DK1150988T3 - Phosphoramidat og mono-, di- og triphosphorsyreestere af (1R,cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopenten-1-methanol som antivirale midler - Google Patents
Phosphoramidat og mono-, di- og triphosphorsyreestere af (1R,cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopenten-1-methanol som antivirale midlerInfo
- Publication number
- DK1150988T3 DK1150988T3 DK00905043T DK00905043T DK1150988T3 DK 1150988 T3 DK1150988 T3 DK 1150988T3 DK 00905043 T DK00905043 T DK 00905043T DK 00905043 T DK00905043 T DK 00905043T DK 1150988 T3 DK1150988 T3 DK 1150988T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclopenten
- purin
- antivirals
- phosphoramidate
- cis
- Prior art date
Links
- COZAZKCWQGBJDE-JGVFFNPUSA-N [(1r,4s)-4-(6-aminopurin-9-yl)cyclopent-2-en-1-yl]methanol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@@H](CO)C=C1 COZAZKCWQGBJDE-JGVFFNPUSA-N 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940121357 antivirals Drugs 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903090.0A GB9903090D0 (en) | 1999-02-12 | 1999-02-12 | Therapeutic compounds |
| US17020599P | 1999-12-10 | 1999-12-10 | |
| PCT/EP2000/001045 WO2000047591A1 (en) | 1999-02-12 | 2000-02-10 | Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1150988T3 true DK1150988T3 (da) | 2003-09-29 |
Family
ID=26315118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00905043T DK1150988T3 (da) | 1999-02-12 | 2000-02-10 | Phosphoramidat og mono-, di- og triphosphorsyreestere af (1R,cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopenten-1-methanol som antivirale midler |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7115590B1 (da) |
| EP (1) | EP1150988B1 (da) |
| JP (1) | JP2002536452A (da) |
| KR (1) | KR20010102082A (da) |
| CN (1) | CN1346360A (da) |
| AR (1) | AR031975A1 (da) |
| AT (1) | ATE241633T1 (da) |
| AU (1) | AU772478B2 (da) |
| BR (1) | BR0008135A (da) |
| CA (1) | CA2362662A1 (da) |
| CZ (1) | CZ20012908A3 (da) |
| DE (1) | DE60002986T2 (da) |
| DK (1) | DK1150988T3 (da) |
| DZ (1) | DZ3007A1 (da) |
| ES (1) | ES2200820T3 (da) |
| HK (1) | HK1039337B (da) |
| HU (1) | HUP0105476A3 (da) |
| IL (1) | IL144647A0 (da) |
| NO (1) | NO20013910L (da) |
| NZ (1) | NZ513450A (da) |
| PL (1) | PL204458B1 (da) |
| PT (1) | PT1150988E (da) |
| TR (1) | TR200102313T2 (da) |
| WO (1) | WO2000047591A1 (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2576001A (en) * | 1999-12-10 | 2001-06-18 | Glaxo Group Limited | (1r,cis)-4-(4-amino-7h-pyrrolo'2,3-i(d) pyrimidine-7-yl)-2-cyclopentene-1-methanol derivatives as antiviral |
| PE20010915A1 (es) * | 1999-12-10 | 2001-09-29 | Glaxo Group Ltd | Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales |
| JP5230052B2 (ja) | 2000-05-26 | 2013-07-10 | イデニクス（ケイマン）リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
| AU2001282941C1 (en) † | 2000-07-21 | 2016-12-22 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| GB0129945D0 (en) * | 2001-12-13 | 2002-02-06 | Mrc Technology Ltd | Chemical compounds |
| GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| EP2691409B1 (en) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US9403863B2 (en) | 2011-09-12 | 2016-08-02 | Idenix Pharmaceuticals Llc | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| EP2768838A1 (en) | 2011-10-14 | 2014-08-27 | IDENIX Pharmaceuticals, Inc. | Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
| AU2013266393B2 (en) | 2012-05-22 | 2017-09-28 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| EA027929B1 (ru) | 2012-05-25 | 2017-09-29 | Янссен Сайенсиз Айрлэнд Юси | Нуклеозиды на основе урацила и спирооксетана |
| EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| US10513534B2 (en) | 2012-10-08 | 2019-12-24 | Idenix Pharmaceuticals Llc | 2′-chloro nucleoside analogs for HCV infection |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| EP2970358B1 (en) | 2013-03-04 | 2021-06-30 | Idenix Pharmaceuticals LLC | 3'-deoxy nucleosides for the treatment of hcv |
| WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
