ES8801822A1 - Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos - Google Patents
Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidosInfo
- Publication number
- ES8801822A1 ES8801822A1 ES557390A ES557390A ES8801822A1 ES 8801822 A1 ES8801822 A1 ES 8801822A1 ES 557390 A ES557390 A ES 557390A ES 557390 A ES557390 A ES 557390A ES 8801822 A1 ES8801822 A1 ES 8801822A1
- Authority
- ES
- Spain
- Prior art keywords
- cyclic imide
- butylpiperazin
- pyridines
- compositions
- imide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIPERAZINA 1,4-DISUSTITUIDOS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UN AGENTE RECEPTOR DE ACIDO, A TEMPERATURA ELEVADA, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE R1, R2 Y Z PUEDEN SER VARIOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIPSICOTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/691,952 US4619930A (en) | 1985-01-16 | 1985-01-16 | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8801822A1 true ES8801822A1 (es) | 1988-02-16 |
ES557390A0 ES557390A0 (es) | 1988-02-16 |
Family
ID=24778661
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES550829A Expired ES8705869A1 (es) | 1985-01-16 | 1986-01-13 | Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos. |
ES557390A Expired ES8801822A1 (es) | 1985-01-16 | 1987-02-13 | Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES550829A Expired ES8705869A1 (es) | 1985-01-16 | 1986-01-13 | Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos. |
Country Status (29)
Country | Link |
---|---|
US (1) | US4619930A (es) |
JP (1) | JPH0780873B2 (es) |
KR (1) | KR900000366B1 (es) |
CN (1) | CN1016691B (es) |
AT (1) | AT391698B (es) |
AU (1) | AU591473B2 (es) |
BE (1) | BE904047A (es) |
CA (1) | CA1284325C (es) |
CH (1) | CH666269A5 (es) |
DE (1) | DE3601143C2 (es) |
DK (1) | DK19286A (es) |
EG (1) | EG17759A (es) |
ES (2) | ES8705869A1 (es) |
FI (1) | FI90077C (es) |
FR (1) | FR2580282B1 (es) |
GB (1) | GB2191772B (es) |
HU (1) | HU198202B (es) |
IE (1) | IE58866B1 (es) |
IL (1) | IL77577A (es) |
IT (1) | IT1214497B (es) |
LU (1) | LU86248A1 (es) |
NL (1) | NL8600071A (es) |
NZ (1) | NZ214790A (es) |
OA (1) | OA08187A (es) |
PT (1) | PT81843B (es) |
SE (1) | SE466310B (es) |
SU (1) | SU1521282A3 (es) |
YU (1) | YU45757B (es) |
ZA (1) | ZA859692B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4677104A (en) * | 1985-05-06 | 1987-06-30 | Bristol-Myers Company | Antipsychotic fused-ring pyridinylpiperazine derivatives |
US4812567A (en) * | 1985-10-16 | 1989-03-14 | American Home Products Corporation | Polycyclic spiroimides with psychotropic activity |
MX174210B (es) * | 1987-02-17 | 1994-04-28 | Pfizer | Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos |
US4748240A (en) * | 1987-04-03 | 1988-05-31 | American Home Products Corporation | Psychotropic bicyclic imides |
EP0316723B1 (en) * | 1987-11-20 | 1992-09-30 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments |
US4880930A (en) * | 1987-11-30 | 1989-11-14 | New James S | Psychotropic acyclic amide derivatives |
US5001130A (en) * | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
US5116970A (en) * | 1988-02-18 | 1992-05-26 | New James S | Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones |
DK0482696T3 (da) * | 1990-10-23 | 1996-05-20 | Akzo Nobel Nv | 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
