RS50771B - Postupak za pripremanje skopin estara - Google Patents
Postupak za pripremanje skopin estaraInfo
- Publication number
- RS50771B RS50771B YUP-594/04A YUP59404A RS50771B RS 50771 B RS50771 B RS 50771B YU P59404 A YUP59404 A YU P59404A RS 50771 B RS50771 B RS 50771B
- Authority
- RS
- Serbia
- Prior art keywords
- group
- hydroxy
- formula
- trifluoromethanesulfonate
- methanesulfonate
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- FIMXSEMBHGTNKT-RZVDLVGDSA-N scopine Chemical class C([C@@H]1N2C)[C@H](O)C[C@@H]2[C@@H]2[C@H]1O2 FIMXSEMBHGTNKT-RZVDLVGDSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229960002317 succinimide Drugs 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
- Polyethers (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Postupak za pripremanje jedinjenja formule 1u kojoj mogu da označavajuX- hlor, brom, jod, metansulfonat ili trifluormetansulfonat;R1 hidroksi, C1-C4-alkil, C1-C4-alkoksi, CF3 ili fluoro grupu;Ar ostatak, odabran iz grupe koju čine fenil, naftil, tienil i furil grupa, koja, u datom slučaju, može biti jedno- ili dvostruko supstituisana sa jednim ili dva ostatka, odabrana iz grupe koju čine C1-C4alkil, C1-C4-alkoksi, hidroksi, fluoro, hloro, bromo ili CF3 grupa,naznačen time, što jedinjenje formule 2u kojojY- može da označava hlor, brom, jod, metansulfonat ili trifluorometansulfonat, u jednom stupnju reaguje sa jedinjenjem formule 3u kojoj označava ostatak odabran iz grupe koju čine hidroksi, metoksi, etoksi O-N-sukcinimid, O-N-ftalimid, fenoksi, nitrofenoksi, fluorofenoksi, pentafluorofeniloksi, viniloksi, 2-aliloksi, -S-metil, -S-etil i S-fenil grupa, a ostaci R1 i Ar mogu da imaju neko od prethodno navedenih značenja.Prijava sadrži još 8 patentnih zahteva.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MEP-512/08A MEP51208A (en) | 2002-01-12 | 2002-12-24 | Method for producing scopine esters |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10200943A DE10200943A1 (de) | 2002-01-12 | 2002-01-12 | Verfahren zur Herstellung von Scopinestern |
| PCT/EP2002/014756 WO2003057694A1 (de) | 2002-01-12 | 2002-12-24 | Verfahren zur herstellung von scopinestern |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RS59404A RS59404A (en) | 2007-04-10 |
| RS50771B true RS50771B (sr) | 2010-08-31 |
Family
ID=7711974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-594/04A RS50771B (sr) | 2002-01-12 | 2002-12-24 | Postupak za pripremanje skopin estara |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6747154B2 (sr) |
| EP (2) | EP1972626A3 (sr) |
| JP (1) | JP5134756B2 (sr) |
| KR (1) | KR100929503B1 (sr) |
| CN (1) | CN100406456C (sr) |
| AT (1) | ATE404557T1 (sr) |
| AU (1) | AU2002361218B2 (sr) |
| BR (1) | BR0215493A (sr) |
| CA (1) | CA2471755C (sr) |
| CO (1) | CO5601006A2 (sr) |
| CY (1) | CY1108471T1 (sr) |
| DE (2) | DE10200943A1 (sr) |
| DK (1) | DK1467993T3 (sr) |
| EA (1) | EA007230B1 (sr) |
| EC (1) | ECSP045182A (sr) |
| ES (1) | ES2312655T3 (sr) |
| HK (1) | HK1073847A1 (sr) |
| HR (1) | HRP20040623B1 (sr) |
| HU (1) | HU226665B1 (sr) |
| IL (2) | IL162416A0 (sr) |
| ME (1) | MEP51208A (sr) |
| MX (1) | MXPA04006677A (sr) |
| NO (1) | NO328825B1 (sr) |
| NZ (1) | NZ534339A (sr) |
| PL (1) | PL208132B1 (sr) |
| PT (1) | PT1467993E (sr) |
| RS (1) | RS50771B (sr) |
| SI (1) | SI1467993T1 (sr) |
| UA (1) | UA78753C2 (sr) |
| WO (1) | WO2003057694A1 (sr) |
| ZA (1) | ZA200403852B (sr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10141377A1 (de) | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
