FI109996B - Menetelmä terapeuttisesti käyttökelpoisen D-vitamiinisarjan 25-karboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen D-vitamiinisarjan 25-karboksyylihappojohdannaisten valmistamiseksi Download PDF

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Publication number
FI109996B
FI109996B FI951614A FI951614A FI109996B FI 109996 B FI109996 B FI 109996B FI 951614 A FI951614 A FI 951614A FI 951614 A FI951614 A FI 951614A FI 109996 B FI109996 B FI 109996B
Authority
FI
Finland
Prior art keywords
carboxylic acid
trihydroxy
tetraene
ester
methyl
Prior art date
Application number
FI951614A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI951614A0 (fi
FI951614L (fi
Inventor
Martin Haberey
Guenter Neef
Gerald Kirsch
Andreas Steinmeyer
Katica Schwarz
Herbert Wiesinger
Ruth Thieroffekerdt
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4234382A external-priority patent/DE4234382A1/de
Priority claimed from DE19934317415 external-priority patent/DE4317415A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI951614A0 publication Critical patent/FI951614A0/fi
Publication of FI951614L publication Critical patent/FI951614L/fi
Application granted granted Critical
Publication of FI109996B publication Critical patent/FI109996B/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
FI951614A 1992-10-06 1995-04-05 Menetelmä terapeuttisesti käyttökelpoisen D-vitamiinisarjan 25-karboksyylihappojohdannaisten valmistamiseksi FI109996B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4234382A DE4234382A1 (de) 1992-10-06 1992-10-06 25-Carbonsäure-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4234382 1992-10-06
DE19934317415 DE4317415A1 (de) 1993-05-18 1993-05-18 25-Carbonsäure-Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für diese Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4317415 1993-05-18
EP9302814 1993-10-06
PCT/EP1993/002814 WO1994007853A1 (de) 1992-10-06 1993-10-06 25-carbonsäure-derivate in der vitamin d-reihe, verfahren zu ihrer herstellung, zwischenprodukte für diese verfahren, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung zur herstellung von arzneimitteln

Publications (3)

Publication Number Publication Date
FI951614A0 FI951614A0 (fi) 1995-04-05
FI951614L FI951614L (fi) 1995-04-05
FI109996B true FI109996B (fi) 2002-11-15

Family

ID=25919406

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951614A FI109996B (fi) 1992-10-06 1995-04-05 Menetelmä terapeuttisesti käyttökelpoisen D-vitamiinisarjan 25-karboksyylihappojohdannaisten valmistamiseksi

Country Status (21)

