FI111806B - Farmaceutiska kompositioner - Google Patents
Farmaceutiska kompositioner Download PDFInfo
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- FI111806B FI111806B FI20001749A FI20001749A FI111806B FI 111806 B FI111806 B FI 111806B FI 20001749 A FI20001749 A FI 20001749A FI 20001749 A FI20001749 A FI 20001749A FI 111806 B FI111806 B FI 111806B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (21)
1. Farmaceutisk komposition, kännetecknad därav, att däri ingär (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]- 5 pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra eller ett farmaceutiskt godtagbart sait därav som aktiv bestandsdel och ett tribasiskt fosfatsalt, där katjonen ärflervärd.
2. Farmaceutisk komposition enligt patentkrav 1, kännetecknad därav, att det tribasiska fosfatsaltet, där katjonen är flervärd, är valt 10 bland tribasiskt kalciumfosfat, tribasiskt magnesiumfosfat och tribasiskt alumi-niumfosfat.
3. Farmaceutisk komposition enligt patentkrav 1 eller 2, kännetecknad därav, att det tribasiska fosfatsaltet, där katjonen är flervärd, är tribasiskt kalciumfosfat.
4. Farmaceutisk komposition enligt nagot av patentkraven 1-3, kännetecknad därav, att det tribasiska fosfatsaltets viktförhällande tili den aktiva beständsdelen är 1:80 - 50:1.
5. Farmaceutisk komposition enligt nägot av föregaende patentkrav, kännetecknad därav, att däri ytterligare ingär ett eller flera fyllmedel, 20 bindemedel, disintegreringsmedel eller smörjmedel.
6. Farmaceutisk komposition för oral administrering, kännetecknad därav, att däri ingär (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2- ..il’ [metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra f*.. eller ett farmaceutiskt godtagbart sait därav som aktiv bestandsdel, ett eller fle- ·:··: 25 ra fyllmedel, ett eller flera bindemedel, ett eller flera disintegreringsmedel, ett eller flera smörjmedel och ett tribasiskt fosfatsalt, där katjonen är flervärd. * > ·
7. Farmaceutisk komposition enligt patentkrav 6, känneteck- • · · n a d därav, att den aktiva beständsdelen är närvarande i en mängd av .. §. t 1 - 80 % av kompositionens vikt. • I
8. Farmaceutisk komposition enligt patentkrav 6 eller 7, k ä n n e- • * tecknad därav, att det tribasiska fosfatsaltet är närvarande i en mängd av 1 - 50 % av kompositionens vikt.
9. Farmaceutisk komposition enligt patentkrav 6, 7 eller 8, k ä n n e-tecknad därav, att fyllmedlet är närvarande i en mängd av 30 - 90 % av f · · '. . 35 kompositionens vikt. » # is 111806
10. Farmaceutisk komposition enligt nägot av patentkraven 6-9, kännetecknad därav, att bindemedlet är närvarande i en mängd av 2-90 % av kompositionens vikt.
11. Farmaceutisk komposition enligt nägot av patentkraven 6-10, 5 kännetecknad därav, att disintegreringsmedlet är närvarande i en mängd av 2 - 10 % av kompositionens vikt.
12. Farmaceutisk komposition enligt nägot av patentkraven 6-11, kännetecknad därav, att smörjmedlet är närvarande i en mängd av 0,5 - 3 vikt-%.
13. Farmaceutisk komposition enligt patentkrav 6, känneteck nad därav, att däri ingär (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metyl-sulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra eller ett farmaceutiskt godtagbart sait därav som aktiv beständsdel, tribasiskt kalcium-fosfat, mikrokristallin cellulosa, laktos, natriumstärkelseglykollat, butylerad hyd-15 roxitoluen och magnesiumstearat.
14. Farmaceutisk komposition enligt patentkrav 6, kännetecknad därav, att däri ingär (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl- (metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra eller ett farmaceutiskt godtagbart sait därav som aktiv beständsdel, tribasiskt kal-20 ciumfosfat, povidon, mikrokristallin cellulosa, mannitol, natriumstärkelseglykollat, butylerad hydroxitoluen och magnesiumstearat.
, : 15. Farmaceutisk komposition enligt patentkrav 6, känneteck- n a d därav, att däri ingär (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl- (metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra eller • ;..j 25 ett farmaceutiskt godtagbart sait därav som aktiv beständsdel, tribasiskt kal- .···. ciumfosfat, cros-povidon, mikrokristallin cellulosa, laktos och magnesiumstea- ,···, rat.
16. Farmaceutisk komposition enligt patentkrav 6, känneteck- .. . n a d därav, att däri ingär (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl- 30 (metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra eller • · '·;·* ett farmaceutiskt godtagbart sait därav som aktiv beständsdel, tribasiskt kal- : ciumfosfat, povidon, mikrokristallin cellulosa, laktos, natriumstärkelseglykollat, :1 “; butylerad hydroxitoluen och magnesiumstearat.
