FI110429B - Menetelmä farmaseuttisten dihydropyridiinien valmistamiseksi - Google Patents

Menetelmä farmaseuttisten dihydropyridiinien valmistamiseksi Download PDF

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Publication number
FI110429B
FI110429B FI961914A FI961914A FI110429B FI 110429 B FI110429 B FI 110429B FI 961914 A FI961914 A FI 961914A FI 961914 A FI961914 A FI 961914A FI 110429 B FI110429 B FI 110429B
Authority
FI
Finland
Prior art keywords
dimethyl
hydrogen
dichlorophenyl
pct
dihydro
Prior art date
Application number
FI961914A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI961914A0 (fi
FI961914A (fi
Inventor
Kjell Hjalmar Andersson
Margareta Nordlander
Rolf Christer Westerlund
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI961914A0 publication Critical patent/FI961914A0/fi
Publication of FI961914A publication Critical patent/FI961914A/fi
Application granted granted Critical
Publication of FI110429B publication Critical patent/FI110429B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
FI961914A 1993-11-05 1996-05-06 Menetelmä farmaseuttisten dihydropyridiinien valmistamiseksi FI110429B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9303657 1993-11-05
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines
PCT/SE1994/001031 WO1995012578A1 (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines
SE9401031 1994-11-03

Publications (3)

Publication Number Publication Date
FI961914A0 FI961914A0 (fi) 1996-05-06
FI961914A FI961914A (fi) 1996-05-06
FI110429B true FI110429B (fi) 2003-01-31

Family

ID=20391655

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961914A FI110429B (fi) 1993-11-05 1996-05-06 Menetelmä farmaseuttisten dihydropyridiinien valmistamiseksi

Country Status (36)

Country Link
US (1) US5856346A (lv)
EP (1) EP0726894B1 (lv)
JP (1) JP3712209B2 (lv)
KR (1) KR100331663B1 (lv)
CN (1) CN1049428C (lv)
AT (1) ATE194330T1 (lv)
AU (1) AU685532B2 (lv)
BR (1) BR9407946A (lv)
CA (1) CA2174969C (lv)
CZ (1) CZ285691B6 (lv)
DE (1) DE69425152T2 (lv)
DK (1) DK0726894T3 (lv)
EE (1) EE03230B1 (lv)
EG (1) EG20539A (lv)
ES (1) ES2150544T3 (lv)
FI (1) FI110429B (lv)
FR (1) FR12C0053I2 (lv)
GR (1) GR3034469T3 (lv)
HK (1) HK1013292A1 (lv)
HU (1) HU215591B (lv)
IL (1) IL111127A (lv)
IS (1) IS1674B (lv)
LU (1) LU92209I2 (lv)
MY (1) MY111770A (lv)
NO (1) NO305656B1 (lv)
NZ (1) NZ275915A (lv)
PL (1) PL185099B1 (lv)
PT (1) PT726894E (lv)
RU (1) RU2139278C1 (lv)
SA (1) SA94150250B1 (lv)
SE (1) SE9303657D0 (lv)
SK (1) SK281467B6 (lv)
TW (1) TW279859B (lv)
UA (1) UA45959C2 (lv)
WO (1) WO1995012578A1 (lv)
ZA (1) ZA947570B (lv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
KR100976291B1 (ko) * 2001-12-21 2010-08-16 알콘, 인코퍼레이티드 안과용 조성물중의 살생물제에 대한 담체로서 나노입자의용도
FR2922439B1 (fr) * 2007-10-18 2010-12-10 Hill Rom Ind Sa Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
PL2320740T3 (pl) * 2008-08-01 2014-09-30 The Medicines Co Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń
WO2011041595A1 (en) * 2009-09-30 2011-04-07 Microdose Therapeutx, Inc. Methods and compositions for treatment of raynaud's phenomenon
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
EP2386544B1 (en) 2010-05-07 2016-02-10 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
PT2627173E (pt) 2010-10-12 2015-07-24 Medicines Co Formulações de clevidipina em emulsão contendo agentes antimicrobianos
CN103781479A (zh) * 2011-04-01 2014-05-07 医药公司 用于减轻中风损害的短效二氢吡啶（氯维地平）
CN103906508A (zh) 2011-08-26 2014-07-02 沃克哈特有限公司 治疗心血管疾病的方法
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
CA2889584C (en) 2012-10-26 2018-08-14 The Medicines Company Methods for controlling blood pressure and reducing dyspnea in heart failure
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
CN103073485B (zh) * 2013-01-17 2015-09-02 北京嘉林药业股份有限公司 一种丁酸氯维地平的制备方法
CA2947486C (en) 2014-05-19 2023-09-26 The Medicines Company Clevidipine nanoparticles and pharmaceutical compositions thereof
CN105367487A (zh) * 2014-08-23 2016-03-02 南京海纳医药科技有限公司 一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) * 2014-09-24 2015-02-25 北京蓝丹医药科技有限公司 氯维地平衍生物及其制备方法
SI3298027T1 (sl) 2015-05-20 2021-08-31 Boehringer Ingelheim Animal Health USA Inc. Antihelmintične depsipeptidne spojine
WO2017116702A1 (en) 2015-12-28 2017-07-06 Merial, Inc. Anthelmintic depsipeptide compounds
CN110167921A (zh) 2016-11-16 2019-08-23 勃林格殷格翰动物保健美国公司 驱蠕虫缩肽化合物
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
US5134139A (en) * 1989-08-31 1992-07-28 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and preparation thereof
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
BR9407946A (pt) 1996-11-26
EE03230B1 (et) 1999-10-15
ES2150544T3 (es) 2000-12-01
RU2139278C1 (ru) 1999-10-10
FI961914A0 (fi) 1996-05-06
IS4218A (is) 1995-05-06
HK1013292A1 (en) 1999-08-20
EP0726894B1 (en) 2000-07-05
CN1049428C (zh) 2000-02-16
WO1995012578A1 (en) 1995-05-11
DE69425152T2 (de) 2001-03-22
SE9303657D0 (sv) 1993-11-05
KR100331663B1 (ko) 2002-09-26
NZ275915A (en) 1997-04-24
FR12C0053I1 (lv) 2012-02-11
HU215591B (hu) 1999-01-28
NO961776L (no) 1996-05-02
SK55996A3 (en) 1996-12-04
ZA947570B (en) 1995-05-29
CA2174969C (en) 2005-05-17
LU92209I2 (fr) 2013-08-23
TW279859B (lv) 1996-07-01
PT726894E (pt) 2000-10-31
PL185099B1 (pl) 2003-02-28
DK0726894T3 (da) 2000-10-23
JPH09504542A (ja) 1997-05-06
FI961914A (fi) 1996-05-06
PL314128A1 (en) 1996-08-19
IL111127A0 (en) 1994-12-29
IL111127A (en) 2000-11-21
ATE194330T1 (de) 2000-07-15
NO961776D0 (no) 1996-05-02
GR3034469T3 (en) 2000-12-29
SA94150250B1 (ar) 2006-03-01
SK281467B6 (sk) 2001-04-09
EP0726894A1 (en) 1996-08-21
IS1674B (is) 1997-12-31
MY111770A (en) 2000-12-30
AU8119694A (en) 1995-05-23
UA45959C2 (uk) 2002-05-15
CZ127396A3 (en) 1996-09-11
CA2174969A1 (en) 1995-05-11
HU9601187D0 (en) 1996-07-29
FR12C0053I2 (fr) 2013-08-16
JP3712209B2 (ja) 2005-11-02
US5856346A (en) 1999-01-05
CZ285691B6 (cs) 1999-10-13
HUT75316A (en) 1997-05-28
EG20539A (en) 1999-07-31
NO305656B1 (no) 1999-07-05
CN1137269A (zh) 1996-12-04
AU685532B2 (en) 1998-01-22
DE69425152D1 (de) 2000-08-10

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