SI1789395T1 - Metoda za kiralno inverzijo (S)-(+)- in (R)-(-)-10, 11-dihidro-10-hidroksi-5H-dibenz/b,f/azepin-5-karboksiamida in njunih optično obogatenih mešanic - Google Patents

Metoda za kiralno inverzijo (S)-(+)- in (R)-(-)-10, 11-dihidro-10-hidroksi-5H-dibenz/b,f/azepin-5-karboksiamida in njunih optično obogatenih mešanic

Info

Publication number
SI1789395T1
SI1789395T1 SI200530622T SI200530622T SI1789395T1 SI 1789395 T1 SI1789395 T1 SI 1789395T1 SI 200530622 T SI200530622 T SI 200530622T SI 200530622 T SI200530622 T SI 200530622T SI 1789395 T1 SI1789395 T1 SI 1789395T1
Authority
SI
Slovenia
Prior art keywords
dibenz
azepine
carboxamide
dihydro
hydroxy
Prior art date
Application number
SI200530622T
Other languages
English (en)
Inventor
David Alexander Learmonth
Gunter Weingaertner
Matthias Kraemer
Original Assignee
Bial Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela & Ca Sa filed Critical Bial Portela & Ca Sa
Publication of SI1789395T1 publication Critical patent/SI1789395T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200530622T 2004-07-13 2005-07-13 Metoda za kiralno inverzijo (S)-(+)- in (R)-(-)-10, 11-dihidro-10-hidroksi-5H-dibenz/b,f/azepin-5-karboksiamida in njunih optično obogatenih mešanic SI1789395T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0415664A GB2416167A (en) 2004-07-13 2004-07-13 Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides
EP05759707A EP1789395B8 (en) 2004-07-13 2005-07-13 Method for chiral inversion of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof

Publications (1)

Publication Number Publication Date
SI1789395T1 true SI1789395T1 (sl) 2009-06-30

Family

ID=32893499

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200530622T SI1789395T1 (sl) 2004-07-13 2005-07-13 Metoda za kiralno inverzijo (S)-(+)- in (R)-(-)-10, 11-dihidro-10-hidroksi-5H-dibenz/b,f/azepin-5-karboksiamida in njunih optično obogatenih mešanic

Country Status (20)

Country Link
US (1) US7999100B2 (sl)
EP (1) EP1789395B8 (sl)
JP (1) JP2008506676A (sl)
CN (1) CN100582095C (sl)
AR (1) AR050170A1 (sl)
AT (1) ATE420864T1 (sl)
AU (1) AU2005261497A1 (sl)
BR (1) BRPI0513383A (sl)
CA (1) CA2574002C (sl)
DE (1) DE602005012405D1 (sl)
DK (1) DK1789395T3 (sl)
ES (1) ES2320155T3 (sl)
GB (1) GB2416167A (sl)
HR (1) HRP20090212T1 (sl)
MX (1) MX2007000575A (sl)
PL (1) PL1789395T3 (sl)
PT (1) PT103308B (sl)
RU (1) RU2382772C2 (sl)
SI (1) SI1789395T1 (sl)
WO (1) WO2006005951A1 (sl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB2437078A (en) * 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
EP2414335A2 (en) * 2009-04-02 2012-02-08 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate
WO2011014084A1 (en) 2009-07-27 2011-02-03 Bial - Portela & Ca., S.A. Use of 5h-dibenz / b, f/ azepine-5-carboxamide derivatives for treating fibromyalgia
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs
WO2011117885A1 (en) * 2010-03-23 2011-09-29 Intas Pharmaceuticals Limited Process for preparation of enantiomers of licarbazepine
EP2683691B1 (en) 2011-03-08 2018-06-06 Jubilant Life Sciences Limited PROCESS FOR THE PREPARATION OF (S)-(+)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ[b,f]AZEPINE-5-CARBOXAMIDE AND ESTERS THEREOF BY ENANTIOSELECTIVE REDUCTION OF 10,11-DIHYDRO-10-OXO-5H-DIBENZ[b,f]AZEPINE-5-CARBOXAMIDE
WO2012156987A2 (en) * 2011-05-19 2012-11-22 Glenmark Generics Limited A novel process for the preparation of eslicarbazepine
US20150065704A1 (en) 2011-07-13 2015-03-05 Ketan Hirpara Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
IN2015DN02296A (sl) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
GB0111566D0 (en) * 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide

Also Published As

Publication number Publication date
PT103308A (pt) 2007-01-31
GB0415664D0 (en) 2004-08-18
PL1789395T3 (pl) 2009-06-30
ATE420864T1 (de) 2009-01-15
CN100582095C (zh) 2010-01-20
GB2416167A (en) 2006-01-18
DK1789395T3 (da) 2009-04-20
BRPI0513383A (pt) 2008-05-06
CA2574002C (en) 2014-02-04
AU2005261497A1 (en) 2006-01-19
ES2320155T3 (es) 2009-05-19
EP1789395B1 (en) 2009-01-14
AR050170A1 (es) 2006-10-04
PT103308B (pt) 2008-06-11
RU2007105228A (ru) 2008-08-20
CN101023061A (zh) 2007-08-22
CA2574002A1 (en) 2006-01-19
WO2006005951A1 (en) 2006-01-19
US20080293934A1 (en) 2008-11-27
DE602005012405D1 (de) 2009-03-05
JP2008506676A (ja) 2008-03-06
EP1789395A1 (en) 2007-05-30
RU2382772C2 (ru) 2010-02-27
HRP20090212T1 (hr) 2009-09-30
MX2007000575A (es) 2007-03-30
EP1789395B8 (en) 2009-08-12
US7999100B2 (en) 2011-08-16

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