ES8705869A1 - Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos. - Google Patents

Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos.

Info

Publication number
ES8705869A1
ES8705869A1 ES550829A ES550829A ES8705869A1 ES 8705869 A1 ES8705869 A1 ES 8705869A1 ES 550829 A ES550829 A ES 550829A ES 550829 A ES550829 A ES 550829A ES 8705869 A1 ES8705869 A1 ES 8705869A1
Authority
ES
Spain
Prior art keywords
cyclic imide
butylpiperazin
pyridines
compositions
imide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550829A
Other languages
English (en)
Other versions
ES550829A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8705869A1 publication Critical patent/ES8705869A1/es
Publication of ES550829A0 publication Critical patent/ES550829A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

METODO DE PREPARAR DERIVADOS DE PIPERAZINA 1,4-DISUSTITUIDOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), PARA OBTENER DERIVADOS DE PIPERAZINA 1,4-SUSTITUIDOS DE FORMULA (I) DONDE R1 ES H, ALQUILO INFERIOR CON C 1 A 4, ALCOXI INFERIOR, FORMILO, CARBALCOXI, HALOGENO Y OTROS; R2 ES H, HALOGENO, ALQUILO INFERIOR O ALCOXI INFERIOR, CON LA CONDICION DE QUE R1 Y R2 NO PUEDEN SER AMBOS HIDROGENO; Y Z ES UN COMPUESTO DE FORMULA (IV) U OTROS.TIENEN APLICACIONES FARMACEUTICAS POR SUS PROPIEDADES NEUROLEPTICAS.
ES550829A 1985-01-16 1986-01-13 Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos. Expired ES8705869A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/691,952 US4619930A (en) 1985-01-16 1985-01-16 Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use

Publications (2)

Publication Number Publication Date
ES8705869A1 true ES8705869A1 (es) 1987-05-16
ES550829A0 ES550829A0 (es) 1987-05-16

Family

ID=24778661

Family Applications (2)

Application Number Title Priority Date Filing Date
ES550829A Expired ES8705869A1 (es) 1985-01-16 1986-01-13 Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos.
ES557390A Expired ES8801822A1 (es) 1985-01-16 1987-02-13 Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557390A Expired ES8801822A1 (es) 1985-01-16 1987-02-13 Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos

Country Status (29)

Country Link
US (1) US4619930A (es)
JP (1) JPH0780873B2 (es)
KR (1) KR900000366B1 (es)
CN (1) CN1016691B (es)
AT (1) AT391698B (es)
AU (1) AU591473B2 (es)
BE (1) BE904047A (es)
CA (1) CA1284325C (es)
CH (1) CH666269A5 (es)
DE (1) DE3601143C2 (es)
DK (1) DK19286A (es)
EG (1) EG17759A (es)
ES (2) ES8705869A1 (es)
FI (1) FI90077C (es)
FR (1) FR2580282B1 (es)
GB (1) GB2191772B (es)
HU (1) HU198202B (es)
IE (1) IE58866B1 (es)
IL (1) IL77577A (es)
IT (1) IT1214497B (es)
LU (1) LU86248A1 (es)
NL (1) NL8600071A (es)
NZ (1) NZ214790A (es)
OA (1) OA08187A (es)
PT (1) PT81843B (es)
SE (1) SE466310B (es)
SU (1) SU1521282A3 (es)
YU (1) YU45757B (es)
ZA (1) ZA859692B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4812567A (en) * 1985-10-16 1989-03-14 American Home Products Corporation Polycyclic spiroimides with psychotropic activity
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
US4748240A (en) * 1987-04-03 1988-05-31 American Home Products Corporation Psychotropic bicyclic imides
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
DK0482696T3 (da) * 1990-10-23 1996-05-20 Akzo Nobel Nv 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CN104230915B (zh) * 2014-08-29 2016-08-17 南京大学 含噻唑烷二酮的苯基哌嗪衍生物及其制备方法与用途
CN104513198A (zh) * 2014-11-29 2015-04-15 南京红太阳生物化学有限责任公司 一种2-氯烟酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
AT330777B (de) * 1973-09-08 1976-07-26 Thomae Gmbh Dr K Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
US4456756A (en) * 1981-08-03 1984-06-26 Mead Johnson & Company Spirothiazolidinyl piperazine derivatives
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
DE3135532A1 (de) * 1981-09-08 1983-03-24 NPL po Dvigateli s Vatrešno Gorene, Varna Brennkraftmaschine
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
JPS5976059A (ja) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd 環状イミド誘導体及びその酸付加塩
JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
DE3529872A1 (de) * 1985-08-21 1987-02-26 Kali Chemie Pharma Gmbh Neue tetraoxoverbindungen

