DK160939C - Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater, samt mellemprodukter til anvendelse ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater, samt mellemprodukter til anvendelse ved fremgangsmaaden

Info

Publication number
DK160939C
DK160939C DK566282A DK566282A DK160939C DK 160939 C DK160939 C DK 160939C DK 566282 A DK566282 A DK 566282A DK 566282 A DK566282 A DK 566282A DK 160939 C DK160939 C DK 160939C
Authority
DK
Denmark
Prior art keywords
procedure
benzisoxazolpiperazine
benzisothiazol
intermediates
derivatives
Prior art date
Application number
DK566282A
Other languages
English (en)
Other versions
DK566282A (da
DK160939B (da
Inventor
Davis L Temple
Joseph P Yevich
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to DK279183A priority Critical patent/DK160553C/da
Publication of DK566282A publication Critical patent/DK566282A/da
Publication of DK160939B publication Critical patent/DK160939B/da
Application granted granted Critical
Publication of DK160939C publication Critical patent/DK160939C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK566282A 1981-12-23 1982-12-21 Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater, samt mellemprodukter til anvendelse ved fremgangsmaaden DK160939C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK279183A DK160553C (da) 1981-12-23 1983-06-16 Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/333,830 US4411901A (en) 1981-12-23 1981-12-23 Benzisothiazole and benzisoxazole piperazine derivatives
US33383081 1981-12-23

Publications (3)

Publication Number Publication Date
DK566282A DK566282A (da) 1983-06-24
DK160939B DK160939B (da) 1991-05-06
DK160939C true DK160939C (da) 1991-10-21

Family

ID=23304433

Family Applications (2)

Application Number Title Priority Date Filing Date
DK566282A DK160939C (da) 1981-12-23 1982-12-21 Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater, samt mellemprodukter til anvendelse ved fremgangsmaaden
DK307590A DK162601C (da) 1981-12-23 1990-12-28 Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK307590A DK162601C (da) 1981-12-23 1990-12-28 Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion

Country Status (26)

Country Link
US (1) US4411901A (da)
JP (2) JPS58110576A (da)
KR (1) KR870001022B1 (da)
AU (1) AU550780B2 (da)
BE (1) BE895469A (da)
CA (1) CA1205806A (da)
CH (2) CH659070A5 (da)
CY (1) CY1376A (da)
DE (1) DE3247530A1 (da)
DK (2) DK160939C (da)
ES (4) ES518168A0 (da)
FI (1) FI78697C (da)
FR (2) FR2521561B1 (da)
GB (1) GB2114119B (da)
GR (1) GR77108B (da)
HK (1) HK5088A (da)
HU (2) HU190997B (da)
IE (1) IE54789B1 (da)
IT (1) IT1158037B (da)
KE (1) KE3718A (da)
LU (1) LU84550A1 (da)
NL (1) NL8204910A (da)
PT (1) PT76017B (da)
SE (2) SE453502B (da)
SG (1) SG30087G (da)
ZA (1) ZA828544B (da)

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US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4656280A (en) * 1984-03-07 1987-04-07 E. I. Du Pont De Nemours And Company Radioiodinated dopamine receptor ligand
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
AU2717288A (en) * 1987-11-12 1989-06-01 American Home Products Corporation Polycyclicamines with psychotropic activity
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US5801186A (en) * 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
WO1990002552A1 (en) * 1988-09-16 1990-03-22 Pfizer Inc. Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
US4847252A (en) * 1988-10-25 1989-07-11 Bristol-Myers Company Method for alleviation of vascular headache
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
GB9226857D0 (en) * 1992-12-23 1993-02-17 Boyd Edward A Pharmaceutical compositions
WO1994018197A1 (en) * 1993-02-04 1994-08-18 Meiji Seika Kabushiki Kaisha Compound with antipsychotic effect
HUT69376A (en) * 1993-05-04 1995-09-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing heterocyclic compounds
AU697610B2 (en) 1995-02-28 1998-10-15 H. Lundbeck A/S 4-aminotetrahydrobenzisoxazole or -isothiazole compounds
MX9709451A (es) * 1995-06-06 1998-02-28 Hoechst Marion Roussel Inc Derivados de benzisoxazol e indazol como agentes antipsicoticos.
EP1757292A1 (en) 1997-09-05 2007-02-28 Pfizer Products Inc. Method of treating ocd and tic disorders
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
JP2002541098A (ja) * 1999-04-06 2002-12-03 セプラコア インコーポレーテッド ジプラシドン代謝産物を用いる神経弛緩薬性障害および関連障害を治療するための方法および組成物
MXPA05003658A (es) * 2002-10-28 2005-06-08 Warner Lambert Co Derivados de piperazina sustituidos con oxindol.
EP1562919A1 (en) * 2002-11-08 2005-08-17 Warner-Lambert Company LLC Phenylalkyl and pyridylalkyl piperazine derivatives
EP2578216A1 (en) 2006-11-22 2013-04-10 Seaside Therapeutics, Inc. Methods of treating fragile x syndrome
EP2736905A4 (en) 2011-07-28 2015-07-29 Mapi Pharma Ltd INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF LURASIDONE AND SALTS THEREOF
CN105669665A (zh) * 2016-03-15 2016-06-15 烟台贝森医药科技有限公司 哌罗匹隆的制备方法

