ES8504185A1 - Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina - Google Patents
Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazinaInfo
- Publication number
- ES8504185A1 ES8504185A1 ES526149A ES526149A ES8504185A1 ES 8504185 A1 ES8504185 A1 ES 8504185A1 ES 526149 A ES526149 A ES 526149A ES 526149 A ES526149 A ES 526149A ES 8504185 A1 ES8504185 A1 ES 8504185A1
- Authority
- ES
- Spain
- Prior art keywords
- spirothiazolidinyl
- piperazine derivatives
- selective
- nonan
- thiazolidinedione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO OARA LA PREPARACION DE DERIVADOS DE ESPIROTIAZOLIDINIL PIPERAZINA DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS NO TOXICAS Y FARMACEUTICAMENTE ACEPTABLES.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR 2-CLORO-3 CIANOPIRIDINA Y PIPERAZINA EN ALCOHOL, PARA OBTENER 1-(3-CIANO 2-PIRIDINIL)PIPERAZINA; SEGUNDA, SE HACE REACCIONAR LA PIPERAZINA OBTENIDA CON 3-(4-BROMOBUTIL)-5-ESPIROCICLOPENTIL-2,4-TIAZOLIDINDIONA, EN PRESENCIA DE UNA BASE Y DE UN DISOLVENTE INERTE; Y POR ULTIMO, SE CONVIERTE LA BASE LIBRE OBTENIDA EN UNA SAL DE HIDROCLORURO, DE FORMULA GENERAL (II).DE APLICACION EN EL TRATAMIENTO DE LA ANSIEDAD Y DE LA DEPRESION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/289,351 US4456756A (en) | 1981-08-03 | 1981-08-03 | Spirothiazolidinyl piperazine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES526149A0 ES526149A0 (es) | 1985-04-16 |
ES8504185A1 true ES8504185A1 (es) | 1985-04-16 |
Family
ID=23111156
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514263A Expired ES8401763A1 (es) | 1981-08-03 | 1982-07-23 | Un procedimiento para la preparacion de derivados de espiroti-azolidinil-piperazina. |
ES526149A Expired ES8504185A1 (es) | 1981-08-03 | 1983-09-30 | Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514263A Expired ES8401763A1 (es) | 1981-08-03 | 1982-07-23 | Un procedimiento para la preparacion de derivados de espiroti-azolidinil-piperazina. |
Country Status (28)
Country | Link |
---|---|
US (1) | US4456756A (es) |
JP (1) | JPS5838277A (es) |
KR (1) | KR880001737B1 (es) |
AT (1) | AT380477B (es) |
AU (1) | AU555870B2 (es) |
BE (1) | BE894021A (es) |
CA (1) | CA1208642A (es) |
CH (1) | CH655503B (es) |
DE (1) | DE3228992A1 (es) |
DK (1) | DK156219C (es) |
ES (2) | ES8401763A1 (es) |
FI (1) | FI76794C (es) |
FR (1) | FR2510571B1 (es) |
GB (1) | GB2105714B (es) |
GR (1) | GR76171B (es) |
HU (1) | HU191505B (es) |
IE (1) | IE53613B1 (es) |
IL (1) | IL66433A (es) |
IT (1) | IT1149026B (es) |
LU (1) | LU84315A1 (es) |
NL (1) | NL8203035A (es) |
NZ (1) | NZ201158A (es) |
OA (1) | OA07171A (es) |
PH (1) | PH18688A (es) |
PT (1) | PT75365B (es) |
SE (1) | SE453503B (es) |
YU (1) | YU44073B (es) |
ZA (1) | ZA825481B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61162278A (ja) * | 1985-01-09 | 1986-07-22 | Nippon Yakin Kogyo Co Ltd | 冷却手段を具えたロ−ラ−電極を含む自走式シ−ム溶接機 |
US4619930A (en) * | 1985-01-16 | 1986-10-28 | Bristol-Myers Company | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use |
US4677104A (en) * | 1985-05-06 | 1987-06-30 | Bristol-Myers Company | Antipsychotic fused-ring pyridinylpiperazine derivatives |
US4784998A (en) * | 1987-04-06 | 1988-11-15 | Bristol-Myers Company | 1,3,4-oxadiazole pyschotropic compounds |
US5801186A (en) * | 1987-11-20 | 1998-09-01 | Hoechst Marion Roussel, Inc. | 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds |
EP0316723B1 (en) * | 1987-11-20 | 1992-09-30 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments |
JPH0270878U (es) * | 1988-11-21 | 1990-05-30 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL125835C (es) * | 1960-05-24 | |||
US3106552A (en) * | 1960-07-19 | 1963-10-08 | Geschickter Fund Med Res | Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation |
US3200118A (en) * | 1961-10-31 | 1965-08-10 | Geschickter Fund Med Res | Spirocyclic hydrazine imides |
US3432499A (en) * | 1965-04-02 | 1969-03-11 | Geschickter Fund Med Res | Trifluoromethylazaspiranes and azaspirane diones |
US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
DE1695410A1 (de) * | 1967-04-20 | 1971-04-08 | Merck Patent Gmbh | Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen |
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
US3976776A (en) * | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
EP0002978B1 (fr) * | 1977-12-29 | 1982-10-06 | Synthelabo | Dérivés de thiazolidinedione-2,4, leur préparation et leur application en thérapeutique |
