ES8305755A1 - Procedimiento para preparar derivados de pirimidona. - Google Patents
Procedimiento para preparar derivados de pirimidona.Info
- Publication number
- ES8305755A1 ES8305755A1 ES513469A ES513469A ES8305755A1 ES 8305755 A1 ES8305755 A1 ES 8305755A1 ES 513469 A ES513469 A ES 513469A ES 513469 A ES513469 A ES 513469A ES 8305755 A1 ES8305755 A1 ES 8305755A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridyl
- pharmaceutical compositions
- compositions containing
- pyrimidinone derivatives
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Treating Waste Gases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIMIDONA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HALOGENO O NITRO; R ES ALQUILO C <- ; R ES ALQUILENO C <- ; Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), O UNA DE SUS SALES CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R ES UN GRUPO DESPLAZABLE CON AMINA, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN AUSENCIA DE DISOLVENTE, A UNA TEMPERATURA ENTRE 80 C Y 170 C O EN UN DISOLVENTE INERTE, A UNA TEMPERATURA ENTRE 120 C Y 140 C. SI ES NECESARIO, EN EL COMPUESTO OBTENIDO SE SUSTITUYE EL GRUPO R . ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL AGUA BRONQUIAL, RINITIS, FIEBRE DEL HENO Y ECZEMA ALERGICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8119906 | 1981-06-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8305755A1 true ES8305755A1 (es) | 1983-05-01 |
ES513469A0 ES513469A0 (es) | 1983-05-01 |
Family
ID=10522859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES513469A Granted ES513469A0 (es) | 1981-06-27 | 1982-06-25 | Procedimiento para preparar derivados de pirimidona. |
Country Status (27)
Country | Link |
---|---|
US (4) | US4486434A (es) |
EP (2) | EP0068833B1 (es) |
JP (4) | JPS588080A (es) |
KR (1) | KR880001475B1 (es) |
AT (2) | ATE21900T1 (es) |
AU (2) | AU551066B2 (es) |
BG (1) | BG38163A3 (es) |
CS (1) | CS241036B2 (es) |
DD (1) | DD202291A5 (es) |
DE (2) | DE3273782D1 (es) |
DK (2) | DK286982A (es) |
ES (1) | ES513469A0 (es) |
FI (1) | FI822281L (es) |
GR (2) | GR74926B (es) |
HU (1) | HU190396B (es) |
IE (1) | IE53348B1 (es) |
IL (1) | IL66125A (es) |
JO (1) | JO1185B1 (es) |
NO (1) | NO822120L (es) |
NZ (1) | NZ201077A (es) |
PH (1) | PH19680A (es) |
PL (3) | PL137627B1 (es) |
PT (1) | PT75074B (es) |
SU (1) | SU1232145A3 (es) |
YU (1) | YU138982A (es) |
ZA (2) | ZA824537B (es) |
ZW (1) | ZW13082A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN151188B (es) * | 1978-02-13 | 1983-03-05 | Smith Kline French Lab | |
US4808589A (en) * | 1982-02-20 | 1989-02-28 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives |
GR78463B (es) * | 1982-03-25 | 1984-09-27 | Smith Kline French Lab | |
EP0093490B1 (en) * | 1982-03-25 | 1988-04-27 | Smith Kline & French Laboratories Limited | Process for preparing 3,5-disubstituted 2-pyridylalkyl amines |
PT77287B (en) * | 1982-10-01 | 1986-02-04 | Smith Kline French Lab | Compound |
GB8319874D0 (en) * | 1983-07-23 | 1983-08-24 | Smith Kline French Lab | Compounds |
CA1286297C (en) * | 1985-06-13 | 1991-07-16 | George S. Sach | Pyridine derivatives |
GB8601816D0 (en) * | 1986-01-25 | 1986-02-26 | Smith Kline French Lab | Pyridine derivatives |
GB8610867D0 (en) * | 1986-05-02 | 1986-06-11 | Smith Kline French Lab | 3-hydroxypyridines |
JP2679977B2 (ja) * | 1986-09-19 | 1997-11-19 | 株式会社日立製作所 | 半導体集積回路 |
EP0364584A4 (en) * | 1988-04-27 | 1990-12-05 | Kievsky Nauchno-Issledovatelsky Institut Farmakologii I Toxikologii | Antidote for organic phosphorus compound poisoning |
US5216170A (en) * | 1989-01-26 | 1993-06-01 | Bayer Aktiengesellschaft | (2-aminopropyl) pyridines useful as intermediates |
KR100498005B1 (ko) * | 2002-07-26 | 2005-07-01 | 주식회사 소하드 | 기능성 액상비료 및 그 제조방법 |
CA2510860C (en) * | 2002-12-20 | 2012-10-09 | Exxonmobil Chemical Patents Inc. | Polymerization process utilizing hydrofluorocarbons as diluents |
US7443103B2 (en) * | 2005-06-24 | 2008-10-28 | General Electric Company | High pressure lamp with lamp flicker suppression and lamp voltage control |
