ES8502991A1 - Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina. - Google Patents

Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.

Info

Publication number
ES8502991A1
ES8502991A1 ES525470A ES525470A ES8502991A1 ES 8502991 A1 ES8502991 A1 ES 8502991A1 ES 525470 A ES525470 A ES 525470A ES 525470 A ES525470 A ES 525470A ES 8502991 A1 ES8502991 A1 ES 8502991A1
Authority
ES
Spain
Prior art keywords
benzisothiazole
piperazine derivatives
benzisothiazol
piperazinyl
benzisoxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525470A
Other languages
English (en)
Other versions
ES525470A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8502991A1 publication Critical patent/ES8502991A1/es
Publication of ES525470A0 publication Critical patent/ES525470A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE BENZOISOTIAZOL Y BENZOISOXAZOL PIPERAZINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER DERIVADOS DE BENZOISOTIAZOL Y BENZOISOXAZOL PIPERAZINA DE FORMULA (I) DONDE R REPRESENTA UN RADICAL DE FORMULA (IV) Y OTROS RADICALES; N ES 3 O 4; R1 Y R2 SON INDEPENDIENTEMENTE ALQUILO INFERIOR DE C 1 A 4; Y ES OXIGENO O AZUFRE; Y Z ES H O HALOGENO. LA REACCION SE REALIZA EN UN MEDIO INERTE, EN PRESENCIA DE UNA BASE, A TEMPERATURA ENTRE 50 Y 200JC Y DURANTE 2 A 24 HORAS.TIENE APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIPSICOTICA SELECTIVA.
ES525470A 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina. Granted ES525470A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/333,830 US4411901A (en) 1981-12-23 1981-12-23 Benzisothiazole and benzisoxazole piperazine derivatives

Publications (2)

Publication Number Publication Date
ES8502991A1 true ES8502991A1 (es) 1985-02-01
ES525470A0 ES525470A0 (es) 1985-02-01

Family

ID=23304433

Family Applications (4)

Application Number Title Priority Date Filing Date
ES518168A Expired ES8401970A1 (es) 1981-12-23 1982-12-14 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.
ES524946A Granted ES524946A0 (es) 1981-12-23 1983-08-12 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina
ES525471A Expired ES8503349A1 (es) 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.
ES525470A Granted ES525470A0 (es) 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES518168A Expired ES8401970A1 (es) 1981-12-23 1982-12-14 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.
ES524946A Granted ES524946A0 (es) 1981-12-23 1983-08-12 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina
ES525471A Expired ES8503349A1 (es) 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.

Country Status (26)

Country Link
US (1) US4411901A (es)
JP (2) JPS58110576A (es)
KR (1) KR870001022B1 (es)
AU (1) AU550780B2 (es)
BE (1) BE895469A (es)
CA (1) CA1205806A (es)
CH (2) CH656617A5 (es)
CY (1) CY1376A (es)
DE (1) DE3247530A1 (es)
DK (2) DK160939C (es)
ES (4) ES8401970A1 (es)
FI (1) FI78697C (es)
FR (2) FR2521561B1 (es)
GB (1) GB2114119B (es)
GR (1) GR77108B (es)
HK (1) HK5088A (es)
HU (2) HU190997B (es)
IE (1) IE54789B1 (es)
IT (1) IT1158037B (es)
KE (1) KE3718A (es)
LU (1) LU84550A1 (es)
NL (1) NL8204910A (es)
PT (1) PT76017B (es)
SE (2) SE453502B (es)
SG (1) SG30087G (es)
ZA (1) ZA828544B (es)

