ZA9010365B - Therapeutic nucleosides - Google Patents

Therapeutic nucleosides

Info

Publication number
ZA9010365B
ZA9010365B ZA9010365A ZA9010365A ZA9010365B ZA 9010365 B ZA9010365 B ZA 9010365B ZA 9010365 A ZA9010365 A ZA 9010365A ZA 9010365 A ZA9010365 A ZA 9010365A ZA 9010365 B ZA9010365 B ZA 9010365B
Authority
ZA
South Africa
Prior art keywords
therapeutic nucleosides
nucleosides
therapeutic
Prior art date
Application number
ZA9010365A
Other languages
English (en)
Inventor
Susan Mary Daluge
Mary Daluge Susan
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/455,201 external-priority patent/US5034394A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA9010365B publication Critical patent/ZA9010365B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50Three nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
ZA9010365A 1989-12-22 1990-12-21 Therapeutic nucleosides ZA9010365B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/455,201 US5034394A (en) 1988-06-27 1989-12-22 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
ZA9010365B true ZA9010365B (en) 1992-08-26

Family

ID=23807819

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9010365A ZA9010365B (en) 1989-12-22 1990-12-21 Therapeutic nucleosides

Country Status (30)

Country Link
EP (3) EP0434450B1 (xx)
JP (2) JPH11158160A (xx)
CN (1) CN1028106C (xx)
AP (1) AP196A (xx)
AT (1) ATE181917T1 (xx)
AU (1) AU633672B2 (xx)
CA (1) CA2033044C (xx)
CY (1) CY2145B1 (xx)
CZ (1) CZ283481B6 (xx)
DE (2) DE19975058I1 (xx)
DK (1) DK0434450T3 (xx)
ES (1) ES2133138T3 (xx)
FI (2) FI106461B (xx)
GR (1) GR3031100T3 (xx)
HK (1) HK1009600A1 (xx)
HU (3) HU220067B (xx)
IE (3) IE990825A1 (xx)
IL (1) IL96748A (xx)
LU (1) LU90426I2 (xx)
MX (1) MX9203215A (xx)
MY (1) MY104575A (xx)
NL (1) NL990028I2 (xx)
NZ (1) NZ236593A (xx)
PL (1) PL167097B1 (xx)
PT (1) PT96321B (xx)
RU (2) RU2068849C1 (xx)
SG (1) SG49685A1 (xx)
SK (2) SK658390A3 (xx)
TW (2) TW371660B (xx)
ZA (1) ZA9010365B (xx)

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CA1339896C (en) * 1988-01-20 1998-06-02 Robert Vince Dideoxydidehydrocarbocyclic nucleosides
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
DE69431596D1 (de) * 1993-06-10 2002-11-28 Wake Forest University Winston (phospho)lipide zum bekämpfen einer hepatitis b-infektion
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9417249D0 (en) * 1994-08-26 1994-10-19 Wellcome Found A novel salt
US7135584B2 (en) 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
AU3216695A (en) * 1994-08-29 1996-03-22 University Of North Carolina At Chapel Hill, The Lipid analogs for treating viral infections
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
HUP9903249A3 (en) * 1996-06-25 2001-04-28 Glaxo Group Ltd Combinations comprising vx478, zidovudine, ftc and/or 3tc for use in the treatment of hiv
HUP9903098A3 (en) * 1996-06-25 2000-01-28 Glaxo Group Ltd Combination comprising vx478, zidovudine and/or 1592u89 and pharmaceutical composition containing them
SK285229B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
AU769660B2 (en) * 1997-05-17 2004-01-29 Glaxo Group Limited Carbocyclic nucleoside hemisulfate and its use in treating viral infections
GB9709945D0 (en) * 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
GB9721780D0 (en) 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
AU2702899A (en) * 1997-10-24 1999-05-17 Glaxo Group Limited Process for preparing a chiral nucleoside analogue
JP2001522850A (ja) * 1997-11-12 2001-11-20 グラクソ グループ リミテッド キラルヌクレオシド類似体の製造法
SK284594B6 (sk) * 1997-11-27 2005-07-01 Lonza Ag Spôsob výroby derivátov aminoalkoholov a ich soli
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
GB9802472D0 (en) 1998-02-06 1998-04-01 Glaxo Group Ltd Pharmaceutical compositions
GB9820417D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
GB9821058D0 (en) 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
KR100606625B1 (ko) 1998-10-30 2006-07-28 론자 아게 4-[(2',5'-디아미노-6'-할로피리미딘-4'-일)아미노]-시클로펜트-2-에닐메탄올의 제조 방법
HU227559B1 (en) * 1998-10-30 2011-08-29 Lonza Ag Method for producing 4-[(2',5'-diamino-6'-halopyrimidine-4'-yl)amino]-cyclopent-2-enylmethanols
GB9903091D0 (en) 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
WO2001042255A1 (en) * 1999-12-10 2001-06-14 Glaxo Group Limited (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL
PE20010915A1 (es) * 1999-12-10 2001-09-29 Glaxo Group Ltd Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales
DE10042655A1 (de) * 2000-08-31 2002-03-14 Aventis Pharma Gmbh Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
KR100891366B1 (ko) 2001-06-29 2009-04-02 인스티튜트 오브 오르가닉 케미스트리 앤드 바이오케미스트리, 어케더미 오브 사이언시스 오브 더 체크 리퍼블릭 항 바이러스 활성을 갖는 6-'2-(포스포노메톡시)알콕시 피리미딘 유도체
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
US7550261B2 (en) 2001-08-21 2009-06-23 Smithkline Beecham Corporation Method of screening for drug hypersensitivity reaction
EP1427849B1 (en) * 2001-08-21 2013-05-15 VIIV Healthcare UK Limited Method of screening for drug hypersensitivity reaction
WO2003021959A1 (en) 2001-08-31 2003-03-13 Thomson Licensing Sa Sequence counter for an audio visual stream
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
ES2254941T3 (es) * 2002-06-27 2006-06-16 Medivir Ab Interaccion sinergica entre abacavir y alovudina.
DE602004031115D1 (de) 2003-06-16 2011-03-03 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
GB0320738D0 (en) 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
EP1857458A1 (en) * 2006-05-05 2007-11-21 SOLMAG S.p.A. Process for the preparation of abacavir
EP1905772A1 (en) * 2006-09-28 2008-04-02 Esteve Quimica, S.A. Process for the preparation of abacavir
AU2007301934A1 (en) * 2006-09-28 2008-04-03 Esteve Quimica, S.A. Process for the preparation of abacavir
EP1939196A1 (en) * 2006-12-21 2008-07-02 Esteve Quimica, S.A. Process for the preparation of abacavir
KR101173892B1 (ko) 2007-06-18 2012-08-16 선샤인 레이크 파르마 컴퍼니 리미티드 브로모-페닐 치환된 티아졸릴 디하이드로피리미딘
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
ES2558843T3 (es) 2008-09-09 2016-02-09 Astrazeneca Ab Procedimiento para preparar [1S-[1-alfa,2-alfa,3-beta(1S*,2R*),5-beta]]-3-[7-[2-(3,4-difluorofenil)-ciclopropilamino]-5-(propiltio)-3H-1,2,3-triazolo[4,5-d]pirimidin-3-il]-5-(2-hidroxietoxi)ciclopentano-1,2-diol y a sus productos intermedios
KR101763740B1 (ko) * 2012-01-03 2017-08-01 셀슈틱스 코포레이션 탄소환 뉴클레오시드 및 이들의 약학적 용도 및 조성물
US9457028B2 (en) 2013-02-27 2016-10-04 Kyoto University Pharmaceutical composition for use in prevention or treatment of cancer
WO2015049623A1 (en) 2013-10-03 2015-04-09 Lupin Limited Crystalline abacavir hydrochloride monohydrate and process for its preparation
CN104558035B (zh) * 2013-10-22 2017-12-19 连云港恒运药业有限公司 一种替诺福韦前药的纯化方法
CN104788451A (zh) * 2014-01-21 2015-07-22 浙江九洲药业股份有限公司 一种阿巴卡韦的制备方法
CN109239253B (zh) * 2018-09-21 2021-07-09 江苏威奇达药业有限公司 一种阿巴卡韦的杂质的高效液相检测方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84842A0 (en) * 1986-12-24 1988-06-30 Lilly Co Eli Immunoglobulin conjugates
CA1339896C (en) * 1988-01-20 1998-06-02 Robert Vince Dideoxydidehydrocarbocyclic nucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
DE68907013D1 (de) * 1988-10-24 1993-07-15 Wellcome Found Guaninderivate mit antiviraler wirkung und deren pharmazeutisch vertraegliche salze.
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir

