CO5640089A2 - Proceso para la sintesis de 3-ciano-6-alcoxi-7-nitro-4-quinolinas - Google Patents

Proceso para la sintesis de 3-ciano-6-alcoxi-7-nitro-4-quinolinas

Info

Publication number
CO5640089A2
CO5640089A2 CO05101169A CO05101169A CO5640089A2 CO 5640089 A2 CO5640089 A2 CO 5640089A2 CO 05101169 A CO05101169 A CO 05101169A CO 05101169 A CO05101169 A CO 05101169A CO 5640089 A2 CO5640089 A2 CO 5640089A2
Authority
CO
Colombia
Prior art keywords
formula
compound
nitro
quinolinas
alcoxi
Prior art date
Application number
CO05101169A
Other languages
English (en)
Inventor
Scott Duncan
Miguel Angel Pagan
Middleton Brawner Floyd Jr
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5640089A2 publication Critical patent/CO5640089A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1.- Un proceso para la producción de 3-ciano-6-alcoxi-7-nitro-4-quinolona, caracterizado porque comprende: a) hacer reaccionar un antranilato sustituido de fórmula (I) con dimetilformamida dimetil acetal: donde R es un alquilo;para obtener un compuesto de fórmula (II): b) condensar el compuesto de fórmula (II) con el t-butilcianoacetato para obtener un compuesto de fórmula (III): c) hidrolizar el compuesto de fórmula (III) para producir el compuesto de fórmula (IV): d) descarboxilar el compuesto de fórmula (IV) hasta un compuesto de fórmula (V): ciclar el compuesto de fórmula (V) para obtener una 3-ciano-6-alcoxi-7nitro-4-quinolona de fórmula:
CO05101169A 2003-04-09 2005-10-05 Proceso para la sintesis de 3-ciano-6-alcoxi-7-nitro-4-quinolinas CO5640089A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46164703P 2003-04-09 2003-04-09

Publications (1)

Publication Number Publication Date
CO5640089A2 true CO5640089A2 (es) 2006-05-31

Family

ID=33299849

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05101169A CO5640089A2 (es) 2003-04-09 2005-10-05 Proceso para la sintesis de 3-ciano-6-alcoxi-7-nitro-4-quinolinas

Country Status (21)

Country Link
US (1) US6933388B2 (es)
EP (1) EP1611103A1 (es)
JP (1) JP2006522810A (es)
KR (1) KR20050120788A (es)
CN (1) CN100376558C (es)
AR (1) AR043988A1 (es)
AU (1) AU2004230864A1 (es)
BR (1) BRPI0409134A (es)
CA (1) CA2521294A1 (es)
CL (1) CL2004000758A1 (es)
CO (1) CO5640089A2 (es)
CR (1) CR7991A (es)
EC (1) ECSP056089A (es)
EG (1) EG24122A (es)
MX (1) MXPA05010685A (es)
NI (1) NI200500175A (es)
NO (1) NO20054375L (es)
RU (1) RU2333909C2 (es)
TW (1) TW200504024A (es)
UA (1) UA80607C2 (es)
WO (1) WO2004092138A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101723854A (zh) * 2008-10-24 2010-06-09 上海特化医药科技有限公司 6-取代氨基-3-氰基喹啉类化合物的制备方法及其中间体
CN111116416B (zh) * 2019-12-30 2021-03-23 中国农业大学 一种β-氨基丙烯腈类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73073C2 (uk) * 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
CN1144786C (zh) * 1998-09-29 2004-04-07 美国氰胺公司 作为蛋白质酪氨酸激酶抑制剂的取代的3-氰基喹啉

Also Published As

Publication number Publication date
JP2006522810A (ja) 2006-10-05
TW200504024A (en) 2005-02-01
RU2333909C2 (ru) 2008-09-20
EP1611103A1 (en) 2006-01-04
US20040204587A1 (en) 2004-10-14
NO20054375L (no) 2005-10-12
CN1771230A (zh) 2006-05-10
BRPI0409134A (pt) 2006-03-28
CL2004000758A1 (es) 2005-02-04
AR043988A1 (es) 2005-08-17
CA2521294A1 (en) 2004-10-28
UA80607C2 (en) 2007-10-10
EG24122A (en) 2008-07-06
CR7991A (es) 2006-05-31
WO2004092138A1 (en) 2004-10-28
NI200500175A (es) 2006-05-04
MXPA05010685A (es) 2005-12-12
AU2004230864A1 (en) 2004-10-28
CN100376558C (zh) 2008-03-26
RU2005134653A (ru) 2006-03-27
KR20050120788A (ko) 2005-12-23
US6933388B2 (en) 2005-08-23
ECSP056089A (es) 2006-03-01

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