DK1467993T3 - Fremgangsmåde til fremstilling af scopinestere - Google Patents
Fremgangsmåde til fremstilling af scopinestereInfo
- Publication number
- DK1467993T3 DK1467993T3 DK02796735T DK02796735T DK1467993T3 DK 1467993 T3 DK1467993 T3 DK 1467993T3 DK 02796735 T DK02796735 T DK 02796735T DK 02796735 T DK02796735 T DK 02796735T DK 1467993 T3 DK1467993 T3 DK 1467993T3
- Authority
- DK
- Denmark
- Prior art keywords
- esters
- formula
- quaternized scopine
- quaternized
- scopine
- Prior art date
Links
- FIMXSEMBHGTNKT-UPGAHCIJSA-N scopine Chemical class C([C@@H]1N2C)C(O)C[C@@H]2[C@@H]2[C@H]1O2 FIMXSEMBHGTNKT-UPGAHCIJSA-N 0.000 title 1
- -1 scopine compound Chemical class 0.000 abstract 4
- FIMXSEMBHGTNKT-UHFFFAOYSA-N Scopine Natural products CN1C2CC(O)CC1C1C2O1 FIMXSEMBHGTNKT-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- FIMXSEMBHGTNKT-RZVDLVGDSA-N scopine Chemical compound C([C@@H]1N2C)[C@H](O)C[C@@H]2[C@@H]2[C@H]1O2 FIMXSEMBHGTNKT-RZVDLVGDSA-N 0.000 abstract 2
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10200943A DE10200943A1 (de) | 2002-01-12 | 2002-01-12 | Verfahren zur Herstellung von Scopinestern |
PCT/EP2002/014756 WO2003057694A1 (de) | 2002-01-12 | 2002-12-24 | Verfahren zur herstellung von scopinestern |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1467993T3 true DK1467993T3 (da) | 2008-11-10 |
Family
ID=7711974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02796735T DK1467993T3 (da) | 2002-01-12 | 2002-12-24 | Fremgangsmåde til fremstilling af scopinestere |
Country Status (31)
Country | Link |
---|---|
US (1) | US6747154B2 (da) |
EP (2) | EP1972626A3 (da) |
JP (1) | JP5134756B2 (da) |
KR (1) | KR100929503B1 (da) |
CN (1) | CN100406456C (da) |
AT (1) | ATE404557T1 (da) |
AU (1) | AU2002361218B2 (da) |
BR (1) | BR0215493A (da) |
CA (1) | CA2471755C (da) |
CO (1) | CO5601006A2 (da) |
CY (1) | CY1108471T1 (da) |
DE (2) | DE10200943A1 (da) |
DK (1) | DK1467993T3 (da) |
EA (1) | EA007230B1 (da) |
EC (1) | ECSP045182A (da) |
ES (1) | ES2312655T3 (da) |
HK (1) | HK1073847A1 (da) |
HR (1) | HRP20040623B1 (da) |
HU (1) | HU226665B1 (da) |
IL (2) | IL162416A0 (da) |
ME (1) | MEP51208A (da) |
MX (1) | MXPA04006677A (da) |
NO (1) | NO328825B1 (da) |
NZ (1) | NZ534339A (da) |
PL (1) | PL208132B1 (da) |
PT (1) | PT1467993E (da) |
RS (1) | RS50771B (da) |
SI (1) | SI1467993T1 (da) |
UA (1) | UA78753C2 (da) |
WO (1) | WO2003057694A1 (da) |
ZA (1) | ZA200403852B (da) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10141377A1 (de) | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
US7084153B2 (en) * | 2002-04-12 | 2006-08-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising steroids and a novel anticholinergic |
US7417051B2 (en) * | 2002-04-12 | 2008-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising betamimetics and a novel anticholinergic |
DE10216427A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum |
US20040048887A1 (en) * | 2002-07-09 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
US20040048886A1 (en) * | 2002-07-09 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on new anticholinergics and NK1 receptor antagonists |
US20040044020A1 (en) * | 2002-07-09 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors |
US20040058950A1 (en) * | 2002-07-09 | 2004-03-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
US20040166065A1 (en) * | 2002-08-14 | 2004-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosol formulation for inhalation comprising an anticholinergic |
CA2495275C (en) * | 2002-08-14 | 2012-04-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosol formulation for inhalation comprising an anticholinergic agent |
US7244742B2 (en) * | 2002-08-17 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
US7056916B2 (en) * | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
US7332175B2 (en) * | 2003-05-27 | 2008-02-19 | Boehringer Ingelheim International Gmbh | Long-acting drug combinations for the treatment of respiratory complaints |
US7273603B2 (en) * | 2003-07-11 | 2007-09-25 | Boehringer Ingelheim International Gmbh | HFC solution formulations containing an anticholinergic |
US20050025718A1 (en) * | 2003-07-31 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
JP2007500676A (ja) * | 2003-07-31 | 2007-01-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗コリン作用薬とベータ受容体刺激薬を含む吸入用薬剤 |
EP2067779B9 (de) * | 2003-11-03 | 2013-10-16 | Boehringer Ingelheim International GmbH | Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend |
