyano
- amino
- synthesis process
- thiophenecarboxylic acid
- Prior art date
Links
- KNPBNTMMZCNVIE-UHFFFAOYSA-N 5-amino-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid Chemical compound NC=1SC(C(O)=O)=C(CC(O)=O)C=1C#N KNPBNTMMZCNVIE-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000005690 diesters Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211764A FR2844796A1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| PCT/FR2003/002776 WO2004029035A1 (fr) | 2002-09-24 | 2003-09-22 | Nouveau procede de synthese industriel du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IS7808A IS7808A (is) | 2005-04-19 |
| IS2136B true IS2136B (is) | 2006-08-15 |
Family
ID=29415190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS7808A IS2136B (is) | 2002-09-24 | 2005-04-19 | Aðferð til nýmyndunar í iðnaði á metýldíester 5-amínó-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US7105683B2 (is) |
| EP (1) | EP1403264B1 (is) |
| JP (1) | JP4136865B2 (is) |
| KR (1) | KR100551503B1 (is) |
| CN (2) | CN1280285C (is) |
| AP (1) | AP1942A (is) |
| AR (1) | AR041356A1 (is) |
| AT (1) | ATE286041T1 (is) |
| AU (2) | AU2003248279B2 (is) |
| BR (1) | BR0304194A (is) |
| CA (1) | CA2442875C (is) |
| DE (1) | DE60300252T2 (is) |
| DK (1) | DK1403264T3 (is) |
| EA (1) | EA007496B1 (is) |
| EC (1) | ECSP055742A (is) |
| ES (1) | ES2235144T3 (is) |
| FR (1) | FR2844796A1 (is) |
| GE (1) | GEP20074140B (is) |
| HR (1) | HRP20050360B1 (is) |
| IL (1) | IL167314A (is) |
| IS (1) | IS2136B (is) |
| MA (1) | MA26101A1 (is) |
| ME (1) | ME00451B (is) |
| MX (1) | MXPA03008645A (is) |
| MY (1) | MY131939A (is) |
| NI (1) | NI200500065A (is) |
| NO (1) | NO328697B1 (is) |
| NZ (1) | NZ528400A (is) |
| OA (1) | OA12933A (is) |
| PL (1) | PL214414B1 (is) |
| PT (1) | PT1403264E (is) |
| RS (1) | RS50929B (is) |
| SG (1) | SG110070A1 (is) |
| SI (1) | SI1403264T1 (is) |
| TN (1) | TNSN05089A1 (is) |
| UA (1) | UA79991C2 (is) |
| WO (1) | WO2004029035A1 (is) |
| ZA (1) | ZA200307410B (is) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| WO2004098619A2 (en) * | 2003-05-07 | 2004-11-18 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
| EP1622630B1 (en) * | 2003-05-07 | 2012-08-29 | Osteologix A/S | Strontium combinations for the prophylaxis/treatment of cartilage and/or bone conditions |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| CA2557324C (en) * | 2004-02-26 | 2012-10-16 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
| DK1768748T4 (da) | 2004-06-25 | 2019-06-11 | Mokwalo Spf S A | Sammensætninger omfattende strontium og vitamin D og anvendelser deraf |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011110597A1 (de) | 2010-03-11 | 2011-09-15 | Azad Pharmaceutical Ingredients Ag | Verfahren zur herstellung von strontiumranelat |
| CN103319454B (zh) * | 2013-06-14 | 2014-06-18 | 广东众生药业股份有限公司 | 一种高纯度雷尼酸四乙酯及其中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR415850A (fr) | 1909-07-22 | 1910-10-05 | Gustave Auguste Ferrie | Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables |
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844797B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
-
2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
-
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 EP EP03292317A patent/EP1403264B1/fr not_active Expired - Lifetime
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Ceased
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active Expired - Fee Related
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
-
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/is unknown
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
-
2006
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related
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