ES8802614A1 - Un procedimiento para la preparacion de derivados de piperazinilo 1,4 disustituidos - Google Patents

Un procedimiento para la preparacion de derivados de piperazinilo 1,4 disustituidos

Info

Publication number
ES8802614A1
ES8802614A1 ES557809A ES557809A ES8802614A1 ES 8802614 A1 ES8802614 A1 ES 8802614A1 ES 557809 A ES557809 A ES 557809A ES 557809 A ES557809 A ES 557809A ES 8802614 A1 ES8802614 A1 ES 8802614A1
Authority
ES
Spain
Prior art keywords
furo
substituent
piperazinyl
derivatives
antipsychotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557809A
Other languages
English (en)
Other versions
ES557809A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8802614A1 publication Critical patent/ES8802614A1/es
Publication of ES557809A0 publication Critical patent/ES557809A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS DERIVADOS DE PIPERAZINILO 1,4-DISUSTITUIDOS (I) Y SUS SALES DE ADICION, DONDE NO EXCLUSIVAMENTE Z ES UN RADICAL TIPO GLUTARIMIDA (II) Y R3 Y R4 ALQUILO INFERIOR O JUNTOS UN RADICAL TIPO MALEIDIMIDA (III), CON R5 Y R6 ALQUILO INFERIOR O FENILO Y W AZUFRE O CH2; N VA DE 2 A 4; X E Y SON CH2, OXIGENO O AZUFRE Y R1 Y R2 HIDROGENO O ALQUILO INFERIOR; SE OBTIENEN HACIENDO REACCIONAR UN HETEROCICLO CON OXIGENO, O O, DEL TIPO (II) O (III) CON EL N SUSTITUIDO POR O, CON UN COMPUESTO DE FORMULA (IV), EN DISOLVENTE SECO Y CON ELIMINACION DE AGUA. PRESENTAN UNA ACTIVIDAD ANTIPSICOTICA (NEUROLEPTICA) SIN EFECTOS SECUNDARIOS EN CUANTO A DESORDENES DE MOVIMIENTO. *FORMULA*
ES557809A 1985-05-06 1988-01-28 Un procedimiento para la preparacion de derivados de piperazinilo 1,4 disustituidos Expired ES8802614A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73120185A 1985-05-06 1985-05-06

Publications (2)

Publication Number Publication Date
ES8802614A1 true ES8802614A1 (es) 1988-09-01
ES557809A0 ES557809A0 (es) 1988-09-01

Family

ID=24938510

Family Applications (6)

Application Number Title Priority Date Filing Date
ES554659A Expired ES8801250A1 (es) 1985-05-06 1986-05-05 Un procedimiento para la preparacion de derivados de piperazimilo 1,4-di sustituidos.
ES557757A Expired ES8802149A1 (es) 1985-05-06 1987-09-25 Un procedimiento para la preparacion de derivados de piperazinilo 1,4-disustituidos
ES557809A Expired ES8802614A1 (es) 1985-05-06 1988-01-28 Un procedimiento para la preparacion de derivados de piperazinilo 1,4 disustituidos
ES557839A Expired ES8900138A1 (es) 1985-05-06 1988-05-26 Un procedimiento para la preparacion de derivados de piperazinilo 1-4-disustituidos.
ES557855A Expired ES8900253A1 (es) 1985-05-06 1988-11-16 Un procedimiento para la preparacion de derivados de piperazinilo 1,4disustituidos
ES557865A Expired ES9000005A1 (es) 1985-05-06 1989-02-27 Un procedimiento para la preparacion de derivados de piperazinilo 1,4-disustituidos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES554659A Expired ES8801250A1 (es) 1985-05-06 1986-05-05 Un procedimiento para la preparacion de derivados de piperazimilo 1,4-di sustituidos.
ES557757A Expired ES8802149A1 (es) 1985-05-06 1987-09-25 Un procedimiento para la preparacion de derivados de piperazinilo 1,4-disustituidos

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES557839A Expired ES8900138A1 (es) 1985-05-06 1988-05-26 Un procedimiento para la preparacion de derivados de piperazinilo 1-4-disustituidos.
ES557855A Expired ES8900253A1 (es) 1985-05-06 1988-11-16 Un procedimiento para la preparacion de derivados de piperazinilo 1,4disustituidos
ES557865A Expired ES9000005A1 (es) 1985-05-06 1989-02-27 Un procedimiento para la preparacion de derivados de piperazinilo 1,4-disustituidos