CN104230915B (zh) * | 2014-08-29 | 2016-08-17 | 南京大学 | 含噻唑烷二酮的苯基哌嗪衍生物及其制备方法与用途 |
CN104513198A (zh) * | 2014-11-29 | 2015-04-15 | 南京红太阳生物化学有限责任公司 | 一种2-氯烟酸的合成方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
US3976776A (en) * | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
AT330777B (de) * | 1973-09-08 | 1976-07-26 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen |
US4305944A (en) * | 1980-09-08 | 1981-12-15 | Mead Johnson & Company | N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones |
US4456756A (en) * | 1981-08-03 | 1984-06-26 | Mead Johnson & Company | Spirothiazolidinyl piperazine derivatives |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
DE3135532A1 (de) * | 1981-09-08 | 1983-03-24 | NPL po Dvigateli s Vatrešno Gorene, Varna | Brennkraftmaschine |
US4361565A (en) * | 1981-12-28 | 1982-11-30 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines |
JPS5976059A (ja) * | 1982-10-21 | 1984-04-28 | Sumitomo Chem Co Ltd | 環状イミド誘導体及びその酸付加塩 |
JPS61238784A (ja) * | 1985-04-17 | 1986-10-24 | Sumitomo Seiyaku Kk | コハク酸イミド誘導体及びその酸付加塩 |
DE3529872A1 (de) * | 1985-08-21 | 1987-02-26 | Kali Chemie Pharma Gmbh | Neue tetraoxoverbindungen |
-
1985
- 1985-01-16 US US06/691,952 patent/US4619930A/en not_active Expired - Lifetime
- 1985-12-19 ZA ZA859692A patent/ZA859692B/xx unknown
- 1985-12-31 FR FR8519488A patent/FR2580282B1/fr not_active Expired - Lifetime
-
1986
- 1986-01-10 NZ NZ214790A patent/NZ214790A/xx unknown
- 1986-01-10 CA CA000499331A patent/CA1284325C/en not_active Expired - Fee Related
- 1986-01-13 FI FI860136A patent/FI90077C/fi not_active IP Right Cessation
- 1986-01-13 ES ES550829A patent/ES8705869A1/es not_active Expired
- 1986-01-13 YU YU4186A patent/YU45757B/sh unknown
- 1986-01-13 IL IL77577A patent/IL77577A/xx not_active IP Right Cessation
- 1986-01-14 JP JP61006146A patent/JPH0780873B2/ja not_active Expired - Lifetime
- 1986-01-15 IT IT8619081A patent/IT1214497B/it active
- 1986-01-15 NL NL8600071A patent/NL8600071A/nl active Search and Examination
- 1986-01-15 SU SU864011790A patent/SU1521282A3/ru active
- 1986-01-15 HU HU86207A patent/HU198202B/hu unknown
- 1986-01-15 LU LU86248A patent/LU86248A1/fr unknown
- 1986-01-15 KR KR1019860000203A patent/KR900000366B1/ko not_active IP Right Cessation
- 1986-01-15 IE IE12586A patent/IE58866B1/en not_active IP Right Cessation
- 1986-01-15 DK DK19286A patent/DK19286A/da not_active Application Discontinuation
- 1986-01-15 CH CH130/86A patent/CH666269A5/de not_active IP Right Cessation
- 1986-01-15 SE SE8600173A patent/SE466310B/sv not_active IP Right Cessation
- 1986-01-15 CN CN86100224A patent/CN1016691B/zh not_active Expired
- 1986-01-15 PT PT81843A patent/PT81843B/pt unknown
- 1986-01-15 OA OA58765A patent/OA08187A/xx unknown
- 1986-01-15 BE BE0/216140A patent/BE904047A/fr not_active IP Right Cessation
- 1986-01-16 EG EG20/86A patent/EG17759A/xx active
- 1986-01-16 DE DE3601143A patent/DE3601143C2/de not_active Expired - Lifetime
- 1986-01-16 AU AU52294/86A patent/AU591473B2/en not_active Expired
- 1986-01-16 AT AT0010086A patent/AT391698B/de not_active IP Right Cessation
- 1986-06-17 GB GB8614686A patent/GB2191772B/en not_active Expired - Lifetime
-
1987
- 1987-02-13 ES ES557390A patent/ES8801822A1/es not_active Expired
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20051124 |