FI108611B - Menetelmä mikropartikkelien valmistamiseksi - Google Patents

Menetelmä mikropartikkelien valmistamiseksi Download PDF

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Publication number
FI108611B
FI108611B FI903429A FI903429A FI108611B FI 108611 B FI108611 B FI 108611B FI 903429 A FI903429 A FI 903429A FI 903429 A FI903429 A FI 903429A FI 108611 B FI108611 B FI 108611B
Authority
FI
Finland
Prior art keywords
water
drug
microparticles
emulsion
polymer
Prior art date
Application number
FI903429A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI903429A0 (fi
Inventor
Thomas Kissel
David Bodmer
Jones Wing Fong
Hawkins Valliant Maulding
Oskar Nagele
Jane Edna Pearson
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI903429A0 publication Critical patent/FI903429A0/fi
Priority to FI991120A priority Critical patent/FI106926B/fi
Application granted granted Critical
Publication of FI108611B publication Critical patent/FI108611B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
FI903429A 1989-07-07 1990-07-06 Menetelmä mikropartikkelien valmistamiseksi FI108611B (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI991120A FI106926B (fi) 1989-07-07 1999-05-17 Menetelmä pitkäaikaisesti vapautuvan koostumuksen muodostamiseksi

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US37702389 1989-07-07
US41134789A 1989-09-22 1989-09-22
US41134789 1989-09-22

Publications (2)

Publication Number Publication Date
FI903429A0 FI903429A0 (fi) 1990-07-06
FI108611B true FI108611B (fi) 2002-02-28

Family

ID=27007654

Family Applications (3)

Application Number Title Priority Date Filing Date
FI903429A FI108611B (fi) 1989-07-07 1990-07-06 Menetelmä mikropartikkelien valmistamiseksi
FI20000059A FI109543B (fi) 1989-07-07 2000-01-12 Menetelmä terapeuttisesti käyttökelpoisen oktreotidipamoaatin valmistamiseksi
FI20000060A FI109334B (fi) 1989-07-07 2000-01-12 Menetelmä pitkäaikaisesti vapautuvan koostumuksen muodostamiseksi

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI20000059A FI109543B (fi) 1989-07-07 2000-01-12 Menetelmä terapeuttisesti käyttökelpoisen oktreotidipamoaatin valmistamiseksi
FI20000060A FI109334B (fi) 1989-07-07 2000-01-12 Menetelmä pitkäaikaisesti vapautuvan koostumuksen muodostamiseksi

Country Status (27)

Country Link
JP (5) JPH0832624B2 (de)
KR (2) KR100303681B1 (de)
AT (1) AT406225B (de)
AU (2) AU641407B2 (de)
BE (1) BE1004486A3 (de)
CA (1) CA2020477C (de)
CH (1) CH685230A5 (de)
CY (1) CY1965A (de)
DE (2) DE4042752B4 (de)
DK (1) DK175849B1 (de)
FI (3) FI108611B (de)
FR (1) FR2649319A1 (de)
GB (2) GB2234896B (de)
GR (1) GR1001121B (de)
HK (2) HK97695A (de)
HU (2) HU221294B1 (de)
IE (2) IE64216B1 (de)
IL (3) IL131880A (de)
IT (1) IT1241460B (de)
LU (1) LU87764A1 (de)
MY (1) MY106722A (de)
NL (1) NL195027C (de)
NO (2) NO302928B1 (de)
NZ (1) NZ234384A (de)
PT (1) PT94628B (de)
SE (1) SE512992C2 (de)
SG (1) SG26416G (de)

