IT1265341B1 - Procedimento per la preparazione di cefalosporine - Google Patents
Procedimento per la preparazione di cefalosporineInfo
- Publication number
- IT1265341B1 IT1265341B1 IT93MI001580A ITMI931580A IT1265341B1 IT 1265341 B1 IT1265341 B1 IT 1265341B1 IT 93MI001580 A IT93MI001580 A IT 93MI001580A IT MI931580 A ITMI931580 A IT MI931580A IT 1265341 B1 IT1265341 B1 IT 1265341B1
- Authority
- IT
- Italy
- Prior art keywords
- acid
- carboxylic
- deformilation
- sulfoalkyl
- tetrazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
E' descritto un procedimento per preparare acidi 7-(?-idrossiacilammino)-3-(1-solfoalchil-tetrazol-5-il-tiometil)-3-cefem-4-carbossilici e i relativi sali, comprendente l'acilazione di un acido 7-ammino-3-(1-solfoalchil-tetrazol-5-il-tiometil)-3-cefem-4-carbossilico con l'opportuno cloruro di un acido ?-formilossi carbossilico, in un mezzo diluente, a pH 6,5-7,0; la deformilazione per trattamento con un acido, a pH compreso fra 1,0 e 1,5; una o più estrazioni con solvente organico della fase acquosa acida proveniente dalla deformilazione, seguita da salatura e da estrazione con un solvente scelto fra tetraidrofurano, metiletilchetone e acetonitrile; l'evaporazione del solvente e la salificazione in ambiente non acquoso.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI001580A IT1265341B1 (it) | 1993-07-16 | 1993-07-16 | Procedimento per la preparazione di cefalosporine |
US08/273,841 US5625058A (en) | 1993-07-16 | 1994-07-12 | Process for the preparation of cephalosporins |
ES09401569A ES2097086B1 (es) | 1993-07-16 | 1994-07-12 | Procedimiento para la preparacion de cefalosporinas. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI001580A IT1265341B1 (it) | 1993-07-16 | 1993-07-16 | Procedimento per la preparazione di cefalosporine |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI931580A0 ITMI931580A0 (it) | 1993-07-16 |
ITMI931580A1 ITMI931580A1 (it) | 1995-01-16 |
IT1265341B1 true IT1265341B1 (it) | 1996-11-22 |
Family
ID=11366624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93MI001580A IT1265341B1 (it) | 1993-07-16 | 1993-07-16 | Procedimento per la preparazione di cefalosporine |
Country Status (3)
Country | Link |
---|---|
US (1) | US5625058A (it) |
ES (1) | ES2097086B1 (it) |
IT (1) | IT1265341B1 (it) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1283641B1 (it) * | 1996-07-30 | 1998-04-23 | Ribbon Srl | Procedimento per la preparazione di cefalosporine |
US6211384B1 (en) | 1999-08-30 | 2001-04-03 | Novartis Pharmaceuticals Corp. | Methods for the acylation of amine compounds |
GB0010475D0 (en) | 2000-04-28 | 2000-06-14 | Biochemie Gmbh | Organic compounds |
EP1394262A1 (en) * | 2002-08-30 | 2004-03-03 | Bioferma Murcia, S.A. | An enzymatic process for preparing beta-lactams |
CN101085781B (zh) * | 2007-06-01 | 2010-05-26 | 深圳信立泰药业股份有限公司 | 一种制备头孢尼西或其可药用盐及其中间体的方法 |
CN101417998B (zh) * | 2007-10-24 | 2012-10-24 | 重庆医药工业研究院有限责任公司 | 一种培美曲塞盐的纯化方法 |
CN101792453B (zh) * | 2010-03-17 | 2012-04-18 | 河北九派制药有限公司 | 一种7-氨基-3-磺酸基四氮唑硫甲基头孢烷酸的制备方法 |
CN102212073A (zh) * | 2010-04-08 | 2011-10-12 | 胡梨芳 | 头孢尼西钠水合物及其制备方法和用途 |
CN102286000A (zh) * | 2010-06-18 | 2011-12-21 | 广东立国制药有限公司 | 头孢尼西及其药用盐的制备方法 |
CN102432628A (zh) * | 2011-11-15 | 2012-05-02 | 华北制药奥奇德药业有限公司 | 一种制备头孢尼西中间体的方法 |
CN103224504B (zh) * | 2013-04-03 | 2015-04-01 | 海南合瑞制药股份有限公司 | 一种注射用头孢尼西钠化合物、制备方法及药物组合物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3954745A (en) * | 1974-09-12 | 1976-05-04 | Eli Lilly And Company | Process for preparing cefazolin |
US4093723A (en) * | 1976-05-19 | 1978-06-06 | Smithkline Corporation | 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins |
ZA76757B (en) * | 1975-03-18 | 1977-01-26 | Smithkline Corp | New cephalosporin compounds |
JPS51115493A (en) * | 1975-03-18 | 1976-10-12 | Smithkline Corp | Novel cephalosporine compound |
US4048311A (en) * | 1976-01-08 | 1977-09-13 | Smithkline Corporation | 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins |
EP0029202B1 (en) * | 1979-11-16 | 1983-04-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel tetrazole-5-thiol esters and process for preparing cefamandole using same |
AT383811B (de) * | 1983-09-22 | 1987-08-25 | Biochemie Gmbh | Verfahren zur herstellung von monoalkalisalzen von 7-amino-3-cephem-4-carbonsaeurederivaten |
US4576937A (en) * | 1984-02-29 | 1986-03-18 | Smithkline Beckman Corporation | 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt |
EP0156771A3 (en) * | 1984-03-29 | 1986-03-19 | Biochemie Gesellschaft M.B.H. | Cephalosporins |
IE921073A1 (en) * | 1991-04-04 | 1992-10-07 | Smithkline Beecham Corp | Enzymatic process for the production of cefonicid |
-
1993
- 1993-07-16 IT IT93MI001580A patent/IT1265341B1/it active IP Right Grant
-
1994
- 1994-07-12 ES ES09401569A patent/ES2097086B1/es not_active Expired - Lifetime
- 1994-07-12 US US08/273,841 patent/US5625058A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ITMI931580A1 (it) | 1995-01-16 |
US5625058A (en) | 1997-04-29 |
ES2097086B1 (es) | 1997-12-16 |
ITMI931580A0 (it) | 1993-07-16 |
ES2097086A1 (es) | 1997-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970730 |