SG164282A1 - Taxane derivatives functionalized at the 14-position and a process for the preparation thereof - Google Patents

Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

Info

Publication number
SG164282A1
SG164282A1 SG200703232-9A SG2007032329A SG164282A1 SG 164282 A1 SG164282 A1 SG 164282A1 SG 2007032329 A SG2007032329 A SG 2007032329A SG 164282 A1 SG164282 A1 SG 164282A1
Authority
SG
Singapore
Prior art keywords
preparation
taxane derivatives
formula
derivatives functionalized
functionalized
Prior art date
Application number
SG200703232-9A
Inventor
Gabriele Fontana
Ezio Bombardelli
Arturo Battaglia
Eleonora Baldelli
Andrea Guerrini
Maria Luisa Gelmi
Giacomo Carenzi
Donato Pocar
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of SG164282A1 publication Critical patent/SG164282A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A general process for the functionalization at the 14- position of 13- ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described.
SG200703232-9A 2002-09-10 2003-09-05 Taxane derivatives functionalized at the 14-position and a process for the preparation thereof SG164282A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001921A ITMI20021921A1 (en) 2002-09-10 2002-09-10 FUNCTIONALIZATION OF POSITION 14 OF TASSANIC NUCLEI AND SUMMARY OF NEW ANTI-TUMOR DERIVATIVES.

Publications (1)

Publication Number Publication Date
SG164282A1 true SG164282A1 (en) 2010-09-29

Family

ID=31986024

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200703232-9A SG164282A1 (en) 2002-09-10 2003-09-05 Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

Country Status (20)

Country Link
US (1) US7498452B2 (en)
EP (6) EP1537093B1 (en)
JP (2) JP4690039B2 (en)
KR (1) KR101096918B1 (en)
CN (1) CN1681799A (en)
AT (1) ATE398113T1 (en)
AU (1) AU2003267049B8 (en)
CA (1) CA2498277C (en)
DE (1) DE60321577D1 (en)
DK (4) DK2077264T3 (en)
ES (4) ES2398324T3 (en)
IL (5) IL167336A (en)
IT (1) ITMI20021921A1 (en)
NO (3) NO332250B1 (en)
PL (4) PL375625A1 (en)
PT (4) PT1537093E (en)
RU (1) RU2320652C2 (en)
SG (1) SG164282A1 (en)
SI (4) SI1537093T1 (en)
WO (1) WO2004024706A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012185A1 (en) * 2001-10-19 2003-04-19 Indena Spa PROCEDURE FOR THE PREPARATION OF 14BETA-HYDROXY-BACCATIN III-1,14-CARBONATE
CN107056767B (en) * 2015-12-04 2022-07-15 江苏恩华络康药物研发有限公司 Process and intermediates for the preparation of water-soluble taxane derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022856A1 (en) * 1993-03-26 1994-10-13 The Research Foundation Of The State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5821363A (en) * 1994-01-28 1998-10-13 Pharmacia & Upjohn Company Antineoplastic use and pharmaceutical compositions containing them
WO2002012215A1 (en) * 2000-08-10 2002-02-14 Indena S.P.A. Process for the preparation of baccatin iii derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504222A (en) 1993-08-20 1996-04-02 The Scripps Research Institute Transformations of taxol
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them
JPH09509431A (en) 1994-11-04 1997-09-22 フアルマシア・エツセ・ピー・アー Taxane derivative
IT1275936B1 (en) * 1995-03-17 1997-10-24 Indena Spa DERIVATIVES OF 10-DEACETYLBACCATIN III AND OF 10-DEACETYL-14B- HYDROXYBACCATIN III THEIR METHOD OF PREPARATION AND FORMULATIONS
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ITMI991483A1 (en) * 1999-07-06 2001-01-06 Indena Spa TAXANIC DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION
CN101845116B (en) * 2000-08-04 2013-04-24 传感技术股份有限公司 Detection of analytes in aqueous environments
ITMI20012186A1 (en) * 2001-10-19 2003-04-19 Indena Spa PROCEDURE FOR THE PREPARATION OF 14-BETA-HYDROXY-BACCATIN III-1,14-CARBONATE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022856A1 (en) * 1993-03-26 1994-10-13 The Research Foundation Of The State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5821363A (en) * 1994-01-28 1998-10-13 Pharmacia & Upjohn Company Antineoplastic use and pharmaceutical compositions containing them
WO2002012215A1 (en) * 2000-08-10 2002-02-14 Indena S.P.A. Process for the preparation of baccatin iii derivatives

Also Published As

Publication number Publication date
NO332366B1 (en) 2012-09-03
PT2264019E (en) 2013-10-28
AU2003267049A1 (en) 2004-04-30
CA2498277A1 (en) 2004-03-25
IL214430A0 (en) 2011-09-27
SI2298754T1 (en) 2013-11-29
ITMI20021921A1 (en) 2004-03-11
EP2298754B1 (en) 2013-08-07
IL197815A (en) 2013-02-28
NO20110781L (en) 2005-05-10
ES2398324T3 (en) 2013-03-15
IL214432A (en) 2014-05-28
WO2004024706A2 (en) 2004-03-25
NO20110782L (en) 2005-05-10
PL375625A1 (en) 2005-12-12
ATE398113T1 (en) 2008-07-15
AU2003267049B2 (en) 2010-02-11
RU2005106361A (en) 2005-10-10
ES2432024T3 (en) 2013-11-29
EP2077264A2 (en) 2009-07-08
US20060122258A1 (en) 2006-06-08
JP2010270145A (en) 2010-12-02
EP2077264B1 (en) 2012-11-14
EP2077264A3 (en) 2009-09-16
IL214431A0 (en) 2011-09-27
IL214431A (en) 2014-05-28
PT2077264E (en) 2013-01-29
JP4690039B2 (en) 2011-06-01
AU2003267049B8 (en) 2010-03-04
PL402332A1 (en) 2013-04-02
EP1537093A2 (en) 2005-06-08
DK1537093T3 (en) 2008-10-27
EP2298754A1 (en) 2011-03-23
NO20051774L (en) 2005-05-10
CN1681799A (en) 2005-10-12
PL402323A1 (en) 2013-04-02
DK2264019T3 (en) 2013-10-28
WO2004024706A3 (en) 2004-07-08
NO332250B1 (en) 2012-08-06
EP2298754B9 (en) 2013-12-18
DE60321577D1 (en) 2008-07-24
IL214432A0 (en) 2011-09-27
PL402333A1 (en) 2013-04-02
ES2433580T3 (en) 2013-12-11
SI2264019T1 (en) 2013-10-30
NO332367B1 (en) 2012-09-03
KR101096918B1 (en) 2011-12-22
JP2006503030A (en) 2006-01-26
RU2320652C2 (en) 2008-03-27
DK2298754T3 (en) 2013-11-04
PT2298754E (en) 2013-11-07
CA2498277C (en) 2011-07-05
EP1980557A2 (en) 2008-10-15
EP2281820A2 (en) 2011-02-09
KR20050035540A (en) 2005-04-18
EP2264019A1 (en) 2010-12-22
US7498452B2 (en) 2009-03-03
DK2077264T3 (en) 2013-03-04
ES2307965T3 (en) 2008-12-01
EP1980557A3 (en) 2008-12-31
EP2281820A3 (en) 2011-05-04
PT1537093E (en) 2008-09-02
EP2264019B1 (en) 2013-07-24
IL167336A (en) 2009-11-18
SI2077264T1 (en) 2013-03-29
EP1537093B1 (en) 2008-06-11
SI1537093T1 (en) 2008-10-31

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