AR041356A1 - Un procedimiento para la sintesis industrial del diester metilico del acido 5- amino-3-carboximetil -4-ciano-2- tiofencarboxilico y aplicacion del mismo a la produccion industrial de sales bivalentes de acido ranelico y sus hidratos - Google Patents
Un procedimiento para la sintesis industrial del diester metilico del acido 5- amino-3-carboximetil -4-ciano-2- tiofencarboxilico y aplicacion del mismo a la produccion industrial de sales bivalentes de acido ranelico y sus hidratosInfo
- Publication number
- AR041356A1 AR041356A1 ARP030103454A ARP030103454A AR041356A1 AR 041356 A1 AR041356 A1 AR 041356A1 AR P030103454 A ARP030103454 A AR P030103454A AR P030103454 A ARP030103454 A AR P030103454A AR 041356 A1 AR041356 A1 AR 041356A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- formula
- industrial
- thiofencarboxilico
- carboximetil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Procedimiento para la síntesis industrial del compuesto de fórmula (1), caracterizado porque el 3-oxogluturato de dimetilo de fórmula (2), se hace reaccionar con malonitrilo de fórmula (3) en metanol, en presencia de morfolina enuna cantidad de más de 0,95 mol por mol de compuesto de fórmula (2), para rendir el compuesto de fórmula (4), que se hace reaccionar luego con azufre en una cantidad de más de 0,95 mol por mol de compuesto de fórmula (2); la mezcla de reacción secalienta luego a reflujo; y el compuesto de fórmula (1) así obtenido se aísla por precipitación en presencia de agua, seguida por filtración.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211764A FR2844796A1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041356A1 true AR041356A1 (es) | 2005-05-11 |
Family
ID=29415190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103454A AR041356A1 (es) | 2002-09-24 | 2003-09-23 | Un procedimiento para la sintesis industrial del diester metilico del acido 5- amino-3-carboximetil -4-ciano-2- tiofencarboxilico y aplicacion del mismo a la produccion industrial de sales bivalentes de acido ranelico y sus hidratos |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US7105683B2 (es) |
| EP (1) | EP1403264B1 (es) |
| JP (1) | JP4136865B2 (es) |
| KR (1) | KR100551503B1 (es) |
| CN (2) | CN1280285C (es) |
| AP (1) | AP1942A (es) |
| AR (1) | AR041356A1 (es) |
| AT (1) | ATE286041T1 (es) |
| AU (2) | AU2003248279B2 (es) |
| BR (1) | BR0304194A (es) |
| CA (1) | CA2442875C (es) |
| DE (1) | DE60300252T2 (es) |
| DK (1) | DK1403264T3 (es) |
| EA (1) | EA007496B1 (es) |
| EC (1) | ECSP055742A (es) |
| ES (1) | ES2235144T3 (es) |
| FR (1) | FR2844796A1 (es) |
| GE (1) | GEP20074140B (es) |
| HK (2) | HK1061845A1 (es) |
| HR (1) | HRP20050360B1 (es) |
| IL (1) | IL167314A (es) |
| IS (1) | IS2136B (es) |
| MA (1) | MA26101A1 (es) |
| ME (1) | ME00451B (es) |
| MX (1) | MXPA03008645A (es) |
| MY (1) | MY131939A (es) |
| NI (1) | NI200500065A (es) |
| NO (1) | NO328697B1 (es) |
| NZ (1) | NZ528400A (es) |
| OA (1) | OA12933A (es) |
| PL (1) | PL214414B1 (es) |
| PT (1) | PT1403264E (es) |
| RS (1) | RS50929B (es) |
| SG (1) | SG110070A1 (es) |
| SI (1) | SI1403264T1 (es) |
| TN (1) | TNSN05089A1 (es) |
| UA (1) | UA79991C2 (es) |
| WO (1) | WO2004029035A1 (es) |
| ZA (1) | ZA200307410B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| AU2004237438B2 (en) * | 2003-05-07 | 2011-01-20 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| CA2519189C (en) * | 2003-05-07 | 2012-07-17 | Osteologix A/S | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| EP1732575B1 (en) * | 2004-02-26 | 2010-12-29 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
| DK1768748T4 (da) | 2004-06-25 | 2019-06-11 | Mokwalo Spf S A | Sammensætninger omfattende strontium og vitamin D og anvendelser deraf |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011110597A1 (de) | 2010-03-11 | 2011-09-15 | Azad Pharmaceutical Ingredients Ag | Verfahren zur herstellung von strontiumranelat |
| CN103319454B (zh) * | 2013-06-14 | 2014-06-18 | 广东众生药业股份有限公司 | 一种高纯度雷尼酸四乙酯及其中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR415850A (fr) | 1909-07-22 | 1910-10-05 | Gustave Auguste Ferrie | Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables |
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2844797B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
-
2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
-
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 EP EP03292317A patent/EP1403264B1/fr not_active Expired - Lifetime
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Application Discontinuation
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active IP Right Cessation
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
-
2004
- 2004-07-05 HK HK04104808A patent/HK1061845A1/xx not_active IP Right Cessation
-
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/xx unknown
- 2005-04-21 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
-
2006
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related
-
2007
- 2007-02-01 HK HK07101197A patent/HK1096661A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |