ATE287889T1 - Cefalosporin-zwischenprodukte - Google Patents

Cefalosporin-zwischenprodukte

Info

Publication number
ATE287889T1
ATE287889T1 AT01933896T AT01933896T ATE287889T1 AT E287889 T1 ATE287889 T1 AT E287889T1 AT 01933896 T AT01933896 T AT 01933896T AT 01933896 T AT01933896 T AT 01933896T AT E287889 T1 ATE287889 T1 AT E287889T1
Authority
AT
Austria
Prior art keywords
cefalosporin
compound
formula
intermediate products
ivto
Prior art date
Application number
AT01933896T
Other languages
English (en)
Inventor
Peter Kremminger
Johannes Ludescher
Siegfried Wolf
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE287889T1 publication Critical patent/ATE287889T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01933896T 2000-04-28 2001-04-26 Cefalosporin-zwischenprodukte ATE287889T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0010475.2A GB0010475D0 (en) 2000-04-28 2000-04-28 Organic compounds
PCT/EP2001/004735 WO2001083491A1 (en) 2000-04-28 2001-04-26 Cephalosporin intermediates

Publications (1)

Publication Number Publication Date
ATE287889T1 true ATE287889T1 (de) 2005-02-15

Family

ID=9890746

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01933896T ATE287889T1 (de) 2000-04-28 2001-04-26 Cefalosporin-zwischenprodukte

Country Status (12)

Country Link
US (1) US6787649B2 (de)
EP (1) EP1278754B1 (de)
JP (1) JP4990462B2 (de)
KR (1) KR100789156B1 (de)
CN (1) CN1195761C (de)
AT (1) ATE287889T1 (de)
AU (1) AU2001260255A1 (de)
CA (1) CA2405621C (de)
DE (1) DE60108627T2 (de)
GB (1) GB0010475D0 (de)
TW (1) TWI281920B (de)
WO (1) WO2001083491A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101045733B (zh) * 2007-01-26 2011-11-16 浙江永宁药业股份有限公司 一种头孢替安盐酸盐制备方法
CN101633666B (zh) * 2009-08-26 2010-08-18 海南永田药物研究院有限公司 一种盐酸头孢替安化合物及其新制法
CN102190667B (zh) * 2011-03-24 2013-05-29 海南灵康制药有限公司 一种纯化盐酸头孢替安的制法
CN102898441A (zh) * 2012-10-11 2013-01-30 南通康鑫药业有限公司 一种头孢替安的合成方法
CN102977123B (zh) * 2012-12-03 2015-04-29 邓世碧 一种头孢类化合物及其药学可接受盐
CN103012436B (zh) * 2012-12-04 2015-07-01 山东鑫泉医药有限公司 头孢替安盐酸盐的制备方法
CN103232477B (zh) * 2013-05-08 2014-04-09 四川省惠达药业有限公司 一种盐酸头孢替安化合物、其制备方法及其药物组合物
CN103601737B (zh) * 2013-12-04 2016-02-03 哈药集团制药总厂 一种盐酸头孢替安的制备方法
CN105125558A (zh) * 2015-09-18 2015-12-09 青岛华之草医药科技有限公司 一种抗菌药物盐酸头孢替安组合物
CN105820162B (zh) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 一种头孢替安工艺杂质的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0025199B1 (de) * 1979-09-03 1984-10-31 Fujisawa Pharmaceutical Co., Ltd. Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
NZ208281A (en) * 1983-06-02 1986-11-12 Takeda Chemical Industries Ltd Cephalosporin ester derivatives and pharmaceutical compositions
JPS6011490A (ja) * 1983-06-24 1985-01-21 Sagami Chem Res Center β−ラクタム誘導体
IT1265341B1 (it) * 1993-07-16 1996-11-22 Farmabios Srl Procedimento per la preparazione di cefalosporine
WO1996017850A1 (en) * 1994-12-09 1996-06-13 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and pharmaceutical use thereof

Also Published As

Publication number Publication date
JP2003531911A (ja) 2003-10-28
US6787649B2 (en) 2004-09-07
AU2001260255A1 (en) 2001-11-12
KR100789156B1 (ko) 2007-12-28
CN1426416A (zh) 2003-06-25
DE60108627T2 (de) 2005-12-29
KR20030005274A (ko) 2003-01-17
WO2001083491A1 (en) 2001-11-08
US20030153748A1 (en) 2003-08-14
JP4990462B2 (ja) 2012-08-01
EP1278754B1 (de) 2005-01-26
CA2405621A1 (en) 2001-11-08
TWI281920B (en) 2007-06-01
CA2405621C (en) 2009-12-15
GB0010475D0 (en) 2000-06-14
EP1278754A1 (de) 2003-01-29
DE60108627D1 (de) 2005-03-03
CN1195761C (zh) 2005-04-06

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