CY1108471T1 - Μεθοδος για την παραγωγη εστερων σκοπινης - Google Patents

Μεθοδος για την παραγωγη εστερων σκοπινης

Info

Publication number
CY1108471T1
CY1108471T1 CY20081101236T CY081101236T CY1108471T1 CY 1108471 T1 CY1108471 T1 CY 1108471T1 CY 20081101236 T CY20081101236 T CY 20081101236T CY 081101236 T CY081101236 T CY 081101236T CY 1108471 T1 CY1108471 T1 CY 1108471T1
Authority
CY
Cyprus
Prior art keywords
production
steel
scorpine
radicals
esters
Prior art date
Application number
CY20081101236T
Other languages
English (en)
Inventor
Jörg Brandenburg
Waldemar Pfrengle
Werner Rall
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of CY1108471T1 publication Critical patent/CY1108471T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyethers (AREA)

Abstract

Η εφεύρεση αναφέρεται σε πρωτότυπη μέθοδο για την παραγωγή εστέρων σκοπίνης του γενικού τύπου (1), όπου Χˉ και οι ρίζες R1 και Ar μπορούν να έχουν τις σημασίες που αναφέρονται στις αξιώσεις και στην περιγραφή.
CY20081101236T 2002-01-12 2008-10-31 Μεθοδος για την παραγωγη εστερων σκοπινης CY1108471T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10200943A DE10200943A1 (de) 2002-01-12 2002-01-12 Verfahren zur Herstellung von Scopinestern
EP02796735A EP1467993B1 (de) 2002-01-12 2002-12-24 Verfahren zur herstellung von scopinestern

Publications (1)

Publication Number Publication Date
CY1108471T1 true CY1108471T1 (el) 2014-04-09

Family

ID=7711974

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101236T CY1108471T1 (el) 2002-01-12 2008-10-31 Μεθοδος για την παραγωγη εστερων σκοπινης

Country Status (31)

Country Link
US (1) US6747154B2 (el)
EP (2) EP1467993B1 (el)
JP (1) JP5134756B2 (el)
KR (1) KR100929503B1 (el)
CN (1) CN100406456C (el)
AT (1) ATE404557T1 (el)
AU (1) AU2002361218B2 (el)
BR (1) BR0215493A (el)
CA (1) CA2471755C (el)
CO (1) CO5601006A2 (el)
CY (1) CY1108471T1 (el)
DE (2) DE10200943A1 (el)
DK (1) DK1467993T3 (el)
EA (1) EA007230B1 (el)
EC (1) ECSP045182A (el)
ES (1) ES2312655T3 (el)
HK (1) HK1073847A1 (el)
HR (1) HRP20040623B1 (el)
HU (1) HU226665B1 (el)
IL (2) IL162416A0 (el)
ME (1) MEP51208A (el)
MX (1) MXPA04006677A (el)
NO (1) NO328825B1 (el)
NZ (1) NZ534339A (el)
PL (1) PL208132B1 (el)
PT (1) PT1467993E (el)
RS (1) RS50771B (el)
SI (1) SI1467993T1 (el)
UA (1) UA78753C2 (el)
WO (1) WO2003057694A1 (el)
ZA (1) ZA200403852B (el)

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US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US20040048886A1 (en) * 2002-07-09 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on new anticholinergics and NK1 receptor antagonists
US20040048887A1 (en) * 2002-07-09 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
US20040044020A1 (en) * 2002-07-09 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors
US20040058950A1 (en) * 2002-07-09 2004-03-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20040166065A1 (en) 2002-08-14 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for inhalation comprising an anticholinergic
PT1530464E (pt) * 2002-08-14 2008-08-28 Boehringer Ingelheim Pharma Formulação de aerossol para a inalação contendo um agente anticolinérgico
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
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US20050025718A1 (en) * 2003-07-31 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
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EP2336127A1 (de) * 2003-11-03 2011-06-22 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
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NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
AU2006281449B2 (en) * 2005-08-15 2013-01-31 Boehringer Ingelheim International Gmbh Method for producing betamimetics
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP1997819A1 (de) * 2007-05-25 2008-12-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopinestern
SI2240477T1 (sl) * 2008-01-10 2015-02-27 Generics (Uk) Limited Nov postopek za pripravo estrov skopina
US8263623B2 (en) 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
EP2462140A2 (en) 2009-08-07 2012-06-13 Generics [UK] Limited Anhydrate of triotropium bromide
TR201005222A2 (tr) * 2010-04-01 2011-10-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür sentez yöntemi
TR201005221A2 (tr) * 2010-04-01 2012-01-23 Bi̇lgi̇ç Mahmut Geliştirilmiş sentez metodu.
TR201002520A2 (tr) * 2010-04-01 2010-05-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür imalat metodu.
US8957209B2 (en) 2010-04-01 2015-02-17 Mahmut Bilgic Methods for the synthesis of tiotropium bromide
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
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Also Published As

Publication number Publication date
NO20043341L (no) 2004-08-11
CA2471755A1 (en) 2003-07-17
EP1467993A1 (de) 2004-10-20
JP2005519890A (ja) 2005-07-07
NO328825B1 (no) 2010-05-25
EA200400875A1 (ru) 2004-12-30
UA78753C2 (en) 2007-04-25
HUP0402604A3 (en) 2008-05-28
CN1610680A (zh) 2005-04-27
CO5601006A2 (es) 2006-01-31
SI1467993T1 (sl) 2009-02-28
NZ534339A (en) 2005-04-29
IL162416A0 (en) 2005-11-20
BR0215493A (pt) 2004-12-28
HRP20040623B1 (en) 2012-09-30
JP5134756B2 (ja) 2013-01-30
EP1467993B1 (de) 2008-08-13
EP1972626A3 (de) 2008-10-01
PL208132B1 (pl) 2011-03-31
ES2312655T3 (es) 2009-03-01
HUP0402604A2 (hu) 2005-04-28
WO2003057694A1 (de) 2003-07-17
MXPA04006677A (es) 2004-10-04
ATE404557T1 (de) 2008-08-15
DE50212650D1 (de) 2008-09-25
PL369126A1 (en) 2005-04-18
ECSP045182A (es) 2004-08-27
MEP51208A (en) 2011-05-10
AU2002361218A1 (en) 2003-07-24
US6747154B2 (en) 2004-06-08
CN100406456C (zh) 2008-07-30
HU226665B1 (en) 2009-06-29
RS50771B (sr) 2010-08-31
AU2002361218B2 (en) 2008-04-24
DE10200943A1 (de) 2003-07-24
KR20040072715A (ko) 2004-08-18
KR100929503B1 (ko) 2009-12-03
EP1972626A2 (de) 2008-09-24
RS59404A (en) 2007-04-10
US20030232993A1 (en) 2003-12-18
DK1467993T3 (da) 2008-11-10
EA007230B1 (ru) 2006-08-25
HRP20040623A2 (en) 2005-04-30
HK1073847A1 (en) 2005-10-21
IL162416A (en) 2010-06-30
ZA200403852B (en) 2005-06-22
CA2471755C (en) 2011-02-08
PT1467993E (pt) 2008-09-03

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