ES8202000A1 - Procedimiento para preparar pirimidil-quinazolinas - Google Patents

Procedimiento para preparar pirimidil-quinazolinas

Info

Publication number
ES8202000A1
ES8202000A1 ES500738A ES500738A ES8202000A1 ES 8202000 A1 ES8202000 A1 ES 8202000A1 ES 500738 A ES500738 A ES 500738A ES 500738 A ES500738 A ES 500738A ES 8202000 A1 ES8202000 A1 ES 8202000A1
Authority
ES
Spain
Prior art keywords
formula
quinazolines
procedure
reaction
pirimidil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500738A
Other languages
English (en)
Other versions
ES500738A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella AG
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG, Cassella Farbwerke Mainkur AG filed Critical Cassella AG
Publication of ES500738A0 publication Critical patent/ES500738A0/es
Publication of ES8202000A1 publication Critical patent/ES8202000A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Catching Or Destruction (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PIRIMIDIL-QUINAZOLINAS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO, EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE LA PIPERAZINA CON UN COMPUESTO DE FORMULA (II), SEGUIDA DE LA REACCION CON UN COMPUESTO DE FORMULA (III)), EN LAS QUE R1, R2 Y R3, TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); X ES HALOGENO O UN GRUPO MERCAPTO, T HAL ES HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO, Y A UNA TEMPERATURA ENTRE 20 Y 160 C. LOS REACTIVOS (II) Y (III) SE PUEDEN HACER REACCIONAR CON LA PIPERAZINA EN EL ORDEN INVERSO.
ES500738A 1980-03-27 1981-03-26 Procedimiento para preparar pirimidil-quinazolinas Expired ES8202000A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803011809 DE3011809A1 (de) 1980-03-27 1980-03-27 Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung

Publications (2)

Publication Number Publication Date
ES500738A0 ES500738A0 (es) 1982-01-16
ES8202000A1 true ES8202000A1 (es) 1982-01-16

Family

ID=6098481

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500738A Expired ES8202000A1 (es) 1980-03-27 1981-03-26 Procedimiento para preparar pirimidil-quinazolinas

Country Status (18)

Country Link
EP (1) EP0037495A1 (es)
JP (1) JPS56150088A (es)
AR (1) AR227542A1 (es)
AU (1) AU6877481A (es)
CA (1) CA1156656A (es)
CS (1) CS219898B2 (es)
DD (1) DD157614A5 (es)
DE (1) DE3011809A1 (es)
DK (1) DK115581A (es)
ES (1) ES8202000A1 (es)
FI (1) FI810778L (es)
GR (1) GR71870B (es)
IL (1) IL62495A0 (es)
NO (1) NO810870L (es)
PL (2) PL230320A1 (es)
PT (1) PT72724B (es)
SU (1) SU1052158A3 (es)
ZA (1) ZA812034B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61140568A (ja) * 1984-12-14 1986-06-27 Mitsui Petrochem Ind Ltd キナゾリン誘導体及びそれを有効成分とする血圧降下剤
JPS6267077A (ja) * 1985-09-18 1987-03-26 Mitsui Petrochem Ind Ltd キナゾリン誘導体及び医薬
EA013427B1 (ru) * 2004-03-15 2010-04-30 Такеда Фармасьютикал Компани Лимитед Ингибиторы дипептидилпептидазы
ES2348667T3 (es) * 2004-07-02 2010-12-10 Corcept Therapeutics, Inc. Moduladores de receptores de glucocorticoides de pirimidina modificada.
CN103596431B (zh) 2011-03-18 2016-06-22 科赛普特治疗公司 嘧啶环己基糖皮质激素受体调节剂
SG11202011948SA (en) 2018-06-04 2020-12-30 Corcept Therapeutics Inc Pyrimidine cyclohexenyl glucocorticoid receptor modulators
KR20220113767A (ko) 2019-12-11 2022-08-16 코어셉트 쎄라퓨틱스 인코포레이티드 미리코릴란트로 항정신병약-유도 체중 증가를 치료하는 방법
US11548856B2 (en) 2020-05-06 2023-01-10 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
US12144812B2 (en) 2020-05-06 2024-11-19 Corcept Therapeutics Incorporated Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators
WO2022140293A1 (en) 2020-12-21 2022-06-30 Corcept Therapeutics Incorporated Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2007656B (en) * 1977-11-05 1982-05-19 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
FI810778A7 (fi) 1981-09-28
DD157614A5 (de) 1982-11-24
NO810870L (no) 1981-09-28
PL230320A1 (es) 1982-03-29
DE3011809A1 (de) 1981-10-01
FI810778L (fi) 1981-09-28
DK115581A (da) 1981-09-28
AR227542A1 (es) 1982-11-15
SU1052158A3 (ru) 1983-10-30
CS219898B2 (en) 1983-03-25
CA1156656A (en) 1983-11-08
ES500738A0 (es) 1982-01-16
PT72724A (de) 1981-04-01
EP0037495A1 (de) 1981-10-14
PL233882A1 (es) 1982-05-10
JPS56150088A (en) 1981-11-20
PT72724B (de) 1982-03-24
ZA812034B (en) 1982-05-26
AU6877481A (en) 1981-10-01
GR71870B (es) 1983-07-08
IL62495A0 (en) 1981-05-20

