PE20010915A1 - Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales - Google Patents

Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales

Info

Publication number
PE20010915A1
PE20010915A1 PE2000001295A PE0012952000A PE20010915A1 PE 20010915 A1 PE20010915 A1 PE 20010915A1 PE 2000001295 A PE2000001295 A PE 2000001295A PE 0012952000 A PE0012952000 A PE 0012952000A PE 20010915 A1 PE20010915 A1 PE 20010915A1
Authority
PE
Peru
Prior art keywords
amino
cyclopenten
purin
cis
methanol
Prior art date
Application number
PE2000001295A
Other languages
English (en)
Inventor
Susan M Daluge
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20010915A1 publication Critical patent/PE20010915A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A FOSFORAMIDATOS DE ANALOGOS 6-MODIFICADOS DE (1S,CIS)-4-(2-AMINO-9H-PURIN-9-IL)-2-CICLOPENTEN-1-METANOL DE FORMULA I, DONDE R1 ES H, ARILO C6-C14, HETEROARILO; R2 Y R3 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8, ALQUENILO C2-C8, CICLOALQUENILO C5-C8, ENTRE OTROS; R4 ES OR8, NR8R9, SR8; R8 Y R9 SON H, ALQUILO C1-C8, ALQUENILO C2-C8, ENTRE OTROS; R5 ES H, ALQUILO C1-C8, ARILO C6-C14, R2 Y R5 O R3 Y R5 FORMAN JUNTOS UN ANILLO DE 5-6 MIEMBROS; X ES ALCOXI C1-C6, HETEROCICLO, IMIDAZOLILO, ENTRE OTROS; CUANDO X NO ES AMINO SUSTITUIDO CON CICLOPROPILO. SON COMPUESTOS PREFERIDOS O-[FENIL(METOXI-L-ALANINIL)]FOSFORAMIDATO DE (1S,CIS)-4-[2-AMINO-6-(1-AZETIDINIL)-9H-PURIN-9-IL]-2-CICLOPENTEN-1-METANOL; O-[FENIL(METOXI-L-ALANINIL)]FOSFORAMIDATO DE (1S,CIS)-4-[2-AMINO-6-(CICLOPROPILMETILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTEN-1-METANOL, ENTRE OTROS. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES POR VIRUS VIH, HEPATITIS B, C
PE2000001295A 1999-12-10 2000-12-05 Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales PE20010915A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17022599P 1999-12-10 1999-12-10

Publications (1)

Publication Number Publication Date
PE20010915A1 true PE20010915A1 (es) 2001-09-29

Family

ID=22619059

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001295A PE20010915A1 (es) 1999-12-10 2000-12-05 Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales

Country Status (9)

Country Link
EP (1) EP1235833B1 (es)
JP (1) JP2003516409A (es)
AR (1) AR026913A1 (es)
AT (1) ATE260288T1 (es)
AU (1) AU2068901A (es)
DE (1) DE60008580T2 (es)
ES (1) ES2213061T3 (es)
PE (1) PE20010915A1 (es)
WO (1) WO2001042256A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201513601D0 (en) * 2015-07-31 2015-09-16 Univ Liverpool Antiviral compounds
TW202019942A (zh) 2018-07-27 2020-06-01 日商富士軟片股份有限公司 環戊烯嘌呤衍生物或其鹽

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
GB9821058D0 (en) * 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
DK1150988T3 (da) * 1999-02-12 2003-09-29 Glaxo Group Ltd Phosphoramidat og mono-, di- og triphosphorsyreestere af (1R,cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopenten-1-methanol som antivirale midler

Also Published As

Publication number Publication date
DE60008580D1 (en) 2004-04-01
ES2213061T3 (es) 2004-08-16
JP2003516409A (ja) 2003-05-13
AU2068901A (en) 2001-06-18
WO2001042256A1 (en) 2001-06-14
AR026913A1 (es) 2003-03-05
DE60008580T2 (de) 2004-08-05
ATE260288T1 (de) 2004-03-15
EP1235833B1 (en) 2004-02-25
EP1235833A1 (en) 2002-09-04

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