| US7417051B2 (en) * | 2002-04-12 | 2008-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising betamimetics and a novel anticholinergic |
| US7084153B2 (en) * | 2002-04-12 | 2006-08-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising steroids and a novel anticholinergic |
| DE10216427A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum |
| US20040058950A1 (en) * | 2002-07-09 | 2004-03-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| US20040048886A1 (en) * | 2002-07-09 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on new anticholinergics and NK1 receptor antagonists |
| US20040048887A1 (en) * | 2002-07-09 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
| US20040044020A1 (en) * | 2002-07-09 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors |
| NZ538743A (en) * | 2002-08-14 | 2006-05-26 | Boehringer Ingelheim Pharma | Aerosol formulation for inhalation containing an anticholinergic agent |
| US20040166065A1 (en) * | 2002-08-14 | 2004-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosol formulation for inhalation comprising an anticholinergic |
| US7244742B2 (en) * | 2002-08-17 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| US7332175B2 (en) * | 2003-05-27 | 2008-02-19 | Boehringer Ingelheim International Gmbh | Long-acting drug combinations for the treatment of respiratory complaints |
| US7273603B2 (en) * | 2003-07-11 | 2007-09-25 | Boehringer Ingelheim International Gmbh | HFC solution formulations containing an anticholinergic |
| CA2534120C (en) * | 2003-07-31 | 2012-09-11 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising anticholinergics and a betamimetic |
| US20050025718A1 (en) * | 2003-07-31 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
| PT1682541E (pt) * | 2003-11-03 | 2010-04-14 | Boehringer Ingelheim Int | Processo para a preparação de sais de tiotrópio |
| ES2422730T3 (es) * | 2003-11-03 | 2013-09-13 | Boehringer Ingelheim Int | Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen |
| US20050272726A1 (en) * | 2004-04-22 | 2005-12-08 | Boehringer Ingelheim International Gmbh | Novel medicaments for the treatment of respiratory diseases |
| US20050256115A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Aerosol formulation for the inhalation of beta-agonists |
| US20050255050A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation, comprising enantiomerically pure beta agonists |
| US7220742B2 (en) * | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| DE102004041253A1 (de) * | 2004-08-26 | 2006-03-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen |
| EP2085396A3 (en) * | 2005-05-02 | 2009-11-25 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
| MX2007015997A (es) * | 2005-06-15 | 2008-03-07 | Boehringer Ingelheim Int | Procedimiento para preparar nuevas sales de tiotropio, nuevas sales de tiotropio como tales y composiciones farmaceuticas de las mismas. |
| DE102005035112A1 (de) * | 2005-07-27 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen |
| BRPI0614410A2 (pt) * | 2005-08-15 | 2011-03-29 | Boehringer Ingelheim Int | processo para preparação de betamiméticos |
| WO2008089852A1 (de) * | 2007-01-26 | 2008-07-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Neues verfahren zur herstellung von tiotropiumsalzen |
| EP1953156A1 (de) * | 2007-01-29 | 2008-08-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Scopiniumsalzen |
| EP1997819A1 (de) | 2007-05-25 | 2008-12-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Scopinestern |
| CA2710523C (en) * | 2008-01-10 | 2014-11-18 | Generics [Uk] Limited | Process for the preparation of scopine esters |
