PT103115A - Metodo para a racemizacao de (s)-(+)-e(r)-(-)-10,11-di-hidro-10-hidroxi-5h-dibenzo/b,f/azepina-5-carboxamida e respectivas misturas opticamente enriquecidas - Google Patents

Metodo para a racemizacao de (s)-(+)-e(r)-(-)-10,11-di-hidro-10-hidroxi-5h-dibenzo/b,f/azepina-5-carboxamida e respectivas misturas opticamente enriquecidas

Info

Publication number
PT103115A
PT103115A PT103115A PT10311504A PT103115A PT 103115 A PT103115 A PT 103115A PT 103115 A PT103115 A PT 103115A PT 10311504 A PT10311504 A PT 10311504A PT 103115 A PT103115 A PT 103115A
Authority
PT
Portugal
Prior art keywords
racemization
azepine
dibenzo
carboxamide
dihydro
Prior art date
Application number
PT103115A
Other languages
English (en)
Inventor
David Alexander Learmonth
Original Assignee
Portela & Comp S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portela & Comp S A filed Critical Portela & Comp S A
Publication of PT103115A publication Critical patent/PT103115A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT103115A 2003-05-12 2004-05-11 Metodo para a racemizacao de (s)-(+)-e(r)-(-)-10,11-di-hidro-10-hidroxi-5h-dibenzo/b,f/azepina-5-carboxamida e respectivas misturas opticamente enriquecidas PT103115A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0310856A GB2401605A (en) 2003-05-12 2003-05-12 Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof

Publications (1)

Publication Number Publication Date
PT103115A true PT103115A (pt) 2004-11-30

Family

ID=9957887

Family Applications (1)

Application Number Title Priority Date Filing Date
PT103115A PT103115A (pt) 2003-05-12 2004-05-11 Metodo para a racemizacao de (s)-(+)-e(r)-(-)-10,11-di-hidro-10-hidroxi-5h-dibenzo/b,f/azepina-5-carboxamida e respectivas misturas opticamente enriquecidas

Country Status (20)

Country Link
US (1) US7189846B2 (pt)
EP (1) EP1477480B1 (pt)
JP (1) JP2006525985A (pt)
KR (1) KR20060055456A (pt)
CN (1) CN100519535C (pt)
AR (1) AR044296A1 (pt)
AT (1) ATE334118T1 (pt)
AU (1) AU2004236022B2 (pt)
BR (1) BRPI0410282A (pt)
CA (1) CA2525419C (pt)
DE (1) DE602004001627T2 (pt)
DK (1) DK1477480T3 (pt)
ES (1) ES2270293T3 (pt)
GB (1) GB2401605A (pt)
MX (1) MXPA05012209A (pt)
PL (1) PL1477480T3 (pt)
PT (1) PT103115A (pt)
RU (1) RU2345986C2 (pt)
SI (1) SI1477480T1 (pt)
WO (1) WO2004099153A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2384755A1 (en) * 2005-05-06 2011-11-09 Bial-Portela & CA, S.A. Eslicarbazepine acetate and methods of use
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB2437078A (en) * 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) * 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
RU2012106827A (ru) 2009-07-27 2013-09-10 БИАЛ-ПОРТЕЛА энд КА., С.А. Применение производных 5н-дибенз/в, f/азепин-5-карбоксамида для лечения фибромиалгии
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
EP2383261B1 (en) 2010-04-23 2013-09-04 Euticals GmbH Process for the asymmetric hydrogenation of ketones
WO2012156987A2 (en) * 2011-05-19 2012-11-22 Glenmark Generics Limited A novel process for the preparation of eslicarbazepine
EP2847169A4 (en) * 2012-05-07 2015-09-30 Cellix Bio Private Ltd COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate
CN105130899A (zh) * 2015-08-25 2015-12-09 安徽省新星药物开发有限责任公司 一种醋酸艾司利卡西平的合成方法
FR3047172B1 (fr) * 2016-01-29 2020-05-08 Societe Industrielle Limousine D'application Biologique Agent cosmetique tenseur et/ou filmogene constitue par des galactomannanes et/ou des galactanes sulfates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH605791A5 (pt) * 1974-09-27 1978-10-13 Ciba Geigy Ag
CH642950A5 (en) 1979-10-30 1984-05-15 Ciba Geigy Ag Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
GB0111566D0 (en) 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide

Also Published As

Publication number Publication date
EP1477480A1 (en) 2004-11-17
MXPA05012209A (es) 2006-02-10
RU2005138516A (ru) 2007-06-20
AR044296A1 (es) 2005-09-07
ES2270293T3 (es) 2007-04-01
WO2004099153A1 (en) 2004-11-18
CA2525419A1 (en) 2004-11-18
BRPI0410282A (pt) 2006-05-16
AU2004236022B2 (en) 2010-09-23
EP1477480B1 (en) 2006-07-26
AU2004236022A1 (en) 2004-11-18
CN1823047A (zh) 2006-08-23
CN100519535C (zh) 2009-07-29
JP2006525985A (ja) 2006-11-16
CA2525419C (en) 2014-07-22
GB0310856D0 (en) 2003-06-18
SI1477480T1 (sl) 2006-12-31
DE602004001627T2 (de) 2007-08-23
RU2345986C2 (ru) 2009-02-10
DE602004001627D1 (de) 2006-09-07
DK1477480T3 (da) 2006-11-27
GB2401605A (en) 2004-11-17
ATE334118T1 (de) 2006-08-15
KR20060055456A (ko) 2006-05-23
PL1477480T3 (pl) 2006-12-29
US20040266754A1 (en) 2004-12-30
US7189846B2 (en) 2007-03-13

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Legal Events

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FG3A Patent granted, date of granting

Effective date: 20040511

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20151111