FI106461B - Menetelmä terapeuttisesti käyttökelpoisten enantiomeeristen yhdisteiden valmistamiseksi sekä menetelmässä käyttökelpoinen välituote - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten enantiomeeristen yhdisteiden valmistamiseksi sekä menetelmässä käyttökelpoinen välituote Download PDFInfo
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- FI106461B FI106461B FI906367A FI906367A FI106461B FI 106461 B FI106461 B FI 106461B FI 906367 A FI906367 A FI 906367A FI 906367 A FI906367 A FI 906367A FI 106461 B FI106461 B FI 106461B
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- methanol
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- salt
- amino
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI970666A FI105813B (fi) | 1989-12-22 | 1997-02-17 | Enantiomeerisia välituotteita |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45520189 | 1989-12-22 | ||
| US07/455,201 US5034394A (en) | 1988-06-27 | 1989-12-22 | Therapeutic nucleosides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI906367A0 FI906367A0 (fi) | 1990-12-21 |
| FI906367A FI906367A (fi) | 1991-06-23 |
| FI106461B true FI106461B (fi) | 2001-02-15 |
Family
ID=23807819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI906367A FI106461B (fi) | 1989-12-22 | 1990-12-21 | Menetelmä terapeuttisesti käyttökelpoisten enantiomeeristen yhdisteiden valmistamiseksi sekä menetelmässä käyttökelpoinen välituote |
| FI20001175A FI20001175A (fi) | 1989-12-22 | 2000-05-16 | Enantiomeerisia yhdisteitä, jotka ovat oleellisesti vapaita vastaenantiomeereista |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI20001175A FI20001175A (fi) | 1989-12-22 | 2000-05-16 | Enantiomeerisia yhdisteitä, jotka ovat oleellisesti vapaita vastaenantiomeereista |
Country Status (30)
| Country | Link |
|---|---|
| EP (3) | EP0921114A1 (es) |
| JP (2) | JPH11158160A (es) |
| CN (1) | CN1028106C (es) |
| AP (1) | AP196A (es) |
| AT (1) | ATE181917T1 (es) |
| AU (1) | AU633672B2 (es) |
| CA (1) | CA2033044C (es) |
| CY (1) | CY2145B1 (es) |
| CZ (1) | CZ283481B6 (es) |
| DE (2) | DE69033197T2 (es) |
| DK (1) | DK0434450T3 (es) |
| ES (1) | ES2133138T3 (es) |
| FI (2) | FI106461B (es) |
| GR (1) | GR3031100T3 (es) |
| HK (1) | HK1009600A1 (es) |
| HU (3) | HU219454B (es) |
| IE (3) | IE904652A1 (es) |
| IL (1) | IL96748A (es) |
| LU (1) | LU90426I2 (es) |
| MX (1) | MX9203215A (es) |
| MY (1) | MY104575A (es) |
| NL (1) | NL990028I2 (es) |
| NZ (1) | NZ236593A (es) |
| PL (1) | PL167097B1 (es) |
| PT (1) | PT96321B (es) |
| RU (2) | RU2068849C1 (es) |
| SG (1) | SG49685A1 (es) |
| SK (2) | SK280216B6 (es) |
| TW (2) | TW473466B (es) |
| ZA (1) | ZA9010365B (es) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU47791B (sr) * | 1988-01-20 | 1996-01-09 | Regents Of The University Of Minnesota | Postupak za dobijanje dideoksihidrokar-bocikličnih nukleozida |
| CA2001401A1 (en) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
| GB9108376D0 (en) * | 1991-04-19 | 1991-06-05 | Enzymatix Ltd | Cyclopentenes |
| GB9204015D0 (en) * | 1992-02-25 | 1992-04-08 | Wellcome Found | Therapeutic nucleosides |
| GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| EP0702556B1 (en) * | 1993-06-10 | 2002-10-23 | Wake Forest University | (phospho)lipids for combatting hepatitis b virus infection |
| GB9402161D0 (en) | 1994-02-04 | 1994-03-30 | Wellcome Found | Chloropyrimidine intermediates |
| GB9417249D0 (en) * | 1994-08-26 | 1994-10-19 | Wellcome Found | A novel salt |
| AU3216695A (en) * | 1994-08-29 | 1996-03-22 | University Of North Carolina At Chapel Hill, The | Lipid analogs for treating viral infections |
| US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
| US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
| HUP9903249A3 (en) * | 1996-06-25 | 2001-04-28 | Glaxo Group Ltd | Combinations comprising vx478, zidovudine, ftc and/or 3tc for use in the treatment of hiv |
| CZ429398A3 (cs) | 1996-06-25 | 1999-05-12 | Glaxo Group Limited | Kombinace účinných látek a farmaceutický prostředek |
| SK285229B6 (sk) * | 1997-05-13 | 2006-09-07 | Lonza Ag | Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu |
| GB9709945D0 (en) * | 1997-05-17 | 1997-07-09 | Glaxo Group Ltd | A novel salt |
| AU769660B2 (en) * | 1997-05-17 | 2004-01-29 | Glaxo Group Limited | Carbocyclic nucleoside hemisulfate and its use in treating viral infections |
| GB9721780D0 (en) * | 1997-10-14 | 1997-12-10 | Glaxo Group Ltd | Process for the synthesis of chloropurine intermediates |
| WO1999021861A1 (en) * | 1997-10-24 | 1999-05-06 | Glaxo Group Limited | Process for preparing a chiral nucleoside analogue |
| WO1999024431A1 (en) * | 1997-11-12 | 1999-05-20 | Glaxo Group Limited | Process for preparing a chiral nucleoside analogue |
| CZ298102B6 (cs) * | 1997-11-27 | 2007-06-20 | Lonza Ag | Zpusob výroby aminoalkoholu |
| YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
| GB9802472D0 (en) * | 1998-02-06 | 1998-04-01 | Glaxo Group Ltd | Pharmaceutical compositions |
| GB9820417D0 (en) * | 1998-09-18 | 1998-11-11 | Glaxo Group Ltd | Antiviral combinations |
| GB9821058D0 (en) * | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| KR100606625B1 (ko) | 1998-10-30 | 2006-07-28 | 론자 아게 | 4-[(2',5'-디아미노-6'-할로피리미딘-4'-일)아미노]-시클로펜트-2-에닐메탄올의 제조 방법 |
| DK1124805T3 (da) * | 1998-10-30 | 2003-09-15 | Lonza Ag | Fremgangsmåde til fremstilling af 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]cyclopent-2-enylmethanoler |
| GB9903091D0 (en) | 1999-02-12 | 1999-03-31 | Glaxo Group Ltd | Therapeutic nucleoside compound |
| US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| PE20010915A1 (es) * | 1999-12-10 | 2001-09-29 | Glaxo Group Ltd | Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales |
| WO2001042255A1 (en) * | 1999-12-10 | 2001-06-14 | Glaxo Group Limited | (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL |
| DE10042655A1 (de) * | 2000-08-31 | 2002-03-14 | Aventis Pharma Gmbh | Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion |
| US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
| TR200302288T2 (tr) | 2001-06-29 | 2004-12-21 | Institute Of Organic Chemistry And Biochemistry Academy Of | Terapi için yeni bileşikler ve metotlar. |
| MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| US7550261B2 (en) | 2001-08-21 | 2009-06-23 | Smithkline Beecham Corporation | Method of screening for drug hypersensitivity reaction |
| JP4102301B2 (ja) * | 2001-08-21 | 2008-06-18 | グラクソ グループ リミテッド | 薬剤過敏症反応についてのスクリーニング方法 |
| WO2003021959A1 (en) | 2001-08-31 | 2003-03-13 | Thomson Licensing Sa | Sequence counter for an audio visual stream |
| US6780635B2 (en) | 2001-12-27 | 2004-08-24 | Council Of Scientific And Industrial Research | Process for the preparation of optically active azabicyclo heptanone derivatives |
| PL373758A1 (en) * | 2002-06-27 | 2005-09-05 | Medivir Ab | Synergistic interaction of abacavir and alovudine |
| ATE496056T1 (de) | 2003-06-16 | 2011-02-15 | Acad Of Science Czech Republic | Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga |
| GB0320738D0 (en) | 2003-09-04 | 2003-10-08 | Glaxo Group Ltd | Novel process |
| EP1857458A1 (en) * | 2006-05-05 | 2007-11-21 | SOLMAG S.p.A. | Process for the preparation of abacavir |
| JP5334852B2 (ja) * | 2006-09-28 | 2013-11-06 | エステヴェ キミカ， エス．エー． | アバカビルの製造方法 |
| EP1905772A1 (en) | 2006-09-28 | 2008-04-02 | Esteve Quimica, S.A. | Process for the preparation of abacavir |
| EP1939196A1 (en) * | 2006-12-21 | 2008-07-02 | Esteve Quimica, S.A. | Process for the preparation of abacavir |
| PT2514750E (pt) | 2007-06-18 | 2014-01-23 | Sunshine Lake Pharma Co Ltd | Tiazolil dihidropirimidinas substituídas com bromo-fenilo |
| EP2085397A1 (en) | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
| TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| SI2340252T1 (sl) * | 2008-09-09 | 2016-02-29 | Astrazeneca Ab | Postopek priprave (1S-)1-alfa, 2-alfa, 3-beta(1S*,2R*)5-beta))-3-(7-(2-(3,4-difluorofenil)-ciklopropilamino)-5- (propiltio)-3H-1,2,3-triazolo(4,5-D)pirimidin-3-il)-5-(2-hidroksietoksi) ciklopentan-1,2-diola in njegovih vmesnih spojin |
| JP5881864B2 (ja) * | 2012-01-03 | 2016-03-09 | セルセウティックス コーポレイション | 炭素環ヌクレオシドならびにその医薬的使用および組成物 |
| US9457028B2 (en) | 2013-02-27 | 2016-10-04 | Kyoto University | Pharmaceutical composition for use in prevention or treatment of cancer |
| IN2013MU03145A (es) | 2013-10-03 | 2015-07-03 | Lupin Ltd | |
| CN104558035B (zh) * | 2013-10-22 | 2017-12-19 | 连云港恒运药业有限公司 | 一种替诺福韦前药的纯化方法 |
| CN104788451A (zh) * | 2014-01-21 | 2015-07-22 | 浙江九洲药业股份有限公司 | 一种阿巴卡韦的制备方法 |
| CN109239253B (zh) * | 2018-09-21 | 2021-07-09 | 江苏威奇达药业有限公司 | 一种阿巴卡韦的杂质的高效液相检测方法 |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL84842A0 (en) * | 1986-12-24 | 1988-06-30 | Lilly Co Eli | Immunoglobulin conjugates |
| YU47791B (sr) * | 1988-01-20 | 1996-01-09 | Regents Of The University Of Minnesota | Postupak za dobijanje dideoksihidrokar-bocikličnih nukleozida |
| GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| JPH02164881A (ja) * | 1988-10-24 | 1990-06-25 | Wellcome Found Ltd:The | 治療用ヌクレオシド化合物 |
| NZ233197A (en) * | 1989-04-13 | 1991-11-26 | Richard Thomas Walker | Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions |
| US4939252A (en) * | 1989-04-20 | 1990-07-03 | Hoffmann-La Roche Inc. | Novel intermediates for the preparation of Carbovir |
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1990
