DE69106388T2 - Antipsychotische 4-(1,2-benzisoazolyl)piperidinderivate. - Google Patents

Antipsychotische 4-(1,2-benzisoazolyl)piperidinderivate.

Info

Publication number
DE69106388T2
DE69106388T2 DE69106388T DE69106388T DE69106388T2 DE 69106388 T2 DE69106388 T2 DE 69106388T2 DE 69106388 T DE69106388 T DE 69106388T DE 69106388 T DE69106388 T DE 69106388T DE 69106388 T2 DE69106388 T2 DE 69106388T2
Authority
DE
Germany
Prior art keywords
benzisoazolyl
antipsychotic
piperidine derivatives
piperidine
benzisoxazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69106388T
Other languages
English (en)
Other versions
DE69106388D1 (de
Inventor
Harry Howard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69106388D1 publication Critical patent/DE69106388D1/de
Application granted granted Critical
Publication of DE69106388T2 publication Critical patent/DE69106388T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69106388T 1990-11-14 1991-08-16 Antipsychotische 4-(1,2-benzisoazolyl)piperidinderivate. Expired - Fee Related DE69106388T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/612,776 US5147881A (en) 1990-11-14 1990-11-14 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
PCT/US1991/005593 WO1992008718A1 (en) 1990-11-14 1991-08-16 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents

Publications (2)

Publication Number Publication Date
DE69106388D1 DE69106388D1 (de) 1995-02-09
DE69106388T2 true DE69106388T2 (de) 1995-05-04

Family

ID=24454621

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69106388T Expired - Fee Related DE69106388T2 (de) 1990-11-14 1991-08-16 Antipsychotische 4-(1,2-benzisoazolyl)piperidinderivate.

Country Status (10)

Country Link
US (3) US5147881A (de)
EP (1) EP0557289B1 (de)
JP (1) JPH05507281A (de)
AT (1) ATE116316T1 (de)
CA (1) CA2094246A1 (de)
DE (1) DE69106388T2 (de)
FI (1) FI932173A (de)
IE (1) IE913940A1 (de)
PT (1) PT99482A (de)
WO (1) WO1992008718A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
CA2129995C (en) * 1992-02-13 2000-04-11 Albert A. Carr Piperidinyl thiacyclic derivatives
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
JP3462501B2 (ja) * 1992-11-23 2003-11-05 アベンティス・ファーマスーティカルズ・インコーポレイテツド 置換された３−（アミノアルキルアミノ）−１，２−ベンゾイソキサゾールおよび関連化合物
DK60493D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
FR2761067B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
EE200200134A (et) * 1999-09-14 2003-04-15 Aventis Pharmaceuticals Inc. D4 retseptori antagonistidena toimivad bensisoksasolüül-, püridoisoksasolüül- ja benstienüülfenoksüderivaadid
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
BR0314393A (pt) * 2002-09-17 2005-07-19 Warner Lambert Co Piperazinas heterocìclicas substituìdas para o tratamento de esquizofrenia
EP1736474A4 (de) * 2004-04-07 2010-04-21 Kyowa Hakko Kirin Co Ltd Piperidinderivat
KR101457339B1 (ko) * 2008-07-28 2014-11-03 지앙쑤 구오후아 인베스트먼트 컴퍼니 리미티드 아랄킬 치환된 피페리딘 또는 피페라진 유도체 및 정신분열증 치료를 위한 이의 용도
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
JP5714152B2 (ja) * 2014-03-26 2015-05-07 江蘇恒誼薬業有限公司 アラルキルピペリジン（又はピペラジン）誘導体及びその統合失調症治療のための使用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS5846079A (ja) * 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
FR2536749A1 (fr) * 1982-11-25 1984-06-01 Cerm Cent Europ Rech Mauvernay (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB2176474A (en) * 1985-06-15 1986-12-31 Tanabe Seiyaku Co Thiazolidine derivatives
GB8531666D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2621588B1 (fr) * 1987-10-08 1991-05-24 Roussel Uclaf Nouveaux derives de la 1,1-dioxo 1,2-benzoisothiazol 3-one, leur procede de preparation et leur application comme medicaments
GB8726763D0 (en) * 1987-11-16 1987-12-23 Fujisawa Pharmaceutical Co Thiazole compounds
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5034392A (en) * 1990-04-16 1991-07-23 Hoechst-Roussel Pharmaceuticals Incorporated 4-(3-(4-oxothiazolidinyl)butynylamines

Also Published As

Publication number Publication date
WO1992008718A1 (en) 1992-05-29
EP0557289A1 (de) 1993-09-01
FI932173A0 (fi) 1993-05-13
US5147881A (en) 1992-09-15
US5385916A (en) 1995-01-31
DE69106388D1 (de) 1995-02-09
PT99482A (pt) 1992-09-30
US5276040A (en) 1994-01-04
EP0557289B1 (de) 1994-12-28
ATE116316T1 (de) 1995-01-15
JPH05507281A (ja) 1993-10-21
IE913940A1 (en) 1992-05-20
FI932173A (fi) 1993-05-13
CA2094246A1 (en) 1992-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee