FR2790472B1 - Derives de cyclobutene-3, 4-dione, leur preparation et leur application en therapeutique - Google Patents

Derives de cyclobutene-3, 4-dione, leur preparation et leur application en therapeutique

Info

Publication number
FR2790472B1
FR2790472B1 FR9902679A FR9902679A FR2790472B1 FR 2790472 B1 FR2790472 B1 FR 2790472B1 FR 9902679 A FR9902679 A FR 9902679A FR 9902679 A FR9902679 A FR 9902679A FR 2790472 B1 FR2790472 B1 FR 2790472B1
Authority
FR
France
Prior art keywords
cyclobutene
dione
derivatives
preparation
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9902679A
Other languages
English (en)
Other versions
FR2790472A1 (fr
Inventor
Philippe R Bovy
Christophe Philippo
Gilbert Marciniak
Gerard Defosse
Dorsselaer Viviane Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR9902679A priority Critical patent/FR2790472B1/fr
Priority to PCT/FR2000/000503 priority patent/WO2000051973A1/fr
Priority to AU29227/00A priority patent/AU2922700A/en
Priority to ARP000100922A priority patent/AR022809A1/es
Priority to CO00015525A priority patent/CO5160254A1/es
Priority to PE2000000185A priority patent/PE20001494A1/es
Publication of FR2790472A1 publication Critical patent/FR2790472A1/fr
Application granted granted Critical
Publication of FR2790472B1 publication Critical patent/FR2790472B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR9902679A 1999-03-04 1999-03-04 Derives de cyclobutene-3, 4-dione, leur preparation et leur application en therapeutique Expired - Fee Related FR2790472B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR9902679A FR2790472B1 (fr) 1999-03-04 1999-03-04 Derives de cyclobutene-3, 4-dione, leur preparation et leur application en therapeutique
PCT/FR2000/000503 WO2000051973A1 (fr) 1999-03-04 2000-03-01 Derives de cyclobutene-3,4-dione leur preparation et leur application en therapeutique
AU29227/00A AU2922700A (en) 1999-03-04 2000-03-01 Cyclobutene-3,4-dione derivatives, preparation method and therapeutic use
ARP000100922A AR022809A1 (es) 1999-03-04 2000-03-02 Derivados de ciclobuten-3,4-diona, su preparacion y su aplicacion en terapeutica
CO00015525A CO5160254A1 (es) 1999-03-04 2000-03-03 Derivados de ciclobuten-3,4-diona, su preparacion y su aplicacion en terapeutica
PE2000000185A PE20001494A1 (es) 1999-03-04 2000-03-03 Derivados de ciclobuten-3,4-diona su preparacion y su aplicacion en terapeutica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9902679A FR2790472B1 (fr) 1999-03-04 1999-03-04 Derives de cyclobutene-3, 4-dione, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2790472A1 FR2790472A1 (fr) 2000-09-08
FR2790472B1 true FR2790472B1 (fr) 2001-04-06

Family

ID=9542807

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9902679A Expired - Fee Related FR2790472B1 (fr) 1999-03-04 1999-03-04 Derives de cyclobutene-3, 4-dione, leur preparation et leur application en therapeutique

Country Status (6)

Country Link
AR (1) AR022809A1 (fr)
AU (1) AU2922700A (fr)
CO (1) CO5160254A1 (fr)
FR (1) FR2790472B1 (fr)
PE (1) PE20001494A1 (fr)
WO (1) WO2000051973A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548508B2 (en) 2000-10-20 2003-04-15 Pfizer, Inc. Use of PDE V inhibitors for improved fecundity in mammals
US6495576B2 (en) 2001-02-07 2002-12-17 Abbott Laboratories Aminal diones as potassium channel openers
AR068509A1 (es) * 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312210D0 (en) * 1993-06-14 1993-07-28 Smithkline Beecham Plc Chemical compounds

Also Published As

Publication number Publication date
CO5160254A1 (es) 2002-05-30
AR022809A1 (es) 2002-09-04
AU2922700A (en) 2000-09-21
PE20001494A1 (es) 2001-03-04
WO2000051973A1 (fr) 2000-09-08
FR2790472A1 (fr) 2000-09-08

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse