MXPA04003938A - Compuestos retinoides heterociclicos. - Google Patents
Compuestos retinoides heterociclicos.Info
- Publication number
- MXPA04003938A MXPA04003938A MXPA04003938A MXPA04003938A MXPA04003938A MX PA04003938 A MXPA04003938 A MX PA04003938A MX PA04003938 A MXPA04003938 A MX PA04003938A MX PA04003938 A MXPA04003938 A MX PA04003938A MX PA04003938 A MXPA04003938 A MX PA04003938A
- Authority
- MX
- Mexico
- Prior art keywords
- retinoid compounds
- compounds
- heterocyclic retinoid
- heterocyclic
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
Abstract
La presente invencion proporciona nuevos compuestos retinoides heterociclicos de formula (I)(Ver formula I)en donde R1 a R5, A, B, Z y n son como se definen en la descripcion y reivindicaciones. Los compuestos de la presente invencion son utiles para el tratamiento y/o prevencion de enfermedades tales como enfermedad pulmonar obstructiva cronica, cancer y trastornos dermatologicos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33512901P | 2001-10-31 | 2001-10-31 | |
| PCT/EP2002/011746 WO2003037882A1 (en) | 2001-10-31 | 2002-10-21 | Heterocyclic retinoid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04003938A true MXPA04003938A (es) | 2004-06-18 |
Family
ID=23310382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04003938A MXPA04003938A (es) | 2001-10-31 | 2002-10-21 | Compuestos retinoides heterociclicos. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6818652B2 (es) |
| EP (1) | EP1442032B1 (es) |
| JP (1) | JP4234599B2 (es) |
| KR (1) | KR100706589B1 (es) |
| CN (1) | CN1283635C (es) |
| AR (1) | AR037129A1 (es) |
| AT (1) | ATE360010T1 (es) |
| AU (1) | AU2002363170B2 (es) |
| BR (1) | BR0213678A (es) |
| CA (1) | CA2464289C (es) |
| DE (1) | DE60219659T2 (es) |
| ES (1) | ES2283649T3 (es) |
| GT (1) | GT200200225A (es) |
| MX (1) | MXPA04003938A (es) |
| PA (1) | PA8557301A1 (es) |
| PE (1) | PE20030691A1 (es) |
| PL (1) | PL370598A1 (es) |
| RU (1) | RU2275367C2 (es) |
| TW (1) | TW200302085A (es) |
| UY (1) | UY27526A1 (es) |
| WO (1) | WO2003037882A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006025395A1 (ja) * | 2004-08-31 | 2008-05-08 | 慶彦 清水 | キャリアフリーの細胞増殖因子を用いた慢性閉塞性肺疾患に対する医薬および処置システム |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4895868A (en) * | 1988-06-29 | 1990-01-23 | Allergan, Inc. | Thiochroman esters of phenols and terephthallates having retinoid-like activity |
| AU626881B2 (en) * | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
| FR2713635B1 (fr) * | 1993-12-15 | 1996-01-05 | Cird Galderma | Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US5675024A (en) * | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
| FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
| US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
| FR2764604B1 (fr) * | 1997-06-13 | 1999-09-10 | Cird Galderma | Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant |
| DE60112741T2 (de) * | 2000-05-02 | 2006-06-01 | F. Hoffmann-La Roche Ag | Gamma-selektive retinoide |
-
2002
- 2002-10-21 BR BR0213678-3A patent/BR0213678A/pt not_active IP Right Cessation
- 2002-10-21 CN CNB028217608A patent/CN1283635C/zh not_active Expired - Fee Related
- 2002-10-21 DE DE60219659T patent/DE60219659T2/de not_active Expired - Lifetime
- 2002-10-21 PL PL02370598A patent/PL370598A1/xx not_active IP Right Cessation
- 2002-10-21 RU RU2004116695/04A patent/RU2275367C2/ru not_active IP Right Cessation
- 2002-10-21 KR KR1020047006635A patent/KR100706589B1/ko not_active IP Right Cessation
- 2002-10-21 MX MXPA04003938A patent/MXPA04003938A/es active IP Right Grant
- 2002-10-21 JP JP2003540163A patent/JP4234599B2/ja not_active Expired - Fee Related
- 2002-10-21 AT AT02802300T patent/ATE360010T1/de active
- 2002-10-21 ES ES02802300T patent/ES2283649T3/es not_active Expired - Lifetime
- 2002-10-21 WO PCT/EP2002/011746 patent/WO2003037882A1/en active IP Right Grant