- 1990-12-20 MY MYPI90002230A patent/MY104575A/en unknown
- 1990-12-21 HU HU407/90A patent/HU219454B/hu unknown
- 1990-12-21 CN CN91100671A patent/CN1028106C/zh not_active Expired - Lifetime
- 1990-12-21 IE IE465290A patent/IE904652A1/en not_active IP Right Cessation
- 1990-12-21 CZ CS906583A patent/CZ283481B6/cs not_active IP Right Cessation
- 1990-12-21 RU SU904894161A patent/RU2068849C1/ru active
- 1990-12-21 FI FI906367A patent/FI106461B/fi active Protection Beyond IP Right Term
- 1990-12-21 EP EP99103526A patent/EP0921114A1/en not_active Withdrawn
- 1990-12-21 DE DE69033197T patent/DE69033197T2/de not_active Expired - Lifetime
- 1990-12-21 ZA ZA9010365A patent/ZA9010365B/xx unknown
- 1990-12-21 CA CA002033044A patent/CA2033044C/en not_active Expired - Lifetime
- 1990-12-21 IE IE19990826A patent/IE990826A1/en unknown
- 1990-12-21 EP EP99103525A patent/EP0921121A1/en not_active Withdrawn
- 1990-12-21 EP EP90314089A patent/EP0434450B1/en not_active Expired - Lifetime
- 1990-12-21 DE DE1990633197 patent/DE19975058I1/de active Pending
- 1990-12-21 PT PT96321A patent/PT96321B/pt not_active IP Right Cessation
- 1990-12-21 DK DK90314089T patent/DK0434450T3/da active
- 1990-12-21 AT AT90314089T patent/ATE181917T1/de active
- 1990-12-21 PL PL90288403A patent/PL167097B1/pl unknown
- 1990-12-21 IL IL9674890A patent/IL96748A/en not_active IP Right Cessation
- 1990-12-21 ES ES90314089T patent/ES2133138T3/es not_active Expired - Lifetime
- 1990-12-21 IE IE19990825A patent/IE990825A1/en unknown
- 1990-12-21 SK SK6583-90A patent/SK280216B6/sk not_active IP Right Cessation
- 1990-12-21 NZ NZ236593A patent/NZ236593A/en unknown
- 1990-12-21 AU AU68419/90A patent/AU633672B2/en not_active Expired
- 1990-12-21 HU HU9902543A patent/HU220630B1/hu unknown
- 1990-12-21 HU HU9902539A patent/HU220067B/hu unknown
- 1990-12-21 SG SG1996004082A patent/SG49685A1/en unknown
- 1990-12-21 AP APAP/P/1990/000234A patent/AP196A/en active
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1991
- 1991-04-09 TW TW088111311A patent/TW473466B/zh not_active IP Right Cessation
- 1991-04-09 TW TW080102699A patent/TW371660B/zh not_active IP Right Cessation
-
1992
- 1992-06-04 RU SU925011830A patent/RU2091386C1/ru active
- 1992-06-24 MX MX9203215A patent/MX9203215A/es active IP Right Grant
- 1992-08-10 SK SK2470-92A patent/SK280000B6/sk not_active IP Right Cessation
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1998
- 1998-08-31 HK HK98110320A patent/HK1009600A1/xx not_active IP Right Cessation
- 1998-09-28 JP JP10273408A patent/JPH11158160A/ja active Pending
-
1999
- 1999-05-06 JP JP11126185A patent/JPH11343292A/ja active Pending
- 1999-08-06 LU LU90426C patent/LU90426I2/fr unknown
- 1999-08-26 GR GR990402183T patent/GR3031100T3/el unknown
- 1999-09-14 NL NL990028C patent/NL990028I2/nl unknown
- 1999-12-09 CY CY9900044A patent/CY2145B1/xx unknown
-
2000
- 2000-05-16 FI FI20001175A patent/FI20001175A/fi unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: THE WELLCOME FOUNDATION LIMITED |
|
| SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L190 Extension date: 20140627 |