FI913142A - Migraenfoerhindrande alkoxipyrimidinderivat. - Google Patents

Migraenfoerhindrande alkoxipyrimidinderivat. Download PDF

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Publication number
FI913142A
FI913142A FI913142A FI913142A FI913142A FI 913142 A FI913142 A FI 913142A FI 913142 A FI913142 A FI 913142A FI 913142 A FI913142 A FI 913142A FI 913142 A FI913142 A FI 913142A
Authority
FI
Finland
Prior art keywords
migraenfoerhindrande
alkoxipyrimidinderivat
indolylalkyl
piperazines
pyrimidinyl
Prior art date
Application number
FI913142A
Other languages
English (en)
Other versions
FI913142A0 (fi
FI101224B1 (fi
FI101224B (fi
Inventor
David W Smith
Frank D Yocca
Joseph P Yevich
Ronald J Mattson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FI913142A0 publication Critical patent/FI913142A0/fi
Publication of FI913142A publication Critical patent/FI913142A/fi
Application granted granted Critical
Publication of FI101224B1 publication Critical patent/FI101224B1/fi
Publication of FI101224B publication Critical patent/FI101224B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI913142A 1990-06-29 1991-06-27 Menetelmä terapeuttisesti käyttökelpoisten alkoksipyrimidiinijohdannai sten valmistamiseksi FI101224B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US54612290A 1990-06-29 1990-06-29
US54612290 1990-06-29
US68020891A 1991-04-04 1991-04-04
US68020891 1991-04-04
SG15595A SG15595G (en) 1990-06-29 1995-01-30 Antimigraine alkoxypyrimidine derivatives
SG15595 1995-01-30

Publications (4)

Publication Number Publication Date
FI913142A0 FI913142A0 (fi) 1991-06-27
FI913142A true FI913142A (fi) 1991-12-30
FI101224B1 FI101224B1 (fi) 1998-05-15
FI101224B FI101224B (fi) 1998-05-15

Family

ID=27356028

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913142A FI101224B (fi) 1990-06-29 1991-06-27 Menetelmä terapeuttisesti käyttökelpoisten alkoksipyrimidiinijohdannai sten valmistamiseksi

Country Status (15)

Country Link
US (1) US5300506A (fi)
EP (1) EP0464558B1 (fi)
JP (1) JPH04230378A (fi)
AT (1) ATE116312T1 (fi)
AU (1) AU643038B2 (fi)
CA (1) CA2043709C (fi)
CY (1) CY1831A (fi)
DE (1) DE69106237T2 (fi)
DK (1) DK0464558T3 (fi)
ES (1) ES2066278T3 (fi)
FI (1) FI101224B (fi)
HK (1) HK51995A (fi)
IE (1) IE66687B1 (fi)
PT (1) PT98115B (fi)
SG (1) SG15595G (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226610D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
CA2130078A1 (en) * 1993-09-16 1995-03-17 Jonas A. Gylys Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5521188A (en) * 1993-09-16 1996-05-28 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
US5550239A (en) * 1994-11-08 1996-08-27 Bristol-Myers Squibb Company Process for large-scale production of indolyl alkyl pyrimidinyl piperazine compounds
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
WO1997000244A1 (en) * 1995-06-19 1997-01-03 Eli Lilly And Company Process for parallel synthesis of a non-peptide library
US5889008A (en) * 1995-08-07 1999-03-30 Merck Sharp & Dohme, Ltd. Substituted 1-indolylpropyl-4-phenethylpiperazadine derivatives
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
WO2002079153A1 (en) * 2001-03-28 2002-10-10 Biocatalytics, Inc. Method for producing tryptamine derivatives
US6800637B2 (en) 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
JP2009515834A (ja) * 2006-08-29 2009-04-16 テバ ファーマシューティカル インダストリーズ リミティド ５−フェニル−１−トリチル−１ｈ−テトラゾールの合成のための方法
EP2036888A1 (en) * 2007-09-17 2009-03-18 Laboratorios del Dr. Esteve S.A. Naphthyl-substituted sulfonamides
MX2010009920A (es) * 2008-03-14 2010-09-30 Merck Patent Gmbh Compuestos de azaindol para tratamiento de trastornos del sistema nervioso central.
US20090281114A1 (en) * 2008-05-08 2009-11-12 Fabre-Kramer Pharmaceuticals, Inc. Indolylalkyl derivatives of pyrimidinylpiperazine and metabolites thereof for treatment of anxiety, depression, and sexual dysfunction
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (fi) * 1959-09-25 1900-01-01
GB1189064A (en) * 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
NL7103002A (fi) * 1970-03-06 1971-09-08
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines

Also Published As

Publication number Publication date
CA2043709C (en) 2002-01-22
EP0464558B1 (en) 1994-12-28
AU643038B2 (en) 1993-11-04
CY1831A (en) 1995-12-01
HK51995A (en) 1995-04-13
US5300506A (en) 1994-04-05
PT98115A (pt) 1992-03-31
ES2066278T3 (es) 1995-03-01
DE69106237T2 (de) 1995-05-11
ATE116312T1 (de) 1995-01-15
IE912280A1 (en) 1992-01-01
DK0464558T3 (da) 1995-03-13
FI913142A0 (fi) 1991-06-27
FI101224B1 (fi) 1998-05-15
CA2043709A1 (en) 1991-12-30
FI101224B (fi) 1998-05-15
PT98115B (pt) 1998-12-31
JPH04230378A (ja) 1992-08-19
EP0464558A1 (en) 1992-01-08
IE66687B1 (en) 1996-01-24
SG15595G (en) 1995-06-16
AU7941691A (en) 1992-01-02
DE69106237D1 (de) 1995-02-09

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