MXPA04001088A - Derivados de pirazol como inhibidores de cinasa y uso de los mismos. - Google Patents

Derivados de pirazol como inhibidores de cinasa y uso de los mismos.

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Publication number
MXPA04001088A
MXPA04001088A MXPA04001088A MXPA04001088A MXPA04001088A MX PA04001088 A MXPA04001088 A MX PA04001088A MX PA04001088 A MXPA04001088 A MX PA04001088A MX PA04001088 A MXPA04001088 A MX PA04001088A MX PA04001088 A MXPA04001088 A MX PA04001088A
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
pyrazole
derived kinase
compounds
useful
Prior art date
Application number
MXPA04001088A
Other languages
English (en)
Inventor
Maltais Francois
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MXPA04001088A publication Critical patent/MXPA04001088A/es

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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
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  • Oncology (AREA)
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Abstract

Se describen en la presente compuestos que son utiles como inhibidores de proteinas cinasas que tienen la formula: (ver formula) donde B, R1, n, R3, Q, y R4 se describen en la especificacion. Los compuestos son utiles para tratar estados de enfermedad en mamiferos que se alivian mediante un inhibidor de proteina cinasa, en particular enfermedades tales como por ejemplo, cancer, trastornos inflamatorios, restenosis, y enfermedad cardiovascular.
MXPA04001088A 2001-08-03 2002-08-02 Derivados de pirazol como inhibidores de cinasa y uso de los mismos. MXPA04001088A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30988601P 2001-08-03 2001-08-03
PCT/US2002/024723 WO2003011854A1 (en) 2001-08-03 2002-08-02 Pyrazole-derived kinase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
MXPA04001088A true MXPA04001088A (es) 2004-05-20

Family

ID=23200097

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001088A MXPA04001088A (es) 2001-08-03 2002-08-02 Derivados de pirazol como inhibidores de cinasa y uso de los mismos.

Country Status (8)

Country Link
US (2) US6875789B2 (es)
EP (1) EP1423380B1 (es)
JP (1) JP4342939B2 (es)
AT (1) ATE491701T1 (es)
CA (1) CA2456187A1 (es)
DE (1) DE60238620D1 (es)
MX (1) MXPA04001088A (es)
WO (1) WO2003011854A1 (es)

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US20040092552A1 (en) * 2000-04-25 2004-05-13 Brown David L 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation
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SE0104140D0 (sv) * 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
UA79804C2 (en) * 2002-07-03 2007-07-25 Janssen Pharmaceutica Nv Cck-1 receptor modulators
WO2004096135A2 (en) * 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
EP1620411B1 (en) * 2003-04-24 2010-03-17 Merck Sharp & Dohme Corp. Inhibitors of akt activity
PL1651612T3 (pl) 2003-07-22 2012-09-28 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
CA2587427A1 (en) 2004-11-17 2006-05-26 Miikana Therapeutics, Inc. Kinase inhibitors
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
TW200639163A (en) * 2005-02-04 2006-11-16 Genentech Inc RAF inhibitor compounds and methods
ES2308731T3 (es) * 2005-02-16 2008-12-01 Astrazeneca Ab Compuestos quimicos.
US20080287437A1 (en) * 2005-05-16 2008-11-20 Astrazeneca Ab Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
KR101487027B1 (ko) * 2005-09-30 2015-01-28 미카나 테라퓨틱스, 인크. 치환된 피라졸 화합물
PT1945631E (pt) * 2005-10-28 2012-10-15 Astrazeneca Ab Derivados de 4-(3-aminopirazole)pirimidina para utilização como inibidores da tirosina-cinase no tratamento do cancro
US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
EP1984331B1 (en) 2006-02-16 2010-10-20 Schering Corporation Pyrrolidine derivatives as erk inhibitors
AU2012233017B2 (en) * 2007-02-07 2013-01-10 Novartis Ag Inhibitors of Akt activity
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
EP2134175A4 (en) * 2007-03-29 2012-01-11 Glaxosmithkline Llc HAMMER OF ACT ACTIVITY
EP2155742A1 (en) * 2007-04-18 2010-02-24 AstraZeneca AB 5-aminopyrazol-3-yl-3h-imidazo [4,5-b]pyridine derivatives and their use for the treatment of cancer
UA99459C2 (en) * 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
US20100204231A1 (en) * 2007-05-04 2010-08-12 Astrazeneca Ab Amino-thiazolyl-pyrimidine derivatives and their use for the treatment of cancer
CA2683152A1 (en) * 2007-06-11 2008-12-18 Miikana Therapeutics, Inc. Substituted pyrazole compounds
WO2009105500A1 (en) 2008-02-21 2009-08-27 Schering Corporation Compounds that are erk inhibitors
KR20110017445A (ko) * 2008-06-11 2011-02-21 아스트라제네카 아베 암 및 골수증식성 장애의 치료에 유용한 트리시클릭 2,4-디아미노-ｌ,3,5-트리아진 유도체
CA2737217A1 (en) * 2008-09-30 2010-04-08 Astrazeneca Ab Heterocyclic jak kinase inhibitors
PE20120003A1 (es) * 2009-01-30 2012-02-12 Glaxosmithkline Llc Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
KR101111247B1 (ko) 2009-07-17 2012-06-12 한국과학기술연구원 Ｒｏｓ 카이네이즈 저해활성을 갖는 피라졸 화합물
CA2861066C (en) * 2012-01-12 2024-01-02 Yale University Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
US9828345B2 (en) 2013-02-28 2017-11-28 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
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GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound

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SK14082001A3 (sk) 2000-02-05 2002-03-05 Vertex Pharmaceuticals Incorporated Deriváty pyrazolu ako inhibítory ERK a farmaceutická kompozícia, ktorá ich obsahuje
AU782878B2 (en) 2000-02-05 2005-09-08 Vertex Pharmaceuticals Incorporated Pyrazole compositions useful as inhibitors of erk
ATE335737T1 (de) 2000-09-15 2006-09-15 Vertex Pharma Isoxazole und ihre verwendung als erk-inhibitoren
EP1423380B1 (en) * 2001-08-03 2010-12-15 Vertex Pharmaceuticals Incorporated Pyrazole-derived kinase inhibitors and uses thereof

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Publication number Publication date
ATE491701T1 (de) 2011-01-15
EP1423380A1 (en) 2004-06-02
JP2005501835A (ja) 2005-01-20
EP1423380B1 (en) 2010-12-15
US20050215550A1 (en) 2005-09-29
DE60238620D1 (de) 2011-01-27
US7279476B2 (en) 2007-10-09
JP4342939B2 (ja) 2009-10-14
CA2456187A1 (en) 2003-02-13
US20030139452A1 (en) 2003-07-24
US6875789B2 (en) 2005-04-05
WO2003011854A1 (en) 2003-02-13

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