| US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
| WO2011015884A1 (en) * | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Process to prepare scopine esters |
| IN2012DN00968A (sr) | 2009-08-07 | 2015-04-10 | Generics Uk Ltd | |
| TR201005221A2 (tr) * | 2010-04-01 | 2012-01-23 | Bi̇lgi̇ç Mahmut | Geliştirilmiş sentez metodu. |
| TR201005222A2 (tr) * | 2010-04-01 | 2011-10-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür sentez yöntemi |
| US8957209B2 (en) | 2010-04-01 | 2015-02-17 | Mahmut Bilgic | Methods for the synthesis of tiotropium bromide |
| TR201002520A2 (tr) * | 2010-04-01 | 2010-05-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür imalat metodu. |
| ITRM20110508A1 (it) | 2011-09-27 | 2013-03-28 | Lusochimica Spa | Processo per la preparazione degli esteri della scopina. |
| PT106142B (pt) | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| CZ304808B6 (cs) | 2012-03-16 | 2014-11-05 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma |
| CZ305012B6 (cs) | 2012-03-30 | 2015-03-25 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2540633A1 (de) | 1975-09-12 | 1977-04-28 | Boehringer Sohn Ingelheim | Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung |
| DE3211185A1 (de) | 1982-03-26 | 1983-09-29 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung |
| DE3215493A1 (de) | 1982-04-26 | 1983-11-03 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung |
| US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| DE4108393A1 (de) | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
| US5770738A (en) | 1992-03-05 | 1998-06-23 | Boehringer Ingelheim Kg | Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions |
| EP0756596B1 (en) * | 1994-04-19 | 2002-08-21 | Neurosearch A/S | Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors |
| DE19515625C2 (de) | 1995-04-28 | 1998-02-19 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern |
| US6153618A (en) * | 1996-10-11 | 2000-11-28 | Chiron Corporation | Inhibitors of glycogen synthase 3 kinase |
| DE10050994A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
| DE10050995A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE10064816A1 (de) * | 2000-12-22 | 2002-06-27 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung eines Anticholinergikums |
| US6506900B1 (en) | 2001-01-31 | 2003-01-14 | Boehringer Ingelheim Pharma Ag | Process for preparing a scopine ester intermediate |
-
2002
- 2002-01-12 DE DE10200943A patent/DE10200943A1/de not_active Withdrawn
- 2002-12-24 ME MEP-512/08A patent/MEP51208A/xx unknown
- 2002-12-24 AU AU2002361218A patent/AU2002361218B2/en not_active Ceased
- 2002-12-24 RS YUP-594/04A patent/RS50771B/sr unknown
- 2002-12-24 DK DK02796735T patent/DK1467993T3/da active
- 2002-12-24 UA UA20040806731A patent/UA78753C2/uk unknown
- 2002-12-24 DE DE50212650T patent/DE50212650D1/de not_active Expired - Lifetime
- 2002-12-24 WO PCT/EP2002/014756 patent/WO2003057694A1/de active IP Right Grant
- 2002-12-24 EA EA200400875A patent/EA007230B1/ru not_active IP Right Cessation
- 2002-12-24 BR BR0215493-5A patent/BR0215493A/pt not_active Expired - Fee Related
- 2002-12-24 HU HU0402604A patent/HU226665B1/hu not_active IP Right Cessation
- 2002-12-24 AT AT02796735T patent/ATE404557T1/de active
- 2002-12-24 IL IL16241602A patent/IL162416A0/xx unknown
- 2002-12-24 NZ NZ534339A patent/NZ534339A/en not_active IP Right Cessation
- 2002-12-24 PT PT02796735T patent/PT1467993E/pt unknown
- 2002-12-24 EP EP08159580A patent/EP1972626A3/de not_active Withdrawn
- 2002-12-24 SI SI200230756T patent/SI1467993T1/sl unknown