Country Link
US (1) US5583125A (cs)
EP (1) EP0663902B1 (cs)
JP (1) JP3565847B2 (cs)
KR (1) KR100294600B1 (cs)
CN (1) CN1042026C (cs)
AT (1) ATE163923T1 (cs)
AU (1) AU671313B2 (cs)
CA (1) CA2146429C (cs)
CZ (1) CZ284926B6 (cs)
DE (1) DE59308257D1 (cs)
DK (1) DK0663902T3 (cs)
ES (1) ES2117150T3 (cs)
FI (1) FI109996B (cs)
HU (1) HU221588B (cs)
IL (1) IL107185A (cs)
MX (1) MX9306204A (cs)
NO (1) NO309599B1 (cs)
NZ (1) NZ256862A (cs)
PL (1) PL175636B1 (cs)
SK (1) SK280651B6 (cs)
WO (1) WO1994007853A1 (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
EP0972762B1 (en) * 1993-07-09 2003-10-01 Laboratoire Theramex Novel structural analogues of vitamin D
GB9315253D0 (en) * 1993-07-23 1993-09-08 Res Inst Medicine Chem Chemical compounds
DK0832063T3 (da) * 1995-06-14 2000-06-13 Schering Ag Vitamin D-derivater med substituenter på C-25, fremgangsmåde til deres fremstilling, mellemprodukter samt deres anvendelse
DE19549243A1 (de) * 1995-12-21 1997-06-26 Schering Ag Pharmazeutische Präparate enthaltend Clathrate von Cyclodextrinen und nichtnatürliche Vitamin D-Analoga
AU2101997A (en) * 1996-03-08 1997-09-22 Isis Innovation Limited Materials and methods relating to the identification of a polymorphism associated with disease susceptibility
DE69814109T2 (de) * 1997-09-08 2004-02-26 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga
DE19744127B4 (de) * 1997-10-01 2006-10-05 Schering Ag Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln
EP0927721A1 (de) * 1997-12-17 1999-07-07 Schering Aktiengesellschaft Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
AU2413499A (en) * 1997-12-17 1999-07-05 Schering Aktiengesellschaft Vitamin d derivatives with phosphorous atoms in the side chains
CA2348235A1 (en) 1998-10-23 2000-05-04 Teijin Limited Vitamin d3 derivatives and treating agent for inflammatory respiratory disease using same
WO2001042205A2 (en) * 1999-12-02 2001-06-14 The Penn State Research Foundation Treatment of inflammatory bowel disease with vitamin d compounds
US20030188756A1 (en) * 2002-08-19 2003-10-09 Cantorna Margherita T Treatment of inflammatory bowel disease with vitamin d compounds
US6989377B2 (en) * 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
DE10156596A1 (de) * 2001-11-13 2003-05-28 Schering Ag Vitamin D-Derivate mit Acyloxygruppen in der Seitenkette, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US7163933B2 (en) * 2002-02-22 2007-01-16 Teijin Limited Treating agent for Paget's disease of bone
EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
US7704980B2 (en) * 2003-10-08 2010-04-27 Wisconsin Alumni Research Foundation Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US20110207944A1 (en) 2008-11-04 2011-08-25 Teijin Pharma Limited Vitamin d3 lactam derivative
US20100196308A1 (en) 2009-01-27 2010-08-05 Jimenez Joaquin J Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
US10314395B2 (en) 2017-02-21 2019-06-11 James E. McGhee, III Pallet spacer system and method of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022891A (en) * 1974-06-18 1977-05-10 Teijin Limited Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them
US4866048A (en) * 1985-08-02 1989-09-12 Leo Pharmaceutical Products Ltd. Novel vitamin D analogues
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
WO1993009093A1 (en) * 1991-11-07 1993-05-13 Holmes, Michael, John Vitamin d amide derivatives
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate

Also Published As

Publication number Publication date
ES2117150T3 (es) 1998-08-01
JP3565847B2 (ja) 2004-09-15
KR950703526A (ko) 1995-09-20
CN1094034A (zh) 1994-10-26
KR100294600B1 (ko) 2001-09-17
DK0663902T3 (da) 1998-12-21
FI951614A0 (fi) 1995-04-05
AU5177193A (en) 1994-04-26
NO951318L (no) 1995-06-02
NO951318D0 (no) 1995-04-05
SK280651B6 (sk) 2000-05-16
CA2146429C (en) 2006-12-05
HU9501002D0 (en) 1995-06-28
DE59308257D1 (de) 1998-04-16
HU221588B (hu) 2002-11-28
HUT70562A (en) 1995-10-30
ATE163923T1 (de) 1998-03-15
IL107185A (en) 1998-02-22
EP0663902B1 (de) 1998-03-11
CZ284926B6 (cs) 1999-04-14
SK45895A3 (en) 1995-08-09
WO1994007853A1 (de) 1994-04-14
IL107185A0 (en) 1994-01-25
CA2146429A1 (en) 1994-04-14
CN1042026C (zh) 1999-02-10
JPH08501784A (ja) 1996-02-27
MX9306204A (es) 1994-05-31
PL308260A1 (en) 1995-07-24
AU671313B2 (en) 1996-08-22
NO309599B1 (no) 2001-02-26
CZ87395A3 (en) 1995-10-18
US5583125A (en) 1996-12-10
NZ256862A (en) 1996-03-26
FI951614L (fi) 1995-04-05
PL175636B1 (pl) 1999-01-29
EP0663902A1 (de) 1995-07-26

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