Also Published As

Publication number Publication date
NL990028I1 (nl) 1999-11-01
DE69033197T2 (de) 1999-10-28
DE19975058I1 (de) 2007-01-25
HU9008407D0 (en) 1991-07-29
CN1054981A (zh) 1991-10-02
HU9902543D0 (en) 1999-10-28
SK280216B6 (sk) 1999-10-08
CA2033044A1 (en) 1991-06-23
ES2133138T3 (es) 1999-09-01
TW371660B (en) 1999-10-11
SK658390A3 (en) 1999-10-08
IL96748A0 (en) 1991-09-16
GR3031100T3 (en) 1999-12-31
RU2068849C1 (ru) 1996-11-10
IL96748A (en) 1995-07-31
EP0434450A3 (en) 1992-07-08
FI906367A0 (fi) 1990-12-21
TW473466B (en) 2002-01-21
DE69033197D1 (de) 1999-08-12
HK1009600A1 (en) 1999-06-04
JPH11158160A (ja) 1999-06-15
MX9203215A (es) 1992-07-01
LU90426I2 (fr) 1999-10-06
EP0921121A1 (en) 1999-06-09
PL167097B1 (pl) 1995-07-31
AU633672B2 (en) 1993-02-04
PT96321B (pt) 1998-06-30
EP0434450B1 (en) 1999-07-07
FI906367A (fi) 1991-06-23
AU6841990A (en) 1991-06-27
CA2033044C (en) 1999-07-13
IE990826A1 (en) 2000-12-13
IE904652A1 (en) 1991-07-17
RU2091386C1 (ru) 1997-09-27
CY2145B1 (en) 2002-06-21
CZ658390A3 (en) 1997-11-12
AP9000234A0 (en) 1991-01-31
IE990825A1 (en) 2000-12-13
PT96321A (pt) 1991-09-30
ATE181917T1 (de) 1999-07-15
FI106461B (fi) 2001-02-15
JPH11343292A (ja) 1999-12-14
HU219454B (hu) 2001-04-28
CN1028106C (zh) 1995-04-05
AP196A (en) 1992-06-30
SG49685A1 (en) 1998-06-15
HU9902539D0 (en) 1999-10-28
HU220630B1 (hu) 2002-03-28
FI20001175A (fi) 2000-05-16
HU220067B (hu) 2001-10-28
PL288403A1 (en) 1992-06-26
EP0921114A1 (en) 1999-06-09
MY104575A (en) 1994-04-30
SK280000B6 (sk) 1999-06-11
NZ236593A (en) 1994-01-26
DK0434450T3 (da) 2000-01-31
EP0434450A2 (en) 1991-06-26
CZ283481B6 (cs) 1998-04-15
NL990028I2 (nl) 2000-02-01
SK247092A3 (en) 1999-06-11

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