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DE1595920B2 (de) * 1964-11-04 1978-08-10 Merck Patent Gmbh, 6100 Darmstadt 4-(co-Piperazinoalkyl)-pyrazole, ihre Salze und Verfahren zu ihrer Herstellung
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
DE1695410A1 (de) * 1967-04-20 1971-04-08 Merck Patent Gmbh Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
DE1670907B2 (de) * 1967-08-16 1976-07-22 Bayer Ag, 5090 Leverkusen N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US3528989A (en) * 1967-11-14 1970-09-15 Colgate Palmolive Co 3-aminoalkyl derivatives of 2,1-benzisothiazoline
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
AR207986A1 (es) * 1974-07-01 1976-11-22 Sumitomo Chemical Co Un procedimiento para producir compuestos del 3-(aminoalquil n-sustituido)-benz-2,1-isoxazol
US3940398A (en) * 1975-01-23 1976-02-24 E. R. Squibb & Sons, Inc. 2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
DE2734866A1 (de) * 1977-08-03 1979-02-22 Basf Ag Neue 1,2-benzisothiazole und verfahren zu ihrer herstellung
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FI791926A (fi) * 1978-06-20 1979-12-21 Synthelabo Fenylpiperazinderivat

Also Published As

Publication number Publication date
KR840002832A (ko) 1984-07-21
ES8502991A1 (es) 1985-02-01
ES525470A0 (es) 1985-02-01
IE823053L (en) 1983-06-23
IE54789B1 (en) 1990-02-14
DK162601B (da) 1991-11-18
SG30087G (en) 1987-07-17
SE8207350L (sv) 1983-08-10
SE8702389L (sv) 1987-06-09
HK5088A (en) 1988-01-29
FI824379A0 (fi) 1982-12-20
CH659070A5 (de) 1986-12-31
CH656617A5 (de) 1986-07-15
LU84550A1 (fr) 1983-09-08
IT1158037B (it) 1987-02-18
ES8503349A1 (es) 1985-02-01
AU550780B2 (en) 1986-04-10
ES524946A0 (es) 1985-04-01
ES8503683A1 (es) 1985-04-01
FR2521561B1 (fr) 1986-10-10
GR77108B (da) 1984-09-06
SE8702389D0 (sv) 1987-06-09
DK162601C (da) 1992-05-11
FR2521561A1 (fr) 1983-08-19
JPS58110576A (ja) 1983-07-01
SE453502B (sv) 1988-02-08
DK566282A (da) 1983-06-24
DK307590D0 (da) 1990-12-28
ES8401970A1 (es) 1984-01-16
FR2531431A1 (da) 1984-02-10
AU9087282A (en) 1983-06-23
SE462162B (sv) 1990-05-14
BE895469A (fr) 1983-06-23
KE3718A (en) 1987-04-16
GB2114119A (en) 1983-08-17
CA1205806A (en) 1986-06-10
DE3247530A1 (de) 1983-06-30
DK160939B (da) 1991-05-06
SE8207350D0 (sv) 1982-12-22
DK307590A (da) 1990-12-28
HU190997B (en) 1986-12-28
PT76017A (en) 1983-01-01
FR2531431B1 (da) 1986-10-10
KR870001022B1 (ko) 1987-05-23
ES518168A0 (es) 1984-01-16
HU195806B (en) 1988-07-28
FI78697B (fi) 1989-05-31
JPH0517457A (ja) 1993-01-26
ZA828544B (en) 1983-09-28
ES525471A0 (es) 1985-02-01
FI78697C (fi) 1989-09-11
IT8249709A0 (it) 1982-12-21
US4411901A (en) 1983-10-25
GB2114119B (en) 1985-11-27
FI824379L (fi) 1983-06-24
NL8204910A (nl) 1983-07-18
PT76017B (en) 1985-12-20
JPH0577669B2 (da) 1993-10-27
CY1376A (en) 1987-08-07

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