Similar Documents

Publication Publication Date Title
ES8401970A1 (es) Un procedimiento para la preparacion de derivados de benzoisotiazol y benzoisoxazol piperazina.
ES8306155A1 (es) Un procedimiento para la produccion de nuevas cefalosporinas.
ES8301980A1 (es) Procedimiento para la preparacion de 8-arilalcohil-3-fenil-3-nortropanoles .
ES8507479A1 (es) Un metodo para producir un derivado de amina
ES8801642A1 (es) Un procedimiento para la preparacion de l,2,4-triazoles
DK43882A (da) Fremgangsmaade til fremstilling af cephemforbindelser
ES8601992A1 (es) Procedimiento para preparar 2-fenil-imidazoles
ES8603497A1 (es) Procedimiento para preparar derivados de cefalosporina
ES8307824A1 (es) Un procedimiento para preparar nuevos compuestos de cefem.
ES8306749A1 (es) Un procedimiento para la preparacion de 2-guanidino-4-heteroariltiazoles.
ES8604215A1 (es) Un procedimiento para la preparacion de derivados enol-eteres de oxicanis.
ES8202000A1 (es) Procedimiento para preparar pirimidil-quinazolinas
ES8604529A1 (es) Un procedimiento para la preparacion de 1-(4 pirimidiniloxi)-3(heterilalquilamino)-2-propanoles.
ES8305755A1 (es) Procedimiento para preparar derivados de pirimidona.
ES8201116A1 (es) Procedimiento para preparar derivados de 2-nitro-5-(fenoxi sustituido)-benzoilo
ES8205837A1 (es) Un procedimiento para la produccion de derivados de halogeno-triacinilo.
SE8102337L (sv) Radiomottagare
ES8607982A1 (es) Un procedimiento para preparar un derivado de uridina
ES8609246A1 (es) Un procedimiento para preparar un derivado de 3-carbonil-1- aminoalquil-1h-indol
ES8606321A1 (es) Un procedimiento para preparar un derivado de 2-hidroxi-3- (4-fenilpiperazimil)propoxi-benzofurano
ES484255A1 (es) Un procedimiento para la preparacion de derivados de n-ben- cilnalocetamida.
ES8305750A1 (es) "procedimiento de preparacion de nuevas 2-(4-(difenilmetilen)-1-piperidinil)-acetamidas".
ES8702390A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,5-benzotiazepina
ES8304976A1 (es) "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos".
ES8300741A1 (es) Un procedimiento para la preparacion de tiofen-sulfonamidas con actividad insecticida.