ECSP055742A - Nuevo método para la síntesis industrial de diéster de metilo del ácido 5-amino-3-carboximetil-4-ciano-2-tiofencarboxílico y aplicación para la síntesis de sales bivalentes de ácido ranélico y sus hidratos - Google Patents

Nuevo método para la síntesis industrial de diéster de metilo del ácido 5-amino-3-carboximetil-4-ciano-2-tiofencarboxílico y aplicación para la síntesis de sales bivalentes de ácido ranélico y sus hidratos

Info

Publication number
ECSP055742A
ECSP055742A EC2005005742A ECSP055742A ECSP055742A EC SP055742 A ECSP055742 A EC SP055742A EC 2005005742 A EC2005005742 A EC 2005005742A EC SP055742 A ECSP055742 A EC SP055742A EC SP055742 A ECSP055742 A EC SP055742A
Authority
EC
Ecuador
Prior art keywords
synthesis
acid
application
thiophencarboxyl
hydrats
Prior art date
Application number
EC2005005742A
Other languages
English (en)
Inventor
Jean-Pierre Lecouve
Lucile Vaysse-Ludot
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29415190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP055742(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of ECSP055742A publication Critical patent/ECSP055742A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Proceso para la síntesis industrial del compuesto de fórmula (I): Aplicación a la síntesis de sales bivalentes de ácido ranélico y más específicamente de ranelato de estroncio y sus hidratos.
EC2005005742A 2002-09-24 2005-04-22 Nuevo método para la síntesis industrial de diéster de metilo del ácido 5-amino-3-carboximetil-4-ciano-2-tiofencarboxílico y aplicación para la síntesis de sales bivalentes de ácido ranélico y sus hidratos ECSP055742A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0211764A FR2844796A1 (fr) 2002-09-24 2002-09-24 Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (1)

Publication Number Publication Date
ECSP055742A true ECSP055742A (es) 2005-07-06

Family

ID=29415190

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005742A ECSP055742A (es) 2002-09-24 2005-04-22 Nuevo método para la síntesis industrial de diéster de metilo del ácido 5-amino-3-carboximetil-4-ciano-2-tiofencarboxílico y aplicación para la síntesis de sales bivalentes de ácido ranélico y sus hidratos

Country Status (39)

Country Link
US (3) US7105683B2 (es)
EP (1) EP1403264B1 (es)
JP (1) JP4136865B2 (es)
KR (1) KR100551503B1 (es)
CN (2) CN1280285C (es)
AP (1) AP1942A (es)
AR (1) AR041356A1 (es)
AT (1) ATE286041T1 (es)
AU (2) AU2003248279B2 (es)
BR (1) BR0304194A (es)
CA (1) CA2442875C (es)
DE (1) DE60300252T2 (es)
DK (1) DK1403264T3 (es)
EA (1) EA007496B1 (es)
EC (1) ECSP055742A (es)
ES (1) ES2235144T3 (es)
FR (1) FR2844796A1 (es)
GE (1) GEP20074140B (es)
HK (2) HK1061845A1 (es)
HR (1) HRP20050360B1 (es)
IL (1) IL167314A (es)
IS (1) IS2136B (es)
MA (1) MA26101A1 (es)
ME (1) ME00451B (es)
MX (1) MXPA03008645A (es)
MY (1) MY131939A (es)
NI (1) NI200500065A (es)
NO (1) NO328697B1 (es)
NZ (1) NZ528400A (es)
OA (1) OA12933A (es)
PL (1) PL214414B1 (es)
PT (1) PT1403264E (es)
RS (1) RS50929B (es)
SG (1) SG110070A1 (es)
SI (1) SI1403264T1 (es)
TN (1) TNSN05089A1 (es)
UA (1) UA79991C2 (es)
WO (1) WO2004029035A1 (es)
ZA (1) ZA200307410B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2844795B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) * 2002-09-24 2004-03-26 Servier Lab Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
SI1622630T1 (sl) * 2003-05-07 2012-12-31 Osteologix A/S Stroncijeva kombinacije za profilakso/zdravljenje patologij hrustanca in/ali kosti
JP4354984B2 (ja) * 2003-05-07 2009-10-28 オステオロジックス エイ／エス 水溶性ストロンチウム塩を用いる軟骨／骨症状の治療
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
AU2005216596B2 (en) * 2004-02-26 2011-03-24 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
MXPA06015187A (es) 2004-06-25 2007-09-27 Strontin Aps Composiciones que comprenden estroncio y vitamina d y usos de las mismas.
FR2875807B1 (fr) * 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US20070292529A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating osteoporotic conditions
CN101665483B (zh) * 2008-09-01 2013-01-23 河北医科大学 一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011110597A1 (de) 2010-03-11 2011-09-15 Azad Pharmaceutical Ingredients Ag Verfahren zur herstellung von strontiumranelat
CN103319454B (zh) * 2013-06-14 2014-06-18 广东众生药业股份有限公司 一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR415850A (fr) 1909-07-22 1910-10-05 Gustave Auguste Ferrie Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables
FR2651497B1 (fr) * 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2844797B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844796A1 (fr) * 2002-09-24 2004-03-26 Servier Lab Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Also Published As