CN102076678A (zh) * | 2008-07-10 | 2011-05-25 | 诺瓦提斯公司 | 作为bace抑制剂的具有氨基苄基取代基的环砜类化合物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN146736B (es) * | 1975-10-02 | 1979-08-25 | Smith Kline French Lab | |
MW5076A1 (en) * | 1975-12-29 | 1978-02-08 | Smith Kline French Lab | Pharmacologicalle active compounds |
US4216318A (en) * | 1975-12-29 | 1980-08-05 | Smith Kline & French Laboratories Limited | Heterocyclic alkyl 4-pyrimidones |
US4154834A (en) * | 1975-12-29 | 1979-05-15 | Smith Kline & French Laboratories Limited | Substituted isocytosines having histamine H2 -antagonist activity |
US4227000A (en) * | 1978-04-11 | 1980-10-07 | Smith Kline & French Laboratories Limited | Intermediates in the process for making histamine antagonists |
ZA792608B (en) * | 1978-05-30 | 1980-06-25 | Smith Kline French Lab | Nitro compounds |
US4255428A (en) * | 1979-03-24 | 1981-03-10 | Smith Kline & French Laboratories Limited | 5-(Hydroxypyridylalkyl)-4-pyrimidones |
JPS55133379A (en) * | 1979-04-05 | 1980-10-17 | Smith Kline French Lab | Pyrimidone compound |
EP0017680B1 (en) * | 1979-04-11 | 1982-04-21 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them |
JPS55145683A (en) * | 1979-04-26 | 1980-11-13 | Smith Kline French Lab | Pyrimidone derivative |
-
1982
- 1982-06-18 PT PT75074A patent/PT75074B/pt unknown
- 1982-06-22 US US06/391,076 patent/US4486434A/en not_active Expired - Fee Related
- 1982-06-22 US US06/391,077 patent/US4444772A/en not_active Expired - Fee Related
- 1982-06-24 FI FI822281A patent/FI822281L/fi not_active Application Discontinuation
- 1982-06-24 GR GR68558A patent/GR74926B/el unknown
- 1982-06-24 IL IL66125A patent/IL66125A/xx unknown
- 1982-06-24 NO NO822120A patent/NO822120L/no unknown
- 1982-06-24 GR GR68557A patent/GR74925B/el unknown
- 1982-06-25 PH PH27497A patent/PH19680A/en unknown
- 1982-06-25 ZW ZW130/82A patent/ZW13082A1/xx unknown
- 1982-06-25 EP EP82303310A patent/EP0068833B1/en not_active Expired
- 1982-06-25 PL PL1982240628A patent/PL137627B1/pl unknown
- 1982-06-25 NZ NZ201077A patent/NZ201077A/xx unknown
- 1982-06-25 PL PL1982247290A patent/PL138524B1/pl unknown
- 1982-06-25 CS CS824800A patent/CS241036B2/cs unknown
- 1982-06-25 DE DE8282303310T patent/DE3273782D1/de not_active Expired
- 1982-06-25 AT AT82303311T patent/ATE21900T1/de not_active IP Right Cessation
- 1982-06-25 IE IE1533/82A patent/IE53348B1/en unknown
- 1982-06-25 AU AU85351/82A patent/AU551066B2/en not_active Ceased
- 1982-06-25 EP EP82303311A patent/EP0068834B1/en not_active Expired
- 1982-06-25 SU SU823459055A patent/SU1232145A3/ru active
- 1982-06-25 DK DK286982A patent/DK286982A/da unknown
- 1982-06-25 PL PL1982237110A patent/PL137600B1/pl unknown
- 1982-06-25 AT AT82303310T patent/ATE22891T1/de active
- 1982-06-25 HU HU822075A patent/HU190396B/hu unknown
- 1982-06-25 ES ES513469A patent/ES513469A0/es active Granted
- 1982-06-25 BG BG057164A patent/BG38163A3/xx unknown
- 1982-06-25 ZA ZA824537A patent/ZA824537B/xx unknown
- 1982-06-25 DE DE8282303311T patent/DE3273019D1/de not_active Expired
- 1982-06-25 DK DK287082A patent/DK287082A/da unknown
- 1982-06-25 AU AU85352/82A patent/AU8535282A/en not_active Abandoned
- 1982-06-25 YU YU01389/82A patent/YU138982A/xx unknown
- 1982-06-26 JP JP57110568A patent/JPS588080A/ja active Granted
- 1982-06-26 KR KR8202869A patent/KR880001475B1/ko active
- 1982-06-26 JP JP57110567A patent/JPS588079A/ja active Granted
- 1982-06-27 JO JO19821185A patent/JO1185B1/en active
- 1982-06-28 DD DD82241156A patent/DD202291A5/de unknown
- 1982-06-28 ZA ZA824580A patent/ZA824580B/xx unknown
-
1984
- 1984-02-02 US US06/576,244 patent/US4535163A/en not_active Expired - Fee Related
- 1984-09-17 US US06/651,197 patent/US4584381A/en not_active Expired - Fee Related
-
1986
- 1986-04-21 JP JP61093193A patent/JPS61233616A/ja active Granted
- 1986-04-21 JP JP61093194A patent/JPS61233670A/ja active Pending
Also Published As
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