ATE535241T1 - Verwendung von 3-(indolyl)- oder 3-(azaindolyl)-4-arylmaleimid-derivaten bei der behandlung von leukämie - Google Patents

Verwendung von 3-(indolyl)- oder 3-(azaindolyl)-4-arylmaleimid-derivaten bei der behandlung von leukämie

Info

Publication number
ATE535241T1
ATE535241T1 AT08857282T AT08857282T ATE535241T1 AT E535241 T1 ATE535241 T1 AT E535241T1 AT 08857282 T AT08857282 T AT 08857282T AT 08857282 T AT08857282 T AT 08857282T AT E535241 T1 ATE535241 T1 AT E535241T1
Authority
AT
Austria
Prior art keywords
azaindolyl
indolyl
leukemia
treatment
phenyl
Prior art date
Application number
AT08857282T
Other languages
English (en)
Inventor
Gerd Dannhardt
Thomas Fischer
Florian Heidel
Jan-Peter Kramb
Stanislav Plutizki
Original Assignee
Univ Mainz Johannes Gutenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mainz Johannes Gutenberg filed Critical Univ Mainz Johannes Gutenberg
Application granted granted Critical
Publication of ATE535241T1 publication Critical patent/ATE535241T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT08857282T 2007-12-05 2008-12-04 Verwendung von 3-(indolyl)- oder 3-(azaindolyl)-4-arylmaleimid-derivaten bei der behandlung von leukämie ATE535241T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07023588 2007-12-05
PCT/EP2008/066776 WO2009071620A1 (en) 2007-12-05 2008-12-04 Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management

Publications (1)

Publication Number Publication Date
ATE535241T1 true ATE535241T1 (de) 2011-12-15

Family

ID=40328303

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08857282T ATE535241T1 (de) 2007-12-05 2008-12-04 Verwendung von 3-(indolyl)- oder 3-(azaindolyl)-4-arylmaleimid-derivaten bei der behandlung von leukämie

Country Status (7)

Country Link
US (1) US8841319B2 (de)
EP (1) EP2217231B1 (de)
JP (1) JP5576290B2 (de)
AT (1) ATE535241T1 (de)
AU (1) AU2008333215B2 (de)
CA (1) CA2707554C (de)
WO (1) WO2009071620A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG175207A1 (en) 2009-04-14 2011-11-28 Lilly Co Eli Benzodiazepine derivative for the treatment of hematopoietic neoplasm and leukemia
EP2343291A1 (de) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- oder 3-(Azaindolyl)-4-Arylmaleimid-Verbindungen und ihre Verwendung bei der Behandlung von Tumoren
EP2338486A1 (de) 2009-12-18 2011-06-29 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- oder 3-(Azaindolyl)-4-Arylmaleimid-Derivaten zurVerwendung in der Behandlung von Colon und Magen Adenocarzinoma
EP2474541A1 (de) * 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Konjugierte 3-(Indolyl)- und 3-(Azaindolyl)-4-arylmaleinimid-Verbindungen und deren Verwendung bei der Behandlung von Tumoren
EP2867236B1 (de) 2012-06-29 2017-06-14 Pfizer Inc Neue 4-(substituierte amino)-7h-pyrrolo[2,3-d]pyrimidine als lrrk2 hemmer
US9993463B2 (en) * 2012-12-10 2018-06-12 Centogene Ag Use of maleimide derivatives for preventing and treating cancer
ES2845298T3 (es) * 2012-12-10 2021-07-26 Centogene Gmbh Uso de derivados de maleimida para prevenir y tratar la leucemia
CA2933767C (en) 2013-12-17 2018-11-06 Pfizer Inc. Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
CN108137586B (zh) 2015-09-14 2021-04-13 辉瑞大药厂 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物
EP3187495A1 (de) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluorindolyl)-4-arylmaleimid-verbindungen und deren verwendung bei der tumorbehandlung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ535616A (en) * 2000-11-07 2006-03-31 Novartis Ag Indolymaleimide derivatives as protein kinase c inhibitors
ATE387444T1 (de) 2002-05-08 2008-03-15 Janssen Pharmaceutica Nv Substituierte pyrroline als kinase inhibitoren
US7232906B2 (en) * 2002-06-05 2007-06-19 Janssen Pharmaceutica N.V. Substituted pyrrolines as kinase inhibitors
JP2006521386A (ja) * 2003-03-27 2006-09-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤である置換ピロリン
US8008320B2 (en) * 2004-12-08 2011-08-30 Johannes Gutenberg-Universitatis 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors

Also Published As

Publication number Publication date
CA2707554A1 (en) 2009-06-11
WO2009071620A1 (en) 2009-06-11
AU2008333215B2 (en) 2013-06-13
EP2217231B1 (de) 2011-11-30
JP5576290B2 (ja) 2014-08-20
EP2217231A1 (de) 2010-08-18
JP2011506288A (ja) 2011-03-03
US20110028415A1 (en) 2011-02-03
US8841319B2 (en) 2014-09-23
CA2707554C (en) 2015-06-30
AU2008333215A1 (en) 2009-06-11

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