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JP2000500744A (ja) 1995-11-09 2000-01-25 マイクロバイオロジカル リサーチ オーソリティー ワクチン接種および遺伝子治療のためのマイクロカプセル化ｄｎａ
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
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US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100392501B1 (ko) * 2000-06-28 2003-07-22 동국제약 주식회사 다중 에멀젼법에 의한 서방출성 미립구의 제조방법
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
EP1343480B2 (de) 2000-12-21 2016-02-17 Alrise Biosystems GmbH Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
AR044852A1 (es) * 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
ES2600554T3 (es) * 2003-07-18 2017-02-09 Oakwood Laboratories L.L.C. Prevención de la reducción del peso molecular del polímero, de la formación de impurezas y de la gelificación en composiciones poliméricas
MY158342A (en) 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
CN1921880A (zh) * 2004-02-26 2007-02-28 独立行政法人科学技术振兴机构 蛋白质类药物的注射用缓释微粒制剂及其制造方法
DE102004053373A1 (de) * 2004-11-02 2006-05-04 Justus-Liebig-Universität Giessen Erfindung betreffend anisometrische Partikel in Form von Nano-/Meso-Fasern -Röhren, -Kabeln -Bändern und deren gekrümmte oder verzweigte Abwandlungen
KR100741867B1 (ko) * 2005-07-05 2007-07-24 전북대학교산학협력단 수중유적 및 용매 증발법을 이용한 이중층 미립구의제조방법
CN103251929A (zh) * 2005-12-22 2013-08-21 诺瓦提斯公司 包含奥曲肽和两种或更多种聚丙交酯-共-乙交酯聚合物的缓释制剂
KR100816065B1 (ko) * 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
ES2522342T3 (es) 2008-01-30 2014-11-14 Novartis Ag Formulación de liberación sostenida que comprende octreótido y tres polímeros lineales de polilactida-co-glicolida
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TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
KR102464650B1 (ko) 2016-05-03 2022-11-10 엘에스일렉트릭(주) 배선용 차단기의 한류장치
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Also Published As

Publication number Publication date
FR2649319A1 (fr) 1991-01-11
CY1965A (en) 1997-07-04
ATA144090A (de) 1999-08-15
AU2332195A (en) 1995-09-07
JPH08198771A (ja) 1996-08-06
CA2020477C (en) 2000-11-21
GB2265311A (en) 1993-09-29
AU5874690A (en) 1991-01-10
IT1241460B (it) 1994-01-17
FI20000059A (fi) 2000-01-12
KR100303681B1 (ko) 2002-05-16
GB2234896A (en) 1991-02-20
IL131880A (en) 2001-12-23
NO983923D0 (no) 1998-08-26
PT94628B (pt) 1997-06-30
GR900100513A (en) 1991-12-10
IE64411B1 (en) 1995-08-09
SG26416G (en) 1995-09-01
LU87764A1 (fr) 1992-03-11
CA2020477A1 (en) 1991-01-08
BE1004486A3 (fr) 1992-12-01
CH685230A5 (de) 1995-05-15
NL195027C (nl) 2003-12-02
HU903974D0 (en) 1990-11-28
SE9002364D0 (sv) 1990-07-05
AT406225B (de) 2000-03-27
IT9048113A0 (it) 1990-07-05
NO320444B1 (no) 2005-12-05
FI20000060A (fi) 2000-01-12
DK162590A (da) 1991-01-08
NL9001537A (nl) 1991-02-01
SE9002364L (sv) 1991-01-08
HU211602A9 (en) 1995-12-28
DK162590D0 (da) 1990-07-05
IT9048113A1 (it) 1992-01-05
NO903001L (no) 1991-01-08
GB9014704D0 (en) 1990-08-22
AU641407B2 (en) 1993-09-23
IL131881A (en) 2001-12-23
DE4021517B4 (de) 2009-04-09
MY106722A (en) 1995-07-31
FI903429A0 (fi) 1990-07-06
DE4042752B4 (de) 2009-05-07
DK175849B1 (da) 2005-03-29
PT94628A (pt) 1991-03-20
JPH07285853A (ja) 1995-10-31
DE4021517A1 (de) 1991-01-17
HU221294B1 (en) 2002-09-28
KR100442931B1 (ko) 2004-08-02
FR2649319B1 (de) 1994-12-09
JPH07309897A (ja) 1995-11-28
IE902435A1 (en) 1991-02-13
FI109543B (fi) 2002-08-30
HK97695A (en) 1995-06-23
SE512992C2 (sv) 2000-06-12
GB2265311B (en) 1994-02-09
NO983923L (no) 1991-01-08
HK197496A (en) 1996-11-08
IL94983A0 (en) 1991-06-10
FI109334B (fi) 2002-07-15
JP2931773B2 (ja) 1999-08-09
NO903001D0 (no) 1990-07-05
HUT54037A (en) 1991-01-28
JPH0368511A (ja) 1991-03-25
KR910002430A (ko) 1991-02-25
JP2001233897A (ja) 2001-08-28
GB2234896B (en) 1994-01-19
NZ234384A (en) 1994-05-26
IE64216B1 (en) 1995-07-26
JPH0832624B2 (ja) 1996-03-29
NO302928B1 (no) 1998-05-11
AU687553B2 (en) 1998-02-26
NL195027B (nl) 2003-08-01
GR1001121B (el) 1993-04-28
IL94983A (en) 1999-08-17
GB9306204D0 (en) 1993-05-19

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