17. Farmaceutisk komposition enligt nägot av föregäende patent-35 krav, kännetecknad därav, att den aktiva beständsdelen däri är kai- » » » » I 14 111806 ciumsaltet av (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)-amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydiOxihept-6-ensyra.
18. Användning av ett tribasiskt fosfatsalt, där katjonen är flervärd, för stabilisering av (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfo- 5 nyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra eller ett farma-ceutiskt godtagbart sait därav.
19. Användning enligt patentkrav 18, kännetecknad därav, att det tribasiska fosfatsaltet, där katjonen är flervärd, är valt bland tribasiskt kalciumfosfat, tribasiskt magnesiumfosfat och tribasiskt aluminiumfosfat.
20. Användning enligt patentkrav 18 eller 19, kän-netecknad därav, att det tribasiska fosfatsaltet, där katjonen är flervärd, är tribasiskt kalciumfosfat.
21 Förfarande för framställning av en stabilserad farmaceutisk komposition, kännetecknat därav, att ett tribasiskt fosfatsalt, där katjonen 15 är flervärd, inkorporeras i en farmaceutisk komposition, som innehäller fö-reningen (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxihept-6-ensyra eller ett farmaceutiskt godtagbart sait därav. • 4 · > · · • l I * * 4 « · < f 1si • » I « 1 I · • · 1 • · • · • · I at > • 1 1 • I I I • I • I 1 • t i • » I t t 1 • I < • » • · * » a » ia • i « » I a
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0001621.2A GB0001621D0 (en) | 2000-01-26 | 2000-01-26 | Pharmaceutical compositions |
GB0001621 | 2000-01-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI20001749A0 FI20001749A0 (sv) | 2000-08-04 |
FI20001749A FI20001749A (sv) | 2001-07-27 |
FI111806B true FI111806B (sv) | 2003-09-30 |
Family
ID=9884259
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20001749A FI111806B (sv) | 2000-01-26 | 2000-08-04 | Farmaceutiska kompositioner |
FI20001750A FI121365B (sv) | 2000-01-26 | 2000-08-04 | Farmaceutisk komposition, som omfattar (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxi-6-heptensyra och förfarande för framställning därav |
FI20105657A FI121589B (sv) | 2000-01-26 | 2010-06-10 | Farmaceutisk sammansättning som omfattar (E)-7[4-(4-fluorofenyl)-6-isopropyl-2[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R, 5S)-3,5-dihydroxi-6-heptensyra |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20001750A FI121365B (sv) | 2000-01-26 | 2000-08-04 | Farmaceutisk komposition, som omfattar (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxi-6-heptensyra och förfarande för framställning därav |
FI20105657A FI121589B (sv) | 2000-01-26 | 2010-06-10 | Farmaceutisk sammansättning som omfattar (E)-7[4-(4-fluorofenyl)-6-isopropyl-2[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R, 5S)-3,5-dihydroxi-6-heptensyra |
Country Status (48)
Families Citing this family (95)
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GB0001621D0 (en) | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
USRE44578E1 (en) | 2000-04-10 | 2013-11-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
CA2406574C (en) † | 2000-04-10 | 2006-12-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
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GB0028429D0 (en) * | 2000-11-22 | 2001-01-10 | Astrazeneca Ab | Therapy |
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US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
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GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
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US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
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SI21402A (sl) | 2003-02-12 | 2004-08-31 | LEK farmacevtska dru�ba d.d. | Obloženi delci in farmacevtske oblike |
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GB0322552D0 (en) | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
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GB0411378D0 (en) * | 2004-05-21 | 2004-06-23 | Astrazeneca Ab | Pharmaceutical compositions |
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2003
- 2003-02-18 HK HK03101240.3A patent/HK1048950A1/zh unknown
- 2003-04-11 KR KR1020030022854A patent/KR20030036492A/ko active Search and Examination
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2005
- 2005-06-02 AU AU2005202392A patent/AU2005202392C1/en not_active Expired
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2007
- 2007-03-07 IS IS8620A patent/IS2805B/is unknown
- 2007-03-09 NO NO20071303A patent/NO327554B1/no not_active IP Right Cessation
- 2007-03-12 JP JP2007062353A patent/JP4800988B2/ja not_active Expired - Lifetime
- 2007-03-30 AR ARP070101365A patent/AR060248A2/es unknown
- 2007-06-20 CL CL2007001807A patent/CL2007001807A1/es unknown
- 2007-11-15 IL IL187416A patent/IL187416A0/en unknown
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2008
- 2008-06-24 CR CR10114A patent/CR10114A/es not_active Application Discontinuation
- 2008-10-20 HR HR20080525A patent/HRP20080525A2/xx not_active Application Discontinuation
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2009
- 2009-03-26 BG BG10110353A patent/BG66159B1/bg unknown
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2010
- 2010-03-10 NO NO2010005C patent/NO2010005I1/no unknown
- 2010-06-10 FI FI20105657A patent/FI121589B/sv not_active IP Right Cessation
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2015
- 2015-02-02 HK HK15101088.4A patent/HK1200368A1/xx unknown
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