| EP2970357A1 (en) | 2013-03-13 | 2016-01-20 | IDENIX Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
| WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| EP3131914B1 (en) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| GEP20247600B (en) | 2015-03-06 | 2024-02-26 | Atea Pharmaceuticals Inc | B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT |
| US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| EP3512863B1 (en) | 2016-09-07 | 2021-12-08 | ATEA Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| WO2024107859A1 (en) * | 2022-11-15 | 2024-05-23 | Rome Therapeutics, Inc. | Cyclopentene-oxymethylene phosphonamidates and related compounds and their use in treating medical conditions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5244896A (en) * | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| US6887707B2 (en) * | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| GB9821058D0 (en) * | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| AU2576001A (en) * | 1999-12-10 | 2001-06-18 | Glaxo Group Limited | (1r,cis)-4-(4-amino-7h-pyrrolo'2,3-i(d) pyrimidine-7-yl)-2-cyclopentene-1-methanol derivatives as antiviral |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
-
2000
- 2000-02-10 IL IL14464700A patent/IL144647A0/xx unknown
- 2000-02-10 TR TR2001/02313T patent/TR200102313T2/xx unknown
- 2000-02-10 ES ES00905043T patent/ES2200820T3/es not_active Expired - Lifetime
- 2000-02-10 JP JP2000598510A patent/JP2002536452A/ja active Pending
- 2000-02-10 EP EP00905043A patent/EP1150988B1/en not_active Expired - Lifetime
- 2000-02-10 DK DK00905043T patent/DK1150988T3/da active
- 2000-02-10 DE DE60002986T patent/DE60002986T2/de not_active Expired - Fee Related
- 2000-02-10 BR BR0008135-3A patent/BR0008135A/pt not_active IP Right Cessation
- 2000-02-10 PT PT00905043T patent/PT1150988E/pt unknown
- 2000-02-10 PL PL350023A patent/PL204458B1/pl not_active IP Right Cessation
- 2000-02-10 AR ARP000100596A patent/AR031975A1/es not_active Application Discontinuation
- 2000-02-10 AU AU26713/00A patent/AU772478B2/en not_active Ceased
- 2000-02-10 CZ CZ20012908A patent/CZ20012908A3/cs unknown
- 2000-02-10 HU HU0105476A patent/HUP0105476A3/hu unknown
- 2000-02-10 AT AT00905043T patent/ATE241633T1/de not_active IP Right Cessation
- 2000-02-10 US US09/913,226 patent/US7115590B1/en not_active Expired - Fee Related
- 2000-02-10 CA CA002362662A patent/CA2362662A1/en not_active Abandoned
- 2000-02-10 CN CN00806002A patent/CN1346360A/zh active Pending
- 2000-02-10 NZ NZ513450A patent/NZ513450A/xx unknown
- 2000-02-10 KR KR1020017010198A patent/KR20010102082A/ko not_active Application Discontinuation
- 2000-02-10 WO PCT/EP2000/001045 patent/WO2000047591A1/en not_active Application Discontinuation
- 2000-03-09 DZ DZ000019A patent/DZ3007A1/xx active
-
2001
- 2001-08-10 NO NO20013910A patent/NO20013910L/no not_active Application Discontinuation
-
2002
- 2002-02-05 HK HK02100897.2A patent/HK1039337B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1150988E (pt) | 2003-10-31 |
| AR031975A1 (es) | 2003-10-22 |
| IL144647A0 (en) | 2002-05-23 |
| HUP0105476A2 (en) | 2002-06-29 |
| ES2200820T3 (es) | 2004-03-16 |
| KR20010102082A (ko) | 2001-11-15 |
| NO20013910D0 (no) | 2001-08-10 |
| AU772478B2 (en) | 2004-04-29 |
| DE60002986D1 (en) | 2003-07-03 |
| DZ3007A1 (fr) | 2003-03-27 |
| NZ513450A (en) | 2004-03-26 |
| TR200102313T2 (tr) | 2002-03-21 |
| EP1150988B1 (en) | 2003-05-28 |
| CZ20012908A3 (cs) | 2002-10-16 |
| CA2362662A1 (en) | 2000-08-17 |
| US7115590B1 (en) | 2006-10-03 |
| NO20013910L (no) | 2001-10-10 |
| DE60002986T2 (de) | 2004-05-19 |
| EP1150988A1 (en) | 2001-11-07 |
| PL350023A1 (en) | 2002-10-21 |
| HK1039337B (zh) | 2003-11-21 |
| AU2671300A (en) | 2000-08-29 |
| CN1346360A (zh) | 2002-04-24 |
| WO2000047591A1 (en) | 2000-08-17 |
| HUP0105476A3 (en) | 2002-08-28 |
| ATE241633T1 (de) | 2003-06-15 |
| HK1039337A1 (en) | 2002-04-19 |
| JP2002536452A (ja) | 2002-10-29 |
| BR0008135A (pt) | 2002-02-19 |
| PL204458B1 (pl) | 2010-01-29 |
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