AU521110B2 (en) * | 1978-06-20 | 1982-03-18 | Synthelabo | Phenylpiperazine derivatives |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
-
1981
- 1981-08-03 US US06/289,351 patent/US4456756A/en not_active Expired - Fee Related
-
1982
- 1982-07-05 NZ NZ201158A patent/NZ201158A/en unknown
- 1982-07-13 AU AU85973/82A patent/AU555870B2/en not_active Ceased
- 1982-07-13 GR GR68740A patent/GR76171B/el unknown
- 1982-07-20 YU YU1585/82A patent/YU44073B/xx unknown
- 1982-07-23 ES ES514263A patent/ES8401763A1/es not_active Expired
- 1982-07-28 FR FR8213176A patent/FR2510571B1/fr not_active Expired
- 1982-07-28 IT IT48901/82A patent/IT1149026B/it active
- 1982-07-29 NL NL8203035A patent/NL8203035A/nl not_active Application Discontinuation
- 1982-07-29 ZA ZA825481A patent/ZA825481B/xx unknown
- 1982-07-30 PH PH27655A patent/PH18688A/en unknown
- 1982-07-30 CA CA000408451A patent/CA1208642A/en not_active Expired
- 1982-07-30 DK DK343782A patent/DK156219C/da not_active IP Right Cessation
- 1982-07-30 IE IE1851/82A patent/IE53613B1/en unknown
- 1982-07-30 FI FI822666A patent/FI76794C/fi not_active IP Right Cessation
- 1982-08-01 IL IL66433A patent/IL66433A/xx unknown
- 1982-08-02 SE SE8204549A patent/SE453503B/sv not_active IP Right Cessation
- 1982-08-02 CH CH466082A patent/CH655503B/de unknown
- 1982-08-02 HU HU822483A patent/HU191505B/hu not_active IP Right Cessation
- 1982-08-02 GB GB08222210A patent/GB2105714B/en not_active Expired
- 1982-08-02 PT PT75365A patent/PT75365B/pt not_active IP Right Cessation
- 1982-08-03 OA OA57764A patent/OA07171A/xx unknown
- 1982-08-03 KR KR8203481A patent/KR880001737B1/ko active
- 1982-08-03 JP JP57134807A patent/JPS5838277A/ja active Granted
- 1982-08-03 LU LU84315A patent/LU84315A1/fr unknown
- 1982-08-03 DE DE19823228992 patent/DE3228992A1/de not_active Withdrawn
- 1982-08-03 AT AT0299382A patent/AT380477B/de active
- 1982-08-03 BE BE0/208747A patent/BE894021A/fr not_active IP Right Cessation
-
1983
- 1983-09-30 ES ES526149A patent/ES8504185A1/es not_active Expired
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8307800A1 (es) | Un procedimiento para la preparacion de derivados de tiazolidi-nilalquilen-piperazinas. | |
IE823053L (en) | Piperazinylbenzisoxazoles and piperazinylbenzisothiazoles | |
MX9305277A (es) | Monohidrato de 5-(2-4(1,2-benzisotiazol-3-il)-1-piperazinil)-etil-6-cloro-1,3-dihidro-2h-indol-2-1-clorhidrato. | |
SE8207425L (sv) | 2-(4-((4,4-dialkyl-2,6-piperidindion-1-yl)butyl)-1-piperazinyl)pyrimidiner | |
NO924696D0 (no) | Fremgangsmaate for fremstilling av oksazolidinon- og tiazolidinon-derivater | |
DK13082A (da) | Analogifremgangsmaade til fremstilling af n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-derivater | |
SG29687G (en) | 2-(4-((4, 4-dialkyl-2, 6-piperidinedion-1-yl) butyl)-1-piperazinyl) pyridines | |
SE8600174D0 (sv) | Nytt forfarande for framstellning av n-(2-pyrimidinyl)-piperazinylalkylazaspiroalkandioner | |
IE812069L (en) | Azaspirodecanediones | |
ES8504185A1 (es) | Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina | |
DE69106388D1 (de) | Antipsychotische 4-(1,2-benzisoazolyl)piperidinderivate. | |
AU553045B2 (en) | Diamino isothiazole-1-oxides and -1,1-dioxides as gastric secretion inhibitors | |
IE43951L (en) | 1-benzazolylalkyl-4-substituted-piperdines | |
ES8801822A1 (es) | Un procedimiento para la preparacion de derivados de piperazina 1,4-disustituidos | |
KR960702835A (ko) | 헤테로사이클릭 화학(Heterocyclic chemistry) | |
IL84096A (en) | Therapeutic compositions for the treatment of peptic ulcer disease comprising a 1-(oxoalkyl)-3,7-dialkylxanthine | |
EG17529A (en) | Improved formulation of antiinflammatory drugs | |
NO167571C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2h-(1)-benzoxepino-(5,4-b)-1,4-oxazinderivater. | |
AU6960787A (en) | 4-(2-pyrimidinyl)-1-piperazinyl heterocyclic carbonyl derivatives | |
NO882861L (no) | Fremgangsmaate for fremstilling av krystallinsk 2-(1-pentyl-3-guanidino)-4-(2-metyl-4-imidazolyl)-tiazol-dihydroklorid-trihydrat. | |
ES2083319A1 (es) | Monohidrato de clorhidrato de 5-(2-(4-(1,2-benzisotiazol-3-il)-1-piperazinil)-etil)-6-cloro-1,3-dihidro-2h-indol-2-ona. | |
JPS5677276A (en) | Guanidine compound* its manufacture and composition containing it | |
IT1140281B (it) | Procedimento per la preparazione di 4-idrossi-2-metil-n-(2-piridil)-2h-1,2-benzotiazin-3-carbossamide 1,1-diossido | |
EP0244319A3 (en) | Amide derivatives and antiallergic agents containing the same | |
IT8619484A0 (it) | Procedimento di preparazione di derivati eterociclici. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |