ES8504185A1 - Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina - Google Patents

Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina

Info

Publication number
ES8504185A1
ES8504185A1 ES526149A ES526149A ES8504185A1 ES 8504185 A1 ES8504185 A1 ES 8504185A1 ES 526149 A ES526149 A ES 526149A ES 526149 A ES526149 A ES 526149A ES 8504185 A1 ES8504185 A1 ES 8504185A1
Authority
ES
Spain
Prior art keywords
spirothiazolidinyl
piperazine derivatives
selective
nonan
thiazolidinedione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526149A
Other languages
English (en)
Other versions
ES526149A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8504185A1 publication Critical patent/ES8504185A1/es
Publication of ES526149A0 publication Critical patent/ES526149A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO OARA LA PREPARACION DE DERIVADOS DE ESPIROTIAZOLIDINIL PIPERAZINA DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS NO TOXICAS Y FARMACEUTICAMENTE ACEPTABLES.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR 2-CLORO-3 CIANOPIRIDINA Y PIPERAZINA EN ALCOHOL, PARA OBTENER 1-(3-CIANO 2-PIRIDINIL)PIPERAZINA; SEGUNDA, SE HACE REACCIONAR LA PIPERAZINA OBTENIDA CON 3-(4-BROMOBUTIL)-5-ESPIROCICLOPENTIL-2,4-TIAZOLIDINDIONA, EN PRESENCIA DE UNA BASE Y DE UN DISOLVENTE INERTE; Y POR ULTIMO, SE CONVIERTE LA BASE LIBRE OBTENIDA EN UNA SAL DE HIDROCLORURO, DE FORMULA GENERAL (II).DE APLICACION EN EL TRATAMIENTO DE LA ANSIEDAD Y DE LA DEPRESION.
ES526149A 1981-08-03 1983-09-30 Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina Granted ES526149A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/289,351 US4456756A (en) 1981-08-03 1981-08-03 Spirothiazolidinyl piperazine derivatives

Publications (2)

Publication Number Publication Date
ES8504185A1 true ES8504185A1 (es) 1985-04-16
ES526149A0 ES526149A0 (es) 1985-04-16

Family

ID=23111156

Family Applications (2)

Application Number Title Priority Date Filing Date
ES514263A Expired ES8401763A1 (es) 1981-08-03 1982-07-23 Un procedimiento para la preparacion de derivados de espiroti-azolidinil-piperazina.
ES526149A Granted ES526149A0 (es) 1981-08-03 1983-09-30 Un procedimiento para la preparacion de derivados de espirotiazolidinil-piperazina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES514263A Expired ES8401763A1 (es) 1981-08-03 1982-07-23 Un procedimiento para la preparacion de derivados de espiroti-azolidinil-piperazina.

Country Status (28)

Country Link
US (1) US4456756A (es)
JP (1) JPS5838277A (es)
KR (1) KR880001737B1 (es)
AT (1) AT380477B (es)
AU (1) AU555870B2 (es)
BE (1) BE894021A (es)
CA (1) CA1208642A (es)
CH (1) CH655503B (es)
DE (1) DE3228992A1 (es)
DK (1) DK156219C (es)
ES (2) ES8401763A1 (es)
FI (1) FI76794C (es)
FR (1) FR2510571B1 (es)
GB (1) GB2105714B (es)
GR (1) GR76171B (es)
HU (1) HU191505B (es)
IE (1) IE53613B1 (es)
IL (1) IL66433A (es)
IT (1) IT1149026B (es)
LU (1) LU84315A1 (es)
NL (1) NL8203035A (es)
NZ (1) NZ201158A (es)
OA (1) OA07171A (es)
PH (1) PH18688A (es)
PT (1) PT75365B (es)
SE (1) SE453503B (es)
YU (1) YU44073B (es)
ZA (1) ZA825481B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61162278A (ja) * 1985-01-09 1986-07-22 Nippon Yakin Kogyo Co Ltd 冷却手段を具えたロ−ラ−電極を含む自走式シ−ム溶接機
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4784998A (en) * 1987-04-06 1988-11-15 Bristol-Myers Company 1,3,4-oxadiazole pyschotropic compounds
US5801186A (en) * 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
ES2052675T3 (es) * 1987-11-20 1994-07-16 Hoechst Roussel Pharma 3-(4-piperazinil-sustituido en 1)butil)-4-tiazolidinonas, un procedimiento para su preparacion y su uso como medicamentos.
JPH0270878U (es) * 1988-11-21 1990-05-30

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL265085A (es) * 1960-05-24
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3200118A (en) * 1961-10-31 1965-08-10 Geschickter Fund Med Res Spirocyclic hydrazine imides
US3432499A (en) * 1965-04-02 1969-03-11 Geschickter Fund Med Res Trifluoromethylazaspiranes and azaspirane diones
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
DE1695410A1 (de) * 1967-04-20 1971-04-08 Merck Patent Gmbh Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
DE2862059D1 (en) * 1977-12-29 1982-11-11 Synthelabo Thiazolidinedione-2,4 derivatives, their preparation and pharmaceutical applications
FI791926A (fi) * 1978-06-20 1979-12-21 Synthelabo Fenylpiperazinderivat
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives

Also Published As

Publication number Publication date
FR2510571B1 (fr) 1987-07-10
CH655503B (es) 1986-04-30
JPS5838277A (ja) 1983-03-05
KR840001166A (ko) 1984-03-28
PT75365A (en) 1982-09-01
BE894021A (fr) 1983-02-03
DK156219B (da) 1989-07-10
DE3228992A1 (de) 1983-02-17
GB2105714A (en) 1983-03-30
AU8597382A (en) 1983-02-10
FI76794B (fi) 1988-08-31
FI76794C (fi) 1988-12-12
YU158582A (en) 1985-04-30
ES514263A0 (es) 1984-01-01
PH18688A (en) 1985-09-05
HU191505B (en) 1987-02-27
DK343782A (da) 1983-02-04
FR2510571A1 (fr) 1983-02-04
IT1149026B (it) 1986-12-03
IE821851L (en) 1983-02-03
SE453503B (sv) 1988-02-08
SE8204549D0 (sv) 1982-08-02
IL66433A0 (en) 1982-12-31
DK156219C (da) 1989-12-04
GR76171B (es) 1984-08-03
FI822666A0 (fi) 1982-07-30
IE53613B1 (en) 1988-12-21
NL8203035A (nl) 1983-03-01
LU84315A1 (fr) 1983-06-07
GB2105714B (en) 1985-05-15
ATA299382A (de) 1985-10-15
AT380477B (de) 1986-05-26
NZ201158A (en) 1985-12-13
ES526149A0 (es) 1985-04-16
ZA825481B (en) 1983-04-27
FI822666L (fi) 1983-02-04
SE8204549L (sv) 1983-02-04
AU555870B2 (en) 1986-10-16
CA1208642A (en) 1986-07-29
OA07171A (fr) 1984-04-30
US4456756A (en) 1984-06-26
KR880001737B1 (ko) 1988-09-10
JPH039912B2 (es) 1991-02-12
IT8248901A0 (it) 1982-07-28
PT75365B (en) 1985-11-20
ES8401763A1 (es) 1984-01-01
YU44073B (en) 1990-02-28
IL66433A (en) 1985-10-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203