FR2738822B1 - Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique - Google Patents

Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique

Info

Publication number
FR2738822B1
FR2738822B1 FR9510815A FR9510815A FR2738822B1 FR 2738822 B1 FR2738822 B1 FR 2738822B1 FR 9510815 A FR9510815 A FR 9510815A FR 9510815 A FR9510815 A FR 9510815A FR 2738822 B1 FR2738822 B1 FR 2738822B1
Authority
FR
France
Prior art keywords
quinolein
thieno
piperazin
pyridin
omega
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9510815A
Other languages
English (en)
Other versions
FR2738822A1 (fr
Inventor
Gary Mccort
Christian Hoornaert
Genevieve Dellac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9510815A priority Critical patent/FR2738822B1/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to RU98106501/04A priority patent/RU2167874C2/ru
Priority to PCT/FR1996/001401 priority patent/WO1997010238A1/fr
Priority to CN96198333A priority patent/CN1094490C/zh
Priority to KR10-1998-0701920A priority patent/KR100422850B1/ko
Priority to ES96931112T priority patent/ES2142089T3/es
Priority to PL96325467A priority patent/PL184808B1/pl
Priority to ARP960104322A priority patent/AR003996A1/es
Priority to CO96048698A priority patent/CO4750663A1/es
Priority to JP51170797A priority patent/JP3335362B2/ja
Priority to TR1998/00464T priority patent/TR199800464T1/xx
Priority to HU9802940A priority patent/HU222745B1/hu
Priority to SI9630151T priority patent/SI0850235T1/xx
Priority to EP96931112A priority patent/EP0850235B1/fr
Priority to AU69919/96A priority patent/AU715879B2/en
Priority to TW085111123A priority patent/TW449592B/zh
Priority to EE9800089A priority patent/EE04116B1/xx
Priority to CA002228038A priority patent/CA2228038C/fr
Priority to BR9610579A priority patent/BR9610579A/pt
Priority to CZ1998786A priority patent/CZ288149B6/cs
Priority to NZ318436A priority patent/NZ318436A/xx
Priority to UA98031235A priority patent/UA44332C2/uk
Priority to DK96931112T priority patent/DK0850235T3/da
Priority to AT96931112T priority patent/ATE187172T1/de
Priority to IL12360096A priority patent/IL123600A/en
Priority to SK346-98A priority patent/SK282222B6/sk
Priority to DE69605430T priority patent/DE69605430T2/de
Priority to US09/011,482 priority patent/US5958924A/en
Priority to ZA967769A priority patent/ZA967769B/xx
Publication of FR2738822A1 publication Critical patent/FR2738822A1/fr
Publication of FR2738822B1 publication Critical patent/FR2738822B1/fr
Application granted granted Critical
Priority to BG102316A priority patent/BG63779B1/bg
Priority to NO19981141A priority patent/NO323841B1/no
Priority to MXPA/A/1998/002028A priority patent/MXPA98002028A/xx
Priority to HK98119241A priority patent/HK1014868A1/xx
Priority to GR20000400317T priority patent/GR3032618T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9510815A 1995-09-15 1995-09-15 Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique Expired - Fee Related FR2738822B1 (fr)

Priority Applications (34)