Country Status (25)

Country Link
JP (1) JPH0753728B2 (es)
KR (1) KR940000829B1 (es)
CN (1) CN1017901B (es)
AT (1) AT398572B (es)
AU (1) AU593244B2 (es)
BE (1) BE904724A (es)
CA (1) CA1278792C (es)
CH (1) CH672787A5 (es)
DE (1) DE3615180C2 (es)
DK (1) DK165745C (es)
EG (1) EG18206A (es)
ES (6) ES8801250A1 (es)
FI (1) FI85484C (es)
FR (1) FR2581385B1 (es)
GB (1) GB2174703B (es)
GR (1) GR861149B (es)
HU (1) HU195509B (es)
IE (1) IE59201B1 (es)
IT (1) IT1208607B (es)
LU (1) LU86421A1 (es)
MY (1) MY100777A (es)
NL (1) NL8601146A (es)
PT (1) PT82523B (es)
SE (1) SE465270B (es)
ZA (1) ZA862046B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) * 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
IE903410A1 (en) * 1989-10-09 1991-04-10 Novo Nordisk As Indole derivatives, their preparation and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
ATE187172T1 (de) * 1995-09-15 1999-12-15 Sanofi Synthelabo Chinolin-2-on derivate als serotonin antagonisten
FR2738824B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1 -yl)alkyl)-3,4-dihydroquinazolin-2(1h)-one,leur preparation et leur application en therapeutique
FR2738822B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
FR2761071B1 (fr) * 1997-03-20 1999-12-03 Synthelabo Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Also Published As

Publication number Publication date
DE3615180C2 (de) 1996-03-07
FI85484B (fi) 1992-01-15
FI85484C (fi) 1992-04-27
ZA862046B (en) 1986-11-26
ES8900253A1 (es) 1989-05-16
AU5679586A (en) 1986-11-13
SE465270B (sv) 1991-08-19
GB2174703B (en) 1988-10-26
AU593244B2 (en) 1990-02-08
CA1278792C (en) 1991-01-08
CN1017901B (zh) 1992-08-19
LU86421A1 (fr) 1986-12-05
KR860009008A (ko) 1986-12-19
DK207186A (da) 1986-11-07
ES8801250A1 (es) 1987-12-16
JPH0753728B2 (ja) 1995-06-07
FR2581385B1 (fr) 1991-10-04
KR940000829B1 (ko) 1994-02-02
NL8601146A (nl) 1986-12-01
IT1208607B (it) 1989-07-10
ES557839A0 (es) 1989-01-16
DK165745C (da) 1993-06-14
ES557757A0 (es) 1988-04-01
FI861820A0 (fi) 1986-04-30
DK165745B (da) 1993-01-11
SE8602061D0 (sv) 1986-05-05
IE861193L (en) 1986-11-06
SE8602061L (sv) 1986-11-07
IE59201B1 (en) 1994-01-26
CH672787A5 (es) 1989-12-29
ES8802149A1 (es) 1988-04-01
GB8610810D0 (en) 1986-06-11
AT398572B (de) 1994-12-27
ES554659A0 (es) 1987-12-16
ES9000005A1 (es) 1989-11-01
PT82523B (pt) 1988-10-14
ES8900138A1 (es) 1989-01-16
DE3615180A1 (de) 1986-11-06
GR861149B (en) 1986-09-09
MY100777A (en) 1991-02-14
EG18206A (en) 1992-09-30
IT8620313A0 (it) 1986-05-06
ES557855A0 (es) 1989-05-16
FI861820A (fi) 1986-11-07
CN86103071A (zh) 1987-03-18
HUT43848A (en) 1987-12-28
HU195509B (en) 1988-05-30
JPS61268681A (ja) 1986-11-28
GB2174703A (en) 1986-11-12
ES557809A0 (es) 1988-09-01
BE904724A (fr) 1986-11-05
FR2581385A1 (fr) 1986-11-07
PT82523A (en) 1986-06-01
ATA121486A (de) 1994-05-15
DK207186D0 (da) 1986-05-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060616