Also Published As

Publication number Publication date
ZA859692B (en) 1986-07-14
JPH0780873B2 (ja) 1995-08-30
HU198202B (en) 1989-08-28
FR2580282A1 (fr) 1986-10-17
AU5229486A (en) 1986-07-24
FI90077C (fi) 1993-12-27
AT391698B (de) 1990-11-12
GB8614686D0 (en) 1986-07-23
ES8801822A1 (es) 1988-02-16
BE904047A (fr) 1986-07-15
FI860136A0 (fi) 1986-01-13
CH666269A5 (de) 1988-07-15
SU1521282A3 (ru) 1989-11-07
ES557390A0 (es) 1988-02-16
DK19286A (da) 1986-07-17
IE860125L (en) 1986-07-16
DK19286D0 (da) 1986-01-15
IL77577A (en) 1990-02-09
GB2191772B (en) 1990-05-23
NZ214790A (en) 1989-04-26
HUT39743A (en) 1986-10-29
OA08187A (fr) 1987-10-30
YU45757B (sh) 1992-07-20
ATA10086A (de) 1990-05-15
SE466310B (sv) 1992-01-27
DE3601143C2 (de) 1994-05-11
DE3601143A1 (de) 1986-07-17
CA1284325C (en) 1991-05-21
IT8619081A0 (it) 1986-01-15
FR2580282B1 (fr) 1992-10-16
JPS61167682A (ja) 1986-07-29
US4619930A (en) 1986-10-28
IT1214497B (it) 1990-01-18
PT81843A (en) 1986-02-01
SE8600173D0 (sv) 1986-01-15
EG17759A (en) 1991-03-30
KR860005808A (ko) 1986-08-13
FI90077B (fi) 1993-09-15
CN1016691B (zh) 1992-05-20
PT81843B (pt) 1988-05-27
CN86100224A (zh) 1986-11-19
AU591473B2 (en) 1989-12-07
LU86248A1 (fr) 1986-08-04
NL8600071A (nl) 1986-08-18
SE8600173L (sv) 1986-07-17
FI860136A (fi) 1986-07-17
IE58866B1 (en) 1993-11-17
KR900000366B1 (ko) 1990-01-25
ES550829A0 (es) 1987-05-16
YU4186A (en) 1987-10-31
GB2191772A (en) 1987-12-23

Similar Documents

Publication Publication Date Title
SE8702389D0 (sv) Mellanprodukter for framstellning av 1,4-disubstituerade piperazinderivat
ES8801822A1 (es) Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos
NO900336D0 (no) Fremgangsmaate til fremstilling av heterocykliske forbindelser.
ES8700666A1 (es) Procedimiento para la preparacion de derivados de 2-(piridi-lalquilenosulfinil)benzimidazoles n-substituidos como agen- tes antisecretorios gastricos
SE7610409L (sv) Farmakologiskt aktiva foreningar
DE69106388T2 (de) Antipsychotische 4-(1,2-benzisoazolyl)piperidinderivate.
SE8105341L (sv) N-((4-(3-substituerad pyridyl)piperazino)alkyl)azaspirodekandioner
ES8802614A1 (es) Un procedimiento para la preparacion de derivados de piperazinilo 1,4 disustituidos
BE902847A (fr) Nouvelles isoindolinylalcoylpiperazines
AU576269B2 (en) Heterocyclic histamine h2-receptor antagonists
ES8504185A1 (es) Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina
ATE112569T1 (de) Verwendung von imidazopyrazolderivaten als analgesische und antiinflammatorische mittel.
MY104207A (en) Antipsychotic 4-[4-(3-benzisothiazolyl)-1- piperazinyl]butyl bridged bicyclic imides.
AU6368080A (en) Thiazolyl derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060318