EP2336127A1 (de) * | 2003-11-03 | 2011-06-22 | Boehringer Ingelheim International GmbH | Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen |
US20050272726A1 (en) * | 2004-04-22 | 2005-12-08 | Boehringer Ingelheim International Gmbh | Novel medicaments for the treatment of respiratory diseases |
US20050255050A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation, comprising enantiomerically pure beta agonists |
US7220742B2 (en) * | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
US20050256115A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Aerosol formulation for the inhalation of beta-agonists |
DE102004041253A1 (de) | 2004-08-26 | 2006-03-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen |
WO2006117299A2 (en) * | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
MX2007015997A (es) * | 2005-06-15 | 2008-03-07 | Boehringer Ingelheim Int | Procedimiento para preparar nuevas sales de tiotropio, nuevas sales de tiotropio como tales y composiciones farmaceuticas de las mismas. |
DE102005035112A1 (de) * | 2005-07-27 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen |
US20070088160A1 (en) * | 2005-08-15 | 2007-04-19 | Thomas Krueger | Process for the manufacturing of betamimetics |
WO2008089852A1 (de) * | 2007-01-26 | 2008-07-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Neues verfahren zur herstellung von tiotropiumsalzen |
EP1953156A1 (de) * | 2007-01-29 | 2008-08-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Scopiniumsalzen |
EP1997819A1 (de) | 2007-05-25 | 2008-12-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Scopinestern |
US20110028508A1 (en) * | 2008-01-10 | 2011-02-03 | Gemerocs [UK] Limited | Novel process for the preparation of scopine esters |
US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
AU2010280497B2 (en) | 2009-08-07 | 2015-10-22 | Generics [Uk] Limited | Anhydrate of tiotropium bromide |
WO2011015884A1 (en) * | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Process to prepare scopine esters |
TR201002520A2 (tr) * | 2010-04-01 | 2010-05-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür imalat metodu. |
US8957209B2 (en) | 2010-04-01 | 2015-02-17 | Mahmut Bilgic | Methods for the synthesis of tiotropium bromide |
TR201005222A2 (tr) * | 2010-04-01 | 2011-10-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür sentez yöntemi |
TR201005221A2 (tr) * | 2010-04-01 | 2012-01-23 | Bi̇lgi̇ç Mahmut | Geliştirilmiş sentez metodu. |
ITRM20110508A1 (it) | 2011-09-27 | 2013-03-28 | Lusochimica Spa | Processo per la preparazione degli esteri della scopina. |
PT106142B (pt) | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
CZ304808B6 (cs) | 2012-03-16 | 2014-11-05 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma |
CZ305012B6 (cs) | 2012-03-30 | 2015-03-25 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2540633A1 (de) | 1975-09-12 | 1977-04-28 | Boehringer Sohn Ingelheim | Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung |
DE3211185A1 (de) | 1982-03-26 | 1983-09-29 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung |
DE3215493A1 (de) | 1982-04-26 | 1983-11-03 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung |
DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
DE4108393A1 (de) | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
US5770738A (en) | 1992-03-05 | 1998-06-23 | Boehringer Ingelheim Kg | Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions |
ATE222587T1 (de) * | 1994-04-19 | 2002-09-15 | Neurosearch As | TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN |
DE19515625C2 (de) | 1995-04-28 | 1998-02-19 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern |
US6153618A (en) * | 1996-10-11 | 2000-11-28 | Chiron Corporation | Inhibitors of glycogen synthase 3 kinase |
DE10050995A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
DE10050994A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
DE10064816A1 (de) | 2000-12-22 | 2002-06-27 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung eines Anticholinergikums |
US6506900B1 (en) | 2001-01-31 | 2003-01-14 | Boehringer Ingelheim Pharma Ag | Process for preparing a scopine ester intermediate |
-
2002
- 2002-01-12 DE DE10200943A patent/DE10200943A1/de not_active Withdrawn
- 2002-12-24 UA UA20040806731A patent/UA78753C2/uk unknown
- 2002-12-24 PT PT02796735T patent/PT1467993E/pt unknown
- 2002-12-24 ES ES02796735T patent/ES2312655T3/es not_active Expired - Lifetime