Publication number Publication date
AP1942A (en) 2009-01-28
US7462714B2 (en) 2008-12-09
PL362367A1 (en) 2004-04-05
HRP20050360A2 (en) 2005-06-30
HK1096661A1 (en) 2007-06-08
KR100551503B1 (ko) 2006-02-13
AU2003282178A1 (en) 2004-04-19
SI1403264T1 (en) 2005-04-30
AP2005003259A0 (en) 2005-03-31
CN1280285C (zh) 2006-10-18
KR20040026627A (ko) 2004-03-31
AR041356A1 (es) 2005-05-11
US20060142596A1 (en) 2006-06-29
EA200300926A1 (ru) 2004-04-29
NO20034237D0 (no) 2003-09-23
US7105683B2 (en) 2006-09-12
IL167314A (en) 2010-04-29
RS20050242A (en) 2007-06-04
MXPA03008645A (es) 2005-04-19
SG110070A1 (en) 2005-04-28
PL214414B1 (pl) 2013-07-31
CA2442875C (fr) 2009-06-02
PT1403264E (pt) 2005-04-29
EP1403264A1 (fr) 2004-03-31
IS2136B (is) 2006-08-15
HRP20050360B1 (hr) 2013-08-31
ME00451B (me) 2011-10-10
MA26101A1 (fr) 2004-04-01
ES2235144T3 (es) 2005-07-01
DE60300252T2 (de) 2005-12-22
NI200500065A (es) 2006-01-03
TNSN05089A1 (fr) 2007-05-14
DK1403264T3 (da) 2005-04-04
EP1403264B1 (fr) 2004-12-29
BR0304194A (pt) 2004-09-08
CN1500783A (zh) 2004-06-02
MY131939A (en) 2007-09-28
CA2442875A1 (fr) 2004-03-24
GEP20074140B (en) 2007-06-25
US20060142567A1 (en) 2006-06-29
IS7808A (is) 2005-04-19
US20040059135A1 (en) 2004-03-25
ATE286041T1 (de) 2005-01-15
NZ528400A (en) 2004-06-25
FR2844796A1 (fr) 2004-03-26
JP2004269495A (ja) 2004-09-30
NO328697B1 (no) 2010-04-26
DE60300252D1 (de) 2005-02-03
NO20034237L (no) 2004-03-25
EA007496B1 (ru) 2006-10-27
UA79991C2 (en) 2007-08-10
HK1061845A1 (en) 2004-10-08
CN100393707C (zh) 2008-06-11
JP4136865B2 (ja) 2008-08-20
WO2004029035A1 (fr) 2004-04-08
AU2003248279B2 (en) 2009-08-06
RS50929B (sr) 2010-08-31
ZA200307410B (en) 2004-07-07
CN1817869A (zh) 2006-08-16
US7238815B2 (en) 2007-07-03
OA12933A (en) 2006-10-13
AU2003248279A1 (en) 2004-04-08

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