ES8401970A1 - Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina. - Google Patents

Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.

Info

Publication number
ES8401970A1
ES8401970A1 ES518168A ES518168A ES8401970A1 ES 8401970 A1 ES8401970 A1 ES 8401970A1 ES 518168 A ES518168 A ES 518168A ES 518168 A ES518168 A ES 518168A ES 8401970 A1 ES8401970 A1 ES 8401970A1
Authority
ES
Spain
Prior art keywords
benzisothiazole
piperazine derivatives
benzisothiazol
piperazinyl
benzisoxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518168A
Other languages
English (en)
Other versions
ES518168A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES518168A0 publication Critical patent/ES518168A0/es
Publication of ES8401970A1 publication Critical patent/ES8401970A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENZOISOTIAZOL Y BENZOISOXAZOL PIPERAZINA Y DE SUS SALES DE ADICION DE ACIDO NO TOXICAS Y FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE Y ES OXIGENO O AZUFRE; Z ES HALOGENO O HIDROGENO Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES.18CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA IMIDO-A, CON UN COMPUESTO DE FORMULA (II), EN LAS QUE A ES -(CH2- )N-X, DONDE N VALE 3 O 4 Y X ES EL RESTO ACIDO DE UN GRUPO ESTER E Y Y Z SON LOS MISMOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE,EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA ENTRE 0 Y 200J.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIPSICOTICA.
ES518168A 1981-12-23 1982-12-14 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina. Expired ES8401970A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/333,830 US4411901A (en) 1981-12-23 1981-12-23 Benzisothiazole and benzisoxazole piperazine derivatives

Publications (2)

Publication Number Publication Date
ES518168A0 ES518168A0 (es) 1984-01-16
ES8401970A1 true ES8401970A1 (es) 1984-01-16

Family

ID=23304433

Family Applications (4)

Application Number Title Priority Date Filing Date
ES518168A Expired ES8401970A1 (es) 1981-12-23 1982-12-14 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.
ES524946A Granted ES524946A0 (es) 1981-12-23 1983-08-12 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina
ES525470A Granted ES525470A0 (es) 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.
ES525471A Granted ES525471A0 (es) 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES524946A Granted ES524946A0 (es) 1981-12-23 1983-08-12 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina
ES525470A Granted ES525470A0 (es) 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.
ES525471A Granted ES525471A0 (es) 1981-12-23 1983-09-08 Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.

Country Status (26)

Country Link
US (1) US4411901A (es)
JP (2) JPS58110576A (es)
KR (1) KR870001022B1 (es)
AU (1) AU550780B2 (es)
BE (1) BE895469A (es)
CA (1) CA1205806A (es)
CH (2) CH659070A5 (es)
CY (1) CY1376A (es)
DE (1) DE3247530A1 (es)
DK (2) DK160939C (es)
ES (4) ES8401970A1 (es)
FI (1) FI78697C (es)
FR (2) FR2521561B1 (es)
GB (1) GB2114119B (es)
GR (1) GR77108B (es)
HK (1) HK5088A (es)
HU (2) HU195806B (es)
IE (1) IE54789B1 (es)
IT (1) IT1158037B (es)
KE (1) KE3718A (es)
LU (1) LU84550A1 (es)
NL (1) NL8204910A (es)
PT (1) PT76017B (es)
SE (2) SE453502B (es)
SG (1) SG30087G (es)
ZA (1) ZA828544B (es)

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US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4656280A (en) * 1984-03-07 1987-04-07 E. I. Du Pont De Nemours And Company Radioiodinated dopamine receptor ligand
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
EP0348460A4 (en) * 1987-11-12 1991-11-27 American Home Products Corporation Polycyclicamines with psychotropic activity
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
US5801186A (en) * 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
ES2052675T3 (es) * 1987-11-20 1994-07-16 Hoechst Roussel Pharma 3-(4-piperazinil-sustituido en 1)butil)-4-tiazolidinonas, un procedimiento para su preparacion y su uso como medicamentos.
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
US4847252A (en) * 1988-10-25 1989-07-11 Bristol-Myers Company Method for alleviation of vascular headache
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
GB9226857D0 (en) * 1992-12-23 1993-02-17 Boyd Edward A Pharmaceutical compositions
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
HUT69376A (en) * 1993-05-04 1995-09-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing heterocyclic compounds
ZA961591B (en) * 1995-02-28 1996-08-28 Lundbeck & Co As H 4-aminotetrahydrobenzisoxazole or -isothiazole compounds
MX9709451A (es) * 1995-06-06 1998-02-28 Hoechst Marion Roussel Inc Derivados de benzisoxazol e indazol como agentes antipsicoticos.
EP1757292A1 (en) 1997-09-05 2007-02-28 Pfizer Products Inc. Method of treating ocd and tic disorders
EP1165083A2 (en) * 1999-04-06 2002-01-02 Sepracor Inc. Methods and compositions for the treatment of psychotic and related disorders using ziprasidone metabolites
US7030142B1 (en) 1999-04-06 2006-04-18 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites
AU2003267801A1 (en) * 2002-10-28 2004-05-13 Warner-Lambert Company Llc Oxindole substituted piperazine derivatives
WO2004041793A1 (en) * 2002-11-08 2004-05-21 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
EP2578216A1 (en) 2006-11-22 2013-04-10 Seaside Therapeutics, Inc. Methods of treating fragile x syndrome
EP2736905A4 (en) 2011-07-28 2015-07-29 Mapi Pharma Ltd INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF LURASIDONE AND SALTS THEREOF
CN105669665A (zh) * 2016-03-15 2016-06-15 烟台贝森医药科技有限公司 哌罗匹隆的制备方法