- 2002-12-24 JP JP2003558009A patent/JP5134756B2/ja not_active Expired - Fee Related
- 2002-12-24 CN CNB028265610A patent/CN100406456C/zh not_active Expired - Fee Related
- 2002-12-24 KR KR1020047010736A patent/KR100929503B1/ko not_active IP Right Cessation
- 2002-12-24 ES ES02796735T patent/ES2312655T3/es not_active Expired - Lifetime
- 2002-12-24 MX MXPA04006677A patent/MXPA04006677A/es active IP Right Grant
- 2002-12-24 PL PL369126A patent/PL208132B1/pl not_active IP Right Cessation
- 2002-12-24 EP EP02796735A patent/EP1467993B1/de not_active Expired - Lifetime
- 2002-12-24 CA CA2471755A patent/CA2471755C/en not_active Expired - Fee Related
-
2003
- 2003-01-09 US US10/339,480 patent/US6747154B2/en not_active Expired - Lifetime
-
2004
- 2004-05-19 ZA ZA200403852A patent/ZA200403852B/en unknown
- 2004-06-09 IL IL162416A patent/IL162416A/en not_active IP Right Cessation
- 2004-07-09 HR HRP20040623AA patent/HRP20040623B1/xx not_active IP Right Cessation
- 2004-07-12 EC EC2004005182A patent/ECSP045182A/es unknown
- 2004-07-23 CO CO04070837A patent/CO5601006A2/es not_active Application Discontinuation
- 2004-08-11 NO NO20043341A patent/NO328825B1/no not_active IP Right Cessation
-
2005
- 2005-07-29 HK HK05106514A patent/HK1073847A1/xx not_active IP Right Cessation
-
2008
- 2008-10-31 CY CY20081101236T patent/CY1108471T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS50771B (sr) | Postupak za pripremanje skopin estara | |
| ATE460439T1 (de) | Photochrome zusammensetzungen und gegenstände mit polyetheroligomer | |
| HUP0303183A2 (hu) | Gerinctelen kártevőírtó hatású heterociklusos diamidszármazékok, azokat tartalmazó készítmények és alkalmazásuk | |
| RS51210B (sr) | Dobijanje pregaballina i srodnih jedinjenja | |
| RS52998B (sr) | Novi pirazinoilguanidinski blokatori natrijumskih kanala sa zaštitnim "kapicama" | |
| WO2004037811A8 (de) | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel | |
| MY148669A (en) | Optical glass | |
| MY142018A (en) | Thiophene derivatives as chk 1 inihibitors | |
| MX368848B (es) | Composición curable fotocrómica. | |
| TW200745077A (en) | Thiophene compound having sulfonyl group and process for producing the same | |
| DE602005013975D1 (de) | Neue flammhemmende polystyrene | |
| DK1961734T3 (da) | Aminforbindelse og anvendelse deraf til medicinske formål | |
| MX2010004893A (es) | Compuesto heterociclico y composicion farmaceutica del mismo. | |
| TW200745228A (en) | Method for producing product having stain-proofing layer and product having stain-proofing layer | |
| GB0600763D0 (en) | 6, 7-dihydrobenzimidazo[1,2-C]quininazolin-6-one carboxylic acid, its esters and method of synthesis thereof | |
| WO2008033229A3 (en) | A method of making porous crystalline materials | |
| WO2003059900A1 (fr) | Derives de coumarine, leur procede de production et d'utilisation | |
| ATE553102T1 (de) | 6-(biphenylester)-3h-naphtho ä2,1-büpyrane als photochrome dichroische farbstoffe und optischer artikel, der diese enthält | |
| WO2007122792A3 (en) | Biofilm formation inhibitor composition | |
| AR041968A1 (es) | Compuestos derivados de imidazol como ligandos del receptor de adenosina | |
| WO2008102669A1 (ja) | 新規な糖連結クロリン誘導体及びその製造方法 | |
| TW200730581A (en) | Composition for optical materials, optical materials, and lens of spectacles | |
| NO20065057L (no) | benzoksazociner og terapeutisk anvendelse derav som monoamin reopptaks inhibitorer | |
| TW200628555A (en) | Optical recording medium and optical recording-reproducing method using thereof | |
| WO2008033230A3 (en) | A method of making porous crystalline materials |