- 2002-12-24 CN CNB028265610A patent/CN100406456C/zh not_active Expired - Fee Related
- 2002-12-24 PL PL369126A patent/PL208132B1/pl not_active IP Right Cessation
- 2002-12-24 JP JP2003558009A patent/JP5134756B2/ja not_active Expired - Fee Related
- 2002-12-24 IL IL16241602A patent/IL162416A0/xx unknown
- 2002-12-24 ME MEP-512/08A patent/MEP51208A/xx unknown
- 2002-12-24 DE DE50212650T patent/DE50212650D1/de not_active Expired - Lifetime
- 2002-12-24 EA EA200400875A patent/EA007230B1/ru not_active IP Right Cessation
- 2002-12-24 MX MXPA04006677A patent/MXPA04006677A/es active IP Right Grant
- 2002-12-24 CA CA2471755A patent/CA2471755C/en not_active Expired - Fee Related
- 2002-12-24 DK DK02796735T patent/DK1467993T3/da active
- 2002-12-24 EP EP08159580A patent/EP1972626A3/de not_active Withdrawn
- 2002-12-24 RS YUP-594/04A patent/RS50771B/sr unknown
- 2002-12-24 WO PCT/EP2002/014756 patent/WO2003057694A1/de active IP Right Grant
- 2002-12-24 HU HU0402604A patent/HU226665B1/hu not_active IP Right Cessation
- 2002-12-24 AT AT02796735T patent/ATE404557T1/de active
- 2002-12-24 AU AU2002361218A patent/AU2002361218B2/en not_active Ceased
- 2002-12-24 KR KR1020047010736A patent/KR100929503B1/ko not_active IP Right Cessation
- 2002-12-24 BR BR0215493-5A patent/BR0215493A/pt not_active Expired - Fee Related
- 2002-12-24 SI SI200230756T patent/SI1467993T1/sl unknown
- 2002-12-24 EP EP02796735A patent/EP1467993B1/de not_active Expired - Lifetime
- 2002-12-24 NZ NZ534339A patent/NZ534339A/en not_active IP Right Cessation
-
2003
- 2003-01-09 US US10/339,480 patent/US6747154B2/en not_active Expired - Lifetime
-
2004
- 2004-05-19 ZA ZA200403852A patent/ZA200403852B/en unknown
- 2004-06-09 IL IL162416A patent/IL162416A/en not_active IP Right Cessation
- 2004-07-09 HR HRP20040623AA patent/HRP20040623B1/xx not_active IP Right Cessation
- 2004-07-12 EC EC2004005182A patent/ECSP045182A/es unknown
- 2004-07-23 CO CO04070837A patent/CO5601006A2/es not_active Application Discontinuation
- 2004-08-11 NO NO20043341A patent/NO328825B1/no not_active IP Right Cessation
-
2005
- 2005-07-29 HK HK05106514A patent/HK1073847A1/xx not_active IP Right Cessation
-
2008
- 2008-10-31 CY CY20081101236T patent/CY1108471T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1467993T3 (da) | Fremgangsmåde til fremstilling af scopinestere | |
ES2237144T3 (es) | Nuevos derivados de cefalotaxano y procedimiento para su preparacion. | |
CA2738706C (en) | Synthesis of boronic ester and acid compounds | |
PT94187B (pt) | Metodo para a preparacao de taxol | |
MA29464B1 (fr) | Methode de preparation d'acides 1,6-dihydro-6-oxo-4-pyrimidinecarboxyliques eventuellement 2-substitues | |
DK0540356T3 (da) | Fremgangsmåde til fremstilling af visse substituerede biphenyltetrazolderivater | |
WO2002085849A3 (en) | Process to prepare oxazolidinones | |
HUE032259T2 (en) | A new process for the preparation of thiotropium salts | |
Hirama et al. | Enantiospecific syntheses of trifunctional (R)-3-hydroxy esters by baker's yeast reduction | |
JP2006516273A5 (da) | ||
DK1515962T3 (da) | Fremgangsmåde til fremstilling af dioxaneddikesyreestere | |
ES2206738T3 (es) | Procedimientos e intermediarios para la preparacion de derivados sustituidos de cromanol. | |
CA2451573A1 (en) | Technical process for the manufacture of tropenol | |
WO2006031788A3 (en) | Process for preparing substituted 8-azabicyclo[3.2.1] octan-3-ols | |
SU1169527A3 (ru) | Способ получени хлорформиатов @ - @ -алкиловых эфиров @ - @ - @ -алкилтартроновой кислоты | |
DD222315A5 (de) | Verfahren zur herstellung von halogenmethyl-1,1-dioxopenicillan-oyloxymethyl-carbonaten | |
EP1369408A4 (en) | PROCESS FOR PREPARING BICYCLOCARBOXYLIC ACID DERIVATIVES | |
KR890004693B1 (ko) | 아미노사이클로펜탄알케노산의 제조방법 | |
HU0001727D0 (en) | Novel 1-aza-2-alkyl-6-aryl-cycloalkane compounds, process for producing them and medicaments containing the same | |
JP4404186B2 (ja) | ビタミンd中間体−a環部シクロヘキサン誘導体の製造法 | |
KR20020025212A (ko) | 시클로헥산 카르복실산의 제조 방법 | |
CA1111865A (en) | Intermediate in the preparation of cyclopropylcarboxylate esters and process for its manufacture | |
ZA916013B (en) | Process and intermediate for the preparation of 2-hydroxy-3-sulfido-3-phenyl propanoic acids | |
Jones | Attempted Separation of 8-Fluoroquininone (96a) and 8-Fluoroquinidinone (96b) with D-Tartaric Acid | |
JPS6483039A (en) | Meta-substituted benzaldehyde acetal derivative |