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US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4656280A (en) * 1984-03-07 1987-04-07 E. I. Du Pont De Nemours And Company Radioiodinated dopamine receptor ligand
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
EP0348460A4 (en) * 1987-11-12 1991-11-27 American Home Products Corporation Polycyclicamines with psychotropic activity
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
ATE81123T1 (de) * 1987-11-20 1992-10-15 Hoechst Roussel Pharma 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
HUT61760A (en) * 1988-09-16 1993-03-01 Pfizer Process for producing bridged, bicyclic imides comprising 4-/4-(3-benzisothiazolyl)-1-piperazinyl/-butyl group and pharmaceutical compositions comprising such compounds
US4847252A (en) * 1988-10-25 1989-07-11 Bristol-Myers Company Method for alleviation of vascular headache
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
GB9226857D0 (en) * 1992-12-23 1993-02-17 Boyd Edward A Pharmaceutical compositions
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
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HUP9800631A3 (en) * 1995-02-28 1998-12-28 Lundbeck & Co As H 4-aminotetrahydrobenzisoxazole or -isothiazole derivatives, pharmaceutical compositions containing them and their use for the preparation of pharmaceutical compositions
JP3122469B2 (ja) * 1995-06-06 2001-01-09 ヘキスト・マリオン・ルセル・インコーポレイテツド 抗精神病剤としてのピリジンイミニル−１，２−ベイゾイソオキサゾール類及び−ベンゾイソチアゾール類
EP1757292A1 (en) 1997-09-05 2007-02-28 Pfizer Products Inc. Method of treating ocd and tic disorders
JP2002541098A (ja) * 1999-04-06 2002-12-03 セプラコア インコーポレーテッド ジプラシドン代謝産物を用いる神経弛緩薬性障害および関連障害を治療するための方法および組成物
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
BR0315809A (pt) * 2002-10-28 2005-09-13 Warner Lambert Co Derivados de piperazina substituìdos com oxindol
WO2004041793A1 (en) * 2002-11-08 2004-05-21 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
ES2610508T3 (es) 2006-11-22 2017-04-27 Clinical Research Associates, Llc Métodos para tratar el síndrome de Down, el síndrome del cromosoma X frágil y el autismo
WO2013014665A1 (en) 2011-07-28 2013-01-31 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof
CN105669665A (zh) * 2016-03-15 2016-06-15 烟台贝森医药科技有限公司 哌罗匹隆的制备方法

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US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
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Also Published As

Publication number Publication date
KE3718A (en) 1987-04-16
CA1205806A (en) 1986-06-10
FI824379L (fi) 1983-06-24
DK160939C (da) 1991-10-21
AU9087282A (en) 1983-06-23
IT8249709A0 (it) 1982-12-21
FR2521561A1 (fr) 1983-08-19
FI78697B (fi) 1989-05-31
US4411901A (en) 1983-10-25
LU84550A1 (fr) 1983-09-08
ES525471A0 (es) 1985-02-01
ZA828544B (en) 1983-09-28
FI78697C (fi) 1989-09-11
HK5088A (en) 1988-01-29
AU550780B2 (en) 1986-04-10
HU195806B (en) 1988-07-28
SE462162B (sv) 1990-05-14
DK162601B (da) 1991-11-18
CH656617A5 (de) 1986-07-15
FR2531431B1 (es) 1986-10-10
DK307590A (da) 1990-12-28
IE54789B1 (en) 1990-02-14
SE8207350D0 (sv) 1982-12-22
KR870001022B1 (ko) 1987-05-23
JPH0517457A (ja) 1993-01-26
SG30087G (en) 1987-07-17
IE823053L (en) 1983-06-23
ES525470A0 (es) 1985-02-01
GB2114119A (en) 1983-08-17
KR840002832A (ko) 1984-07-21
DK566282A (da) 1983-06-24
IT1158037B (it) 1987-02-18
JPS58110576A (ja) 1983-07-01
SE453502B (sv) 1988-02-08
SE8702389D0 (sv) 1987-06-09
DK307590D0 (da) 1990-12-28
FI824379A0 (fi) 1982-12-20
DE3247530A1 (de) 1983-06-30
GB2114119B (en) 1985-11-27
ES8503683A1 (es) 1985-04-01
PT76017B (en) 1985-12-20
NL8204910A (nl) 1983-07-18
ES518168A0 (es) 1984-01-16
GR77108B (es) 1984-09-06
FR2521561B1 (fr) 1986-10-10
DK160939B (da) 1991-05-06
SE8702389L (sv) 1987-06-09
BE895469A (fr) 1983-06-23
ES8401970A1 (es) 1984-01-16
CH659070A5 (de) 1986-12-31
JPH0577669B2 (es) 1993-10-27
HU190997B (en) 1986-12-28
DK162601C (da) 1992-05-11
ES524946A0 (es) 1985-04-01
FR2531431A1 (es) 1984-02-10
PT76017A (en) 1983-01-01
CY1376A (en) 1987-08-07
SE8207350L (sv) 1983-08-10
ES8503349A1 (es) 1985-02-01

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