Application Number Priority Date Filing Date Title
FR9510815A FR2738822B1 (fr) 1995-09-15 1995-09-15 Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
NZ318436A NZ318436A (en) 1995-09-15 1996-09-12 Quinolein-2(1h)-one derivatives substituted with a 4-(thieno[3,2-c]pyridin-4-yl)piperazine-1-yl or 4-(4-fluorobenzoyl)piperidin-1-yl group as serotonin antagonists
CN96198333A CN1094490C (zh) 1995-09-15 1996-09-12 作为血清素拮抗剂的喹诺－2(1h)－酮衍生物
KR10-1998-0701920A KR100422850B1 (ko) 1995-09-15 1996-09-12 세로토닌길항제로서의2(1h)-퀴놀론유도체
ES96931112T ES2142089T3 (es) 1995-09-15 1996-09-12 Derivados de quinolein-2(1h)-ona, su preparacion y su aplicacion en terapeutica.
PL96325467A PL184808B1 (pl) 1995-09-15 1996-09-12 Pochodne 2(1H)-chinolonu, sposób ich otrzymywania oraz ich zastosowanie terapeutyczne
ARP960104322A AR003996A1 (es) 1995-09-15 1996-09-12 Compuestos derivados de quinolein-2 (1h)-ona, procedimiento de preparacion de dichos compuestos y medicamento y composicion farmaceutica que los contienen.
CO96048698A CO4750663A1 (es) 1995-09-15 1996-09-12 Derivados de quinolein-2 (1h)-ona, su preparacion y su aplicacion en terapeutica
CZ1998786A CZ288149B6 (en) 1995-09-15 1996-09-12 Derivatives of 2(1H)-quinolone, process of their preparation and pharmaceutical preparation in which they are comprised
TR1998/00464T TR199800464T1 (xx) 1995-09-15 1996-09-12 Serotonin antagonistleri olarak kinolein-2(1H)-on t�revleri
HU9802940A HU222745B1 (hu) 1995-09-15 1996-09-12 Kinolin-2(1H)-on-származékok mint szerotonin antagonisták, elżállításuk és alkalmazásuk
SI9630151T SI0850235T1 (en) 1995-09-15 1996-09-12 Quinolein-2(1h)-one derivatives as serotonin antagonists
EP96931112A EP0850235B1 (fr) 1995-09-15 1996-09-12 Derives de quinolein-2(1h)-one comme antagonistes de la serotonine
PCT/FR1996/001401 WO1997010238A1 (fr) 1995-09-15 1996-09-12 Derives de quinolein-2(1h)-one comme antagonistes de la serotonine
TW085111123A TW449592B (en) 1995-09-15 1996-09-12 2-(1H)-Quinolone derivatives, their preparation and their use in therapy
EE9800089A EE04116B1 (et) 1995-09-15 1996-09-12 Kinolin-2(1H)-ooni derivaadid kui serotoniini antagonistid
CA002228038A CA2228038C (fr) 1995-09-15 1996-09-12 Derives de quinolein-2(1h)-one comme antagonistes de la serotonine
BR9610579A BR9610579A (pt) 1995-09-15 1996-09-12 Derivados de quinolein-2(1H)-ona como antagonistas da serotonina
RU98106501/04A RU2167874C2 (ru) 1995-09-15 1996-09-12 Производные хинолин-2(1н)-она, способы их получения, лекарственное средство и фармацевтическая композиция на их основе
JP51170797A JP3335362B2 (ja) 1995-09-15 1996-09-12 キノレイン−２（１ｈ）−オン誘導体セロトニンアンタゴニスト
DE69605430T DE69605430T2 (de) 1995-09-15 1996-09-12 Chinolin-2-on derivate als serotonin antagonisten
DK96931112T DK0850235T3 (da) 1995-09-15 1996-09-12 Derivater af quinolin-2(1H)-on som serotoninantagonister
AT96931112T ATE187172T1 (de) 1995-09-15 1996-09-12 Chinolin-2-on derivate als serotonin antagonisten
IL12360096A IL123600A (en) 1995-09-15 1996-09-12 History of quinolone - 2 (1H), their preparation and pharmaceutical preparations containing them
SK346-98A SK282222B6 (sk) 1995-09-15 1996-09-12 Deriváty 2(1h)-chinolónu, spôsob ich prípravy a ich použitie ako liečiv
UA98031235A UA44332C2 (uk) 1995-09-15 1996-09-12 Похідні 2(1h)-хінолінону як антагоністи серотоніну, спосіб їх одержання (варіанти), медичний препарат та фармацевтична композиція на їх основі
US09/011,482 US5958924A (en) 1995-09-15 1996-09-12 Quinolein-2 (1H)-one derivatives as serotonin antagonists
AU69919/96A AU715879B2 (en) 1995-09-15 1996-09-12 2(1H)-quinolone derivatives as serotonin antagonists
ZA967769A ZA967769B (en) 1995-09-15 1996-09-13 2(1H)-quinolone derivatives their preparation and their use in therapy
BG102316A BG63779B1 (bg) 1995-09-15 1998-03-11 Производни на хинолин-2(1н)-он, антагонисти на серотонина
NO19981141A NO323841B1 (no) 1995-09-15 1998-03-13 Kinolon-2(1H)-on derivater, fremgangsmate for deres fremstilling, medisinsk produkt samt farmasoytisk preparat.
MXPA/A/1998/002028A MXPA98002028A (en) 1995-09-15 1998-03-13 Quinolein-2 (1h) -ona derivatives as seroton antagonists
HK98119241A HK1014868A1 (en) 1995-09-15 1998-12-30 Quinolein-2(1h)-one derivatives as serotonin antagonists
GR20000400317T GR3032618T3 (en) 1995-09-15 2000-02-09 Quinolein-2(1h)-one derivatives as serotonin antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9510815A FR2738822B1 (fr) 1995-09-15 1995-09-15 Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2738822A1 FR2738822A1 (fr) 1997-03-21
FR2738822B1 true FR2738822B1 (fr) 1997-10-31

Family

ID=9482571

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9510815A Expired - Fee Related FR2738822B1 (fr) 1995-09-15 1995-09-15 Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique

Country Status (3)

Country Link
FR (1) FR2738822B1 (fr)
TW (1) TW449592B (fr)
ZA (1) ZA967769B (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1278792C (fr) * 1985-05-06 1991-01-08 Joseph P. Yevich Derives antipsychotiques de pyridinylpiperazine a anneaux condenses

Also Published As

Publication number Publication date
TW449592B (en) 2001-08-11
FR2738822A1 (fr) 1997-03-21
ZA967769B (en) 1997-04-07

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