ES8604215A1 - Un procedimiento para la preparacion de derivados enol-eteres de oxicanis. - Google Patents

Un procedimiento para la preparacion de derivados enol-eteres de oxicanis.

Info

Publication number
ES8604215A1
ES8604215A1 ES538907A ES538907A ES8604215A1 ES 8604215 A1 ES8604215 A1 ES 8604215A1 ES 538907 A ES538907 A ES 538907A ES 538907 A ES538907 A ES 538907A ES 8604215 A1 ES8604215 A1 ES 8604215A1
Authority
ES
Spain
Prior art keywords
oxicams
inflammatory
prodrugs
ether prodrugs
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538907A
Other languages
English (en)
Other versions
ES538907A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES538907A0 publication Critical patent/ES538907A0/es
Publication of ES8604215A1 publication Critical patent/ES8604215A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS ENOL-ETERES DE OXICAMS, DE FORMULA (I) O (II), EN LAS QUE R Y R1D PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA SAL ANIONICA DE UN COMPUESTO DE FORMULA (III) O (IV) CON UN COMPUESTO DE FORMULA R, EN LAS QUE X ES UN GRUPO DESPLAZABLE NUCLEOLIFICAMENTE, Y R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE ANHIDRO, COMO ACETONA, EN PRESENCIA DE UNA BASE, COMO CARBONATO POTASICO, A UNA TEMPERATURA COMPRENDIDA ENTRE 50JC Y 100JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA.
ES538907A 1983-12-21 1984-12-20 Un procedimiento para la preparacion de derivados enol-eteres de oxicanis. Expired ES8604215A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56390283A 1983-12-21 1983-12-21
US06/606,113 US4551452A (en) 1983-12-21 1984-05-02 Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor

Publications (2)

Publication Number Publication Date
ES538907A0 ES538907A0 (es) 1986-01-16
ES8604215A1 true ES8604215A1 (es) 1986-01-16

Family

ID=27073413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538907A Expired ES8604215A1 (es) 1983-12-21 1984-12-20 Un procedimiento para la preparacion de derivados enol-eteres de oxicanis.

Country Status (26)

Country Link
US (1) US4551452A (es)
EP (1) EP0147177B1 (es)
KR (1) KR860002035B1 (es)
AU (1) AU552940B2 (es)
BG (1) BG47946A3 (es)
CA (1) CA1255302A (es)
DD (1) DD229125A5 (es)
DE (1) DE3466776D1 (es)
DK (1) DK166678B1 (es)
EG (1) EG17049A (es)
ES (1) ES8604215A1 (es)
FI (1) FI79850C (es)
GR (1) GR82512B (es)
HK (1) HK58589A (es)
HU (1) HU201063B (es)
IE (1) IE57680B1 (es)
IL (1) IL73873A (es)
MX (2) MX174596B (es)
NO (1) NO161317C (es)
NZ (1) NZ210632A (es)
PH (1) PH21447A (es)
PL (1) PL145989B1 (es)
PT (1) PT79700B (es)
RO (1) RO90048A (es)
SG (1) SG27001G (es)
YU (1) YU43677B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017567A (en) * 1983-11-25 1991-05-21 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4616012A (en) * 1983-11-25 1986-10-07 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4906635A (en) * 1983-11-25 1990-03-06 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4778795A (en) * 1983-11-25 1988-10-18 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
KR890001236B1 (ko) * 1985-10-02 1989-04-28 화이자 인코포레이티드 소염제 조성물의 제조방법
US4771071A (en) * 1986-05-05 1988-09-13 Merck & Co., Inc. Antihypercholesterolemic compounds
HU199833B (en) * 1986-05-16 1990-03-28 Pfizer Process for producing benzothiazine dioxide derivatives
US5081118A (en) * 1987-10-26 1992-01-14 Pfizer Inc. Benzothiazine dioxide derivatives
NZ226477A (en) * 1987-10-29 1990-07-26 Cl Pharma Substituted thieno (2,3-e)-1,2 thiazine derivatives and pharmaceutical compositions
ZA945190B (en) * 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
CN100389114C (zh) * 2006-01-17 2008-05-21 南京新港医药有限公司 一种安吡昔康的精制方法
US20090238763A1 (en) * 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
JP5378221B2 (ja) * 2006-10-11 2013-12-25 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するオキシカム及び関連化合物の正荷電水溶性プロドラッグ
CN101687792B (zh) 2007-06-04 2016-03-02 于崇曦 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其医药用途
KR101946297B1 (ko) 2008-12-04 2019-02-11 충시 위 고투과력을 가진 조성물 및 이의 적용
WO2013093931A2 (en) 2011-09-19 2013-06-27 Sun Pharma Advanced Research Company Ltd. Novel prodrugs of phenolic drugs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3892740A (en) * 1974-10-15 1975-07-01 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
IT1168064B (it) * 1981-11-12 1987-05-20 Prodotti Antibiotici Spa Composto ad azione antinfiammatoria
IT8219486A0 (it) * 1982-02-05 1982-02-05 Chiesi Farma Spa Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Also Published As

Publication number Publication date
PT79700B (en) 1986-12-30
EG17049A (en) 1991-03-30
DD229125A5 (de) 1985-10-30
DK614984D0 (da) 1984-12-20
NO845145L (no) 1985-06-24
YU216084A (en) 1986-10-31
EP0147177B1 (en) 1987-10-14
NO161317B (no) 1989-04-24
PL145989B1 (en) 1988-12-31
IL73873A0 (en) 1985-03-31
IE843260L (en) 1985-06-21
DK166678B1 (da) 1993-06-28
DE3466776D1 (en) 1987-11-19
US4551452A (en) 1985-11-05
MX9203740A (es) 1992-09-01
PL251040A1 (en) 1985-10-22
YU43677B (en) 1989-10-31
DK614984A (da) 1985-07-17
NZ210632A (en) 1987-02-20
PT79700A (en) 1985-01-01
RO90048A (ro) 1986-09-30
IL73873A (en) 1988-02-29
KR860002035B1 (ko) 1986-11-17
AU552940B2 (en) 1986-06-26
CA1255302A (en) 1989-06-06
PH21447A (en) 1987-10-28
HU201063B (en) 1990-09-28
KR850004492A (ko) 1985-07-15
FI845074L (fi) 1985-06-22
FI79850B (fi) 1989-11-30
BG47946A3 (en) 1990-10-15
SG27001G (en) 1989-08-11
AU3699784A (en) 1985-07-04
EP0147177A2 (en) 1985-07-03
GR82512B (en) 1985-04-22
IE57680B1 (en) 1993-02-24
EP0147177A3 (en) 1985-08-14
MX174596B (es) 1994-05-30
ES538907A0 (es) 1986-01-16
NO161317C (no) 1989-08-02
FI845074A0 (fi) 1984-12-20
HK58589A (en) 1989-07-28
FI79850C (fi) 1990-03-12
HUT37426A (en) 1985-12-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051019