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DE1595920B2 (de) * 1964-11-04 1978-08-10 Merck Patent Gmbh, 6100 Darmstadt 4-(co-Piperazinoalkyl)-pyrazole, ihre Salze und Verfahren zu ihrer Herstellung
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
DE1695410A1 (de) * 1967-04-20 1971-04-08 Merck Patent Gmbh Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
DE1670907B2 (de) * 1967-08-16 1976-07-22 Bayer Ag, 5090 Leverkusen N-disubstituierte 3-amino-1,2benzisothiazole und verfahren in ihrer herstellung
US3528989A (en) * 1967-11-14 1970-09-15 Colgate Palmolive Co 3-aminoalkyl derivatives of 2,1-benzisothiazoline
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
AR207986A1 (es) * 1974-07-01 1976-11-22 Sumitomo Chemical Co Un procedimiento para producir compuestos del 3-(aminoalquil n-sustituido)-benz-2,1-isoxazol
US3940398A (en) * 1975-01-23 1976-02-24 E. R. Squibb & Sons, Inc. 2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
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FI791926A (fi) * 1978-06-20 1979-12-21 Synthelabo Fenylpiperazinderivat

Also Published As

Publication number Publication date
DE3247530A1 (de) 1983-06-30
ES8502991A1 (es) 1985-02-01
FI824379L (fi) 1983-06-24
BE895469A (fr) 1983-06-23
GB2114119B (en) 1985-11-27
IE54789B1 (en) 1990-02-14
ES518168A0 (es) 1984-01-16
DK566282A (da) 1983-06-24
ZA828544B (en) 1983-09-28
JPH0517457A (ja) 1993-01-26
ES8503683A1 (es) 1985-04-01
SE8702389L (sv) 1987-06-09
AU550780B2 (en) 1986-04-10
CY1376A (en) 1987-08-07
JPS58110576A (ja) 1983-07-01
FR2531431B1 (es) 1986-10-10
SE453502B (sv) 1988-02-08
IT8249709A0 (it) 1982-12-21
IT1158037B (it) 1987-02-18
PT76017B (en) 1985-12-20
LU84550A1 (fr) 1983-09-08
AU9087282A (en) 1983-06-23
SE462162B (sv) 1990-05-14
DK162601B (da) 1991-11-18
GR77108B (es) 1984-09-06
CH659070A5 (de) 1986-12-31
FR2521561A1 (fr) 1983-08-19
ES8503349A1 (es) 1985-02-01
ES525470A0 (es) 1985-02-01
SG30087G (en) 1987-07-17
DK307590A (da) 1990-12-28
FR2521561B1 (fr) 1986-10-10
SE8207350L (sv) 1983-08-10
FR2531431A1 (es) 1984-02-10
FI78697C (fi) 1989-09-11
CA1205806A (en) 1986-06-10
ES525471A0 (es) 1985-02-01
KR870001022B1 (ko) 1987-05-23
FI78697B (fi) 1989-05-31
US4411901A (en) 1983-10-25
DK160939C (da) 1991-10-21
CH656617A5 (de) 1986-07-15
GB2114119A (en) 1983-08-17
DK162601C (da) 1992-05-11
PT76017A (en) 1983-01-01
SE8207350D0 (sv) 1982-12-22
DK160939B (da) 1991-05-06
FI824379A0 (fi) 1982-12-20
DK307590D0 (da) 1990-12-28
HU195806B (en) 1988-07-28
NL8204910A (nl) 1983-07-18
HK5088A (en) 1988-01-29
KE3718A (en) 1987-04-16
KR840002832A (ko) 1984-07-21
JPH0577669B2 (es) 1993-10-27
HU190997B (en) 1986-12-28
IE823053L (en) 1983-06-23
ES524946A0 (es) 1985-04-01
SE8702389D0 (sv) 1987-06-09

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