BR0213678A - Compostos retinóides heterocìclicos - Google Patents

Compostos retinóides heterocìclicos

Info

Publication number
BR0213678A
BR0213678A BR0213678-3A BR0213678A BR0213678A BR 0213678 A BR0213678 A BR 0213678A BR 0213678 A BR0213678 A BR 0213678A BR 0213678 A BR0213678 A BR 0213678A
Authority
BR
Brazil
Prior art keywords
retinoid compounds
compounds
heterocyclic retinoid
heterocyclic
present
Prior art date
Application number
BR0213678-3A
Other languages
English (en)
Inventor
Michael Klaus
Jean-Marc Lapierre
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0213678A publication Critical patent/BR0213678A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

"COMPOSTOS RETINóIDES HETEROCìCLICOS". A presente invenção refere-se a novos compostos retinóides heterocíclicos de fórmula (I) onde R^ 1^ a R^ 5^, A, B, Z e n são como definidos no relatório descritivo e nas reivindicações. Os compostos da presente invenção são úteis para o tratamento e/ou a prevenção de doenças como doença pulmonar obstrutiva crónica, câncer e distúrbios dermatológicos.
BR0213678-3A 2001-10-31 2002-10-21 Compostos retinóides heterocìclicos BR0213678A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33512901P 2001-10-31 2001-10-31
PCT/EP2002/011746 WO2003037882A1 (en) 2001-10-31 2002-10-21 Heterocyclic retinoid compounds

Publications (1)

Publication Number Publication Date
BR0213678A true BR0213678A (pt) 2004-10-26

Family

ID=23310382

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213678-3A BR0213678A (pt) 2001-10-31 2002-10-21 Compostos retinóides heterocìclicos

Country Status (21)

Country Link
US (2) US6818652B2 (pt)
EP (1) EP1442032B1 (pt)
JP (1) JP4234599B2 (pt)
KR (1) KR100706589B1 (pt)
CN (1) CN1283635C (pt)
AR (1) AR037129A1 (pt)
AT (1) ATE360010T1 (pt)
AU (1) AU2002363170B2 (pt)
BR (1) BR0213678A (pt)
CA (1) CA2464289C (pt)
DE (1) DE60219659T2 (pt)
ES (1) ES2283649T3 (pt)
GT (1) GT200200225A (pt)
MX (1) MXPA04003938A (pt)
PA (1) PA8557301A1 (pt)
PE (1) PE20030691A1 (pt)
PL (1) PL370598A1 (pt)
RU (1) RU2275367C2 (pt)
TW (1) TW200302085A (pt)
UY (1) UY27526A1 (pt)
WO (1) WO2003037882A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006025395A1 (ja) * 2004-08-31 2006-03-09 Yasuhiko Shimizu キャリアフリーの細胞増殖因子を用いた慢性閉塞性肺疾患に対する医薬および処置システム

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895868A (en) * 1988-06-29 1990-01-23 Allergan, Inc. Thiochroman esters of phenols and terephthallates having retinoid-like activity
AU626881B2 (en) * 1988-07-14 1992-08-13 F. Hoffmann-La Roche Ag Benzofused heterocyclics used as pharmaceuticals
FR2713635B1 (fr) * 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US5599967A (en) * 1994-12-29 1997-02-04 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity
US5675024A (en) * 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
FR2746098B1 (fr) 1996-03-14 1998-04-30 Composes propynyl biaromatiques
US5739338A (en) * 1996-11-05 1998-04-14 Allergan N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
FR2764604B1 (fr) * 1997-06-13 1999-09-10 Cird Galderma Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant
BR0110499A (pt) * 2000-05-02 2003-04-01 Hoffmann La Roche Retinóides gama seletivos

Also Published As

Publication number Publication date
ATE360010T1 (de) 2007-05-15
GT200200225A (es) 2003-06-19
RU2275367C2 (ru) 2006-04-27
US20030158178A1 (en) 2003-08-21
KR100706589B1 (ko) 2007-04-11
JP2005507421A (ja) 2005-03-17
PE20030691A1 (es) 2003-08-18
EP1442032A1 (en) 2004-08-04
RU2004116695A (ru) 2005-11-10
US6818652B2 (en) 2004-11-16
AU2002363170B2 (en) 2007-12-13
JP4234599B2 (ja) 2009-03-04
CA2464289A1 (en) 2003-05-08
PL370598A1 (en) 2005-05-30
US7354931B2 (en) 2008-04-08
PA8557301A1 (es) 2004-02-07
DE60219659T2 (de) 2008-01-17
TW200302085A (en) 2003-08-01
CN1283635C (zh) 2006-11-08
KR20050038586A (ko) 2005-04-27
CA2464289C (en) 2009-09-15
WO2003037882A1 (en) 2003-05-08
MXPA04003938A (es) 2004-06-18
US20050049238A1 (en) 2005-03-03
CN1578776A (zh) 2005-02-09
UY27526A1 (es) 2003-04-30
ES2283649T3 (es) 2007-11-01
EP1442032B1 (en) 2007-04-18
DE60219659D1 (de) 2007-05-31
AR037129A1 (es) 2004-10-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.