- 2002-10-21 EP EP02802300A patent/EP1442032B1/en not_active Expired - Lifetime
- 2002-10-21 CA CA002464289A patent/CA2464289C/en not_active Expired - Fee Related
- 2002-10-21 AU AU2002363170A patent/AU2002363170B2/en not_active Ceased
- 2002-10-28 PA PA20028557301A patent/PA8557301A1/es unknown
- 2002-10-29 PE PE2002001064A patent/PE20030691A1/es not_active Application Discontinuation
- 2002-10-29 AR ARP020104106A patent/AR037129A1/es not_active Application Discontinuation
- 2002-10-30 US US10/283,841 patent/US6818652B2/en not_active Expired - Fee Related
- 2002-10-30 UY UY27526A patent/UY27526A1/es not_active Application Discontinuation
- 2002-10-31 GT GT200200225A patent/GT200200225A/es unknown
- 2002-10-31 TW TW091132266A patent/TW200302085A/zh unknown
-
2004
- 2004-10-07 US US10/960,372 patent/US7354931B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1442032B1 (en) | 2007-04-18 |
| RU2275367C2 (ru) | 2006-04-27 |
| US20030158178A1 (en) | 2003-08-21 |
| CA2464289A1 (en) | 2003-05-08 |
| EP1442032A1 (en) | 2004-08-04 |
| ES2283649T3 (es) | 2007-11-01 |
| DE60219659D1 (de) | 2007-05-31 |
| ATE360010T1 (de) | 2007-05-15 |
| KR100706589B1 (ko) | 2007-04-11 |
| BR0213678A (pt) | 2004-10-26 |
| RU2004116695A (ru) | 2005-11-10 |
| JP2005507421A (ja) | 2005-03-17 |
| US6818652B2 (en) | 2004-11-16 |
| US20050049238A1 (en) | 2005-03-03 |
| PE20030691A1 (es) | 2003-08-18 |
| CA2464289C (en) | 2009-09-15 |
| CN1578776A (zh) | 2005-02-09 |
| AU2002363170B2 (en) | 2007-12-13 |
| UY27526A1 (es) | 2003-04-30 |
| WO2003037882A1 (en) | 2003-05-08 |
| GT200200225A (es) | 2003-06-19 |
| PA8557301A1 (es) | 2004-02-07 |
| AR037129A1 (es) | 2004-10-20 |
| CN1283635C (zh) | 2006-11-08 |
| KR20050038586A (ko) | 2005-04-27 |
| JP4234599B2 (ja) | 2009-03-04 |
| TW200302085A (en) | 2003-08-01 |
| PL370598A1 (en) | 2005-05-30 |
| US7354931B2 (en) | 2008-04-08 |
| DE60219659T2 (de) | 2008-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS20050361A (en) | Novel medicament for the treatment of chronic obstructive pulmonary diseases | |
| TW200510325A (en) | 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof | |
| MXPA04003439A (es) | Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc. | |
| UA85559C2 (en) | Aminobenzophenone compounds | |
| NO20063275L (no) | Anvendelse av substituerte 2-aminotetraliner for forebyggende behandling av Parkinsons sykdom | |
| MXPA03011484A (es) | Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades. | |
| NZ521681A (en) | Substituted benzoic acid amides and use thereof for the inhibition of angiogenesis | |
| HK1080467A1 (en) | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders | |
| MY141528A (en) | Anilinopyrazole derivatives useful for the treatment of diabetes | |
| PL371127A1 (en) | 6-aminomorphinane derivatives, method for the production and use thereof | |
| WO2003106450A8 (de) | Phenylaminopyrimidine und ihre verwendung als rho-kinase inhibitoren | |
| DE60015508T2 (de) | C-16 ungesätigte fp-selektive prostaglandin analoge | |
| IL166057A0 (en) | Urea-substituted and urethane-substituted acylureas methods for the production thereof and their useas medicaments | |
| EP1441724B8 (en) | Methods of increasing endogenous testosterone levels | |
| AU2003303217A1 (en) | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases | |
| MXPA04003938A (es) | Compuestos retinoides heterociclicos. | |
| DE60326348D1 (de) | Makrozyclen zur behandlung von krebserkrankungen | |
| WO2004056762A3 (en) | Novel aminobenzophenone compounds | |
| TW200603801A (en) | Novel dialkoxy-imidazopyridines | |
| ATE265418T1 (de) | Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine | |
| ATE328883T1 (de) | Imidazopyridin-8-one | |
| EA200500903A1 (ru) | Силиловые простые эфиры | |
| DE60203740D1 (de) | Luminacine analoge und deren verwendung | |
| SE0301798D0 (sv) | New use IV |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |