NO20065057L - benzoksazociner og terapeutisk anvendelse derav som monoamin reopptaks inhibitorer - Google Patents
benzoksazociner og terapeutisk anvendelse derav som monoamin reopptaks inhibitorerInfo
- Publication number
- NO20065057L NO20065057L NO20065057A NO20065057A NO20065057L NO 20065057 L NO20065057 L NO 20065057L NO 20065057 A NO20065057 A NO 20065057A NO 20065057 A NO20065057 A NO 20065057A NO 20065057 L NO20065057 L NO 20065057L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- alkyl
- unsubstituted
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Forbindelser som er terapeutisk anvendelige har den generelle formel (1) hvor R1 er H, C1-C6 alkyl eventuelt substituert med F eller C3-C6 cykloalkyl eller C2-C4 alkenyl; A er O, CH2 eller S(O)n hvor n er 0-2; en av W, X, Y og Z er N, CH eller CR3 og de andre er CH; R2 er C5-C6 heteroaryl, C5-C10 cykloalkyl eller cykloalkenyl eventuelt inneholdende ett eller flere heteroatomer valgt fra O, N og S(O)n hvor n er 0-2 og eventuelt substituert med R3; eller en fenylgruppe eventuelt substituert i en eller flere stillinger med en eller flere substituenter uavhengig valgt fra halogen, CN, CF3, C1-C6 alkyl og OR1 eller fenylgruppen er kondensert til en fem- eller seksleddet ring som kan være karbosyklisk, heterosyklisk (inneholdende 1-2 heteroatomer valgt fra O, N og S), aromatisk eller heteroaromatisk (inneholdende 1-2 heteroatomer valgt fra O og N); R3 er valgt fra halogen; CF3; CN; OR5; SO2N(R5)2; COR5; CO2R5; CON(R5)2; NR1COR4; NR1SO2R4; NR1CO2R4; NR1CON(R5)2; OC1- C6 alkyl substituert med R3; C1-C6 alkyl eventuelt substituert med usubstituert R3; C3-C6 cykloalkyl eventuelt substituert med usubstituert R3; C2-C6 alkenyl eventuelt substituert med usubstituert R3; C2-C6 alkynyl eventuelt substituert med usubstituert R3; aryl eventuelt substituert med usubstituert R3; og fem- eller seksleddet aromatiske heterocykliske grupper inneholdende 1-4 heteroatomer valgt fra N og 0; R4 er C1- C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cykloalkyl, aryl og heteroaryl; og R5 er H, C1- C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cykloalkyl, aryl eller heteroaryl og er like som eller forskjellige fra en annen R5; eller et farmasøytisk akseptabelt salt derav.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0408863A GB0408863D0 (en) | 2004-04-21 | 2004-04-21 | Novel benzoxazocines |
| GB0408862A GB0408862D0 (en) | 2004-04-21 | 2004-04-21 | Novel benzoxazocines |
| PCT/GB2005/001519 WO2005103019A1 (en) | 2004-04-21 | 2005-04-21 | Benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20065057L true NO20065057L (no) | 2006-11-21 |
Family
ID=34965745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20065057A NO20065057L (no) | 2004-04-21 | 2006-11-02 | benzoksazociner og terapeutisk anvendelse derav som monoamin reopptaks inhibitorer |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1740558A1 (no) |
| JP (1) | JP2007533718A (no) |
| AU (1) | AU2005235786A1 (no) |
| BR (1) | BRPI0510075A (no) |
| CA (1) | CA2558741A1 (no) |
| IL (1) | IL177750A0 (no) |
| NO (1) | NO20065057L (no) |
| WO (1) | WO2005103019A1 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0504960D0 (en) * | 2005-03-10 | 2005-04-20 | Arakis Ltd | Benzoxazocines |
| GB0506835D0 (en) * | 2005-04-04 | 2005-05-11 | Arakis Ltd | Therapeutic use of nefopam |
| CA2782472C (en) | 2009-12-15 | 2019-04-16 | The Hospital For Sick Children | Method of treating scars and beta-catenin-mediated disorders |
| JP5996532B2 (ja) | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除剤としての新規複素環式化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3830803A (en) * | 1965-05-10 | 1974-08-20 | Riker Laboratories Inc | 5-loweralkyl-1-phenyl-1,3,4,6-tetrahydro-5h-benz(f)-2,5-oxazocines and 4-ones |
| US3978085A (en) * | 1975-03-07 | 1976-08-31 | Riker Laboratories, Inc. | Process for benz[f]-2,5-oxazocines |
| JPS5913760A (ja) * | 1982-07-13 | 1984-01-24 | Sanwa Kagaku Kenkyusho:Kk | 新規の２−ベンズアゾシン誘導体及びその製法 |
| JPS5913770A (ja) * | 1982-07-13 | 1984-01-24 | Sanwa Kagaku Kenkyusho:Kk | 新規の１−フエニル−２，５−ベンゾチアゾシン誘導体及びその製法 |
| KR100885986B1 (ko) * | 1999-11-03 | 2009-03-03 | 에이엠알 테크놀로지, 인크. | 노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도 |
| WO2004056788A1 (en) * | 2002-12-20 | 2004-07-08 | Arakis Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
-
2005
- 2005-04-21 WO PCT/GB2005/001519 patent/WO2005103019A1/en not_active Application Discontinuation
- 2005-04-21 JP JP2007508968A patent/JP2007533718A/ja not_active Withdrawn
- 2005-04-21 BR BRPI0510075-5A patent/BRPI0510075A/pt not_active IP Right Cessation
- 2005-04-21 CA CA002558741A patent/CA2558741A1/en not_active Abandoned
- 2005-04-21 AU AU2005235786A patent/AU2005235786A1/en not_active Abandoned
- 2005-04-21 EP EP05736028A patent/EP1740558A1/en not_active Withdrawn
-
2006
- 2006-08-29 IL IL177750A patent/IL177750A0/en unknown
- 2006-11-02 NO NO20065057A patent/NO20065057L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005235786A1 (en) | 2005-11-03 |
| EP1740558A1 (en) | 2007-01-10 |
| JP2007533718A (ja) | 2007-11-22 |
| IL177750A0 (en) | 2006-12-31 |
| WO2005103019A1 (en) | 2005-11-03 |
| BRPI0510075A (pt) | 2007-10-16 |
| CA2558741A1 (en) | 2005-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |